Click here to switch to the map view.

The map label for this gene is hisG

Identifier: 13475769

GI number: 13475769

Start: 5698186

End: 5698884

Strand: Direct

Name: hisG

Synonym: mlr6931

Alternate gene names: 13475769

Gene position: 5698186-5698884 (Clockwise)

Preceding gene: 13475768

Following gene: 13475770

Centisome position: 80.99

GC content: 64.23

Gene sequence:

>699_bases
ATGATCACGTTGGCCATTCCCTCGAAAGGCCGGCTCAAGGAACAGGCGCTGGAGGTGCTGGCCAAGGCCGGCCTCGCCAT
CAGCCTGCCCGGCGACGAGCGCAAATATCATGCCCGTGTCGAGGGCCTGGACAATGTCGAGATCGCTTTCCTGTCGGCTT
CCGAGATTGCAGGCGAAATCGGTCAGGGCGCCGTCGACCTTGGCATCACCGGCGAGGATCTGGTGCGGGAAAATCTCGCC
GATTGGGAAGCCCGCGCCGAGATCGCCGCCCGTCTCGGCTTCGGCCATGCCGATGTCGTGGTTGCGGTGCCCGAAATCTG
GCTCGATGTCGACACCATGGCCGATCTCGACGACGTTGCCGCCGATTTCCGCCAGCGCCACGGCCGGCGGCTGCGCATCG
CCACCAAATACTGGCGGCTGACGCAGCAGTTCTTTTCGCAAAAACACGGTATCCAGGTCTATCGCATCGTCGAGAGCCTG
GGTGCCACCGAAGGCGCGCCGGCGGCTGGACTGGCCGATGTCATCGTCGACATCACCACGACAGGCTCGACGCTGCGCGC
CAACCATCTAAAAGTGCTGGGCGACGGCGTGGTGCTGAAGTCGCAGGCCTGTCTGGTGGCATCGAAAAAGGCGCGTACCG
CGGGCGACGAAGCCACCTTGCGCGACATCGTCACGAAGATGGCGGCGGCGGTGGGATAG

Upstream 100 bases:

>100_bases
ACGACCGGCTGCTGACCCTGCTTGGCGCCAAGACGGCGATCCCCGGCGTCGGCTTTTCCGTCTGGCTCGACCGCATCGAG
GCGTTGCGGGAGGCGGCACC

Downstream 100 bases:

>100_bases
CCATGCCCGCCCCCTCCGAGGGACCAGAACTCCACGACCATCGACAGGATTTCCACTGCCCCGCCGGGCTGATAGACTCG
ACGCGGCCTGGGAGGAAACA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MITLAIPSKGRLKEQALEVLAKAGLAISLPGDERKYHARVEGLDNVEIAFLSASEIAGEIGQGAVDLGITGEDLVRENLA
DWEARAEIAARLGFGHADVVVAVPEIWLDVDTMADLDDVAADFRQRHGRRLRIATKYWRLTQQFFSQKHGIQVYRIVESL
GATEGAPAAGLADVIVDITTTGSTLRANHLKVLGDGVVLKSQACLVASKKARTAGDEATLRDIVTKMAAAVG

Sequences:

>Translated_232_residues
MITLAIPSKGRLKEQALEVLAKAGLAISLPGDERKYHARVEGLDNVEIAFLSASEIAGEIGQGAVDLGITGEDLVRENLA
DWEARAEIAARLGFGHADVVVAVPEIWLDVDTMADLDDVAADFRQRHGRRLRIATKYWRLTQQFFSQKHGIQVYRIVESL
GATEGAPAAGLADVIVDITTTGSTLRANHLKVLGDGVVLKSQACLVASKKARTAGDEATLRDIVTKMAAAVG
>Mature_232_residues
MITLAIPSKGRLKEQALEVLAKAGLAISLPGDERKYHARVEGLDNVEIAFLSASEIAGEIGQGAVDLGITGEDLVRENLA
DWEARAEIAARLGFGHADVVVAVPEIWLDVDTMADLDDVAADFRQRHGRRLRIATKYWRLTQQFFSQKHGIQVYRIVESL
GATEGAPAAGLADVIVDITTTGSTLRANHLKVLGDGVVLKSQACLVASKKARTAGDEATLRDIVTKMAAAVG

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=212, Percent_Identity=33.4905660377358, Blast_Score=86, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320896, Length=217, Percent_Identity=30.4147465437788, Blast_Score=79, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_RHILO (Q987S8)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_107336.1
- ProteinModelPortal:   Q987S8
- SMR:   Q987S8
- GeneID:   1229991
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr6931
- NMPDR:   fig|266835.1.peg.5437
- HOGENOM:   HBG391868
- OMA:   RMRVATK
- ProtClustDB:   PRK13583
- BRENDA:   2.4.2.17
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 24822; Mature: 24822

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLAIPSKGRLKEQALEVLAKAGLAISLPGDERKYHARVEGLDNVEIAFLSASEIAGEI
CEEEECCCCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHHCCCCCEEEEEEEHHHHHHHH
GQGAVDLGITGEDLVRENLADWEARAEIAARLGFGHADVVVAVPEIWLDVDTMADLDDVA
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHCCHHHHCCHHHHH
ADFRQRHGRRLRIATKYWRLTQQFFSQKHGIQVYRIVESLGATEGAPAAGLADVIVDITT
HHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHEEEEEC
TGSTLRANHLKVLGDGVVLKSQACLVASKKARTAGDEATLRDIVTKMAAAVG
CCCEEECCCEEEEECCEEEECCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MITLAIPSKGRLKEQALEVLAKAGLAISLPGDERKYHARVEGLDNVEIAFLSASEIAGEI
CEEEECCCCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHHCCCCCEEEEEEEHHHHHHHH
GQGAVDLGITGEDLVRENLADWEARAEIAARLGFGHADVVVAVPEIWLDVDTMADLDDVA
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHCCHHHHCCHHHHH
ADFRQRHGRRLRIATKYWRLTQQFFSQKHGIQVYRIVESLGATEGAPAAGLADVIVDITT
HHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHEEEEEC
TGSTLRANHLKVLGDGVVLKSQACLVASKKARTAGDEATLRDIVTKMAAAVG
CCCEEECCCEEEEECCEEEECCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968