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The map label for this gene is hemN [H]

Identifier: 13475345

GI number: 13475345

Start: 5214702

End: 5216027

Strand: Direct

Name: hemN [H]

Synonym: mlr6390

Alternate gene names: 13475345

Gene position: 5214702-5216027 (Clockwise)

Preceding gene: 13475343

Following gene: 13475348

Centisome position: 74.11

GC content: 61.61

Gene sequence:

>1326_bases
TTGCAGACCACAAAACATCGCGAAGCCCGCCTGCCTTGGTACACCATCTATCCGACTGTCGCGGAGTTCTCTGGGGCGGT
CGGCGCCGACGCTTATGAGGAATGGCTCAGGAACCTACCGGCTAACGATCCGGCGTCACTCTACTTGCACGTTCCGTTCT
GCCGATCAAAGTGCTGGTATTGCGGCTTCCCCACCACCATCACCCGCCATGATGCGCCGATCGTTAATTATCTGGCGGCG
CTGCGTGACGAGATACGTTTGGTCTCGGAGCACGCGCCGCAGGCGCTGCCCGTGAGCGATGTGCATTTCGGCGGCGGAAC
GCCAACTCTCATGGGGCCAGTTGAATTCCTCGCCCTGACGGAATTCCTGCGCCGCCACTTTGCGCTTGCGGAAACAGCTA
CGATCGCCGTCGAGATCGATCCACGCACGTTCACGGCCGATATGGCCGAAGCCTTGCAAGCAGCCGGCGTGAACCGCGCG
AGCCTCGGCGTGCAGAGCTTCGATCCCATTGTTCAAAAAGCGATTAACCGGGTCCAGAGTGAGGCGCAGACGGCGGCTGC
CGTCGAAATGCTGCGTCGGCATGGAGTGACAAGCATCAACTTCGACCTCATCTTTGGTCTCCCGCATCAAACGGTGCAGT
CTTGCGTCGAGACCACGAGGGCGGCGGTCGCCATGCGCCCCAACCGGCTTGCGGTGTTCGGCTACTCGCACATTCCGTCC
TTTATTAAGAATCAGCGCCTCATCGAGGAGGCATCGCTTCCGGGCAGCGCTGCCCGCGCCGAACAGGATGCGGCCATTGC
CGTGACGCTGATTGCCGCCGGCTACCGAGAGATCGGGCTCGACCATTTCGCCTTGCCGGACGACGATCTCGCGCTGGCAC
AGAAAACCGGTCGCCTGCGGCGCAACTCGCTGGGCTACTCGGCCGACACCTGCAAAACCCTGATCGGTTTCGGCGCGTCG
GCTATCGGGCGTGTCGGCGAGGGCTACGTCCAGAACGAGGTTACACGGGATTCCTACTGCCGGCACATCGCAGCTGGCCG
TCTGGCGACGTCAAAGGGCTACCGTCTCACCGACGAAGACCGCGCGCGAGCCGCAATCATCGAGCGACTAATGTGCGATC
TCGAGGCCGATGTGCCGGCAATCTGTGCCGCCCACGGATCTGATCCGATCCATTTTCTCGATTCAGCTGAACGCTTGGCG
ATGCTTGCCAAGGACGGGATTGTGGACATCGAAAAGGGTTTTGTCCGCGTACGGCGGCAGCATCGCTTTGCGATGCGCGT
TGTCGCTGCCGCATTCGACGCTTTTCTCGACCGGGTTGCCCGCTGA

Upstream 100 bases:

>100_bases
GCGAAATAATCGGGCCCAAAGCGGACCGGACTGATATAGCGCAAAGACACAGGAGAGCGCAGTGGTAAGGATGGAAGGCA
ACAACATGGGACGGTAACTG

Downstream 100 bases:

>100_bases
GTCAGCCAACCAAGTGTGAGGAGGCCAAGGCGACGCCGAAGCGAAATTTGACGCCCATGCGGTTTCCTTTCTTCGAGGTC
AGGATTTCACAGCCTTCGCC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MQTTKHREARLPWYTIYPTVAEFSGAVGADAYEEWLRNLPANDPASLYLHVPFCRSKCWYCGFPTTITRHDAPIVNYLAA
LRDEIRLVSEHAPQALPVSDVHFGGGTPTLMGPVEFLALTEFLRRHFALAETATIAVEIDPRTFTADMAEALQAAGVNRA
SLGVQSFDPIVQKAINRVQSEAQTAAAVEMLRRHGVTSINFDLIFGLPHQTVQSCVETTRAAVAMRPNRLAVFGYSHIPS
FIKNQRLIEEASLPGSAARAEQDAAIAVTLIAAGYREIGLDHFALPDDDLALAQKTGRLRRNSLGYSADTCKTLIGFGAS
AIGRVGEGYVQNEVTRDSYCRHIAAGRLATSKGYRLTDEDRARAAIIERLMCDLEADVPAICAAHGSDPIHFLDSAERLA
MLAKDGIVDIEKGFVRVRRQHRFAMRVVAAAFDAFLDRVAR

Sequences:

>Translated_441_residues
MQTTKHREARLPWYTIYPTVAEFSGAVGADAYEEWLRNLPANDPASLYLHVPFCRSKCWYCGFPTTITRHDAPIVNYLAA
LRDEIRLVSEHAPQALPVSDVHFGGGTPTLMGPVEFLALTEFLRRHFALAETATIAVEIDPRTFTADMAEALQAAGVNRA
SLGVQSFDPIVQKAINRVQSEAQTAAAVEMLRRHGVTSINFDLIFGLPHQTVQSCVETTRAAVAMRPNRLAVFGYSHIPS
FIKNQRLIEEASLPGSAARAEQDAAIAVTLIAAGYREIGLDHFALPDDDLALAQKTGRLRRNSLGYSADTCKTLIGFGAS
AIGRVGEGYVQNEVTRDSYCRHIAAGRLATSKGYRLTDEDRARAAIIERLMCDLEADVPAICAAHGSDPIHFLDSAERLA
MLAKDGIVDIEKGFVRVRRQHRFAMRVVAAAFDAFLDRVAR
>Mature_441_residues
MQTTKHREARLPWYTIYPTVAEFSGAVGADAYEEWLRNLPANDPASLYLHVPFCRSKCWYCGFPTTITRHDAPIVNYLAA
LRDEIRLVSEHAPQALPVSDVHFGGGTPTLMGPVEFLALTEFLRRHFALAETATIAVEIDPRTFTADMAEALQAAGVNRA
SLGVQSFDPIVQKAINRVQSEAQTAAAVEMLRRHGVTSINFDLIFGLPHQTVQSCVETTRAAVAMRPNRLAVFGYSHIPS
FIKNQRLIEEASLPGSAARAEQDAAIAVTLIAAGYREIGLDHFALPDDDLALAQKTGRLRRNSLGYSADTCKTLIGFGAS
AIGRVGEGYVQNEVTRDSYCRHIAAGRLATSKGYRLTDEDRARAAIIERLMCDLEADVPAICAAHGSDPIHFLDSAERLA
MLAKDGIVDIEKGFVRVRRQHRFAMRVVAAAFDAFLDRVAR

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=288, Percent_Identity=26.7361111111111, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI87082341, Length=435, Percent_Identity=37.4712643678161, Blast_Score=290, Evalue=9e-80,
Organism=Escherichia coli, GI1789325, Length=299, Percent_Identity=29.0969899665552, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 48408; Mature: 48408

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTTKHREARLPWYTIYPTVAEFSGAVGADAYEEWLRNLPANDPASLYLHVPFCRSKCWY
CCCCCCCCCCCCEEEECCCHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEECCHHHCCCEE
CGFPTTITRHDAPIVNYLAALRDEIRLVSEHAPQALPVSDVHFGGGTPTLMGPVEFLALT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHHHH
EFLRRHFALAETATIAVEIDPRTFTADMAEALQAAGVNRASLGVQSFDPIVQKAINRVQS
HHHHHHHHHHCEEEEEEEECCCHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHH
EAQTAAAVEMLRRHGVTSINFDLIFGLPHQTVQSCVETTRAAVAMRPNRLAVFGYSHIPS
HHHHHHHHHHHHHCCCCEECEEEEECCCHHHHHHHHHHHHHHHEECCCEEEEEEHHHHHH
FIKNQRLIEEASLPGSAARAEQDAAIAVTLIAAGYREIGLDHFALPDDDLALAQKTGRLR
HHHHHHHHHHHCCCCCHHHCCCCCCEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
RNSLGYSADTCKTLIGFGASAIGRVGEGYVQNEVTRDSYCRHIAAGRLATSKGYRLTDED
HHCCCCCHHHHHHHHHCCHHHHHHHCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHH
RARAAIIERLMCDLEADVPAICAAHGSDPIHFLDSAERLAMLAKDGIVDIEKGFVRVRRQ
HHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
HRFAMRVVAAAFDAFLDRVAR
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQTTKHREARLPWYTIYPTVAEFSGAVGADAYEEWLRNLPANDPASLYLHVPFCRSKCWY
CCCCCCCCCCCCEEEECCCHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEECCHHHCCCEE
CGFPTTITRHDAPIVNYLAALRDEIRLVSEHAPQALPVSDVHFGGGTPTLMGPVEFLALT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHHHH
EFLRRHFALAETATIAVEIDPRTFTADMAEALQAAGVNRASLGVQSFDPIVQKAINRVQS
HHHHHHHHHHCEEEEEEEECCCHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHH
EAQTAAAVEMLRRHGVTSINFDLIFGLPHQTVQSCVETTRAAVAMRPNRLAVFGYSHIPS
HHHHHHHHHHHHHCCCCEECEEEEECCCHHHHHHHHHHHHHHHEECCCEEEEEEHHHHHH
FIKNQRLIEEASLPGSAARAEQDAAIAVTLIAAGYREIGLDHFALPDDDLALAQKTGRLR
HHHHHHHHHHHCCCCCHHHCCCCCCEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
RNSLGYSADTCKTLIGFGASAIGRVGEGYVQNEVTRDSYCRHIAAGRLATSKGYRLTDED
HHCCCCCHHHHHHHHHCCHHHHHHHCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHH
RARAAIIERLMCDLEADVPAICAAHGSDPIHFLDSAERLAMLAKDGIVDIEKGFVRVRRQ
HHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
HRFAMRVVAAAFDAFLDRVAR
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11157943; 12597275 [H]