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The map label for this gene is yfnH [H]

Identifier: 13475644

GI number: 13475644

Start: 5564034

End: 5564756

Strand: Direct

Name: yfnH [H]

Synonym: mlr6764

Alternate gene names: 13475644

Gene position: 5564034-5564756 (Clockwise)

Preceding gene: 13475641

Following gene: 13475645

Centisome position: 79.08

GC content: 58.51

Gene sequence:

>723_bases
ATGAAAGCGGTGATTCAATGTGGTGGGATGGGTACGCGCCTTCGGCCCTTCACGTCAGTCCTGCCGAAACCCTTGATGCC
GATAGGAGCCAGGCCCGTTCTTGAGCTGCTTCTGAAGTGGCTGCGGCGCAACGGTATCGAAGAGGTCTATATCACGACCG
GGTATCTCGGGCACCTGATCCGCAGCGTCTGCGGCGACGGATCGCAATGGAATCTGAAGATCAGATACACGCAGGAGATG
GAGCCACTGGGCACCATCGGGCCTCTCTCTCTGATCAGGGATGAACTGAACGAAACATTTGTCGTGCTCAACGGTGATGT
TCTTACCGACCTAAGCCTCAGCCGGTTCGTGGCCGCGCACCGGATGCATAAGGACCCGGTTACGATCGCCACGGCCTGCC
GCCTCATCAAGATGGACTTCGGCGTCATCGACGAGGTCAACAATGCCGTTCAGCTCTTTCGGGAAAAGCCGACGCTCTCC
CATCTCGTCAGCATGGGGATTTACTGCATGAACCCGGATGTCCTGCGGTTCATTCCTTCAGGCATCCCGTTTGGGTTCGA
TGACCTGATGCTGCAGATGATGCAGGGCGGCACGACCGTGCACGTGTACAAGCATGATGGTCTCTGGCTCGACATCGGTC
GCGTCGATGACTTCCAGAACGCGCAGGCGATTGCCTGGGAAGAGCAGTCGACCTCGATCGAGGTCGCGGCCGCGGCCGCA
TGA

Upstream 100 bases:

>100_bases
TTGCCGCCGAGGGTCGAGCCGGATTTGACGGGATGCCAGGTCTGAATGAACTCGAACACGAAATGCCCGGACACAGTCAG
TTGCAAATCAGGAGGATCGG

Downstream 100 bases:

>100_bases
AAATCCGGATGTAGAGGCCGAACCACAATAAGGATTTCAGGAGGTCAAGATGCTCTTGGTGAGCGCCCCGATCCTAGGCG
TGCCGGAGAAGGCAGCCCTG

Product: mannose-1-phosphate guanyltransferase

Products: NA

Alternate protein names: CDP-glucose pyrophosphorylase [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MKAVIQCGGMGTRLRPFTSVLPKPLMPIGARPVLELLLKWLRRNGIEEVYITTGYLGHLIRSVCGDGSQWNLKIRYTQEM
EPLGTIGPLSLIRDELNETFVVLNGDVLTDLSLSRFVAAHRMHKDPVTIATACRLIKMDFGVIDEVNNAVQLFREKPTLS
HLVSMGIYCMNPDVLRFIPSGIPFGFDDLMLQMMQGGTTVHVYKHDGLWLDIGRVDDFQNAQAIAWEEQSTSIEVAAAAA

Sequences:

>Translated_240_residues
MKAVIQCGGMGTRLRPFTSVLPKPLMPIGARPVLELLLKWLRRNGIEEVYITTGYLGHLIRSVCGDGSQWNLKIRYTQEM
EPLGTIGPLSLIRDELNETFVVLNGDVLTDLSLSRFVAAHRMHKDPVTIATACRLIKMDFGVIDEVNNAVQLFREKPTLS
HLVSMGIYCMNPDVLRFIPSGIPFGFDDLMLQMMQGGTTVHVYKHDGLWLDIGRVDDFQNAQAIAWEEQSTSIEVAAAAA
>Mature_240_residues
MKAVIQCGGMGTRLRPFTSVLPKPLMPIGARPVLELLLKWLRRNGIEEVYITTGYLGHLIRSVCGDGSQWNLKIRYTQEM
EPLGTIGPLSLIRDELNETFVVLNGDVLTDLSLSRFVAAHRMHKDPVTIATACRLIKMDFGVIDEVNNAVQLFREKPTLS
HLVSMGIYCMNPDVLRFIPSGIPFGFDDLMLQMMQGGTTVHVYKHDGLWLDIGRVDDFQNAQAIAWEEQSTSIEVAAAAA

Specific function: Catalyzes the transfer of a CMP moiety from CTP to glucose 1-phosphate [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate cytidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=226, Percent_Identity=32.7433628318584, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI11761619, Length=226, Percent_Identity=32.7433628318584, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI31881779, Length=191, Percent_Identity=34.0314136125654, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI45447090, Length=191, Percent_Identity=34.0314136125654, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1790224, Length=244, Percent_Identity=27.4590163934426, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788351, Length=225, Percent_Identity=25.7777777777778, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=231, Percent_Identity=29.8701298701299, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17509979, Length=206, Percent_Identity=28.1553398058252, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320148, Length=227, Percent_Identity=29.5154185022026, Blast_Score=107, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21355443, Length=225, Percent_Identity=32.4444444444444, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24644084, Length=225, Percent_Identity=32.4444444444444, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24653912, Length=194, Percent_Identity=33.5051546391753, Blast_Score=80, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013446
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.33 [H]

Molecular weight: Translated: 26743; Mature: 26743

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00810 ADP_GLC_PYROPHOSPH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVIQCGGMGTRLRPFTSVLPKPLMPIGARPVLELLLKWLRRNGIEEVYITTGYLGHLI
CCCEEEECCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHH
RSVCGDGSQWNLKIRYTQEMEPLGTIGPLSLIRDELNETFVVLNGDVLTDLSLSRFVAAH
HHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHH
RMHKDPVTIATACRLIKMDFGVIDEVNNAVQLFREKPTLSHLVSMGIYCMNPDVLRFIPS
HHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHCCEEEECCHHHHHCCC
GIPFGFDDLMLQMMQGGTTVHVYKHDGLWLDIGRVDDFQNAQAIAWEEQSTSIEVAAAAA
CCCCCHHHHHHHHHCCCCEEEEEECCCEEEECCCCCCCCCCCEEEECCCCCEEEEEEECC
>Mature Secondary Structure
MKAVIQCGGMGTRLRPFTSVLPKPLMPIGARPVLELLLKWLRRNGIEEVYITTGYLGHLI
CCCEEEECCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHH
RSVCGDGSQWNLKIRYTQEMEPLGTIGPLSLIRDELNETFVVLNGDVLTDLSLSRFVAAH
HHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHH
RMHKDPVTIATACRLIKMDFGVIDEVNNAVQLFREKPTLSHLVSMGIYCMNPDVLRFIPS
HHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHCCEEEECCHHHHHCCC
GIPFGFDDLMLQMMQGGTTVHVYKHDGLWLDIGRVDDFQNAQAIAWEEQSTSIEVAAAAA
CCCCCHHHHHHHHHCCCCEEEEEECCCEEEECCCCCCCCCCCEEEECCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]