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The map label for this gene is caiD [H]

Identifier: 13475067

GI number: 13475067

Start: 4907902

End: 4908699

Strand: Reverse

Name: caiD [H]

Synonym: mll8753

Alternate gene names: 13475067

Gene position: 4908699-4907902 (Counterclockwise)

Preceding gene: 13475070

Following gene: 13475065

Centisome position: 69.76

GC content: 54.26

Gene sequence:

>798_bases
GTGCAACTTGGAGGATTTTTTGAATTGTCGAACGAGCCAGTTTCCTTCGAGACCCGTGACAACATCGCTATCATAGCGAT
AAACCGTCCGGATCGGCGAAATGCAATCGATGAGCGAACTAGCCCACAGCTGCGTATTGCAGTGGATCGGTTCGAGAGCG
ACGACCATCTTGCGGTTGGCATTCTTCGCGGTGAAGGACCTGTTTTCTGTTCAGGAATGGACCTTCAAGCGTTCGTCGAT
GGGGAAGCGGAAGAAATACTGTTTGGAGACGGGCATTTGGGCGGCTTGGTAAGCCGGGCACGAACGAAACCTGTTTTAGC
CGCTGTTCAGGGTGCAGCGATCGCCGGCGGATTTGAACTCATGCTGGCCTGCGATCTCGTAGTGTCGACTGAAAACTGTA
AGTTTGGCTTACCTGAAGCAAAGCGCGGTCTAGTGGCAGGCGCTGGTGGGGCGCTTCGGCTGGGTGAGATGTTACCGCCG
GTACTTGCCAACGAGATACTCCTTACCGGCCTCCTTTTTGAGGCTCCCCGAGCATATCAGCTTGGTCTTGTCAATCGGCT
GGTGCCGGAACATTTCCTATTAGAGGCCGCGATGAGTCTGGCTGATTCCATCGCTCAAAATGCACCCCTTTCAGTGCGGG
CGAGCCTCGCACTGGTAAAAGCTCAGAGCGAAAAAGCCCGAAATTCGCTTTGGACACTGAATGACGAGTTGTTACGCGAG
CTCATGCGATCAAATGACGCGTTAGAGGGTGCTACTGCGTACAAAGCCAAGCGCAGGCCGATCTGGCGTGGCGACTAA

Upstream 100 bases:

>100_bases
AAATTACCCGTATTTATCGGGAGCGCGTTGCGCAAGATGGCCCGCCGATGAGGCGGCGGCAGAAACGGCTGCAGCATATG
CGGGAGAGTCGCAAGGCTAC

Downstream 100 bases:

>100_bases
CGACAGTCGCATGCCGAATTGCCAAGCATCTATCGTCTAGCCCGGTTTTCTCACCGCAACTGGCATTAGGCGGTGTTTTG
GCCAGGCCAAGGGCTGGCAT

Product: hypothetical protein

Products: L-Carnitine.; L-carnitinyl-CoA [C]

Alternate protein names: Crotonobetainyl-CoA hydratase [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MQLGGFFELSNEPVSFETRDNIAIIAINRPDRRNAIDERTSPQLRIAVDRFESDDHLAVGILRGEGPVFCSGMDLQAFVD
GEAEEILFGDGHLGGLVSRARTKPVLAAVQGAAIAGGFELMLACDLVVSTENCKFGLPEAKRGLVAGAGGALRLGEMLPP
VLANEILLTGLLFEAPRAYQLGLVNRLVPEHFLLEAAMSLADSIAQNAPLSVRASLALVKAQSEKARNSLWTLNDELLRE
LMRSNDALEGATAYKAKRRPIWRGD

Sequences:

>Translated_265_residues
MQLGGFFELSNEPVSFETRDNIAIIAINRPDRRNAIDERTSPQLRIAVDRFESDDHLAVGILRGEGPVFCSGMDLQAFVD
GEAEEILFGDGHLGGLVSRARTKPVLAAVQGAAIAGGFELMLACDLVVSTENCKFGLPEAKRGLVAGAGGALRLGEMLPP
VLANEILLTGLLFEAPRAYQLGLVNRLVPEHFLLEAAMSLADSIAQNAPLSVRASLALVKAQSEKARNSLWTLNDELLRE
LMRSNDALEGATAYKAKRRPIWRGD
>Mature_265_residues
MQLGGFFELSNEPVSFETRDNIAIIAINRPDRRNAIDERTSPQLRIAVDRFESDDHLAVGILRGEGPVFCSGMDLQAFVD
GEAEEILFGDGHLGGLVSRARTKPVLAAVQGAAIAGGFELMLACDLVVSTENCKFGLPEAKRGLVAGAGGALRLGEMLPP
VLANEILLTGLLFEAPRAYQLGLVNRLVPEHFLLEAAMSLADSIAQNAPLSVRASLALVKAQSEKARNSLWTLNDELLRE
LMRSNDALEGATAYKAKRRPIWRGD

Specific function: Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=249, Percent_Identity=31.7269076305221, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI31542718, Length=262, Percent_Identity=28.6259541984733, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4502327, Length=263, Percent_Identity=27.7566539923954, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI70995211, Length=252, Percent_Identity=27.3809523809524, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI20127408, Length=217, Percent_Identity=25.8064516129032, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI150378541, Length=251, Percent_Identity=29.0836653386454, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI260274832, Length=233, Percent_Identity=24.8927038626609, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI37594469, Length=207, Percent_Identity=26.5700483091787, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI45643119, Length=233, Percent_Identity=24.8927038626609, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI260275230, Length=233, Percent_Identity=24.8927038626609, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI37594471, Length=207, Percent_Identity=26.5700483091787, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI221142681, Length=260, Percent_Identity=37.6923076923077, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1787659, Length=246, Percent_Identity=31.7073170731707, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788597, Length=255, Percent_Identity=31.3725490196078, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1788682, Length=204, Percent_Identity=34.3137254901961, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1790281, Length=186, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787660, Length=253, Percent_Identity=29.2490118577075, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082183, Length=267, Percent_Identity=22.4719101123595, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25145438, Length=243, Percent_Identity=32.9218106995885, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17554946, Length=265, Percent_Identity=28.6792452830189, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17560910, Length=209, Percent_Identity=33.4928229665072, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17540714, Length=203, Percent_Identity=33.9901477832512, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17558304, Length=246, Percent_Identity=25.2032520325203, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17534483, Length=254, Percent_Identity=25.5905511811024, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17536985, Length=273, Percent_Identity=25.2747252747253, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI25144276, Length=179, Percent_Identity=27.9329608938547, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508951, Length=179, Percent_Identity=27.9329608938547, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508953, Length=179, Percent_Identity=27.9329608938547, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17540306, Length=216, Percent_Identity=25.462962962963, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24653139, Length=256, Percent_Identity=33.203125, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI20129971, Length=242, Percent_Identity=31.404958677686, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24653477, Length=242, Percent_Identity=31.404958677686, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI21357171, Length=195, Percent_Identity=38.4615384615385, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24650670, Length=198, Percent_Identity=36.3636363636364, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19920382, Length=208, Percent_Identity=28.3653846153846, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI19922422, Length=242, Percent_Identity=24.7933884297521, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022852
- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: 4.2.1.- [C]

Molecular weight: Translated: 28618; Mature: 28618

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLGGFFELSNEPVSFETRDNIAIIAINRPDRRNAIDERTSPQLRIAVDRFESDDHLAVG
CCCCCEEEECCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEE
ILRGEGPVFCSGMDLQAFVDGEAEEILFGDGHLGGLVSRARTKPVLAAVQGAAIAGGFEL
EEECCCCEEEECCCEEEEECCCCCEEEEECCCHHHHHHHHHCCHHHHHHCCCCCCCCCEE
MLACDLVVSTENCKFGLPEAKRGLVAGAGGALRLGEMLPPVLANEILLTGLLFEAPRAYQ
EEEEEEEEECCCCCCCCCHHHCCEEECCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCHH
LGLVNRLVPEHFLLEAAMSLADSIAQNAPLSVRASLALVKAQSEKARNSLWTLNDELLRE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHEEEEEHHHHHHHHCCCCCCHHHHHH
LMRSNDALEGATAYKAKRRPIWRGD
HHHCCCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MQLGGFFELSNEPVSFETRDNIAIIAINRPDRRNAIDERTSPQLRIAVDRFESDDHLAVG
CCCCCEEEECCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEE
ILRGEGPVFCSGMDLQAFVDGEAEEILFGDGHLGGLVSRARTKPVLAAVQGAAIAGGFEL
EEECCCCEEEECCCEEEEECCCCCEEEEECCCHHHHHHHHHCCHHHHHHCCCCCCCCCEE
MLACDLVVSTENCKFGLPEAKRGLVAGAGGALRLGEMLPPVLANEILLTGLLFEAPRAYQ
EEEEEEEEECCCCCCCCCHHHCCEEECCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCHH
LGLVNRLVPEHFLLEAAMSLADSIAQNAPLSVRASLALVKAQSEKARNSLWTLNDELLRE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHEEEEEHHHHHHHHCCCCCCHHHHHH
LMRSNDALEGATAYKAKRRPIWRGD
HHHCCCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-Carnitine; D-carnitinyl-CoA [C]

Specific reaction: D-Carnitine = L-Carnitine. D-carnitinyl-CoA = L-carnitinyl-CoA [C]

General reaction: Isomerases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA