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The map label for this gene is guaA

Identifier: 13475784

GI number: 13475784

Start: 5712373

End: 5713935

Strand: Direct

Name: guaA

Synonym: mlr6950

Alternate gene names: 13475784

Gene position: 5712373-5713935 (Clockwise)

Preceding gene: 13475783

Following gene: 13475785

Centisome position: 81.19

GC content: 63.79

Gene sequence:

>1563_bases
ATGAAAACAGCCAATCATCCCGACACCGTCCTGATTGTCGATTTCGGCAGCCAGTTTACGCAGCTCATCGCCCGCCGCAT
CCGCGAGGCCGGCGTGTTTTCCGAGATCGTGCCGTTCCAATCGGCCGAAGCCGCGTTCAAGCGCATCAATCCCAAAGCCG
TCATCCTGTCCGGCGGCCCGGCTTCGACGTCCGATATCGGCAGCCCGCGTGCGCCGCAGATCGTCTTCGATGCCGGGGTG
CCGGTGCTTGGCATCTGCTATGGCCAGATGGCCATGTGCGTGCAGATGGGCGGTGTCGCCGAAAGCTCCAACCATCGCGA
GTTCGGCCGCGCTTTCGTCGAAATCGAGAAGGACAGCCCGCTGTTCGAGGGCCTGTGGGCCACCGGCCAGCGCCATCAGG
TGTGGATGAGCCATGGCGACCGGGTCATCGCCTTGCCTCCGGGTTTTCAGGTTTTCGGCAAGTCGGAAAGCTCGCCCTTC
GCCATTTTCGGCAATGTCGAGCGCAAGATGTACGGCATCATGTTCCATCCGGAAGTGGTGCACACGCCCGACGGCGCCCG
GCTGCTCAGGAACTTCGTCCACAACATCGCCGGCATCGAGGGCGACTGGACGATGCGCGCCTACCGCGAACACGCGGTCG
AGGCGATCCGCAAGCAGGTCGGCAAGGGCAAGGTCATCTGCGCGCTGTCGGGCGGTGTGGATTCCTCGGTCGCGGCGCTT
TTGATCCACGAGGCGGTTGGCGACCAGCTCACCTGCATCCTCGTCGACCATGGCCTGATGCGCAAGGACGAGGCGGCGGG
CGTGGTGGCGATGTTCCGCCAGCACTACAACCTGCCGCTGATCCTGGTCGATGCTTCGGAAAAATTCATCTCGGCGCTGG
AAGGCGAGGTTGACCCCGAGAAGAAGCGCAAGACCATCGGCCGGCTGTTCATCGAAGTGTTCGAGGAGGAAGCCAAAAAG
CTCGGCGGCGCCGACTTCCTGGCGCAAGGCACGCTCTATCCCGACGTCATCGAAAGTGTCTCCTTCACCGGCGGCCCGTC
GGTGACCATCAAGTCGCACCACAATGTGGGCGGCCTGCCCGAGCGCATGAACATGCAATTGGTCGAGCCGCTGCGCGAAC
TGTTCAAGGACGAGGTGAGGGCGCTCGGCAAGGAGCTCGGCCTGCCCGAAAGCTTCATCGGTCGCCATCCGTTCCCAGGT
CCAGGCCTTGCCATACGCTGCCCGGGCGGCATCACGCGCGAGAAGTTGGAGATTCTGCGCGAGGCCGACGCCATCTATCT
CGACGAGATCCGCAAGGCCGGCCTCTACGACGCCATCTGGCAGGCCTTCGCCGTGCTCTTGCCGGTGCAGACCGTCGGCG
TGATGGGCGACGGCCGCACCTACGAATTCGTCTGCGCGCTGCGCGCCGTCACCTCGGTCGACGGCATGACGGCGGATTTC
TACCACTACGACATGGCCTTCCTGGGTGCCGCCGCCACACGCATCATCAACGAGGTCCGTGGCATCAACCGCGTCGTCTA
CGACGTCACGTCGAAGCCGCCTGGCACGATCGAGTGGGAATGA

Upstream 100 bases:

>100_bases
CCGGGCAGGCGGACGCCGGCGATAAAAAGGCCGGCGTTCAGTGAACAGCGCGGCTTTGTAACCCATTGCGTCGACTCATT
TCTTTCTCTAAACGCTCGCC

Downstream 100 bases:

>100_bases
TTCAGACCCACTCAAACGCCGCCGAAAATACGCCAATCTGCGACGTAACGCACTGAATACAAATATAAATCCTTTCAGGG
ACAATCAGCGACAATCGGCA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MKTANHPDTVLIVDFGSQFTQLIARRIREAGVFSEIVPFQSAEAAFKRINPKAVILSGGPASTSDIGSPRAPQIVFDAGV
PVLGICYGQMAMCVQMGGVAESSNHREFGRAFVEIEKDSPLFEGLWATGQRHQVWMSHGDRVIALPPGFQVFGKSESSPF
AIFGNVERKMYGIMFHPEVVHTPDGARLLRNFVHNIAGIEGDWTMRAYREHAVEAIRKQVGKGKVICALSGGVDSSVAAL
LIHEAVGDQLTCILVDHGLMRKDEAAGVVAMFRQHYNLPLILVDASEKFISALEGEVDPEKKRKTIGRLFIEVFEEEAKK
LGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMQLVEPLRELFKDEVRALGKELGLPESFIGRHPFPG
PGLAIRCPGGITREKLEILREADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADF
YHYDMAFLGAAATRIINEVRGINRVVYDVTSKPPGTIEWE

Sequences:

>Translated_520_residues
MKTANHPDTVLIVDFGSQFTQLIARRIREAGVFSEIVPFQSAEAAFKRINPKAVILSGGPASTSDIGSPRAPQIVFDAGV
PVLGICYGQMAMCVQMGGVAESSNHREFGRAFVEIEKDSPLFEGLWATGQRHQVWMSHGDRVIALPPGFQVFGKSESSPF
AIFGNVERKMYGIMFHPEVVHTPDGARLLRNFVHNIAGIEGDWTMRAYREHAVEAIRKQVGKGKVICALSGGVDSSVAAL
LIHEAVGDQLTCILVDHGLMRKDEAAGVVAMFRQHYNLPLILVDASEKFISALEGEVDPEKKRKTIGRLFIEVFEEEAKK
LGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMQLVEPLRELFKDEVRALGKELGLPESFIGRHPFPG
PGLAIRCPGGITREKLEILREADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADF
YHYDMAFLGAAATRIINEVRGINRVVYDVTSKPPGTIEWE
>Mature_520_residues
MKTANHPDTVLIVDFGSQFTQLIARRIREAGVFSEIVPFQSAEAAFKRINPKAVILSGGPASTSDIGSPRAPQIVFDAGV
PVLGICYGQMAMCVQMGGVAESSNHREFGRAFVEIEKDSPLFEGLWATGQRHQVWMSHGDRVIALPPGFQVFGKSESSPF
AIFGNVERKMYGIMFHPEVVHTPDGARLLRNFVHNIAGIEGDWTMRAYREHAVEAIRKQVGKGKVICALSGGVDSSVAAL
LIHEAVGDQLTCILVDHGLMRKDEAAGVVAMFRQHYNLPLILVDASEKFISALEGEVDPEKKRKTIGRLFIEVFEEEAKK
LGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMQLVEPLRELFKDEVRALGKELGLPESFIGRHPFPG
PGLAIRCPGGITREKLEILREADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADF
YHYDMAFLGAAATRIINEVRGINRVVYDVTSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=549, Percent_Identity=34.4262295081967, Blast_Score=280, Evalue=2e-75,
Organism=Escherichia coli, GI1788854, Length=525, Percent_Identity=55.6190476190476, Blast_Score=591, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI71992717, Length=572, Percent_Identity=35.6643356643357, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI71992710, Length=572, Percent_Identity=35.6643356643357, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI133901714, Length=572, Percent_Identity=35.6643356643357, Blast_Score=279, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6323873, Length=526, Percent_Identity=50, Blast_Score=519, Evalue=1e-148,
Organism=Drosophila melanogaster, GI281365319, Length=549, Percent_Identity=33.1511839708561, Blast_Score=264, Evalue=1e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_RHILO (Q987R3)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_107351.1
- ProteinModelPortal:   Q987R3
- SMR:   Q987R3
- GeneID:   1230006
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr6950
- NMPDR:   fig|266835.1.peg.5452
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- ProtClustDB:   PRK00074
- BRENDA:   6.3.5.2
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729
- InterPro:   IPR004506
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF03054 tRNA_Me_trans

EC number: =6.3.5.2

Molecular weight: Translated: 56978; Mature: 56978

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 86-86 ACT_SITE 176-176 ACT_SITE 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTANHPDTVLIVDFGSQFTQLIARRIREAGVFSEIVPFQSAEAAFKRINPKAVILSGGP
CCCCCCCCEEEEEECCHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHCCCCEEEEECCC
ASTSDIGSPRAPQIVFDAGVPVLGICYGQMAMCVQMGGVAESSNHREFGRAFVEIEKDSP
CCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCEEEEECCCCC
LFEGLWATGQRHQVWMSHGDRVIALPPGFQVFGKSESSPFAIFGNVERKMYGIMFHPEVV
HHHHHHCCCCCCEEHCCCCCEEEEECCCCEEECCCCCCCEEEEECCCCEEEEEEECCCEE
HTPDGARLLRNFVHNIAGIEGDWTMRAYREHAVEAIRKQVGKGKVICALSGGVDSSVAAL
ECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
LIHEAVGDQLTCILVDHGLMRKDEAAGVVAMFRQHYNLPLILVDASEKFISALEGEVDPE
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCHH
KKRKTIGRLFIEVFEEEAKKLGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCC
ERMNMQLVEPLRELFKDEVRALGKELGLPESFIGRHPFPGPGLAIRCPGGITREKLEILR
HHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHH
EADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADF
HCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCEEHH
YHYDMAFLGAAATRIINEVRGINRVVYDVTSKPPGTIEWE
HHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKTANHPDTVLIVDFGSQFTQLIARRIREAGVFSEIVPFQSAEAAFKRINPKAVILSGGP
CCCCCCCCEEEEEECCHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHCCCCEEEEECCC
ASTSDIGSPRAPQIVFDAGVPVLGICYGQMAMCVQMGGVAESSNHREFGRAFVEIEKDSP
CCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCEEEEECCCCC
LFEGLWATGQRHQVWMSHGDRVIALPPGFQVFGKSESSPFAIFGNVERKMYGIMFHPEVV
HHHHHHCCCCCCEEHCCCCCEEEEECCCCEEECCCCCCCEEEEECCCCEEEEEEECCCEE
HTPDGARLLRNFVHNIAGIEGDWTMRAYREHAVEAIRKQVGKGKVICALSGGVDSSVAAL
ECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
LIHEAVGDQLTCILVDHGLMRKDEAAGVVAMFRQHYNLPLILVDASEKFISALEGEVDPE
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCHH
KKRKTIGRLFIEVFEEEAKKLGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCC
ERMNMQLVEPLRELFKDEVRALGKELGLPESFIGRHPFPGPGLAIRCPGGITREKLEILR
HHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEECCCCCCHHHHHHHH
EADAIYLDEIRKAGLYDAIWQAFAVLLPVQTVGVMGDGRTYEFVCALRAVTSVDGMTADF
HCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHCCCCEEHH
YHYDMAFLGAAATRIINEVRGINRVVYDVTSKPPGTIEWE
HHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968