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The map label for this gene is zwf [H]

Identifier: 13475445

GI number: 13475445

Start: 5324553

End: 5326022

Strand: Reverse

Name: zwf [H]

Synonym: mll6516

Alternate gene names: 13475445

Gene position: 5326022-5324553 (Counterclockwise)

Preceding gene: 13475447

Following gene: 13475444

Centisome position: 75.7

GC content: 63.06

Gene sequence:

>1470_bases
ATGACCAGCCAGATCATTCCCGTCGATCCTTTCGACTTCATCATTTTCGGCGGCACCGGCGACCTGTCGGAACGCAAGCT
TCTGCCGTCGCTCTATTATCGCCAGCGCGACCATCAATTCTCCGAGCCGACGCGCATCATCGGCACATCGCGCTCGAAAA
TGAGCGACGAGGAATTCCGGGCCTTCGCCAGCCAGGCGATCTCCGATCACGTCAAGCCGGCCGATATCGACGCCAAGGAA
TTGAAGACCTTCCTGGCGCGGCTCTCCTATATCTCGGCCGATGCGACGAGCGGCGCTGGCTTCGACAAGCTTAAGAAGGC
GATCGGCGAGAGCGAGAGCATCCGCGCCTTCTATCTGGCGGTGGCGCCGGCGCTGTTCGGCGATATCTCGCACAAGCTGA
AAGAGAACAAGCTGATCACGCCGAACTCGCGCATCGTGCTGGAGAAGCCGATCGGCCGCGACCTTGCCTCGGCGCGGGCA
CTCAACGATTTGGTCGGCGACGACTTCCACGAAAGCCAGATTTTCCGCATCGACCACTATCTCGGCAAGGAGACGGTGCA
GAACCTGATGGCGCTGCGCTTTGCCAACGCGCTCTATGAGCCGCTGTGGAACTCCGCCCATATCGACCACGTACAGATCA
CGGTGGCCGAGACCGTCGGCTTGGAAGACCGCGTCACCTACTACGACAAGGCCGGCGCGCTGCGCGACATGGTGCAGAAC
CACATGCTGCAGTTGCTCTGCCTCGTGGCCATGGAGGCGCCGTCGTCGATGGACGCCGACGCCGTGCGCGACGAGAAGCT
CAAGGTGCTGCGGGCGCTGAAGCGCATCAACGGCAACGAGGCGCCGAAGCACACGGTGCGCGGCCAGTATCGCGCCGGTG
CATCGGCCGGCGGGCCGGTGAAGGGCTATGTCGAGGAGCTCGGCAAGGACAGCAACACCGAGACCTTCGTCGCCATCAAG
GCCGAGATCGGCACCTGGCGCTGGGCCGGCGTTCCGTTCTACCTCAGGACCGGCAAGCGCTTGGCGACCCGGGTTTCGGA
AATCGTCATCGAGTTCAAGCCGATCCCGCATTCGATCTTCGGCGACAGCGCCGGGCCGATCTTCGCCAACCAGCTGGTCA
TCCGGCTGCAGCCGGACGAGGGCGTCAAGCAGTTCATCATGATCAAGGATCCGGGCCCGGGCGGCATGCGGCTGCGCCAG
ATCTCGCTCGACATGAGCTTCGCGCAATCCTTCGACGGCCGCGCGCCCGATGCCTATGAACGGCTGATCATGGACGTCAT
CCGTGGCAACCAGACGCTGTTCATGCGCCGTGACGAGGTCGAGGCGGCGTGGAAATGGATCGACCCGATCCAGAATGCCT
GGGAAGGCGCCAAGCAGGAAGCGCAGGGCTATACGGCAGGCACATGGGGGCCATCTGCCTCGATAGCGCTGATCGAACGT
GACGGGCGGACATGGCACGAGAGCAATTGA

Upstream 100 bases:

>100_bases
CAGCGATTGGTCCTCGATGTGACACCATGGCACTGGAAAATTTAAATCGATTAGAATATATCAGCCGCGTACTCGCGACC
GGCGTCAAAGCGGACAGACC

Downstream 100 bases:

>100_bases
ACGGCGCCAGCTACAACTGGAACGCTTTCCCCGACCGGCCGCAACTGGCCGTGGCGCTGGCCGGCCGCGTGGCCGATCGG
CTGACCAGGGCGATTGCGGA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MTSQIIPVDPFDFIIFGGTGDLSERKLLPSLYYRQRDHQFSEPTRIIGTSRSKMSDEEFRAFASQAISDHVKPADIDAKE
LKTFLARLSYISADATSGAGFDKLKKAIGESESIRAFYLAVAPALFGDISHKLKENKLITPNSRIVLEKPIGRDLASARA
LNDLVGDDFHESQIFRIDHYLGKETVQNLMALRFANALYEPLWNSAHIDHVQITVAETVGLEDRVTYYDKAGALRDMVQN
HMLQLLCLVAMEAPSSMDADAVRDEKLKVLRALKRINGNEAPKHTVRGQYRAGASAGGPVKGYVEELGKDSNTETFVAIK
AEIGTWRWAGVPFYLRTGKRLATRVSEIVIEFKPIPHSIFGDSAGPIFANQLVIRLQPDEGVKQFIMIKDPGPGGMRLRQ
ISLDMSFAQSFDGRAPDAYERLIMDVIRGNQTLFMRRDEVEAAWKWIDPIQNAWEGAKQEAQGYTAGTWGPSASIALIER
DGRTWHESN

Sequences:

>Translated_489_residues
MTSQIIPVDPFDFIIFGGTGDLSERKLLPSLYYRQRDHQFSEPTRIIGTSRSKMSDEEFRAFASQAISDHVKPADIDAKE
LKTFLARLSYISADATSGAGFDKLKKAIGESESIRAFYLAVAPALFGDISHKLKENKLITPNSRIVLEKPIGRDLASARA
LNDLVGDDFHESQIFRIDHYLGKETVQNLMALRFANALYEPLWNSAHIDHVQITVAETVGLEDRVTYYDKAGALRDMVQN
HMLQLLCLVAMEAPSSMDADAVRDEKLKVLRALKRINGNEAPKHTVRGQYRAGASAGGPVKGYVEELGKDSNTETFVAIK
AEIGTWRWAGVPFYLRTGKRLATRVSEIVIEFKPIPHSIFGDSAGPIFANQLVIRLQPDEGVKQFIMIKDPGPGGMRLRQ
ISLDMSFAQSFDGRAPDAYERLIMDVIRGNQTLFMRRDEVEAAWKWIDPIQNAWEGAKQEAQGYTAGTWGPSASIALIER
DGRTWHESN
>Mature_488_residues
TSQIIPVDPFDFIIFGGTGDLSERKLLPSLYYRQRDHQFSEPTRIIGTSRSKMSDEEFRAFASQAISDHVKPADIDAKEL
KTFLARLSYISADATSGAGFDKLKKAIGESESIRAFYLAVAPALFGDISHKLKENKLITPNSRIVLEKPIGRDLASARAL
NDLVGDDFHESQIFRIDHYLGKETVQNLMALRFANALYEPLWNSAHIDHVQITVAETVGLEDRVTYYDKAGALRDMVQNH
MLQLLCLVAMEAPSSMDADAVRDEKLKVLRALKRINGNEAPKHTVRGQYRAGASAGGPVKGYVEELGKDSNTETFVAIKA
EIGTWRWAGVPFYLRTGKRLATRVSEIVIEFKPIPHSIFGDSAGPIFANQLVIRLQPDEGVKQFIMIKDPGPGGMRLRQI
SLDMSFAQSFDGRAPDAYERLIMDVIRGNQTLFMRRDEVEAAWKWIDPIQNAWEGAKQEAQGYTAGTWGPSASIALIERD
GRTWHESN

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=483, Percent_Identity=37.4741200828157, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI109389365, Length=483, Percent_Identity=37.4741200828157, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI52145310, Length=480, Percent_Identity=30, Blast_Score=172, Evalue=8e-43,
Organism=Escherichia coli, GI1788158, Length=480, Percent_Identity=49.375, Blast_Score=473, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17538218, Length=487, Percent_Identity=36.3449691991786, Blast_Score=318, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6324088, Length=476, Percent_Identity=36.5546218487395, Blast_Score=282, Evalue=9e-77,
Organism=Drosophila melanogaster, GI24643350, Length=475, Percent_Identity=36.6315789473684, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24643352, Length=475, Percent_Identity=36.6315789473684, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI221513548, Length=512, Percent_Identity=30.078125, Blast_Score=226, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54618; Mature: 54487

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQIIPVDPFDFIIFGGTGDLSERKLLPSLYYRQRDHQFSEPTRIIGTSRSKMSDEEFR
CCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCCCHHHHH
AFASQAISDHVKPADIDAKELKTFLARLSYISADATSGAGFDKLKKAIGESESIRAFYLA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHH
VAPALFGDISHKLKENKLITPNSRIVLEKPIGRDLASARALNDLVGDDFHESQIFRIDHY
HHHHHHHHHHHHHHCCCEECCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
LGKETVQNLMALRFANALYEPLWNSAHIDHVQITVAETVGLEDRVTYYDKAGALRDMVQN
HCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHCCCCCCHHHHHHHHHHHHHHHH
HMLQLLCLVAMEAPSSMDADAVRDEKLKVLRALKRINGNEAPKHTVRGQYRAGASAGGPV
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCC
KGYVEELGKDSNTETFVAIKAEIGTWRWAGVPFYLRTGKRLATRVSEIVIEFKPIPHSIF
HHHHHHCCCCCCCCEEEEEEEECCCEEECCCCEEECCCHHHHHHHHHHHEEECCCCHHHC
GDSAGPIFANQLVIRLQPDEGVKQFIMIKDPGPGGMRLRQISLDMSFAQSFDGRAPDAYE
CCCCCCEEECEEEEEECCCCCCEEEEEEECCCCCCCEEEEEECCHHHHHHCCCCCCHHHH
RLIMDVIRGNQTLFMRRDEVEAAWKWIDPIQNAWEGAKQEAQGYTAGTWGPSASIALIER
HHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEC
DGRTWHESN
CCCCCCCCC
>Mature Secondary Structure 
TSQIIPVDPFDFIIFGGTGDLSERKLLPSLYYRQRDHQFSEPTRIIGTSRSKMSDEEFR
CCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCCCHHHHH
AFASQAISDHVKPADIDAKELKTFLARLSYISADATSGAGFDKLKKAIGESESIRAFYLA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHH
VAPALFGDISHKLKENKLITPNSRIVLEKPIGRDLASARALNDLVGDDFHESQIFRIDHY
HHHHHHHHHHHHHHCCCEECCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
LGKETVQNLMALRFANALYEPLWNSAHIDHVQITVAETVGLEDRVTYYDKAGALRDMVQN
HCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHCCCCCCHHHHHHHHHHHHHHHH
HMLQLLCLVAMEAPSSMDADAVRDEKLKVLRALKRINGNEAPKHTVRGQYRAGASAGGPV
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCC
KGYVEELGKDSNTETFVAIKAEIGTWRWAGVPFYLRTGKRLATRVSEIVIEFKPIPHSIF
HHHHHHCCCCCCCCEEEEEEEECCCEEECCCCEEECCCHHHHHHHHHHHEEECCCCHHHC
GDSAGPIFANQLVIRLQPDEGVKQFIMIKDPGPGGMRLRQISLDMSFAQSFDGRAPDAYE
CCCCCCEEECEEEEEECCCCCCEEEEEEECCCCCCCEEEEEECCHHHHHHCCCCCCHHHH
RLIMDVIRGNQTLFMRRDEVEAAWKWIDPIQNAWEGAKQEAQGYTAGTWGPSASIALIER
HHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEC
DGRTWHESN
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]