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The map label for this gene is pbp [H]

Identifier: 13475563

GI number: 13475563

Start: 5460039

End: 5461703

Strand: Reverse

Name: pbp [H]

Synonym: mll6665

Alternate gene names: 13475563

Gene position: 5461703-5460039 (Counterclockwise)

Preceding gene: 13475564

Following gene: 13475562

Centisome position: 77.62

GC content: 66.01

Gene sequence:

>1665_bases
ATGAGCAGACTTTCCGCCGCTGCCATCGAGCTGTTCGAGGACCTGATCCGGCAGCAGGTCGAGGACAAGGCGATCCCCTC
CATCTCCTATGGCCTTGTCGACCGCGACGGGCTAATGGGGGCAGGCCATATCCAGCGCCATGACCGCGGCTTCGTCATGG
GCGACGACACCTGTTTCCGCATCGGCTCGATCACCAAGACCTTCACCGCCGTCGCCGTCATGCAGCTGGCCGAAAAGGGG
CTGGTCGACCTCGATGTCGATGTCTCCGAATATCTGCCTGGCTTCAAGCCACAGAACCCATTTGCCGGGCGCGAAGGCGG
GCCGCACGGCGCGCAGATCAGCCTGCGCAAACTGATGAGCCACACCGCCGGCCTGGTGCGCGAGCCCAAGAGCGGCCACT
ATCTCGACGCGGCGCGGCCGCCGCTGGCCGACACCGTTGCCGAACTCGCCACCTCGACACTGAAGCAGGATCCGAGCCTT
GGCCAGATGCATTATTCCAACGCCGGCATCGCCGTGGCCGGGAGGGTCATCGAGACGCTGACGCGCAAGAGCTATGCCGA
ATACGTCAGTGAGAACATCCTGAAGCCGCTTGGCATGGACCAGACCTCGTCGGGCCTGGCGCCCGGCATTGCCGAGCGGC
TCGCGCCTGCCGACATGTGGACGCTGGAAGGCGACAGCCCGGCGCCTGTGTTCGACCTTGGCGGCCCACCGGCCGGCAAC
ATCTATTCGACCACCAGTGACATGGCGCGCTATGTCCAGTGCCTGCTGCGCGGCGGGTTCGCGCCGGATGGCTGGCAAAT
CGTCTCGCCCGGATCGCTACGCGAGATGTGGGTGCCGATCGGCAAGCGCGCCTCAGGCGAAAGGGTGGCGAACACCTATG
GCCTGTGCTTCGGCGTCGGCGACGTCGACGGCTGGACGTCGGTCGGCCATGGCGGCGCCGTCTACGGTTATTCGTCCCAG
ATGATCCTGCTGCCCGCTGCCGGCGTCGGCGTGCTGATTTTCTCGACGCTGGATTTCTCTAATCAGATAGGCGCACGGCT
CGGCGTCGAGGGCCTGCGCATCGCGCTGGCCGAGCGCCGTATGGGAACACTGCCGGTGCGGCCGCAGGGCCTGCCGCCCG
TCGCCGCCGACCAGCTTGTGGCGCTGCCTGGCCACTACCGGCACGACACCTCCGGCGAAGTCGTCGAGGTCAAGGCCAAG
GCCGGCAAGCTCTTTCTGATGGGCGAAGGCGTGCCGTTGCAGATCCGCCCTGTCGCCGGTTCGGATTTCACCATTGACGG
GCGTATCTATGGACACGGCGCTGAATATCCGCACATGAACCTGTCGTTTCCCGCTCCCGGCGCACTGGTGTGGAAAGGGG
TGAACTGGTCGCGCATCGACGCGCTGCCCGCTGAGGCGGTGCCGGCCGAAATCGCGCCGCACCTCGGCGAATACGGCCCG
GACTTCAACATCACCTATCTGAGCTACAGCCATGGCGAGCTGAAATGCCTGATCGAGTATTTCTGCACGCACGGCTGCGA
GCCAGTGGAGGCCGGGCGCTTTCGCATGCGCGGCCTCCTCTACGAGGAGGAGATCCTCGAAATCGACGCCATCGACGATC
ACGGCCGGCGCGGCATCCGGGTCGGCCCGATGTTCCTCGAGCGCCGGCACGCGCCGGCCGCCTGA

Upstream 100 bases:

>100_bases
GTCGACAGCGACTACAGGGTGATCGAAGCGATGAAGACCTTCTTCTGAGCATTCGGCGAAAGACCCTGACTGCTTCCGCT
TGATTTCCGAGGAGACCACA

Downstream 100 bases:

>100_bases
ACGGAAGAACGCCAATGGCAATGCCGATTATGATGGAATCGCCGCTGGCTGCCCGCATGCGCATCAACGGCCGTGAGGTC
GATCATTTCTGCAGCACCAG

Product: hypothetical protein

Products: NA

Alternate protein names: PBP-4 [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MSRLSAAAIELFEDLIRQQVEDKAIPSISYGLVDRDGLMGAGHIQRHDRGFVMGDDTCFRIGSITKTFTAVAVMQLAEKG
LVDLDVDVSEYLPGFKPQNPFAGREGGPHGAQISLRKLMSHTAGLVREPKSGHYLDAARPPLADTVAELATSTLKQDPSL
GQMHYSNAGIAVAGRVIETLTRKSYAEYVSENILKPLGMDQTSSGLAPGIAERLAPADMWTLEGDSPAPVFDLGGPPAGN
IYSTTSDMARYVQCLLRGGFAPDGWQIVSPGSLREMWVPIGKRASGERVANTYGLCFGVGDVDGWTSVGHGGAVYGYSSQ
MILLPAAGVGVLIFSTLDFSNQIGARLGVEGLRIALAERRMGTLPVRPQGLPPVAADQLVALPGHYRHDTSGEVVEVKAK
AGKLFLMGEGVPLQIRPVAGSDFTIDGRIYGHGAEYPHMNLSFPAPGALVWKGVNWSRIDALPAEAVPAEIAPHLGEYGP
DFNITYLSYSHGELKCLIEYFCTHGCEPVEAGRFRMRGLLYEEEILEIDAIDDHGRRGIRVGPMFLERRHAPAA

Sequences:

>Translated_554_residues
MSRLSAAAIELFEDLIRQQVEDKAIPSISYGLVDRDGLMGAGHIQRHDRGFVMGDDTCFRIGSITKTFTAVAVMQLAEKG
LVDLDVDVSEYLPGFKPQNPFAGREGGPHGAQISLRKLMSHTAGLVREPKSGHYLDAARPPLADTVAELATSTLKQDPSL
GQMHYSNAGIAVAGRVIETLTRKSYAEYVSENILKPLGMDQTSSGLAPGIAERLAPADMWTLEGDSPAPVFDLGGPPAGN
IYSTTSDMARYVQCLLRGGFAPDGWQIVSPGSLREMWVPIGKRASGERVANTYGLCFGVGDVDGWTSVGHGGAVYGYSSQ
MILLPAAGVGVLIFSTLDFSNQIGARLGVEGLRIALAERRMGTLPVRPQGLPPVAADQLVALPGHYRHDTSGEVVEVKAK
AGKLFLMGEGVPLQIRPVAGSDFTIDGRIYGHGAEYPHMNLSFPAPGALVWKGVNWSRIDALPAEAVPAEIAPHLGEYGP
DFNITYLSYSHGELKCLIEYFCTHGCEPVEAGRFRMRGLLYEEEILEIDAIDDHGRRGIRVGPMFLERRHAPAA
>Mature_553_residues
SRLSAAAIELFEDLIRQQVEDKAIPSISYGLVDRDGLMGAGHIQRHDRGFVMGDDTCFRIGSITKTFTAVAVMQLAEKGL
VDLDVDVSEYLPGFKPQNPFAGREGGPHGAQISLRKLMSHTAGLVREPKSGHYLDAARPPLADTVAELATSTLKQDPSLG
QMHYSNAGIAVAGRVIETLTRKSYAEYVSENILKPLGMDQTSSGLAPGIAERLAPADMWTLEGDSPAPVFDLGGPPAGNI
YSTTSDMARYVQCLLRGGFAPDGWQIVSPGSLREMWVPIGKRASGERVANTYGLCFGVGDVDGWTSVGHGGAVYGYSSQM
ILLPAAGVGVLIFSTLDFSNQIGARLGVEGLRIALAERRMGTLPVRPQGLPPVAADQLVALPGHYRHDTSGEVVEVKAKA
GKLFLMGEGVPLQIRPVAGSDFTIDGRIYGHGAEYPHMNLSFPAPGALVWKGVNWSRIDALPAEAVPAEIAPHLGEYGPD
FNITYLSYSHGELKCLIEYFCTHGCEPVEAGRFRMRGLLYEEEILEIDAIDDHGRRGIRVGPMFLERRHAPAA

Specific function: Involved in cell wall biosynthesis and may also act as a sensor of external penicillins [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

Organism=Homo sapiens, GI239747261, Length=339, Percent_Identity=26.5486725663717, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI239752721, Length=339, Percent_Identity=26.5486725663717, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI239741085, Length=339, Percent_Identity=26.5486725663717, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1786574, Length=210, Percent_Identity=30.952380952381, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115533026, Length=362, Percent_Identity=25.414364640884, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: NA

Molecular weight: Translated: 59618; Mature: 59487

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLSAAAIELFEDLIRQQVEDKAIPSISYGLVDRDGLMGAGHIQRHDRGFVMGDDTCFR
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCEEECCCCEEE
IGSITKTFTAVAVMQLAEKGLVDLDVDVSEYLPGFKPQNPFAGREGGPHGAQISLRKLMS
CCCHHHHHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
HTAGLVREPKSGHYLDAARPPLADTVAELATSTLKQDPSLGQMHYSNAGIAVAGRVIETL
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHH
TRKSYAEYVSENILKPLGMDQTSSGLAPGIAERLAPADMWTLEGDSPAPVFDLGGPPAGN
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCEEECCCCCCCC
IYSTTSDMARYVQCLLRGGFAPDGWQIVSPGSLREMWVPIGKRASGERVANTYGLCFGVG
CCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHCCCCCCCCCCHHHHHCEEEEECC
DVDGWTSVGHGGAVYGYSSQMILLPAAGVGVLIFSTLDFSNQIGARLGVEGLRIALAERR
CCCCCCCCCCCCEEEECCCCEEEEECCCCEEEEEEECCCCHHHHHHHCHHHHHHHHHHHC
MGTLPVRPQGLPPVAADQLVALPGHYRHDTSGEVVEVKAKAGKLFLMGEGVPLQIRPVAG
CCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCEEEEEECCCEEEEEECCCCEEEEECCC
SDFTIDGRIYGHGAEYPHMNLSFPAPGALVWKGVNWSRIDALPAEAVPAEIAPHLGEYGP
CCEEECCEEEECCCCCCCCEECCCCCCCEEEECCCHHHHCCCCCCCCCHHHHHHHHCCCC
DFNITYLSYSHGELKCLIEYFCTHGCEPVEAGRFRMRGLLYEEEILEIDAIDDHGRRGIR
CCEEEEEEECCCHHHHHHHHHHHCCCCCCHHCHHHHHHHHHHHHHEEEECCCCCCCCCCE
VGPMFLERRHAPAA
ECHHHHHCCCCCCC
>Mature Secondary Structure 
SRLSAAAIELFEDLIRQQVEDKAIPSISYGLVDRDGLMGAGHIQRHDRGFVMGDDTCFR
CCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCEEECCCCEEE
IGSITKTFTAVAVMQLAEKGLVDLDVDVSEYLPGFKPQNPFAGREGGPHGAQISLRKLMS
CCCHHHHHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
HTAGLVREPKSGHYLDAARPPLADTVAELATSTLKQDPSLGQMHYSNAGIAVAGRVIETL
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHH
TRKSYAEYVSENILKPLGMDQTSSGLAPGIAERLAPADMWTLEGDSPAPVFDLGGPPAGN
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCEEECCCCCCCC
IYSTTSDMARYVQCLLRGGFAPDGWQIVSPGSLREMWVPIGKRASGERVANTYGLCFGVG
CCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHCCCCCCCCCCHHHHHCEEEEECC
DVDGWTSVGHGGAVYGYSSQMILLPAAGVGVLIFSTLDFSNQIGARLGVEGLRIALAERR
CCCCCCCCCCCCEEEECCCCEEEEECCCCEEEEEEECCCCHHHHHHHCHHHHHHHHHHHC
MGTLPVRPQGLPPVAADQLVALPGHYRHDTSGEVVEVKAKAGKLFLMGEGVPLQIRPVAG
CCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCEEEEEECCCEEEEEECCCCEEEEECCC
SDFTIDGRIYGHGAEYPHMNLSFPAPGALVWKGVNWSRIDALPAEAVPAEIAPHLGEYGP
CCEEECCEEEECCCCCCCCEECCCCCCCEEEECCCHHHHCCCCCCCCCHHHHHHHHCCCC
DFNITYLSYSHGELKCLIEYFCTHGCEPVEAGRFRMRGLLYEEEILEIDAIDDHGRRGIR
CCEEEEEEECCCHHHHHHHHHHHCCCCCCHHCHHHHHHHHHHHHHEEEECCCCCCCCCCE
VGPMFLERRHAPAA
ECHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8440253 [H]