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The map label for this gene is ubiE [H]

Identifier: 13475594

GI number: 13475594

Start: 5497167

End: 5497919

Strand: Reverse

Name: ubiE [H]

Synonym: mll6702

Alternate gene names: 13475594

Gene position: 5497919-5497167 (Counterclockwise)

Preceding gene: 13475595

Following gene: 13475593

Centisome position: 78.14

GC content: 60.16

Gene sequence:

>753_bases
ATGACATGGCGCCACGAGCGCGCAATCTTGCCGCGACACGGCATGAGGCCCGGGATCGTCATGGCCGACATCTGCTGCGG
GATCGGTGATTTCGCCGTGCTCGTGCAGAAGGAGTTCCAGCCGTCGCGCATCGTCGCCCTTGACCACTCCATGTCAAGCC
TCAGCTATGCTCGACGGGTGATGAAGGAGTTCGATATCCGGGGCATCGAGTATACCTATGGCGATGCGTCGGAGATGCTG
CTCGACGAGGCGCAGTTCGACCTGGTCACCTGCCGGCATTCCCTTCAAATCTTCAATCGGCCTGAACTCATCCTCAAGGA
GCTCTACCGCATATGCAAGCCAGGCGGGCGGGTCTACATTACCAACGAGAAGAATTCGCATTGCCTCGGAGAGCCGCGCT
CCGAAAGCATTCGTTGGACCTACAACGAGGTGGCGAAGCTATTCGGGCATTTCGAGATGGACGTCGAGCTCGGGCCCAAG
AGTCGGCGATACCTGGTCGAAGCCGGGTTCGAAGATATACGTGTGGAGTCCTTCATGGTCACTAACCTTGACGGCGATCC
GCAGGACTTTGCCGATGTCATTGTGGCCTGGGCGGATGTCTATGCGGGCGAGATGGCGACCCGACGCGGCGACGGACCGG
AGTTCATCGCACGGTTCCGGCAGGGCTTCCAGGACCACATTTTCGCTGCACTCCACCCCAAGGGCTACGCGGGTTGGCCG
ATCTGGGTCGCATCGGGGCAACGGCCACAATGA

Upstream 100 bases:

>100_bases
ACCGAACATCACGGTCCAGGAGTATGACAGTCAATTCTATCCGGGCCAGGGCTTCCTTGAAGAAGGCGGGTTCGTTCCGA
TCCTCCGCACACAGACAAAG

Downstream 100 bases:

>100_bases
AAGCCGACAATGAGCCTACACCACGCTTCGGCCTGCATTCCTTTCGAGCGAAATTCGTATTGGTCGTCGGCGGCGCCGTA
CTGTTCGACCTCCTGTTGAG

Product: menaquinone biosynthesis methyltransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MTWRHERAILPRHGMRPGIVMADICCGIGDFAVLVQKEFQPSRIVALDHSMSSLSYARRVMKEFDIRGIEYTYGDASEML
LDEAQFDLVTCRHSLQIFNRPELILKELYRICKPGGRVYITNEKNSHCLGEPRSESIRWTYNEVAKLFGHFEMDVELGPK
SRRYLVEAGFEDIRVESFMVTNLDGDPQDFADVIVAWADVYAGEMATRRGDGPEFIARFRQGFQDHIFAALHPKGYAGWP
IWVASGQRPQ

Sequences:

>Translated_250_residues
MTWRHERAILPRHGMRPGIVMADICCGIGDFAVLVQKEFQPSRIVALDHSMSSLSYARRVMKEFDIRGIEYTYGDASEML
LDEAQFDLVTCRHSLQIFNRPELILKELYRICKPGGRVYITNEKNSHCLGEPRSESIRWTYNEVAKLFGHFEMDVELGPK
SRRYLVEAGFEDIRVESFMVTNLDGDPQDFADVIVAWADVYAGEMATRRGDGPEFIARFRQGFQDHIFAALHPKGYAGWP
IWVASGQRPQ
>Mature_249_residues
TWRHERAILPRHGMRPGIVMADICCGIGDFAVLVQKEFQPSRIVALDHSMSSLSYARRVMKEFDIRGIEYTYGDASEMLL
DEAQFDLVTCRHSLQIFNRPELILKELYRICKPGGRVYITNEKNSHCLGEPRSESIRWTYNEVAKLFGHFEMDVELGPKS
RRYLVEAGFEDIRVESFMVTNLDGDPQDFADVIVAWADVYAGEMATRRGDGPEFIARFRQGFQDHIFAALHPKGYAGWPI
WVASGQRPQ

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014122
- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 28682; Mature: 28551

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWRHERAILPRHGMRPGIVMADICCGIGDFAVLVQKEFQPSRIVALDHSMSSLSYARRV
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHH
MKEFDIRGIEYTYGDASEMLLDEAQFDLVTCRHSLQIFNRPELILKELYRICKPGGRVYI
HHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEE
TNEKNSHCLGEPRSESIRWTYNEVAKLFGHFEMDVELGPKSRRYLVEAGFEDIRVESFMV
ECCCCCCCCCCCCCCCEEECHHHHHHHHCCEEEEEEECCCCCEEEEECCCCHHEEEEEEE
TNLDGDPQDFADVIVAWADVYAGEMATRRGDGPEFIARFRQGFQDHIFAALHPKGYAGWP
ECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHEEEEECCCCCCCCE
IWVASGQRPQ
EEECCCCCCC
>Mature Secondary Structure 
TWRHERAILPRHGMRPGIVMADICCGIGDFAVLVQKEFQPSRIVALDHSMSSLSYARRV
CCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHH
MKEFDIRGIEYTYGDASEMLLDEAQFDLVTCRHSLQIFNRPELILKELYRICKPGGRVYI
HHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEE
TNEKNSHCLGEPRSESIRWTYNEVAKLFGHFEMDVELGPKSRRYLVEAGFEDIRVESFMV
ECCCCCCCCCCCCCCCEEECHHHHHHHHCCEEEEEEECCCCCEEEEECCCCHHEEEEEEE
TNLDGDPQDFADVIVAWADVYAGEMATRRGDGPEFIARFRQGFQDHIFAALHPKGYAGWP
ECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHEEEEECCCCCCCCE
IWVASGQRPQ
EEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]