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The map label for this gene is cadA [H]

Identifier: 13475503

GI number: 13475503

Start: 5396567

End: 5398420

Strand: Reverse

Name: cadA [H]

Synonym: mll6590

Alternate gene names: 13475503

Gene position: 5398420-5396567 (Counterclockwise)

Preceding gene: 13475505

Following gene: 13475502

Centisome position: 76.72

GC content: 65.21

Gene sequence:

>1854_bases
ATGAACGAGTCCATTCTGCGGCGCGCATTGCTGGTCATCGCGGTCCTGGGTCTCGCTGGCGGCATCGGAGCCTGGCGAGC
CGGGCTCGGGCCTCTTGATGCCGACACGATCTGGACGATGGCCACCTTGCCCGTGGTGGCGGCTCTCGCCATCTCCATTC
TGCGTGATTTCTGGATCGGCCGCTTCGGTGTCGATGCAATTGCTTTGGTGTCAATGTCCGCCGCGCTGTTGCTCGGCCAG
CCGCTGGCCGCGATAGTGGTCGCGATCATGTATGCCGGCGGCACTGTGCTCGAGGATTTTGCCCGCGGCCGTGCCGAGCG
GAACCTCAAGGCACTCACTGACCGGTCACCGCGTGTCGCACACCGCGAATCCGCACATGGAACGGAAAGGATTTCCGTCG
AAGAGGTCGTTGTCGGCGACACCCTTTTGGTACGCGCCGGCGAACTGCTTCCCGTCGATGGTATCCTGCTTGATGCTTCA
GCCTCGATCGATGAGTCCGCGGTGACCGGAGAGCCGCTGCCGGAACGACGGACTGCGGGCGACATGCTGCGAAGCGGCAC
CGTCAATGCGGGCGAGACCTTCAGCATGCGGGCTGCGGTCCCCGCTGAAGAAAGCACTTATGCCGCGATCGTGCGCATGG
TCGCCGCAGCACAGACCGCGAAGTCTCCGTTCATTCGCATGGCGGACCGCTTTGCCCTGTTCCTGTTGCCAGCCACTCTG
CTGGTTTCCGCCGCCGCCTGGTATATTTCCGGCGACCCTATCAGAGCGCTTGCGGTGCTGGTCGTCGCAACGCCCTGCCC
GCTCATCCTCGCTGCTCCTGTTGCCTTCATCGGCGGTGTCTCGCGAGCCGCTCGGGCCGGCATCCTGATGAAAGGCAGCA
CGGCTCTGGAGGCCCTCGCGCAAGTCCGAACCGCGATCTTCGACAAGACGGGGACCTTGACCATCGGCGGCGCCGAACTC
ATCGAAATCGAAGCCGCACCCGGCCGTGACGCGAACCATCTGCTGCGGCTGTTGGCATCCCTGGAACAGGCCTCGCACCA
TGTGCTCGCCGACTCGATCATCCGGACAGCGCGCGGCAGGCAGCTGGTGCTTTCGCATCCGCGCGATGTCCGCGAGTACC
GCGGCGCGGGTCTGAAAGGCCGGGTCGATGACATGGCGATCGCGGCGGGATCGCGGGCTCTCGTGCTCACTGACAGGCCC
CTGCCCGACTGGGCGAAATGCGGCGAAGAAAAATACCGGGACGAGCCGGTGCTCAGGGTGTTTGTCGCACTCGGCGGGCG
GCTTGCAGGCGTGTTTACTTTCGGCGATGCGATGCGTGCCGATGCAAATGACACGCTCGCCAAGCTGCGCTCGGCCGGCA
TCGCGCGCGTAATCCTGCTGACAGGTGATGACGGTGCGGCAGCAAAGCGCGTTTCTTCCATGCTGGATCTGGATGCCGTC
GTCGCCGATGCCATTCCCGCGGATAAGGTCGCGATGGTAGAGGCCGAGAAAGCAATGGCGCCGACAATGATGGTCGGCGA
TGGCATCAACGATGCACCCGCCCTTGCCGCCGCGACGGTCGGCGTCGCCATGGGCGCGCGCGGGGCGACGGCCTCTTCCG
AAGCGGCCGATGTCATCGTTCTCGCGGACCGGCTGGAGCCTGTCGCCGAGGCGGTGCAGATTGCCCGACGGACACGCGCG
ATCGCCCTGCAGAGCATTGTTGTCGGGCTGACGCTCTCGGGTGTGGCAATGGCGGCGGCGGCCATGGGGCAGATCACACC
GGTGGCAGGTGCATTGCTTCAGGAAGGGATCGACGTCGCGGTCATCCTGAACGCACTGCGCGCCCTTGGCGACGGACATC
TCGGGCGCACATAG

Upstream 100 bases:

>100_bases
GTCTTCACCAGCCTATCGGGACTAGCTGTTTGCTTGAGTTCGACACGCCCGTCAGCGCCAGCGAAAATTGGCGAGTATCG
ATCAAATCGGAAGGCATCGC

Downstream 100 bases:

>100_bases
TGGACAACAACGGATCGGTGAACGGCCATGGCACAGGACAATCTGGTGGTTTGCGACAAATGCGGCGGGGTCAATCGCCT
GCCGCCGGCCCGCAATGCCG

Product: cation-transporting ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MNESILRRALLVIAVLGLAGGIGAWRAGLGPLDADTIWTMATLPVVAALAISILRDFWIGRFGVDAIALVSMSAALLLGQ
PLAAIVVAIMYAGGTVLEDFARGRAERNLKALTDRSPRVAHRESAHGTERISVEEVVVGDTLLVRAGELLPVDGILLDAS
ASIDESAVTGEPLPERRTAGDMLRSGTVNAGETFSMRAAVPAEESTYAAIVRMVAAAQTAKSPFIRMADRFALFLLPATL
LVSAAAWYISGDPIRALAVLVVATPCPLILAAPVAFIGGVSRAARAGILMKGSTALEALAQVRTAIFDKTGTLTIGGAEL
IEIEAAPGRDANHLLRLLASLEQASHHVLADSIIRTARGRQLVLSHPRDVREYRGAGLKGRVDDMAIAAGSRALVLTDRP
LPDWAKCGEEKYRDEPVLRVFVALGGRLAGVFTFGDAMRADANDTLAKLRSAGIARVILLTGDDGAAAKRVSSMLDLDAV
VADAIPADKVAMVEAEKAMAPTMMVGDGINDAPALAAATVGVAMGARGATASSEAADVIVLADRLEPVAEAVQIARRTRA
IALQSIVVGLTLSGVAMAAAAMGQITPVAGALLQEGIDVAVILNALRALGDGHLGRT

Sequences:

>Translated_617_residues
MNESILRRALLVIAVLGLAGGIGAWRAGLGPLDADTIWTMATLPVVAALAISILRDFWIGRFGVDAIALVSMSAALLLGQ
PLAAIVVAIMYAGGTVLEDFARGRAERNLKALTDRSPRVAHRESAHGTERISVEEVVVGDTLLVRAGELLPVDGILLDAS
ASIDESAVTGEPLPERRTAGDMLRSGTVNAGETFSMRAAVPAEESTYAAIVRMVAAAQTAKSPFIRMADRFALFLLPATL
LVSAAAWYISGDPIRALAVLVVATPCPLILAAPVAFIGGVSRAARAGILMKGSTALEALAQVRTAIFDKTGTLTIGGAEL
IEIEAAPGRDANHLLRLLASLEQASHHVLADSIIRTARGRQLVLSHPRDVREYRGAGLKGRVDDMAIAAGSRALVLTDRP
LPDWAKCGEEKYRDEPVLRVFVALGGRLAGVFTFGDAMRADANDTLAKLRSAGIARVILLTGDDGAAAKRVSSMLDLDAV
VADAIPADKVAMVEAEKAMAPTMMVGDGINDAPALAAATVGVAMGARGATASSEAADVIVLADRLEPVAEAVQIARRTRA
IALQSIVVGLTLSGVAMAAAAMGQITPVAGALLQEGIDVAVILNALRALGDGHLGRT
>Mature_617_residues
MNESILRRALLVIAVLGLAGGIGAWRAGLGPLDADTIWTMATLPVVAALAISILRDFWIGRFGVDAIALVSMSAALLLGQ
PLAAIVVAIMYAGGTVLEDFARGRAERNLKALTDRSPRVAHRESAHGTERISVEEVVVGDTLLVRAGELLPVDGILLDAS
ASIDESAVTGEPLPERRTAGDMLRSGTVNAGETFSMRAAVPAEESTYAAIVRMVAAAQTAKSPFIRMADRFALFLLPATL
LVSAAAWYISGDPIRALAVLVVATPCPLILAAPVAFIGGVSRAARAGILMKGSTALEALAQVRTAIFDKTGTLTIGGAEL
IEIEAAPGRDANHLLRLLASLEQASHHVLADSIIRTARGRQLVLSHPRDVREYRGAGLKGRVDDMAIAAGSRALVLTDRP
LPDWAKCGEEKYRDEPVLRVFVALGGRLAGVFTFGDAMRADANDTLAKLRSAGIARVILLTGDDGAAAKRVSSMLDLDAV
VADAIPADKVAMVEAEKAMAPTMMVGDGINDAPALAAATVGVAMGARGATASSEAADVIVLADRLEPVAEAVQIARRTRA
IALQSIVVGLTLSGVAMAAAAMGQITPVAGALLQEGIDVAVILNALRALGDGHLGRT

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=542, Percent_Identity=28.4132841328413, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI55743073, Length=512, Percent_Identity=28.515625, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI115529486, Length=263, Percent_Identity=29.6577946768061, Blast_Score=117, Evalue=4e-26,
Organism=Escherichia coli, GI1789879, Length=564, Percent_Identity=32.9787234042553, Blast_Score=228, Evalue=8e-61,
Organism=Escherichia coli, GI1786691, Length=600, Percent_Identity=32, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1786914, Length=547, Percent_Identity=27.2394881170018, Blast_Score=132, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17556548, Length=560, Percent_Identity=28.3928571428571, Blast_Score=155, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6320475, Length=544, Percent_Identity=28.125, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6319772, Length=526, Percent_Identity=25.2851711026616, Blast_Score=143, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6321430, Length=517, Percent_Identity=27.0793036750484, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6325221, Length=516, Percent_Identity=26.1627906976744, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320245, Length=131, Percent_Identity=35.1145038167939, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320244, Length=131, Percent_Identity=35.1145038167939, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320243, Length=131, Percent_Identity=35.1145038167939, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221329854, Length=260, Percent_Identity=33.4615384615385, Blast_Score=118, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 63953; Mature: 63953

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNESILRRALLVIAVLGLAGGIGAWRAGLGPLDADTIWTMATLPVVAALAISILRDFWIG
CCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RFGVDAIALVSMSAALLLGQPLAAIVVAIMYAGGTVLEDFARGRAERNLKALTDRSPRVA
HHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHCCCCCCC
HRESAHGTERISVEEVVVGDTLLVRAGELLPVDGILLDASASIDESAVTGEPLPERRTAG
CCCCCCCCCCCCHHHEEECCCCEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHH
DMLRSGTVNAGETFSMRAAVPAEESTYAAIVRMVAAAQTAKSPFIRMADRFALFLLPATL
HHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LVSAAAWYISGDPIRALAVLVVATPCPLILAAPVAFIGGVSRAARAGILMKGSTALEALA
HHHHHHHEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHH
QVRTAIFDKTGTLTIGGAELIEIEAAPGRDANHLLRLLASLEQASHHVLADSIIRTARGR
HHHHHHHCCCCCEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QLVLSHPRDVREYRGAGLKGRVDDMAIAAGSRALVLTDRPLPDWAKCGEEKYRDEPVLRV
EEEECCCHHHHHHCCCCCCCCCCHHHEECCCEEEEEECCCCCHHHHCCHHHHCCCHHHHH
FVALGGRLAGVFTFGDAMRADANDTLAKLRSAGIARVILLTGDDGAAAKRVSSMLDLDAV
HHHHCCHHEEEEEECCHHHCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHH
VADAIPADKVAMVEAEKAMAPTMMVGDGINDAPALAAATVGVAMGARGATASSEAADVIV
HHHCCCCCHHHHEEHHHHHCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEE
LADRLEPVAEAVQIARRTRAIALQSIVVGLTLSGVAMAAAAMGQITPVAGALLQEGIDVA
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHH
VILNALRALGDGHLGRT
HHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNESILRRALLVIAVLGLAGGIGAWRAGLGPLDADTIWTMATLPVVAALAISILRDFWIG
CCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RFGVDAIALVSMSAALLLGQPLAAIVVAIMYAGGTVLEDFARGRAERNLKALTDRSPRVA
HHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHCCCCCCC
HRESAHGTERISVEEVVVGDTLLVRAGELLPVDGILLDASASIDESAVTGEPLPERRTAG
CCCCCCCCCCCCHHHEEECCCCEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHH
DMLRSGTVNAGETFSMRAAVPAEESTYAAIVRMVAAAQTAKSPFIRMADRFALFLLPATL
HHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LVSAAAWYISGDPIRALAVLVVATPCPLILAAPVAFIGGVSRAARAGILMKGSTALEALA
HHHHHHHEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHH
QVRTAIFDKTGTLTIGGAELIEIEAAPGRDANHLLRLLASLEQASHHVLADSIIRTARGR
HHHHHHHCCCCCEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QLVLSHPRDVREYRGAGLKGRVDDMAIAAGSRALVLTDRPLPDWAKCGEEKYRDEPVLRV
EEEECCCHHHHHHCCCCCCCCCCHHHEECCCEEEEEECCCCCHHHHCCHHHHCCCHHHHH
FVALGGRLAGVFTFGDAMRADANDTLAKLRSAGIARVILLTGDDGAAAKRVSSMLDLDAV
HHHHCCHHEEEEEECCHHHCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHH
VADAIPADKVAMVEAEKAMAPTMMVGDGINDAPALAAATVGVAMGARGATASSEAADVIV
HHHCCCCCHHHHEEHHHHHCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEE
LADRLEPVAEAVQIARRTRAIALQSIVVGLTLSGVAMAAAAMGQITPVAGALLQEGIDVA
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHH
VILNALRALGDGHLGRT
HHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]