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The map label for this gene is aqpZ [H]

Identifier: 13475778

GI number: 13475778

Start: 5707931

End: 5708608

Strand: Reverse

Name: aqpZ [H]

Synonym: mll6943

Alternate gene names: 13475778

Gene position: 5708608-5707931 (Counterclockwise)

Preceding gene: 13475782

Following gene: 13475776

Centisome position: 81.13

GC content: 65.19

Gene sequence:

>678_bases
ATGAAAACTTATCTGGCTGAAGTTCTAGGCACATTTCTGTTGGTGTTCATCGGCACGGCGTCGGTGGTGACGGGCGGCTT
CGGCGGCGCGCTGCCGCTCGGCCAGGAAGGTATCGGTCTGGCATTCGGCATCGGCCTCATCGCCGCGGCCTATGCGATCG
GCCCGATTTCGGGCGCACATCTCAATCCGGCGGTGACACTCGGCGTCTTCCTCGCCGGCCGGCTGCCGGCCAAGGACGTC
ATCCCCTACTGGATCGCGCAGATCATTGGCGCCATCCTGGCTTCGCTGGCGCTGTGGATCATTGTTTCCGGCCAGGCCGG
CGGCCACACCGGCGGTTTCGGCGCCAATGGCTGGGACGAGACGAAATGGGGCATGAGCTCGGCCTTCCTGTGGGAACTGA
TCGGCACCTTCACCTTCGTCACGGTGATCCTCGGCGTTACCGCTGAAAAGCACTCGACGGCGTTTGCCGGCCTGGTCATC
GGCCTGACGCTGGCCGGCATTCACTTCGCCATGATCCCGGTCACCGGCACCTCGGTCAATCCGGCCCGCTCCATCGGCCC
GGCTCTGTTCACCGGCGGTGCCGCGCTCAGCCAGCTCTGGCTGTTCATCGTCGCCCCGCTGATCGGCGGCGCCATCGCCG
GCGTCGTCGCCAAGGCACGCATCTTCGAGAAGGATTGA

Upstream 100 bases:

>100_bases
AACCGCTCTGCTTTCCAAGTTTTTCCGTTGGGAATACTCTTAACGCCATGATTCGCGGCGCGGAAAACGCGGACCGGCGG
ATCGCTACGAGGAGAGGGCA

Downstream 100 bases:

>100_bases
TCGAACGCCTGAATGCAAAAGGCGCGGGTCACGGCCCGCGCCTTTTTTGTTGGATAGAGCTTTGTCTGGATCAGCCGGCG
ATGTCGAAACGGTCGGCGTT

Product: aquaporin, nodulin-like intrinsic protein

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKTYLAEVLGTFLLVFIGTASVVTGGFGGALPLGQEGIGLAFGIGLIAAAYAIGPISGAHLNPAVTLGVFLAGRLPAKDV
IPYWIAQIIGAILASLALWIIVSGQAGGHTGGFGANGWDETKWGMSSAFLWELIGTFTFVTVILGVTAEKHSTAFAGLVI
GLTLAGIHFAMIPVTGTSVNPARSIGPALFTGGAALSQLWLFIVAPLIGGAIAGVVAKARIFEKD

Sequences:

>Translated_225_residues
MKTYLAEVLGTFLLVFIGTASVVTGGFGGALPLGQEGIGLAFGIGLIAAAYAIGPISGAHLNPAVTLGVFLAGRLPAKDV
IPYWIAQIIGAILASLALWIIVSGQAGGHTGGFGANGWDETKWGMSSAFLWELIGTFTFVTVILGVTAEKHSTAFAGLVI
GLTLAGIHFAMIPVTGTSVNPARSIGPALFTGGAALSQLWLFIVAPLIGGAIAGVVAKARIFEKD
>Mature_225_residues
MKTYLAEVLGTFLLVFIGTASVVTGGFGGALPLGQEGIGLAFGIGLIAAAYAIGPISGAHLNPAVTLGVFLAGRLPAKDV
IPYWIAQIIGAILASLALWIIVSGQAGGHTGGFGANGWDETKWGMSSAFLWELIGTFTFVTVILGVTAEKHSTAFAGLVI
GLTLAGIHFAMIPVTGTSVNPARSIGPALFTGGAALSQLWLFIVAPLIGGAIAGVVAKARIFEKD

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI37694062, Length=224, Percent_Identity=37.0535714285714, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4755125, Length=216, Percent_Identity=32.4074074074074, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI4502181, Length=216, Percent_Identity=32.4074074074074, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI4502183, Length=218, Percent_Identity=32.5688073394495, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4502179, Length=223, Percent_Identity=31.390134529148, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI6912506, Length=225, Percent_Identity=28, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI22538420, Length=234, Percent_Identity=29.0598290598291, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI4826645, Length=246, Percent_Identity=33.739837398374, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI45446752, Length=190, Percent_Identity=32.6315789473684, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI157266307, Length=244, Percent_Identity=28.6885245901639, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4502187, Length=248, Percent_Identity=27.4193548387097, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI86792455, Length=223, Percent_Identity=29.5964125560538, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787101, Length=207, Percent_Identity=45.4106280193237, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1790362, Length=245, Percent_Identity=30.2040816326531, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71992966, Length=246, Percent_Identity=32.1138211382114, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17558372, Length=237, Percent_Identity=29.1139240506329, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71994009, Length=230, Percent_Identity=29.1304347826087, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17531431, Length=234, Percent_Identity=26.4957264957265, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17531429, Length=234, Percent_Identity=26.4957264957265, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32564052, Length=208, Percent_Identity=31.25, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17533613, Length=208, Percent_Identity=31.25, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71993722, Length=233, Percent_Identity=28.755364806867, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71992961, Length=236, Percent_Identity=28.8135593220339, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321054, Length=206, Percent_Identity=32.5242718446602, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24652747, Length=219, Percent_Identity=32.8767123287671, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI45551084, Length=219, Percent_Identity=32.8767123287671, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24762346, Length=224, Percent_Identity=29.9107142857143, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24762348, Length=224, Percent_Identity=29.9107142857143, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI20130305, Length=224, Percent_Identity=29.9107142857143, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24762344, Length=224, Percent_Identity=29.9107142857143, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI45550503, Length=234, Percent_Identity=27.3504273504274, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 22832; Mature: 22832

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTYLAEVLGTFLLVFIGTASVVTGGFGGALPLGQEGIGLAFGIGLIAAAYAIGPISGAH
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
LNPAVTLGVFLAGRLPAKDVIPYWIAQIIGAILASLALWIIVSGQAGGHTGGFGANGWDE
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
TKWGMSSAFLWELIGTFTFVTVILGVTAEKHSTAFAGLVIGLTLAGIHFAMIPVTGTSVN
HHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCC
PARSIGPALFTGGAALSQLWLFIVAPLIGGAIAGVVAKARIFEKD
CHHHHCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTYLAEVLGTFLLVFIGTASVVTGGFGGALPLGQEGIGLAFGIGLIAAAYAIGPISGAH
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
LNPAVTLGVFLAGRLPAKDVIPYWIAQIIGAILASLALWIIVSGQAGGHTGGFGANGWDE
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
TKWGMSSAFLWELIGTFTFVTVILGVTAEKHSTAFAGLVIGLTLAGIHFAMIPVTGTSVN
HHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCC
PARSIGPALFTGGAALSQLWLFIVAPLIGGAIAGVVAKARIFEKD
CHHHHCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]