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The map label for this gene is hcaR [H]

Identifier: 13475875

GI number: 13475875

Start: 5816831

End: 5817781

Strand: Reverse

Name: hcaR [H]

Synonym: mll7054

Alternate gene names: 13475875

Gene position: 5817781-5816831 (Counterclockwise)

Preceding gene: 13475880

Following gene: 13475873

Centisome position: 82.69

GC content: 57.62

Gene sequence:

>951_bases
ATGGAGCTGAGACACCTTCGATATTTCATCGCTGTCGCCGAGGAGGGGAGCGTGACAGTCGCGGCCGAGCGCCGTCTGCA
CACTGCGCAACCTTCGCTCAGCCGTCAGATCCGGGATCTAGAGCACCAAGTGGGTGCCCAGCTCATGGTCCGCAGCGCGC
GGGGTATCGAGCTGACCCCCGCCGGCCGGATCTTCCTCGATCATGCCAGATTAGTGCTCGCTCAGGTCGAGGCTGCCGGT
GAAGCGGCCCGCCGTGCCGCGGAACCAGGCAAGCTTTCCTTCGCCCTTGGCTTTCTGACTGGACAGGAGATTGACTGGCT
GCCCGAGGCTATGCGCATTCTTCACGATGAACTTCCCAATTTGGAGGTCATCGTCTCCAGCCAGTTTTCACCGCAACTCG
CCAACGCACTCACGAGGGGAAAACTCGACGTCGCCTTCATGCGACCGGAGGCGCAAAGTGCTGATCTAACCTACAGACTG
ATCACGAAGGAGCCGCTTGTCGCCGTTTTGCCGAGCGATCACCGACTTGCTGAGCGCGATTCCATAGACCCGCAAGACAT
TGTGGGCGAAACGTTTATCAGCGTCTCGAATACCGCGCCCACACTACGGGTTGTCATTGAGGAGTATCTCGAACGGTCCA
ATCTTGGTATCCGGCCAGATCACGAGGTCGACAATCTCGCAATGGCAATGTCTCTGGTCGCCTCGACGCGAGGCGTAGCC
TTCTTGCCAGCCTACGCAAAGAGCTTCATGCCCTGGTCCGTGATCAGCCGTCCCATAAGTGGCGATACGCCGACGATTGA
TCTGGTGATCGGCTACAATAAAGCCAATGCATCACCGACGCTAAAACTGTTCCTTTCGAGGATAGACGATCTGATCGGTC
GCGTAGCGAAAAACTATGACCGTGACTTCCAAGGAATAGGACGGTCAGAGAACCTGACTCCGCGTGTTTGA

Upstream 100 bases:

>100_bases
CGAACCAGGACGCTTGCCTTGGAAGCAACGTAGGTTCTTCTGGCATTGCAGGAAAAGACTTTGTAGGCTTGAAGTCATAC
CTCACAGGCATGAGCGACGC

Downstream 100 bases:

>100_bases
GCACGGCACGTCCTGCTTCAGCATTTAGGCCTATGGTCAGCTGATGTTTGTCGCCCGTTGCTTCTGAGCGGTTAAGAGCG
CGAACGCGAACGGCATTGTG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MELRHLRYFIAVAEEGSVTVAAERRLHTAQPSLSRQIRDLEHQVGAQLMVRSARGIELTPAGRIFLDHARLVLAQVEAAG
EAARRAAEPGKLSFALGFLTGQEIDWLPEAMRILHDELPNLEVIVSSQFSPQLANALTRGKLDVAFMRPEAQSADLTYRL
ITKEPLVAVLPSDHRLAERDSIDPQDIVGETFISVSNTAPTLRVVIEEYLERSNLGIRPDHEVDNLAMAMSLVASTRGVA
FLPAYAKSFMPWSVISRPISGDTPTIDLVIGYNKANASPTLKLFLSRIDDLIGRVAKNYDRDFQGIGRSENLTPRV

Sequences:

>Translated_316_residues
MELRHLRYFIAVAEEGSVTVAAERRLHTAQPSLSRQIRDLEHQVGAQLMVRSARGIELTPAGRIFLDHARLVLAQVEAAG
EAARRAAEPGKLSFALGFLTGQEIDWLPEAMRILHDELPNLEVIVSSQFSPQLANALTRGKLDVAFMRPEAQSADLTYRL
ITKEPLVAVLPSDHRLAERDSIDPQDIVGETFISVSNTAPTLRVVIEEYLERSNLGIRPDHEVDNLAMAMSLVASTRGVA
FLPAYAKSFMPWSVISRPISGDTPTIDLVIGYNKANASPTLKLFLSRIDDLIGRVAKNYDRDFQGIGRSENLTPRV
>Mature_316_residues
MELRHLRYFIAVAEEGSVTVAAERRLHTAQPSLSRQIRDLEHQVGAQLMVRSARGIELTPAGRIFLDHARLVLAQVEAAG
EAARRAAEPGKLSFALGFLTGQEIDWLPEAMRILHDELPNLEVIVSSQFSPQLANALTRGKLDVAFMRPEAQSADLTYRL
ITKEPLVAVLPSDHRLAERDSIDPQDIVGETFISVSNTAPTLRVVIEEYLERSNLGIRPDHEVDNLAMAMSLVASTRGVA
FLPAYAKSFMPWSVISRPISGDTPTIDLVIGYNKANASPTLKLFLSRIDDLIGRVAKNYDRDFQGIGRSENLTPRV

Specific function: Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788887, Length=296, Percent_Identity=35.472972972973, Blast_Score=177, Evalue=6e-46,
Organism=Escherichia coli, GI1787879, Length=249, Percent_Identity=32.1285140562249, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790262, Length=251, Percent_Identity=31.0756972111554, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1790399, Length=246, Percent_Identity=28.4552845528455, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788297, Length=247, Percent_Identity=28.7449392712551, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI145693105, Length=254, Percent_Identity=25.1968503937008, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI2367136, Length=300, Percent_Identity=29, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI157672245, Length=241, Percent_Identity=28.6307053941909, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI87081904, Length=203, Percent_Identity=30.0492610837438, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787601, Length=145, Percent_Identity=32.4137931034483, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787806, Length=251, Percent_Identity=25.8964143426295, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787530, Length=146, Percent_Identity=29.4520547945205, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789204, Length=274, Percent_Identity=27.007299270073, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788748, Length=246, Percent_Identity=23.5772357723577, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082132, Length=296, Percent_Identity=22.972972972973, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34941; Mature: 34941

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRHLRYFIAVAEEGSVTVAAERRLHTAQPSLSRQIRDLEHQVGAQLMVRSARGIELTP
CCHHHEEEEEEEECCCCEEEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
AGRIFLDHARLVLAQVEAAGEAARRAAEPGKLSFALGFLTGQEIDWLPEAMRILHDELPN
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCC
LEVIVSSQFSPQLANALTRGKLDVAFMRPEAQSADLTYRLITKEPLVAVLPSDHRLAERD
EEEEEECCCCHHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCCCEEEECCCCCCHHHCC
SIDPQDIVGETFISVSNTAPTLRVVIEEYLERSNLGIRPDHEVDNLAMAMSLVASTRGVA
CCCHHHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCE
FLPAYAKSFMPWSVISRPISGDTPTIDLVIGYNKANASPTLKLFLSRIDDLIGRVAKNYD
EEHHHHHHCCCHHHHCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC
RDFQGIGRSENLTPRV
CHHHCCCCCCCCCCCC
>Mature Secondary Structure
MELRHLRYFIAVAEEGSVTVAAERRLHTAQPSLSRQIRDLEHQVGAQLMVRSARGIELTP
CCHHHEEEEEEEECCCCEEEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
AGRIFLDHARLVLAQVEAAGEAARRAAEPGKLSFALGFLTGQEIDWLPEAMRILHDELPN
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCC
LEVIVSSQFSPQLANALTRGKLDVAFMRPEAQSADLTYRLITKEPLVAVLPSDHRLAERD
EEEEEECCCCHHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCCCEEEECCCCCCHHHCC
SIDPQDIVGETFISVSNTAPTLRVVIEEYLERSNLGIRPDHEVDNLAMAMSLVASTRGVA
CCCHHHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCE
FLPAYAKSFMPWSVISRPISGDTPTIDLVIGYNKANASPTLKLFLSRIDDLIGRVAKNYD
EEHHHHHHCCCHHHHCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC
RDFQGIGRSENLTPRV
CHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 9603882 [H]