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The map label for this gene is appB [H]

Identifier: 13475391

GI number: 13475391

Start: 5268252

End: 5269259

Strand: Direct

Name: appB [H]

Synonym: mlr6445

Alternate gene names: 13475391

Gene position: 5268252-5269259 (Clockwise)

Preceding gene: 13475390

Following gene: 13475392

Centisome position: 74.87

GC content: 62.4

Gene sequence:

>1008_bases
ATGCTGCGATTCCTGCTTATGCGCATAGCGTCGGCAATACCGGTCCTCGCAATCCTGAGCCTCGTCACCTTCGCCATCAT
CCAGGCGCCACCTGGTGACTATGCCGACTACATCCGTTCGCAGCTGATCAACCAGGGCGGTGCCTCCTTCGCCGAGGCCG
ATGCGCAGGCCCAGGCCTACCGCGTCGAACACGGCCTCGATAAGCCGCTGCCCGTCCAGTACCTCAACTGGATCGGCGGA
ATCATTACTCGCGGCGATTTCGGCTACAGCCTCTACTACAACAAGCCGGTCGCCGATGTGGTGGGCGAGCGCCTGCCGCG
CACGCTGCTTCTGGCGCTGGTCTGCCATCTGCTCGCCTCGGTGCTGGGCATCACCTTCGGCATATGGGCGGCGACAAGGC
AATATACCTGGATCGACTCGACGCTCTCGGCCATCGCCTTCCTCGGCATGACCGTGCCACGCTTCCTGATGGCGCTGATC
ATCGTCTACCTGCTGGTCTTCCAGTTCAACGTGTCGGAGATCGGCTCGTTCTTCTCGCCACAATTTGGCGGTGCGCCATG
GTCGTGGGCGAAGTTCGTCGACCTGGTCAAGCATGTCTGGCCGGTGGTCGCGATCGCCACTTTCGGCGGCCTTGCCTACA
ATATGCGTGTCATGCGCGGCAATCTGCTCGATACGCTCAACGCACAATATGTCGAGACGGCGAGAGCAAAGGGCCTGACC
GGCAGCGCCGTCGTCATGCGCCACGCGGTGCCCAATGCGCTGCATCCGCTCGTCATGTACCAGGGCGTGGTGCTGCCCTA
TATGCTCACCGGCGAGATCGAGACGGCAATCATCTTCGCTCTGCCGACCGTCGGCCCGGCGGTTGTCGGCTCGATGGCCG
TCGGCGATGTCTATGTCACCGCCACTTTCATGATGGTGCTGGCGGCGACGCTGATCGTCGGCAACATCATCGCCGACATG
CTGCTCGTCCTGCTCGACCCGCGCATCCGCCAATACGGAGAGAGCTAG

Upstream 100 bases:

>100_bases
CAAAAGAGACCCGGCCGCGCCGCTGGCGCGGCCGGGGCAAACCAACCCTCCGAACGACCCTCAATGGGAGCGTCCGGCGA
AATGAGGAAGCCGACCGTCC

Downstream 100 bases:

>100_bases
ATGCTGGCCCGCGATCCATCACCGCCGCCGCTGCCCGCCGAAGGGCCCATCGTCGCCAAGCCGGCCCGCGGCAATGAAAG
CTACATCGCGCTCGTCTGGC

Product: ABC transporter, permease protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MLRFLLMRIASAIPVLAILSLVTFAIIQAPPGDYADYIRSQLINQGGASFAEADAQAQAYRVEHGLDKPLPVQYLNWIGG
IITRGDFGYSLYYNKPVADVVGERLPRTLLLALVCHLLASVLGITFGIWAATRQYTWIDSTLSAIAFLGMTVPRFLMALI
IVYLLVFQFNVSEIGSFFSPQFGGAPWSWAKFVDLVKHVWPVVAIATFGGLAYNMRVMRGNLLDTLNAQYVETARAKGLT
GSAVVMRHAVPNALHPLVMYQGVVLPYMLTGEIETAIIFALPTVGPAVVGSMAVGDVYVTATFMMVLAATLIVGNIIADM
LLVLLDPRIRQYGES

Sequences:

>Translated_335_residues
MLRFLLMRIASAIPVLAILSLVTFAIIQAPPGDYADYIRSQLINQGGASFAEADAQAQAYRVEHGLDKPLPVQYLNWIGG
IITRGDFGYSLYYNKPVADVVGERLPRTLLLALVCHLLASVLGITFGIWAATRQYTWIDSTLSAIAFLGMTVPRFLMALI
IVYLLVFQFNVSEIGSFFSPQFGGAPWSWAKFVDLVKHVWPVVAIATFGGLAYNMRVMRGNLLDTLNAQYVETARAKGLT
GSAVVMRHAVPNALHPLVMYQGVVLPYMLTGEIETAIIFALPTVGPAVVGSMAVGDVYVTATFMMVLAATLIVGNIIADM
LLVLLDPRIRQYGES
>Mature_335_residues
MLRFLLMRIASAIPVLAILSLVTFAIIQAPPGDYADYIRSQLINQGGASFAEADAQAQAYRVEHGLDKPLPVQYLNWIGG
IITRGDFGYSLYYNKPVADVVGERLPRTLLLALVCHLLASVLGITFGIWAATRQYTWIDSTLSAIAFLGMTVPRFLMALI
IVYLLVFQFNVSEIGSFFSPQFGGAPWSWAKFVDLVKHVWPVVAIATFGGLAYNMRVMRGNLLDTLNAQYVETARAKGLT
GSAVVMRHAVPNALHPLVMYQGVVLPYMLTGEIETAIIFALPTVGPAVVGSMAVGDVYVTATFMMVLAATLIVGNIIADM
LLVLLDPRIRQYGES

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789965, Length=348, Percent_Identity=31.0344827586207, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1787053, Length=331, Percent_Identity=30.2114803625378, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1789888, Length=334, Percent_Identity=32.0359281437126, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1787497, Length=335, Percent_Identity=28.3582089552239, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1787761, Length=343, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788504, Length=345, Percent_Identity=23.768115942029, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787550, Length=270, Percent_Identity=25.1851851851852, Blast_Score=99, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 36536; Mature: 36536

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]