Click here to switch to the map view.

The map label for this gene is hyuA [H]

Identifier: 13475850

GI number: 13475850

Start: 5788809

End: 5790887

Strand: Direct

Name: hyuA [H]

Synonym: mlr7024

Alternate gene names: 13475850

Gene position: 5788809-5790887 (Clockwise)

Preceding gene: 13475849

Following gene: 13475851

Centisome position: 82.27

GC content: 66.04

Gene sequence:

>2079_bases
ATGGATGGTGCCATCGCGGCGGACGAGGCGCGGAACCAAGCTGACTGGAAGGTCGGCGTTGATATCGGCGGCACATTCAT
CGATTTCTGTGCGCTCGAAGCAAATTCCGGGCGCGTTGCCTCGCTGAAAGTGCTGACGACGCCGGAGGATCCGGGCGCCG
AGCTGATGACGGGCCTCAGGCTGCTTGCTGAGCGCGAAGGCTTTGACCCCACCCGCATGACGCGCTTCGTGCACGGAACG
ACCGTCGGCATCAACACCATCATCCAGCGCAAGGGCGCGCCGCTGGCGCTGTTCACCAATGCCGGCTTCGAGGACGTGAT
CGAACTTGCGCGGCTGCGCATGCCGGATATGTATTCGCTGTTCTGCTCGCGGCCGGACCCGCTGATCTCGCGCGACATGG
TGTTCGGCATCCCGACCCGCATGCGTGCCGATGGGAGCGAATCCCAGGCGCCTGATATGGTGGCGGTGGAGAAGGCGGTG
GCCGCGGCGAAAGCGAACGGCGCCCTAGGCATCATCGTCTGTTTTCTCCATGCCTGGCGCAACGCCGCGCAGGAAGCCTC
GGTCAAAGCGGCCATCGCTCGTCTTGCGCCTGATCTCTTCGTCTTCTCTTCGGCCGAGGTGTGGCCGGTCATCCGCGAAT
ATGAGCGCAGTTCGACCGCCATCCTCAACGGCTATGTCCATCCGCGCGTCTCATCCTACCTGACGGCGCTGGAAGCGCGG
CTGAAGGACCGCGGCGTGCCTGCCCGCCCGATGCTGACCAAGTCGAATGGCGGGCTGATGAACGCGGCCGAAGGCAAGCG
CGCCTGCGTGAACATGCTTTTGTCGGGAACGGCCTCCGGCGTCATCGGCGCCTCGTGGCTGGCGCGCCAGGCTGGTGAAA
ACAGGATCCTTACCCTGGACATTGGAGGGACCTCGGCCGACTTCGCGCTCATCATCGACGGCGAGCCGCAGTTCGGGACA
GGTGAGCTTATCGGCGAATTCCCGCTCCATATCCCGTCCGTGTCGGTCAGCTCGATCGGTGTCGGCGGCGGCTCGATCGC
CAGCGTCGATGCTCAAACGGTGCTGCGGGTCGGGCCGGAGTCGGCCGGTTCGACACCTGGGCCAGCCTGCTATGGCCGTG
GCGGCGAACGTGCGACGGTGACGGACGCCATGGTGGTGTGCGGATGGCTCGGCCACAGCGAGATGGCCTATGGCCAGCTC
AGGATCGATACCCAACTGGCGCATCGCGCGGTTGGCGACCTTGCCGCCCGGCTCGGCCGCACGGTCGAGCAGACGGCGCA
GGCGATCCTCGATATCGCGGTGTCGGAAATGTTCGTCGAGGTCGAGAAGCTCGCTTCGCGCGCCGGCGTCGACTTGCGCG
ATTTCACGCTGATGCCCTTTGGTGGCGGCGGCCCGATGCTCGGCGCCTTTCTTGCCCGCGAGCTCGGGATGAAGCGCGTC
ATGGCGCCCCGCCGCCCCGGCGTGGTGTCGGCGCTGGGCGGGCTGGTGGCGAATCTGCGAAGCGACTTCATCCGCACCGT
CTTCACCCCGCTGTCGGGCGCTACGCTCCCGGCAATTCGCGAGGCCTTCGAGGCGCTCGCGCATGAGGGGCGCGGCTGGC
TTGCGGCGCAGGGGCACGACGCGGCGGCGGAACTCACTCTGTCCTGCGACATGCGCTACTTCGGCCAAAGCTATGAGATC
GAGGTCGTCCTTTCGCCGGAATGGCTGACGGACGACGACGTAGCGCCTATCGAGCAGGCCTTCCATCTTACCCATCAGAG
GCTTTACGATTTCCACGACCCGGATGGCGAGGTCGAGCTTGTGGATATCAGGCTGTCCGCCATAGGCGCCGGGCCGAAAC
TCTCCCTCCCGGAGACCGAAGAAGTGGACGTTGCTGCCATCCCGGCGCGCCGGCTCCCTGTCTATACGGGCCTCCGCGTC
GAAACCGTCGACCTCCACGACCGGCAGGCCCTCGTCCCGGGCAGCACGTTCCACGGGCCTGCCGTGGTCGTTCAGGAAGA
CACCACCTTCGCCATTCCCGCCGGAGCGCAGGCACGGGTAGACCGCCATCTCAACCTTCTGCTGACCTTCGCGGAGTGA

Upstream 100 bases:

>100_bases
CAGGGGCATAAGCAAGACTTATATTGTTCCTCGTCATACGTCTTGGACCCCGGCCATCCTGTCGTGTCAGCTTTGGTTGG
CAGACAGGAAGGGACGTATC

Downstream 100 bases:

>100_bases
CGCCATGTTTGACCGCACAAACCTCCAGGTTCTGGCCAACCATGCCCGCGCGGCCGCCGAGAACATGGCCCATACGCTGC
ATCGCACCGCGCACTCCGCC

Product: hydantoin utilization protein A

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 692; Mature: 692

Protein sequence:

>692_residues
MDGAIAADEARNQADWKVGVDIGGTFIDFCALEANSGRVASLKVLTTPEDPGAELMTGLRLLAEREGFDPTRMTRFVHGT
TVGINTIIQRKGAPLALFTNAGFEDVIELARLRMPDMYSLFCSRPDPLISRDMVFGIPTRMRADGSESQAPDMVAVEKAV
AAAKANGALGIIVCFLHAWRNAAQEASVKAAIARLAPDLFVFSSAEVWPVIREYERSSTAILNGYVHPRVSSYLTALEAR
LKDRGVPARPMLTKSNGGLMNAAEGKRACVNMLLSGTASGVIGASWLARQAGENRILTLDIGGTSADFALIIDGEPQFGT
GELIGEFPLHIPSVSVSSIGVGGGSIASVDAQTVLRVGPESAGSTPGPACYGRGGERATVTDAMVVCGWLGHSEMAYGQL
RIDTQLAHRAVGDLAARLGRTVEQTAQAILDIAVSEMFVEVEKLASRAGVDLRDFTLMPFGGGGPMLGAFLARELGMKRV
MAPRRPGVVSALGGLVANLRSDFIRTVFTPLSGATLPAIREAFEALAHEGRGWLAAQGHDAAAELTLSCDMRYFGQSYEI
EVVLSPEWLTDDDVAPIEQAFHLTHQRLYDFHDPDGEVELVDIRLSAIGAGPKLSLPETEEVDVAAIPARRLPVYTGLRV
ETVDLHDRQALVPGSTFHGPAVVVQEDTTFAIPAGAQARVDRHLNLLLTFAE

Sequences:

>Translated_692_residues
MDGAIAADEARNQADWKVGVDIGGTFIDFCALEANSGRVASLKVLTTPEDPGAELMTGLRLLAEREGFDPTRMTRFVHGT
TVGINTIIQRKGAPLALFTNAGFEDVIELARLRMPDMYSLFCSRPDPLISRDMVFGIPTRMRADGSESQAPDMVAVEKAV
AAAKANGALGIIVCFLHAWRNAAQEASVKAAIARLAPDLFVFSSAEVWPVIREYERSSTAILNGYVHPRVSSYLTALEAR
LKDRGVPARPMLTKSNGGLMNAAEGKRACVNMLLSGTASGVIGASWLARQAGENRILTLDIGGTSADFALIIDGEPQFGT
GELIGEFPLHIPSVSVSSIGVGGGSIASVDAQTVLRVGPESAGSTPGPACYGRGGERATVTDAMVVCGWLGHSEMAYGQL
RIDTQLAHRAVGDLAARLGRTVEQTAQAILDIAVSEMFVEVEKLASRAGVDLRDFTLMPFGGGGPMLGAFLARELGMKRV
MAPRRPGVVSALGGLVANLRSDFIRTVFTPLSGATLPAIREAFEALAHEGRGWLAAQGHDAAAELTLSCDMRYFGQSYEI
EVVLSPEWLTDDDVAPIEQAFHLTHQRLYDFHDPDGEVELVDIRLSAIGAGPKLSLPETEEVDVAAIPARRLPVYTGLRV
ETVDLHDRQALVPGSTFHGPAVVVQEDTTFAIPAGAQARVDRHLNLLLTFAE
>Mature_692_residues
MDGAIAADEARNQADWKVGVDIGGTFIDFCALEANSGRVASLKVLTTPEDPGAELMTGLRLLAEREGFDPTRMTRFVHGT
TVGINTIIQRKGAPLALFTNAGFEDVIELARLRMPDMYSLFCSRPDPLISRDMVFGIPTRMRADGSESQAPDMVAVEKAV
AAAKANGALGIIVCFLHAWRNAAQEASVKAAIARLAPDLFVFSSAEVWPVIREYERSSTAILNGYVHPRVSSYLTALEAR
LKDRGVPARPMLTKSNGGLMNAAEGKRACVNMLLSGTASGVIGASWLARQAGENRILTLDIGGTSADFALIIDGEPQFGT
GELIGEFPLHIPSVSVSSIGVGGGSIASVDAQTVLRVGPESAGSTPGPACYGRGGERATVTDAMVVCGWLGHSEMAYGQL
RIDTQLAHRAVGDLAARLGRTVEQTAQAILDIAVSEMFVEVEKLASRAGVDLRDFTLMPFGGGGPMLGAFLARELGMKRV
MAPRRPGVVSALGGLVANLRSDFIRTVFTPLSGATLPAIREAFEALAHEGRGWLAAQGHDAAAELTLSCDMRYFGQSYEI
EVVLSPEWLTDDDVAPIEQAFHLTHQRLYDFHDPDGEVELVDIRLSAIGAGPKLSLPETEEVDVAAIPARRLPVYTGLRV
ETVDLHDRQALVPGSTFHGPAVVVQEDTTFAIPAGAQARVDRHLNLLLTFAE

Specific function: HyuA and hyuB convert D- and L-substituted hydantoins to corresponding N-carbamyl-amino acids [H]

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=524, Percent_Identity=28.2442748091603, Blast_Score=135, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI133901900, Length=385, Percent_Identity=25.7142857142857, Blast_Score=105, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6322634, Length=641, Percent_Identity=26.2090483619345, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45550492, Length=738, Percent_Identity=26.1517615176152, Blast_Score=172, Evalue=6e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: 3.5.2.14

Molecular weight: Translated: 73803; Mature: 73803

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGAIAADEARNQADWKVGVDIGGTFIDFCALEANSGRVASLKVLTTPEDPGAELMTGLR
CCCCCCCHHCCCCCCEEEEEECCCCEEEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHH
LLAEREGFDPTRMTRFVHGTTVGINTIIQRKGAPLALFTNAGFEDVIELARLRMPDMYSL
HHHHHCCCCHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCCHHHH
FCSRPDPLISRDMVFGIPTRMRADGSESQAPDMVAVEKAVAAAKANGALGIIVCFLHAWR
HHCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
NAAQEASVKAAIARLAPDLFVFSSAEVWPVIREYERSSTAILNGYVHPRVSSYLTALEAR
HHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHH
LKDRGVPARPMLTKSNGGLMNAAEGKRACVNMLLSGTASGVIGASWLARQAGENRILTLD
HHHCCCCCCCEEECCCCCEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEE
IGGTSADFALIIDGEPQFGTGELIGEFPLHIPSVSVSSIGVGGGSIASVDAQTVLRVGPE
ECCCCCCEEEEECCCCCCCCCCHHCCCCCCCCCCCHHEECCCCCCEEECCHHHHEEECCC
SAGSTPGPACYGRGGERATVTDAMVVCGWLGHSEMAYGQLRIDTQLAHRAVGDLAARLGR
CCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCEECEEEEHHHHHHHHHHHHHHHHCC
TVEQTAQAILDIAVSEMFVEVEKLASRAGVDLRDFTLMPFGGGGPMLGAFLARELGMKRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEECCCCHHHHHHHHHHHCHHHH
MAPRRPGVVSALGGLVANLRSDFIRTVFTPLSGATLPAIREAFEALAHEGRGWLAAQGHD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCC
AAAELTLSCDMRYFGQSYEIEVVLSPEWLTDDDVAPIEQAFHLTHQRLYDFHDPDGEVEL
CEEEEEEEECHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEE
VDIRLSAIGAGPKLSLPETEEVDVAAIPARRLPVYTGLRVETVDLHDRQALVPGSTFHGP
EEEEEEEECCCCCCCCCCCCCCCEEECCCCCCCEEECCEEEEEECCCCCEECCCCCCCCC
AVVVQEDTTFAIPAGAQARVDRHLNLLLTFAE
EEEEECCCEEEECCCCHHHHHCCEEEEEEECC
>Mature Secondary Structure
MDGAIAADEARNQADWKVGVDIGGTFIDFCALEANSGRVASLKVLTTPEDPGAELMTGLR
CCCCCCCHHCCCCCCEEEEEECCCCEEEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHH
LLAEREGFDPTRMTRFVHGTTVGINTIIQRKGAPLALFTNAGFEDVIELARLRMPDMYSL
HHHHHCCCCHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCCHHHH
FCSRPDPLISRDMVFGIPTRMRADGSESQAPDMVAVEKAVAAAKANGALGIIVCFLHAWR
HHCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
NAAQEASVKAAIARLAPDLFVFSSAEVWPVIREYERSSTAILNGYVHPRVSSYLTALEAR
HHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHH
LKDRGVPARPMLTKSNGGLMNAAEGKRACVNMLLSGTASGVIGASWLARQAGENRILTLD
HHHCCCCCCCEEECCCCCEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEE
IGGTSADFALIIDGEPQFGTGELIGEFPLHIPSVSVSSIGVGGGSIASVDAQTVLRVGPE
ECCCCCCEEEEECCCCCCCCCCHHCCCCCCCCCCCHHEECCCCCCEEECCHHHHEEECCC
SAGSTPGPACYGRGGERATVTDAMVVCGWLGHSEMAYGQLRIDTQLAHRAVGDLAARLGR
CCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCEECEEEEHHHHHHHHHHHHHHHHCC
TVEQTAQAILDIAVSEMFVEVEKLASRAGVDLRDFTLMPFGGGGPMLGAFLARELGMKRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEECCCCHHHHHHHHHHHCHHHH
MAPRRPGVVSALGGLVANLRSDFIRTVFTPLSGATLPAIREAFEALAHEGRGWLAAQGHD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCC
AAAELTLSCDMRYFGQSYEIEVVLSPEWLTDDDVAPIEQAFHLTHQRLYDFHDPDGEVEL
CEEEEEEEECHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEE
VDIRLSAIGAGPKLSLPETEEVDVAAIPARRLPVYTGLRVETVDLHDRQALVPGSTFHGP
EEEEEEEECCCCCCCCCCCCCCCEEECCCCCCCEEECCEEEEEECCCCCEECCCCCCCCC
AVVVQEDTTFAIPAGAQARVDRHLNLLLTFAE
EEEEECCCEEEECCCCHHHHHCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1732229 [H]