Click here to switch to the map view.

The map label for this gene is 13475748

Identifier: 13475748

GI number: 13475748

Start: 5678158

End: 5679531

Strand: Reverse

Name: 13475748

Synonym: mll6902

Alternate gene names: NA

Gene position: 5679531-5678158 (Counterclockwise)

Preceding gene: 229259630

Following gene: 13475747

Centisome position: 80.72

GC content: 65.57

Gene sequence:

>1374_bases
ATGGCGCGCGACACAACCGATTTCCGGCCGATCGAAGGCGTCGACGAACTCGTCGACCACCTGGCCGAGGGCAACAAGCC
GCGCGACAAATGGCGCATCGGCACCGAGCACGAGAAGTTCCCCTTCTATGTCGACGGCAACGCGCCCGTGCCCTATGGCG
GCGAGCGCGGCATCCGCGCCATCCTCGAAGGCATGCAGTCGAAGCTCGGCTGGGACCCGATCATCGACGACGGCCGCATC
ATCGGCCTGGTCGAACCGACCGGCCAGGGCGCGATTTCACTGGAACCGGGCGGCCAGTTCGAGCTTTCCGGTGCGCCGCT
GGAGACCATCCATCAGACCTGCCGCGAGGGCAATGCGCACCTGGCGCAGGTGCGCGAGATCGCCGAGCCGATGGGCATCC
GCTTCCTCGGGCTGGGCGGCAGCCCGAAATGGTCGCTGGCCGAAACGCCGAAAATGCCGAAGTCGCGCTATGAGATCATG
ACGCGCTACATGCCCAAGGTCGGCACCAAGGGCCTCGACATGATGTACCGCACCTGCACGATCCAGGTGAATCTCGACTT
CGAGAGCGAGGCTGACATGCGCCGCAAGATGCAGGTGTCGCTGAAGCTGCAGCCGCTGTCGACGGCGCTGTTCGCCAACT
CGCCCTTCACCGAAAGCCGGCCGAACGGCCTGCAGAGCTGGCGCGGCGACATCTGGCGCGACACCGACAACCAGCGCTCG
GGCCTGCTCGAATTCTGCTTCTCGCCCGATTTCGGTTTCGCCGACTATGTCGAATGGGCGCTCGACGTACCGATGTATTT
CGTCATCCGCGACGGCCACTATCACGACATGACGCACATCACCTTCCGCCAGTTCATGGCCGGTGCCGCGCGCAACGAAG
TGCCGGACGGCCTGCCGACCATGGGCGACTGGGCGAACCACCTGTCGACGCTGTTCCCCGACGTGCGGCTGAAGCGTTTC
CTCGAAATGCGCGGCGCCGATGGCGGCCCGTGGCGGCGCATCTGCGCGCTGCCGGCCTTCTGGGTCGGGCTGCTCTACGA
CGAGGCCGCACTTGATGCGGCCGAGGCGTTGACCGCGAGCTGGACCTACAAGGAAGTGCTGGCGATGCGCAACGCCGTGC
CCGAACTCGGCATTGCCGCGCCCTTCCGCAACGCCACGCTGCGCGAGATGGCGCGTGACGTGCTGGCCATTTCGCGCACC
GGGCTGAAGAACCGCGGCAAGAAAAACCGCGACGGCTACGACGAAACCTCGTTCCTCAACACATTGGACGAGGTGGTCGC
GCGCGGCACGACCAGCGCCGAGGAGATGCTTTCGGCCTACCACACGCGCTGGGGCGGCTCGATCGAACCGGTGTTCATGG
AATACGCCTACTAA

Upstream 100 bases:

>100_bases
TTTACCGCCGGCGGTCACTCGACCGCACTTTGATTGGGCACATGATCCTTCCCGAAAATCGAAAGGTCGATTTTCCGGGT
CATGTGCGGAGGGCTTGATC

Downstream 100 bases:

>100_bases
GCTGGCGCGTTAGGGAGCGGCAAAAGCCGCTTCAATCGACCGTTGAAACGAATTAGGCTCCCTTCCGAGGAATTCAGGAG
GAGAAGCCGATGCCTACCTT

Product: gamma-glutamylcysteine synthetase

Products: ADP; phosphate; gamma-L-glutamyl-L-cysteine

Alternate protein names: Glutamate/Cysteine Ligase; Gamma-Glutamylcysteine Synthetase; Glutamate/Cysteine Ligase Family Protein; Glutamate-Cysteine Ligase GshA; Glutamylcysteine Synthetase; Glutamate-Cysteine Ligase Family 2 Protein; Glutamate-Cysteine Ligase Protein; Glutathione Synthetase; Glutamate-Cysteine Ligase Gsha; Glutamate-Cysteine Ligase Protein; Glutamate-Cysteine Ligase Family Protein; Glutamate Cystein Ligase Protein

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MARDTTDFRPIEGVDELVDHLAEGNKPRDKWRIGTEHEKFPFYVDGNAPVPYGGERGIRAILEGMQSKLGWDPIIDDGRI
IGLVEPTGQGAISLEPGGQFELSGAPLETIHQTCREGNAHLAQVREIAEPMGIRFLGLGGSPKWSLAETPKMPKSRYEIM
TRYMPKVGTKGLDMMYRTCTIQVNLDFESEADMRRKMQVSLKLQPLSTALFANSPFTESRPNGLQSWRGDIWRDTDNQRS
GLLEFCFSPDFGFADYVEWALDVPMYFVIRDGHYHDMTHITFRQFMAGAARNEVPDGLPTMGDWANHLSTLFPDVRLKRF
LEMRGADGGPWRRICALPAFWVGLLYDEAALDAAEALTASWTYKEVLAMRNAVPELGIAAPFRNATLREMARDVLAISRT
GLKNRGKKNRDGYDETSFLNTLDEVVARGTTSAEEMLSAYHTRWGGSIEPVFMEYAY

Sequences:

>Translated_457_residues
MARDTTDFRPIEGVDELVDHLAEGNKPRDKWRIGTEHEKFPFYVDGNAPVPYGGERGIRAILEGMQSKLGWDPIIDDGRI
IGLVEPTGQGAISLEPGGQFELSGAPLETIHQTCREGNAHLAQVREIAEPMGIRFLGLGGSPKWSLAETPKMPKSRYEIM
TRYMPKVGTKGLDMMYRTCTIQVNLDFESEADMRRKMQVSLKLQPLSTALFANSPFTESRPNGLQSWRGDIWRDTDNQRS
GLLEFCFSPDFGFADYVEWALDVPMYFVIRDGHYHDMTHITFRQFMAGAARNEVPDGLPTMGDWANHLSTLFPDVRLKRF
LEMRGADGGPWRRICALPAFWVGLLYDEAALDAAEALTASWTYKEVLAMRNAVPELGIAAPFRNATLREMARDVLAISRT
GLKNRGKKNRDGYDETSFLNTLDEVVARGTTSAEEMLSAYHTRWGGSIEPVFMEYAY
>Mature_456_residues
ARDTTDFRPIEGVDELVDHLAEGNKPRDKWRIGTEHEKFPFYVDGNAPVPYGGERGIRAILEGMQSKLGWDPIIDDGRII
GLVEPTGQGAISLEPGGQFELSGAPLETIHQTCREGNAHLAQVREIAEPMGIRFLGLGGSPKWSLAETPKMPKSRYEIMT
RYMPKVGTKGLDMMYRTCTIQVNLDFESEADMRRKMQVSLKLQPLSTALFANSPFTESRPNGLQSWRGDIWRDTDNQRSG
LLEFCFSPDFGFADYVEWALDVPMYFVIRDGHYHDMTHITFRQFMAGAARNEVPDGLPTMGDWANHLSTLFPDVRLKRFL
EMRGADGGPWRRICALPAFWVGLLYDEAALDAAEALTASWTYKEVLAMRNAVPELGIAAPFRNATLREMARDVLAISRTG
LKNRGKKNRDGYDETSFLNTLDEVVARGTTSAEEMLSAYHTRWGGSIEPVFMEYAY

Specific function: Unknown

COG id: COG3572

COG function: function code H; Gamma-glutamylcysteine synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 6.3.2.2

Molecular weight: Translated: 51438; Mature: 51307

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARDTTDFRPIEGVDELVDHLAEGNKPRDKWRIGTEHEKFPFYVDGNAPVPYGGERGIRA
CCCCCCCCCCCCCHHHHHHHHHCCCCCHHHCCCCCCCCCCCEEECCCCCCCCCCHHHHHH
ILEGMQSKLGWDPIIDDGRIIGLVEPTGQGAISLEPGGQFELSGAPLETIHQTCREGNAH
HHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEECCCCCEEECCCCHHHHHHHHHCCCHH
LAQVREIAEPMGIRFLGLGGSPKWSLAETPKMPKSRYEIMTRYMPKVGTKGLDMMYRTCT
HHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHEEEEEEE
IQVNLDFESEADMRRKMQVSLKLQPLSTALFANSPFTESRPNGLQSWRGDIWRDTDNQRS
EEEEECCCCHHHHHHHEEEEEEEECHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCHHH
GLLEFCFSPDFGFADYVEWALDVPMYFVIRDGHYHDMTHITFRQFMAGAARNEVPDGLPT
HHHHHHCCCCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
MGDWANHLSTLFPDVRLKRFLEMRGADGGPWRRICALPAFWVGLLYDEAALDAAEALTAS
HHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
WTYKEVLAMRNAVPELGIAAPFRNATLREMARDVLAISRTGLKNRGKKNRDGYDETSFLN
CHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCHHHHHH
TLDEVVARGTTSAEEMLSAYHTRWGGSIEPVFMEYAY
HHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHEECC
>Mature Secondary Structure 
ARDTTDFRPIEGVDELVDHLAEGNKPRDKWRIGTEHEKFPFYVDGNAPVPYGGERGIRA
CCCCCCCCCCCCHHHHHHHHHCCCCCHHHCCCCCCCCCCCEEECCCCCCCCCCHHHHHH
ILEGMQSKLGWDPIIDDGRIIGLVEPTGQGAISLEPGGQFELSGAPLETIHQTCREGNAH
HHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEECCCCCEEECCCCHHHHHHHHHCCCHH
LAQVREIAEPMGIRFLGLGGSPKWSLAETPKMPKSRYEIMTRYMPKVGTKGLDMMYRTCT
HHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHEEEEEEE
IQVNLDFESEADMRRKMQVSLKLQPLSTALFANSPFTESRPNGLQSWRGDIWRDTDNQRS
EEEEECCCCHHHHHHHEEEEEEEECHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCHHH
GLLEFCFSPDFGFADYVEWALDVPMYFVIRDGHYHDMTHITFRQFMAGAARNEVPDGLPT
HHHHHHCCCCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
MGDWANHLSTLFPDVRLKRFLEMRGADGGPWRRICALPAFWVGLLYDEAALDAAEALTAS
HHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
WTYKEVLAMRNAVPELGIAAPFRNATLREMARDVLAISRTGLKNRGKKNRDGYDETSFLN
CHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCHHHHHH
TLDEVVARGTTSAEEMLSAYHTRWGGSIEPVFMEYAY
HHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-glutamate; L-cysteine

Specific reaction: ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA