Click here to switch to the map view.

The map label for this gene is yogA [H]

Identifier: 13475934

GI number: 13475934

Start: 5882855

End: 5883925

Strand: Reverse

Name: yogA [H]

Synonym: mll7125

Alternate gene names: 13475934

Gene position: 5883925-5882855 (Counterclockwise)

Preceding gene: 13475935

Following gene: 13475933

Centisome position: 83.63

GC content: 65.36

Gene sequence:

>1071_bases
ATGGCCGCCGTGCTGCTCACCGGGCACGGCGGACCGGAAAAACTCGTCTACCGCACCGACGTGAAAGTGCCCTCGCCTGA
CCCTGGTGAAGTGCTGGTCGAGGTCAGCGCCTGCGGGATGAACAACACCGACGTCTGGGTGCGCCAGGGCGCCTATGGCA
CGGAAGAGGACGCGGCCGCCGTGTCGACCTGGCGGCGTCAGGGCAACACGCTTGTTTTCCCGCGCATCCAGGGCACCGAC
ACGGTTGGCACCATCGTTTCCGTTGGCGAAGGCGTTTCGCCGGAGCGGATCGGTGAGCGGGTGATGGTCGATTTCTCCAT
CTACAACCGCGATGACGATTCACTCGCCGACATCGACTATATGGGTCATGGCCGCGACGGTGGTTATGCCGAATACCAGA
CCGTGCCTGCCGAGAACGCCCATGTCGTCGATACTGATATGAGCGATGTCGAGCTCGCCACCTTCTGCTGCGCCTACCTG
ACCGGCGAACAGATGCTGGAACGCGCCGGCTTGAAGGCCGGTGAGCGTGTGCTGGTCACCGGCGCTTCGGGCGGCGTCGG
CTCCGGCATCGTCCAGCTGGCGCGGGCGCGCGGCGCCATTCCCTATGCCGTCGTCGGCAAGGGCAAGGAACAGGCGGTGC
TCGACATCGGCGCCGAGGCCGTCATCACCCGCGGCGTCGCTGACCTGCCGCGGGCCGTGGCTGAAGTGACCGGCGGCCAG
CCGATCGACGTGGTCGCCGATCTCGTCGGCGGCGCGATCTTCAACGACCTGCTGCGTATTCTCAGGCCCGAAGGCCGCTA
CACCACCGCCGGTGCAATCGCCGGGCCGGTGGTGCAGCTCGATCTCAGGACCATGTATCTCAAGCAATTGCAGCTGCATG
GCTCGAGCCAGGGCACGCGCGCGGATTTCCGCCGTATCGTCGGCTATATCGAGGCGAAAAAGATCCGGCCGCTGGTCGGA
GGTGTCTACAGGCTCTCCGATTTCCACCGCGCACAGGCGGATTTCGTCGCCAAGGATTTTGTCGGCAAGCTGGTGGTCGT
CCCCGATGCCATCGCGGAGCGGCAGGCATAG

Upstream 100 bases:

>100_bases
CCGACATCGTCGTCTCGAAGACTGCGGATGCGGTGAAGAGTGTGTTTGCCAATCTCTGAGATCGACGATGACTGCCATGA
CCACAACCGTCCCTGCCACC

Downstream 100 bases:

>100_bases
TTTCCTGATCCTCGCTCTGGCCACCTTCTCGCCGCTGCCCCAATGGGAATGGCTTGCAGTCGCGTCTGCGAGCCGTCACA
AACGGCTACGCCCGTTGTAA

Product: alcohol dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MAAVLLTGHGGPEKLVYRTDVKVPSPDPGEVLVEVSACGMNNTDVWVRQGAYGTEEDAAAVSTWRRQGNTLVFPRIQGTD
TVGTIVSVGEGVSPERIGERVMVDFSIYNRDDDSLADIDYMGHGRDGGYAEYQTVPAENAHVVDTDMSDVELATFCCAYL
TGEQMLERAGLKAGERVLVTGASGGVGSGIVQLARARGAIPYAVVGKGKEQAVLDIGAEAVITRGVADLPRAVAEVTGGQ
PIDVVADLVGGAIFNDLLRILRPEGRYTTAGAIAGPVVQLDLRTMYLKQLQLHGSSQGTRADFRRIVGYIEAKKIRPLVG
GVYRLSDFHRAQADFVAKDFVGKLVVVPDAIAERQA

Sequences:

>Translated_356_residues
MAAVLLTGHGGPEKLVYRTDVKVPSPDPGEVLVEVSACGMNNTDVWVRQGAYGTEEDAAAVSTWRRQGNTLVFPRIQGTD
TVGTIVSVGEGVSPERIGERVMVDFSIYNRDDDSLADIDYMGHGRDGGYAEYQTVPAENAHVVDTDMSDVELATFCCAYL
TGEQMLERAGLKAGERVLVTGASGGVGSGIVQLARARGAIPYAVVGKGKEQAVLDIGAEAVITRGVADLPRAVAEVTGGQ
PIDVVADLVGGAIFNDLLRILRPEGRYTTAGAIAGPVVQLDLRTMYLKQLQLHGSSQGTRADFRRIVGYIEAKKIRPLVG
GVYRLSDFHRAQADFVAKDFVGKLVVVPDAIAERQA
>Mature_355_residues
AAVLLTGHGGPEKLVYRTDVKVPSPDPGEVLVEVSACGMNNTDVWVRQGAYGTEEDAAAVSTWRRQGNTLVFPRIQGTDT
VGTIVSVGEGVSPERIGERVMVDFSIYNRDDDSLADIDYMGHGRDGGYAEYQTVPAENAHVVDTDMSDVELATFCCAYLT
GEQMLERAGLKAGERVLVTGASGGVGSGIVQLARARGAIPYAVVGKGKEQAVLDIGAEAVITRGVADLPRAVAEVTGGQP
IDVVADLVGGAIFNDLLRILRPEGRYTTAGAIAGPVVQLDLRTMYLKQLQLHGSSQGTRADFRRIVGYIEAKKIRPLVGG
VYRLSDFHRAQADFVAKDFVGKLVVVPDAIAERQA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=356, Percent_Identity=25.561797752809, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI13236495, Length=356, Percent_Identity=25.561797752809, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI22538446, Length=363, Percent_Identity=25.8953168044077, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI22538444, Length=363, Percent_Identity=25.8953168044077, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI194239676, Length=226, Percent_Identity=30.9734513274336, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI24308257, Length=376, Percent_Identity=26.5957446808511, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI18379349, Length=375, Percent_Identity=25.3333333333333, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1790485, Length=308, Percent_Identity=27.5974025974026, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1787863, Length=314, Percent_Identity=23.8853503184713, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17507255, Length=357, Percent_Identity=26.6106442577031, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=321, Percent_Identity=26.4797507788162, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71988145, Length=321, Percent_Identity=22.7414330218069, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562582, Length=300, Percent_Identity=24, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6319621, Length=347, Percent_Identity=27.6657060518732, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323961, Length=311, Percent_Identity=27.9742765273312, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6323729, Length=317, Percent_Identity=26.4984227129338, Blast_Score=96, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6324486, Length=325, Percent_Identity=28.6153846153846, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319520, Length=357, Percent_Identity=24.6498599439776, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 37901; Mature: 37770

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAVLLTGHGGPEKLVYRTDVKVPSPDPGEVLVEVSACGMNNTDVWVRQGAYGTEEDAAA
CEEEEEECCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCCCEEEECCCCCCCHHHHH
VSTWRRQGNTLVFPRIQGTDTVGTIVSVGEGVSPERIGERVMVDFSIYNRDDDSLADIDY
HHHHHHCCCEEEEEEECCCCHHHHHHHCCCCCCHHHCCCEEEEEEEEECCCCCCCCCEEE
MGHGRDGGYAEYQTVPAENAHVVDTDMSDVELATFCCAYLTGEQMLERAGLKAGERVLVT
CCCCCCCCCCEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
GASGGVGSGIVQLARARGAIPYAVVGKGKEQAVLDIGAEAVITRGVADLPRAVAEVTGGQ
ECCCCCHHHHHHHHHHCCCCCEEEECCCCCCEEECCCHHHHHHCCHHHHHHHHHHHCCCC
PIDVVADLVGGAIFNDLLRILRPEGRYTTAGAIAGPVVQLDLRTMYLKQLQLHGSSQGTR
HHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEEHHHHHHHHHHHHCCCCCCCH
ADFRRIVGYIEAKKIRPLVGGVYRLSDFHRAQADFVAKDFVGKLVVVPDAIAERQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCHHHCCCC
>Mature Secondary Structure 
AAVLLTGHGGPEKLVYRTDVKVPSPDPGEVLVEVSACGMNNTDVWVRQGAYGTEEDAAA
EEEEEECCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCCCEEEECCCCCCCHHHHH
VSTWRRQGNTLVFPRIQGTDTVGTIVSVGEGVSPERIGERVMVDFSIYNRDDDSLADIDY
HHHHHHCCCEEEEEEECCCCHHHHHHHCCCCCCHHHCCCEEEEEEEEECCCCCCCCCEEE
MGHGRDGGYAEYQTVPAENAHVVDTDMSDVELATFCCAYLTGEQMLERAGLKAGERVLVT
CCCCCCCCCCEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
GASGGVGSGIVQLARARGAIPYAVVGKGKEQAVLDIGAEAVITRGVADLPRAVAEVTGGQ
ECCCCCHHHHHHHHHHCCCCCEEEECCCCCCEEECCCHHHHHHCCHHHHHHHHHHHCCCC
PIDVVADLVGGAIFNDLLRILRPEGRYTTAGAIAGPVVQLDLRTMYLKQLQLHGSSQGTR
HHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEEHHHHHHHHHHHHCCCCCCCH
ADFRRIVGYIEAKKIRPLVGGVYRLSDFHRAQADFVAKDFVGKLVVVPDAIAERQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]