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The map label for this gene is hutH [H]

Identifier: 13475933

GI number: 13475933

Start: 5881219

End: 5882715

Strand: Reverse

Name: hutH [H]

Synonym: mll7124

Alternate gene names: 13475933

Gene position: 5882715-5881219 (Counterclockwise)

Preceding gene: 13475934

Following gene: 13475932

Centisome position: 83.61

GC content: 67.94

Gene sequence:

>1497_bases
ATGACAGCCCGGATAGTACTGCTCGACGCCAAGCCGCTCGGCGTGGCTGACGTCGCCGAGATCGCACGCCGCAACGCCCG
GTTGATGCTGGGCGAAGAAGCGATGCGCCGAATCCGGGCGAGCCGCGCCCTCATCGAACATCTGACCGGGCTTGGCAAAC
CGATGTACGGCGTCACCACAGGCCTCGGCGCCTGTGTCGACACGCCGCTCGCGCAGGCCGACCTGATCGCCTTCCAGCAC
AGCGTGCCGCTCAGCCACAGCATGGGCATCGGACCGGCGCTCCCGACAGAGGCGGTGCGGGCGCTGATGACCGCGCGCAT
TTCAGGTATGGCCGCCGGTGGCACCGGCACCTCCGAACGCGTGGTGATGGGCCTTGTCGCCGCGCTCAATGCCGGCGTGC
ATCCGGTGATCCCGACCTGGGGCTCGATCGGCGCGGCCGATCTTGCTCATCTCGGCCATATGGCGAGGTCGCTGCGCGGC
GATGGCGAGGCGGAGTTCCAGGGCCGGATCATGCCCTCCGCCGAGGCGCTTGCCTTGGCCCGGCTCGAGCCGCTCGACCT
GCGCGAAAAGGACGGCCACGCCATCATCGTCGCCAACAGCCTGTCGACCGGAACGGCGTGCCTGTACCTTGAAGACGTCG
CCCATCTCATCGACTGGGCGCTGGCCGCCGTGGCGCTCAACTACGAGGCGTTCCGCTCGTCCCTCACCGCGATCGACGAA
CAGGCGCTTGCCGCGCGGCCGGCCTTCGGCCAGCGCGAGATCGGCGCGCGGTTGCGCGCGGAACTAGCCGGAAGCGGCCT
TTGGCAGGACAAGGCGGCACGGCGCTTGCAGGATCCGCTCAGCTATCGCTGCGTGCCGCAGGTCTGGGGTGGCCTGCTCA
ATGCGTTCGAACAGGCAAGGCTAGCGACCGAGATCGAACTGACCCATTCCGGCGATAATCCCGTGATCCTGGCCGAGGGC
GAACGGGTGATTTCCAACGGCAATTTCGACCTGACGGCGATGACGCTGGCCTGGGAGCAACTGGGCCAGGCGCTCGCGCA
TTGCGCCGTCGGCACCGCCAATCGCTGCATGAAGCTGATGTCGCCGACAACAGCCGAACTGCCGCGCTTCCTGTCGGCCA
GGGGCGGCAGCCGCCAGGGCTATGCGGAACTGCAAAAACCCTTGTCCGCGCTGGAGGCCGAAATTCGGCATCTGGCCAAC
CCGATGTCACTCAGCCCGCTCGCGGTGTCGGACGGCATCGAGGATCAGTCGTCGATGGCGCCCAGGGTGGTGGCCAAAAC
CGCTGAGATCGTCGAGCGCATGCGCTATCTCGTGGCGATGGAGCTGATCTTCGCGGCGACGGGTGTGGAGTTGCGCGGTG
TCGTCGACACCATGGGTGAAGGGCCGCAGCGCACCTTCGCCGCCGTGCGCGCGCTCGTCAGCCCGCTCGACGACGACCGC
GAGATGAGCACCGACATGACGCGGGTGGCGCGGATGGTGGCGGGTCCGCGCTGCTGA

Upstream 100 bases:

>100_bases
CCAATGGGAATGGCTTGCAGTCGCGTCTGCGAGCCGTCACAAACGGCTACGCCCGTTGTAATGCTGGTCCGGGCATCTGG
TCACAGGATACAGGCAAGAC

Downstream 100 bases:

>100_bases
GCCGAGGGCCGATCCGCCAGGATCGGTATCCGGATTTTCCGGCGCGAACCTAGGCGTCAAGCACCAACGCGCGCGGCCCG
CTACCAGGGCCATCGGTGTG

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MTARIVLLDAKPLGVADVAEIARRNARLMLGEEAMRRIRASRALIEHLTGLGKPMYGVTTGLGACVDTPLAQADLIAFQH
SVPLSHSMGIGPALPTEAVRALMTARISGMAAGGTGTSERVVMGLVAALNAGVHPVIPTWGSIGAADLAHLGHMARSLRG
DGEAEFQGRIMPSAEALALARLEPLDLREKDGHAIIVANSLSTGTACLYLEDVAHLIDWALAAVALNYEAFRSSLTAIDE
QALAARPAFGQREIGARLRAELAGSGLWQDKAARRLQDPLSYRCVPQVWGGLLNAFEQARLATEIELTHSGDNPVILAEG
ERVISNGNFDLTAMTLAWEQLGQALAHCAVGTANRCMKLMSPTTAELPRFLSARGGSRQGYAELQKPLSALEAEIRHLAN
PMSLSPLAVSDGIEDQSSMAPRVVAKTAEIVERMRYLVAMELIFAATGVELRGVVDTMGEGPQRTFAAVRALVSPLDDDR
EMSTDMTRVARMVAGPRC

Sequences:

>Translated_498_residues
MTARIVLLDAKPLGVADVAEIARRNARLMLGEEAMRRIRASRALIEHLTGLGKPMYGVTTGLGACVDTPLAQADLIAFQH
SVPLSHSMGIGPALPTEAVRALMTARISGMAAGGTGTSERVVMGLVAALNAGVHPVIPTWGSIGAADLAHLGHMARSLRG
DGEAEFQGRIMPSAEALALARLEPLDLREKDGHAIIVANSLSTGTACLYLEDVAHLIDWALAAVALNYEAFRSSLTAIDE
QALAARPAFGQREIGARLRAELAGSGLWQDKAARRLQDPLSYRCVPQVWGGLLNAFEQARLATEIELTHSGDNPVILAEG
ERVISNGNFDLTAMTLAWEQLGQALAHCAVGTANRCMKLMSPTTAELPRFLSARGGSRQGYAELQKPLSALEAEIRHLAN
PMSLSPLAVSDGIEDQSSMAPRVVAKTAEIVERMRYLVAMELIFAATGVELRGVVDTMGEGPQRTFAAVRALVSPLDDDR
EMSTDMTRVARMVAGPRC
>Mature_497_residues
TARIVLLDAKPLGVADVAEIARRNARLMLGEEAMRRIRASRALIEHLTGLGKPMYGVTTGLGACVDTPLAQADLIAFQHS
VPLSHSMGIGPALPTEAVRALMTARISGMAAGGTGTSERVVMGLVAALNAGVHPVIPTWGSIGAADLAHLGHMARSLRGD
GEAEFQGRIMPSAEALALARLEPLDLREKDGHAIIVANSLSTGTACLYLEDVAHLIDWALAAVALNYEAFRSSLTAIDEQ
ALAARPAFGQREIGARLRAELAGSGLWQDKAARRLQDPLSYRCVPQVWGGLLNAFEQARLATEIELTHSGDNPVILAEGE
RVISNGNFDLTAMTLAWEQLGQALAHCAVGTANRCMKLMSPTTAELPRFLSARGGSRQGYAELQKPLSALEAEIRHLANP
MSLSPLAVSDGIEDQSSMAPRVVAKTAEIVERMRYLVAMELIFAATGVELRGVVDTMGEGPQRTFAAVRALVSPLDDDRE
MSTDMTRVARMVAGPRC

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=501, Percent_Identity=28.7425149700599, Blast_Score=195, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI17567831, Length=504, Percent_Identity=27.3809523809524, Blast_Score=177, Evalue=8e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53042; Mature: 52911

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARIVLLDAKPLGVADVAEIARRNARLMLGEEAMRRIRASRALIEHLTGLGKPMYGVTT
CCEEEEEEECCCCCHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
GLGACVDTPLAQADLIAFQHSVPLSHSMGIGPALPTEAVRALMTARISGMAAGGTGTSER
HHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCEECCCCCCHHH
VVMGLVAALNAGVHPVIPTWGSIGAADLAHLGHMARSLRGDGEAEFQGRIMPSAEALALA
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
RLEPLDLREKDGHAIIVANSLSTGTACLYLEDVAHLIDWALAAVALNYEAFRSSLTAIDE
HCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QALAARPAFGQREIGARLRAELAGSGLWQDKAARRLQDPLSYRCVPQVWGGLLNAFEQAR
HHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
LATEIELTHSGDNPVILAEGERVISNGNFDLTAMTLAWEQLGQALAHCAVGTANRCMKLM
HHHEEEEEECCCCCEEEECCCEEECCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SPTTAELPRFLSARGGSRQGYAELQKPLSALEAEIRHLANPMSLSPLAVSDGIEDQSSMA
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCHHHCC
PRVVAKTAEIVERMRYLVAMELIFAATGVELRGVVDTMGEGPQRTFAAVRALVSPLDDDR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCH
EMSTDMTRVARMVAGPRC
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TARIVLLDAKPLGVADVAEIARRNARLMLGEEAMRRIRASRALIEHLTGLGKPMYGVTT
CEEEEEEECCCCCHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
GLGACVDTPLAQADLIAFQHSVPLSHSMGIGPALPTEAVRALMTARISGMAAGGTGTSER
HHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCEECCCCCCHHH
VVMGLVAALNAGVHPVIPTWGSIGAADLAHLGHMARSLRGDGEAEFQGRIMPSAEALALA
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
RLEPLDLREKDGHAIIVANSLSTGTACLYLEDVAHLIDWALAAVALNYEAFRSSLTAIDE
HCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QALAARPAFGQREIGARLRAELAGSGLWQDKAARRLQDPLSYRCVPQVWGGLLNAFEQAR
HHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
LATEIELTHSGDNPVILAEGERVISNGNFDLTAMTLAWEQLGQALAHCAVGTANRCMKLM
HHHEEEEEECCCCCEEEECCCEEECCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SPTTAELPRFLSARGGSRQGYAELQKPLSALEAEIRHLANPMSLSPLAVSDGIEDQSSMA
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCHHHCC
PRVVAKTAEIVERMRYLVAMELIFAATGVELRGVVDTMGEGPQRTFAAVRALVSPLDDDR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCH
EMSTDMTRVARMVAGPRC
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA