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The map label for this gene is ilvD [H]

Identifier: 13475992

GI number: 13475992

Start: 5939297

End: 5941024

Strand: Reverse

Name: ilvD [H]

Synonym: mll7192

Alternate gene names: 13475992

Gene position: 5941024-5939297 (Counterclockwise)

Preceding gene: 13475993

Following gene: 13475991

Centisome position: 84.44

GC content: 65.16

Gene sequence:

>1728_bases
GTGACCGACACCAAACGCAAACTGCGGTCCGAAGCCTGGTTCGGCGGTGAAGGCAAGAACGCCTTCATGCACCGCAGCTG
GATGAAGAACCAGGGCATCCCGGCCGATGCTTTCGACGGCCGCCCGGTGATCGGCATCTGCAACACATGGTCGGAGCTGA
CGCCGTGCAACGCGCATCTGCGGGCGCTGGCCGATCACGTCAAGCGCGGCGTCTACGAGGCCGGGGGCCTGCCGCTCGAA
TTTCCGGTGATGTCGCTCGGTGAGAGCAACATGCGCCCCACAGCCATGCTGTTTCGCAATCTGGTCAGCATGGATGTAGA
GGAATCCATCCGCGGTAACCCCATCGACGGCGTCATCCTGCTGGTGGGCTGCGACAAGACCACGCCGGCGCTCTTGATGG
GGGCCGCCTCGTGCAATTTGCCGACCATCACCGTTTCCGGCGGGCCGATGCTCAACGGCAAGTTCCGCGGGCATGATATC
GGCTCGGGCACCCATGTCTGGAAATTCGCCGAGGAAGTGAAGGCCGGTCGCATGCCGGTCGCCGACTTCCTCGCCGCGGA
ACAGGGCCAGAGCCGGTCGGCCGGCAGTTGCATGACCATGGGCACGGCCTCGACCATGGCCAGCATGGTGGAAGCGCTCG
GCATCGGCATGCCGGACAACGCCGCGATCCCGGCCGTGGATTCGCGCCGTGGCGTGCTCGCCCAGATGGCTGGACGCCAG
ATCGTCGAGCTGGTCCGCCGGGACGTGAAAATTTCGGACATCCTCACAAGGCAAGCCTTCGAGAACGCCATTCGCGTCAA
TGGCGCGATCGGCGGCTCGACCAATGCGGTGCTGCATCTGATCGCCATCGCCAACCGGGTCGGTGTCGACCTCAGCCTTG
AAGACTGGGACCGCCTTGGCCGCGACGTTCCAACCATTGTCGACCTGATGCCGTCGGGCCGGTTCCTGATGGAAGATTTC
TACTATGCCGGGGGGCTGGCTGCGGTCATGGCGTCGCTTGATGAAGTGGGGCTTCTTCATCGCGACGTCATGACCGTCAG
CGACAAGACGATCGGCGCGTTGATCGACGGAGCGCCCAACTACAACCGCGAGGTCATCCGGCCGCTGAGCGAACCTTTGA
CCGACCAAGGCGGCATCTCGATCCTGCGCGGCAATCTGGCGCCCAACGGCGCGGTCATCAAGCCGTCGGCGGCAACGCCC
GAACTGATGCAGCATCGCGGCAAGGCCGTCGTGTTCGAGGACATCGAGCACTACTACGCCCGCATCGACGATCCAGAGCT
GGATATCGACGCCTCCTCGGTGATGGTGCTGAAAAATTGCGGGCCGCGCGGCTATCCCGGCATGGCCGAGGTCGGCAACA
TGCCGCTGCCGGCGAAGCTGCTCAAGCAGGGCGTCTCCGACATGGTGCGCATCTCGGATGCACGCATGAGCGGCACGGCC
TACGGCACGGTGGTGCTGCATATCGCGCCAGAGGCCGCGGCCGGTGGCGTGCTCGCCCTGGTGCGCGACGGGGATCTGAT
CGAGCTCGACGTCGCCGGCCGCCGCTTGGAGCTTTTGGTGTCGGACGAGGAACTGGCGATCCGTCGCCGCGACTGGAAGC
CGCCGGCGCCGCCCGAAGGCGGATATCAGAGCCTCTATGTCGAGCGCGTGCTGCAGGCCGACAAGGGCTGCGATTTCGAC
TTTCTCGTCGGCCGGCGCGATGCCGGCATCCCCCGGCATTCCCATTAG

Upstream 100 bases:

>100_bases
CGCAAAAGGCACTTTTGGTGCTCATCGACAATGCCGAGGACGACGTGCGCCGCAGCGTCGAGAACCGCAACAAACGCCGC
ACCGATCGGGGCCAGCAATC

Downstream 100 bases:

>100_bases
AGAGGCGCGCGATGACGGATGAAATCGGCTACGCCATCTACCCAAGCCTCAAGGGCCGCAGCGTCTTCATAACCGGCGGC
GGCAGCGGCATCGGCGAAAG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 575; Mature: 574

Protein sequence:

>575_residues
MTDTKRKLRSEAWFGGEGKNAFMHRSWMKNQGIPADAFDGRPVIGICNTWSELTPCNAHLRALADHVKRGVYEAGGLPLE
FPVMSLGESNMRPTAMLFRNLVSMDVEESIRGNPIDGVILLVGCDKTTPALLMGAASCNLPTITVSGGPMLNGKFRGHDI
GSGTHVWKFAEEVKAGRMPVADFLAAEQGQSRSAGSCMTMGTASTMASMVEALGIGMPDNAAIPAVDSRRGVLAQMAGRQ
IVELVRRDVKISDILTRQAFENAIRVNGAIGGSTNAVLHLIAIANRVGVDLSLEDWDRLGRDVPTIVDLMPSGRFLMEDF
YYAGGLAAVMASLDEVGLLHRDVMTVSDKTIGALIDGAPNYNREVIRPLSEPLTDQGGISILRGNLAPNGAVIKPSAATP
ELMQHRGKAVVFEDIEHYYARIDDPELDIDASSVMVLKNCGPRGYPGMAEVGNMPLPAKLLKQGVSDMVRISDARMSGTA
YGTVVLHIAPEAAAGGVLALVRDGDLIELDVAGRRLELLVSDEELAIRRRDWKPPAPPEGGYQSLYVERVLQADKGCDFD
FLVGRRDAGIPRHSH

Sequences:

>Translated_575_residues
MTDTKRKLRSEAWFGGEGKNAFMHRSWMKNQGIPADAFDGRPVIGICNTWSELTPCNAHLRALADHVKRGVYEAGGLPLE
FPVMSLGESNMRPTAMLFRNLVSMDVEESIRGNPIDGVILLVGCDKTTPALLMGAASCNLPTITVSGGPMLNGKFRGHDI
GSGTHVWKFAEEVKAGRMPVADFLAAEQGQSRSAGSCMTMGTASTMASMVEALGIGMPDNAAIPAVDSRRGVLAQMAGRQ
IVELVRRDVKISDILTRQAFENAIRVNGAIGGSTNAVLHLIAIANRVGVDLSLEDWDRLGRDVPTIVDLMPSGRFLMEDF
YYAGGLAAVMASLDEVGLLHRDVMTVSDKTIGALIDGAPNYNREVIRPLSEPLTDQGGISILRGNLAPNGAVIKPSAATP
ELMQHRGKAVVFEDIEHYYARIDDPELDIDASSVMVLKNCGPRGYPGMAEVGNMPLPAKLLKQGVSDMVRISDARMSGTA
YGTVVLHIAPEAAAGGVLALVRDGDLIELDVAGRRLELLVSDEELAIRRRDWKPPAPPEGGYQSLYVERVLQADKGCDFD
FLVGRRDAGIPRHSH
>Mature_574_residues
TDTKRKLRSEAWFGGEGKNAFMHRSWMKNQGIPADAFDGRPVIGICNTWSELTPCNAHLRALADHVKRGVYEAGGLPLEF
PVMSLGESNMRPTAMLFRNLVSMDVEESIRGNPIDGVILLVGCDKTTPALLMGAASCNLPTITVSGGPMLNGKFRGHDIG
SGTHVWKFAEEVKAGRMPVADFLAAEQGQSRSAGSCMTMGTASTMASMVEALGIGMPDNAAIPAVDSRRGVLAQMAGRQI
VELVRRDVKISDILTRQAFENAIRVNGAIGGSTNAVLHLIAIANRVGVDLSLEDWDRLGRDVPTIVDLMPSGRFLMEDFY
YAGGLAAVMASLDEVGLLHRDVMTVSDKTIGALIDGAPNYNREVIRPLSEPLTDQGGISILRGNLAPNGAVIKPSAATPE
LMQHRGKAVVFEDIEHYYARIDDPELDIDASSVMVLKNCGPRGYPGMAEVGNMPLPAKLLKQGVSDMVRISDARMSGTAY
GTVVLHIAPEAAAGGVLALVRDGDLIELDVAGRRLELLVSDEELAIRRRDWKPPAPPEGGYQSLYVERVLQADKGCDFDF
LVGRRDAGIPRHSH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=607, Percent_Identity=31.7957166392092, Blast_Score=265, Evalue=5e-72,
Organism=Escherichia coli, GI2367371, Length=467, Percent_Identity=32.5481798715203, Blast_Score=188, Evalue=9e-49,
Organism=Escherichia coli, GI1788157, Length=516, Percent_Identity=29.0697674418605, Blast_Score=178, Evalue=8e-46,
Organism=Escherichia coli, GI1786464, Length=515, Percent_Identity=31.6504854368932, Blast_Score=172, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6322476, Length=574, Percent_Identity=33.4494773519164, Blast_Score=290, Evalue=4e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 61886; Mature: 61755

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTKRKLRSEAWFGGEGKNAFMHRSWMKNQGIPADAFDGRPVIGICNTWSELTPCNAHL
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCHHHH
RALADHVKRGVYEAGGLPLEFPVMSLGESNMRPTAMLFRNLVSMDVEESIRGNPIDGVIL
HHHHHHHHHHHHHCCCCCEECCHHHCCCCCCCHHHHHHHHHHHHCHHHHCCCCCCCCEEE
LVGCDKTTPALLMGAASCNLPTITVSGGPMLNGKFRGHDIGSGTHVWKFAEEVKAGRMPV
EEECCCCCHHHEEECCCCCCCEEEECCCCEECCEECCCCCCCCCHHHHHHHHHHCCCCCH
ADFLAAEQGQSRSAGSCMTMGTASTMASMVEALGIGMPDNAAIPAVDSRRGVLAQMAGRQ
HHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
IVELVRRDVKISDILTRQAFENAIRVNGAIGGSTNAVLHLIAIANRVGVDLSLEDWDRLG
HHHHHHHCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHC
RDVPTIVDLMPSGRFLMEDFYYAGGLAAVMASLDEVGLLHRDVMTVSDKTIGALIDGAPN
CCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEECCCCC
YNREVIRPLSEPLTDQGGISILRGNLAPNGAVIKPSAATPELMQHRGKAVVFEDIEHYYA
CCHHHHHHHHHCCCCCCCEEEEECCCCCCCCEECCCCCCHHHHHHCCCEEEHHHHHHHHH
RIDDPELDIDASSVMVLKNCGPRGYPGMAEVGNMPLPAKLLKQGVSDMVRISDARMSGTA
HCCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCE
YGTVVLHIAPEAAAGGVLALVRDGDLIELDVAGRRLELLVSDEELAIRRRDWKPPAPPEG
EEEEEEEECCCCCCCCEEEEEECCCEEEEECCCCEEEEEECCHHHHHHHCCCCCCCCCCC
GYQSLYVERVLQADKGCDFDFLVGRRDAGIPRHSH
CHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
TDTKRKLRSEAWFGGEGKNAFMHRSWMKNQGIPADAFDGRPVIGICNTWSELTPCNAHL
CCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCHHHH
RALADHVKRGVYEAGGLPLEFPVMSLGESNMRPTAMLFRNLVSMDVEESIRGNPIDGVIL
HHHHHHHHHHHHHCCCCCEECCHHHCCCCCCCHHHHHHHHHHHHCHHHHCCCCCCCCEEE
LVGCDKTTPALLMGAASCNLPTITVSGGPMLNGKFRGHDIGSGTHVWKFAEEVKAGRMPV
EEECCCCCHHHEEECCCCCCCEEEECCCCEECCEECCCCCCCCCHHHHHHHHHHCCCCCH
ADFLAAEQGQSRSAGSCMTMGTASTMASMVEALGIGMPDNAAIPAVDSRRGVLAQMAGRQ
HHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
IVELVRRDVKISDILTRQAFENAIRVNGAIGGSTNAVLHLIAIANRVGVDLSLEDWDRLG
HHHHHHHCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHC
RDVPTIVDLMPSGRFLMEDFYYAGGLAAVMASLDEVGLLHRDVMTVSDKTIGALIDGAPN
CCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEECCCCC
YNREVIRPLSEPLTDQGGISILRGNLAPNGAVIKPSAATPELMQHRGKAVVFEDIEHYYA
CCHHHHHHHHHCCCCCCCEEEEECCCCCCCCEECCCCCCHHHHHHCCCEEEHHHHHHHHH
RIDDPELDIDASSVMVLKNCGPRGYPGMAEVGNMPLPAKLLKQGVSDMVRISDARMSGTA
HCCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCE
YGTVVLHIAPEAAAGGVLALVRDGDLIELDVAGRRLELLVSDEELAIRRRDWKPPAPPEG
EEEEEEEECCCCCCCCEEEEEECCCEEEEECCCCEEEEEECCHHHHHHHCCCCCCCCCCC
GYQSLYVERVLQADKGCDFDFLVGRRDAGIPRHSH
CHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]