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The map label for this gene is dgdA [H]

Identifier: 13475821

GI number: 13475821

Start: 5752493

End: 5753980

Strand: Direct

Name: dgdA [H]

Synonym: mlr6991

Alternate gene names: 13475821

Gene position: 5752493-5753980 (Clockwise)

Preceding gene: 13475820

Following gene: 13475822

Centisome position: 81.76

GC content: 60.62

Gene sequence:

>1488_bases
ATGGCTACCGTGATTGTCGAGGCGAGGGAGGCCACCAGTGAATCCGGCATCCCGCATATCGAAAACGCCGGCCAATATCC
TCGAATGATGGAGTTGCTGAACCGGCAAGGCCGCGCAGAGGCGGTGCGCCGGCTTCGCCAGGCATGCCGGTTTCCGGTGT
ACGGCGCCTTGAGCAAGGATGGCGAGCATCTCACATATGACTATGACGTGCTCAGGCACGAGCGCGAAGCTCACCTGGGA
CCAATATGGCATTTCTACGCCAAGCCATTGCACATTACCCGCGCCCGCGGAGCCTGGATGTATGCCGCCGATGGCACTGC
CTATCTGGATGTCTACAACAACGTCCCCCAGATCGGTCATTGTCATCCGCATGTGGCGAAGGCGATCTACCGCCAGGCCA
GCGCGCTGAACACCAATACCCGGTATATGTGCGACGTAGCCGTCGAGTACGCGGCGCGCCTGACCGCCGACCTGCCTGAT
CACCTCGACACCTGCATCTTCGTCAATTCGGGCAGCGAAGCCAACGACCTGGCGATGCAGATAGCCATGTCACTTAGCAG
GCAGGATGGGGGTCTGATAATTGACCAAGCTTACCATGGATGCACGGAGCTGACGACGGCCCTGTCCAATGAAAGCTGGC
GTCATCTTCCCGCTGACGAGCACCCCAAACGCATTGAGACCCTGACGGCCCCGGATATGTATAGGGGCCCTTTTTCCCGC
GACCGCCAAGCAGCAGCCAAATATGCTGCCGACGCCGACAGGGCGATAGCCGCCTTGCGCGAAAGAGGCCACAGGCCGGC
AGCATTCATGGTCGACACTGCCCTATGTTCGAGCGGGGTGCTGCGGGCGCCTGAAAACTACTTCAATCTTGTCGCGGAAA
AGGTCCGGGCGACGGGCGGATTCGTCATCGCGGACGAGGTGCAGGCAGGTTGTGGCCGCATGGGAGCTTTTTGGGGTTTC
CGGGCAAACGGGCTCAAGGACGAAAACATCGATTTCATAACAATGGGCAAGCCGGTTGGAAACGGCCACCCCCTTGGCGT
CGTCATTCTCAGCTCGGAACTGATGAAGCGGTTCCTCAATGGCACCTACCCGCTGTTGTTCAGCACATTCGGCGGCAACA
CCGTCGCGTGCGCGGCCGGGATGGCTGTGCTGGACGTCCTTGAGCGAGAGGACCTGATCAAGCGGGGCGCCGCCATCGGG
GAGTATCTACGCCAGGAGCTTGGGCGCCTGGCCGAACAGCACCCCGCGATCGGCGACGTACGCGGGCTTGGAATGATGGC
TGGCGTGGAATTGGTGACGGATCGCCTGACGAAGGAGCCGGCCATCACACTGACCGAGCGACTCATTGCCGACATGCTTG
CCCGCAACATCCTCATCGGGAAAGGCACGCCCAACACGCTCAAGCTACGCCCCCCGCTGATTTGGTCGCGCGACGAAGTC
GACATCTTCGTCGACGCTTTCGATGACAGCTTGAGAAAGCACCAATGA

Upstream 100 bases:

>100_bases
CGTCTACCTTTGCGACGTGACATCTGGTTTCGATTCGACATACCCGCTTGAAGAGAACGAGGTCAATCTCCTTTTCGATG
CGCTGCTTCTGCGCCTCGCC

Downstream 100 bases:

>100_bases
GGCCGCCAATGCCTTTGCTGGAGAATGGGTGACAGTCTCGCAGACAATCGGGAGGGAAGGGCAACGCCACTCTCCTTGCC
TTCGAGAATGGAGCAACGGC

Product: aminotransferase

Products: NA

Alternate protein names: DGD [H]

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MATVIVEAREATSESGIPHIENAGQYPRMMELLNRQGRAEAVRRLRQACRFPVYGALSKDGEHLTYDYDVLRHEREAHLG
PIWHFYAKPLHITRARGAWMYAADGTAYLDVYNNVPQIGHCHPHVAKAIYRQASALNTNTRYMCDVAVEYAARLTADLPD
HLDTCIFVNSGSEANDLAMQIAMSLSRQDGGLIIDQAYHGCTELTTALSNESWRHLPADEHPKRIETLTAPDMYRGPFSR
DRQAAAKYAADADRAIAALRERGHRPAAFMVDTALCSSGVLRAPENYFNLVAEKVRATGGFVIADEVQAGCGRMGAFWGF
RANGLKDENIDFITMGKPVGNGHPLGVVILSSELMKRFLNGTYPLLFSTFGGNTVACAAGMAVLDVLEREDLIKRGAAIG
EYLRQELGRLAEQHPAIGDVRGLGMMAGVELVTDRLTKEPAITLTERLIADMLARNILIGKGTPNTLKLRPPLIWSRDEV
DIFVDAFDDSLRKHQ

Sequences:

>Translated_495_residues
MATVIVEAREATSESGIPHIENAGQYPRMMELLNRQGRAEAVRRLRQACRFPVYGALSKDGEHLTYDYDVLRHEREAHLG
PIWHFYAKPLHITRARGAWMYAADGTAYLDVYNNVPQIGHCHPHVAKAIYRQASALNTNTRYMCDVAVEYAARLTADLPD
HLDTCIFVNSGSEANDLAMQIAMSLSRQDGGLIIDQAYHGCTELTTALSNESWRHLPADEHPKRIETLTAPDMYRGPFSR
DRQAAAKYAADADRAIAALRERGHRPAAFMVDTALCSSGVLRAPENYFNLVAEKVRATGGFVIADEVQAGCGRMGAFWGF
RANGLKDENIDFITMGKPVGNGHPLGVVILSSELMKRFLNGTYPLLFSTFGGNTVACAAGMAVLDVLEREDLIKRGAAIG
EYLRQELGRLAEQHPAIGDVRGLGMMAGVELVTDRLTKEPAITLTERLIADMLARNILIGKGTPNTLKLRPPLIWSRDEV
DIFVDAFDDSLRKHQ
>Mature_494_residues
ATVIVEAREATSESGIPHIENAGQYPRMMELLNRQGRAEAVRRLRQACRFPVYGALSKDGEHLTYDYDVLRHEREAHLGP
IWHFYAKPLHITRARGAWMYAADGTAYLDVYNNVPQIGHCHPHVAKAIYRQASALNTNTRYMCDVAVEYAARLTADLPDH
LDTCIFVNSGSEANDLAMQIAMSLSRQDGGLIIDQAYHGCTELTTALSNESWRHLPADEHPKRIETLTAPDMYRGPFSRD
RQAAAKYAADADRAIAALRERGHRPAAFMVDTALCSSGVLRAPENYFNLVAEKVRATGGFVIADEVQAGCGRMGAFWGFR
ANGLKDENIDFITMGKPVGNGHPLGVVILSSELMKRFLNGTYPLLFSTFGGNTVACAAGMAVLDVLEREDLIKRGAAIGE
YLRQELGRLAEQHPAIGDVRGLGMMAGVELVTDRLTKEPAITLTERLIADMLARNILIGKGTPNTLKLRPPLIWSRDEVD
IFVDAFDDSLRKHQ

Specific function: The dialkylglycine decarboxylase is of interest because it normally catalyzes both decarboxylation and amino transfer. It may be more properly described as a decarboxylating aminotransferase rather than an aminotransferring decarboxylase [H]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=421, Percent_Identity=38.479809976247, Blast_Score=312, Evalue=4e-85,
Organism=Homo sapiens, GI24119277, Length=408, Percent_Identity=38.9705882352941, Blast_Score=303, Evalue=4e-82,
Organism=Homo sapiens, GI226442705, Length=421, Percent_Identity=37.29216152019, Blast_Score=290, Evalue=3e-78,
Organism=Homo sapiens, GI226442709, Length=376, Percent_Identity=38.563829787234, Blast_Score=278, Evalue=6e-75,
Organism=Homo sapiens, GI13994255, Length=472, Percent_Identity=31.9915254237288, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI4557809, Length=430, Percent_Identity=26.5116279069767, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI188536080, Length=449, Percent_Identity=24.0534521158129, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI38679950, Length=449, Percent_Identity=24.0534521158129, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI38679946, Length=449, Percent_Identity=24.0534521158129, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI284507298, Length=321, Percent_Identity=27.1028037383178, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1789016, Length=434, Percent_Identity=28.110599078341, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI145693181, Length=456, Percent_Identity=24.1228070175439, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1788044, Length=413, Percent_Identity=24.455205811138, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1787560, Length=423, Percent_Identity=26.0047281323877, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1789759, Length=413, Percent_Identity=22.5181598062954, Blast_Score=96, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71992977, Length=443, Percent_Identity=33.8600451467269, Blast_Score=241, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI32564660, Length=438, Percent_Identity=34.0182648401827, Blast_Score=238, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI25144271, Length=434, Percent_Identity=25.1152073732719, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71992985, Length=116, Percent_Identity=36.2068965517241, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI25144274, Length=234, Percent_Identity=26.0683760683761, Blast_Score=79, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6323470, Length=422, Percent_Identity=26.0663507109005, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6324432, Length=427, Percent_Identity=24.1217798594848, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21356575, Length=427, Percent_Identity=35.1288056206089, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI161085790, Length=454, Percent_Identity=34.1409691629956, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI28574759, Length=447, Percent_Identity=34.2281879194631, Blast_Score=221, Evalue=9e-58,
Organism=Drosophila melanogaster, GI21357415, Length=427, Percent_Identity=26.6978922716628, Blast_Score=108, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =4.1.1.64 [H]

Molecular weight: Translated: 54717; Mature: 54586

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVIVEAREATSESGIPHIENAGQYPRMMELLNRQGRAEAVRRLRQACRFPVYGALSKD
CCEEEEECHHCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCC
GEHLTYDYDVLRHEREAHLGPIWHFYAKPLHITRARGAWMYAADGTAYLDVYNNVPQIGH
CCEEEEHHHHHHHHHHHCCCHHHHHHCCCEEEEECCCCEEEECCCEEEEEECCCCCCCCC
CHPHVAKAIYRQASALNTNTRYMCDVAVEYAARLTADLPDHLDTCIFVNSGSEANDLAMQ
CCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHH
IAMSLSRQDGGLIIDQAYHGCTELTTALSNESWRHLPADEHPKRIETLTAPDMYRGPFSR
HHHHHCCCCCCEEEEHHHCCHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCHHCCCCCC
DRQAAAKYAADADRAIAALRERGHRPAAFMVDTALCSSGVLRAPENYFNLVAEKVRATGG
CHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
FVIADEVQAGCGRMGAFWGFRANGLKDENIDFITMGKPVGNGHPLGVVILSSELMKRFLN
EEEECCHHHCCCCHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECHHHHHHHHC
GTYPLLFSTFGGNTVACAAGMAVLDVLEREDLIKRGAAIGEYLRQELGRLAEQHPAIGDV
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
RGLGMMAGVELVTDRLTKEPAITLTERLIADMLARNILIGKGTPNTLKLRPPLIWSRDEV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCEEEECCCCCEEEECCCEEECCCCC
DIFVDAFDDSLRKHQ
EEEEEHHHHHHHCCC
>Mature Secondary Structure 
ATVIVEAREATSESGIPHIENAGQYPRMMELLNRQGRAEAVRRLRQACRFPVYGALSKD
CEEEEECHHCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCC
GEHLTYDYDVLRHEREAHLGPIWHFYAKPLHITRARGAWMYAADGTAYLDVYNNVPQIGH
CCEEEEHHHHHHHHHHHCCCHHHHHHCCCEEEEECCCCEEEECCCEEEEEECCCCCCCCC
CHPHVAKAIYRQASALNTNTRYMCDVAVEYAARLTADLPDHLDTCIFVNSGSEANDLAMQ
CCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHH
IAMSLSRQDGGLIIDQAYHGCTELTTALSNESWRHLPADEHPKRIETLTAPDMYRGPFSR
HHHHHCCCCCCEEEEHHHCCHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCHHCCCCCC
DRQAAAKYAADADRAIAALRERGHRPAAFMVDTALCSSGVLRAPENYFNLVAEKVRATGG
CHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
FVIADEVQAGCGRMGAFWGFRANGLKDENIDFITMGKPVGNGHPLGVVILSSELMKRFLN
EEEECCHHHCCCCHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECHHHHHHHHC
GTYPLLFSTFGGNTVACAAGMAVLDVLEREDLIKRGAAIGEYLRQELGRLAEQHPAIGDV
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
RGLGMMAGVELVTDRLTKEPAITLTERLIADMLARNILIGKGTPNTLKLRPPLIWSRDEV
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCEEEECCCCCEEEECCCEEECCCCC
DIFVDAFDDSLRKHQ
EEEEEHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2180928; 8342040; 7947767; 7799433; 10556038 [H]