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The map label for this gene is caiD [H]

Identifier: 13475025

GI number: 13475025

Start: 4862685

End: 4863458

Strand: Reverse

Name: caiD [H]

Synonym: mll6015

Alternate gene names: 13475025

Gene position: 4863458-4862685 (Counterclockwise)

Preceding gene: 13475026

Following gene: 13475024

Centisome position: 69.12

GC content: 59.56

Gene sequence:

>774_bases
TTGTCAGACCAACCATTGCTCGTCGAAAAACGGCGGGACATCACTCTCATATCCTTGAACCGGCCCGAACGTCGGAATGC
CGTCGACGGCAAGCTGAGCCGCGCTCTGCGAGAAGCGTTCGACCACTTCGAGGCGGACCCGTCAGCGTCGGTTGCTATCA
TCAACGGTCAGGGTGCCGCGTTCTGCTCAGGGATGGACCTGAAAGCGTTCCTTGACGGCGAGGCGGACGACATTCTGTTT
GGGGAAGGACGTCTCGGAGGACTCGTCAGTCGAAATCTGACGAAGCCTCTCGTCGCCGCTGTCCACGGCGTGGCGGTGGC
AGGAGGTTTTGAATTGATGTTGGCCTGTGACCTCGTCGTTTCTGCGGACACGTGCAGGTTCGGGCTTCCTGAGGCGAAGC
GAGGTCTGGTTGCGGGTGCCGGAGGAGCCTTCCGGCTCGGGGAAATACTCCCGCCAGTCATTGCCGCGGAAATCCTTCTG
ACTGGTGAATTGTTCGGCGCGCAGCGGGCCTACGAACTTGGCCTCGTCAATCGGATCGTTCCCGAGTCCGAAGTATTAGA
AACTGCGTTGATGATGGCCAGAGCAATTGCACTGAATGCCCCGATGTCCCGGAAGGCAAGCCTCGATCTGGCGAGGGCGT
CGTTGGCGACTGGCCGTAGCCTGCGATGGGCGATGAACGACGACTTATTGAAGACTCTCATCGCTTCAGAAGACGCAGTC
GAAGGAGCTGCAGCCTTCAATGAAAAGCGTCCCCCGGTGTGGCGTGGCGTCTGA

Upstream 100 bases:

>100_bases
CCACCGGCAAGATCATCCGGGGAGCGCTCAGGAAGATTGCGCAGGAAGAAGCCGCTCTCGAAGCACGATCCAGGCAGAAA
GATTAAACGGGGACGCTACT

Downstream 100 bases:

>100_bases
CCCAATACAGTATTCCGGAGAGCCAAGTGCCAGTCATCCGCAGTTCGATCTCAACTTCTTCTGACCCGTTCCGAGCCAAC
GCGGGTCGCATGCGGAGCCT

Product: carnitine racemase

Products: L-Carnitine.; L-carnitinyl-CoA [C]

Alternate protein names: Crotonobetainyl-CoA hydratase [H]

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MSDQPLLVEKRRDITLISLNRPERRNAVDGKLSRALREAFDHFEADPSASVAIINGQGAAFCSGMDLKAFLDGEADDILF
GEGRLGGLVSRNLTKPLVAAVHGVAVAGGFELMLACDLVVSADTCRFGLPEAKRGLVAGAGGAFRLGEILPPVIAAEILL
TGELFGAQRAYELGLVNRIVPESEVLETALMMARAIALNAPMSRKASLDLARASLATGRSLRWAMNDDLLKTLIASEDAV
EGAAAFNEKRPPVWRGV

Sequences:

>Translated_257_residues
MSDQPLLVEKRRDITLISLNRPERRNAVDGKLSRALREAFDHFEADPSASVAIINGQGAAFCSGMDLKAFLDGEADDILF
GEGRLGGLVSRNLTKPLVAAVHGVAVAGGFELMLACDLVVSADTCRFGLPEAKRGLVAGAGGAFRLGEILPPVIAAEILL
TGELFGAQRAYELGLVNRIVPESEVLETALMMARAIALNAPMSRKASLDLARASLATGRSLRWAMNDDLLKTLIASEDAV
EGAAAFNEKRPPVWRGV
>Mature_256_residues
SDQPLLVEKRRDITLISLNRPERRNAVDGKLSRALREAFDHFEADPSASVAIINGQGAAFCSGMDLKAFLDGEADDILFG
EGRLGGLVSRNLTKPLVAAVHGVAVAGGFELMLACDLVVSADTCRFGLPEAKRGLVAGAGGAFRLGEILPPVIAAEILLT
GELFGAQRAYELGLVNRIVPESEVLETALMMARAIALNAPMSRKASLDLARASLATGRSLRWAMNDDLLKTLIASEDAVE
GAAAFNEKRPPVWRGV

Specific function: Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=253, Percent_Identity=32.0158102766798, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI31542718, Length=250, Percent_Identity=32.4, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI70995211, Length=258, Percent_Identity=27.906976744186, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI4502327, Length=261, Percent_Identity=28.735632183908, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI37594471, Length=204, Percent_Identity=28.921568627451, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI37594469, Length=204, Percent_Identity=28.921568627451, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI260274832, Length=218, Percent_Identity=26.1467889908257, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI45643119, Length=218, Percent_Identity=26.1467889908257, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI260275230, Length=218, Percent_Identity=26.1467889908257, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI150378541, Length=256, Percent_Identity=31.25, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI68989263, Length=192, Percent_Identity=28.6458333333333, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI221142681, Length=260, Percent_Identity=42.6923076923077, Blast_Score=184, Evalue=4e-48,
Organism=Escherichia coli, GI1787659, Length=251, Percent_Identity=34.6613545816733, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1788597, Length=257, Percent_Identity=31.5175097276265, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1787660, Length=261, Percent_Identity=27.9693486590038, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788682, Length=189, Percent_Identity=29.1005291005291, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790281, Length=203, Percent_Identity=30.0492610837438, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87082183, Length=261, Percent_Identity=24.904214559387, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25145438, Length=242, Percent_Identity=34.297520661157, Blast_Score=139, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17554946, Length=251, Percent_Identity=32.2709163346614, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17560910, Length=249, Percent_Identity=32.1285140562249, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17540714, Length=203, Percent_Identity=35.9605911330049, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17536985, Length=271, Percent_Identity=28.4132841328413, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17534483, Length=249, Percent_Identity=30.1204819277108, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17535521, Length=217, Percent_Identity=25.8064516129032, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17558304, Length=180, Percent_Identity=28.3333333333333, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17549921, Length=215, Percent_Identity=26.046511627907, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17540306, Length=208, Percent_Identity=29.3269230769231, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25144276, Length=180, Percent_Identity=29.4444444444444, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508951, Length=180, Percent_Identity=29.4444444444444, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508953, Length=180, Percent_Identity=29.4444444444444, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357171, Length=197, Percent_Identity=38.0710659898477, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24653139, Length=266, Percent_Identity=32.7067669172932, Blast_Score=127, Evalue=6e-30,
Organism=Drosophila melanogaster, GI20129971, Length=240, Percent_Identity=30, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24653477, Length=240, Percent_Identity=30, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24650670, Length=220, Percent_Identity=39.0909090909091, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24654903, Length=242, Percent_Identity=29.7520661157025, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI19920382, Length=209, Percent_Identity=26.7942583732057, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19922422, Length=253, Percent_Identity=24.5059288537549, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28571729, Length=197, Percent_Identity=28.4263959390863, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28571730, Length=197, Percent_Identity=28.4263959390863, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19921018, Length=179, Percent_Identity=25.6983240223464, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022852
- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: 4.2.1.- [C]

Molecular weight: Translated: 27307; Mature: 27176

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQPLLVEKRRDITLISLNRPERRNAVDGKLSRALREAFDHFEADPSASVAIINGQGAA
CCCCCCEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCE
FCSGMDLKAFLDGEADDILFGEGRLGGLVSRNLTKPLVAAVHGVAVAGGFELMLACDLVV
EECCCCEEEEECCCCCCEEECCCCCCCHHHHCCHHHHHHHHHHHHHHCCHHEEHHHHHHH
SADTCRFGLPEAKRGLVAGAGGAFRLGEILPPVIAAEILLTGELFGAQRAYELGLVNRIV
CCCCCCCCCCHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
PESEVLETALMMARAIALNAPMSRKASLDLARASLATGRSLRWAMNDDLLKTLIASEDAV
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHCCHHH
EGAAAFNEKRPPVWRGV
HHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SDQPLLVEKRRDITLISLNRPERRNAVDGKLSRALREAFDHFEADPSASVAIINGQGAA
CCCCCEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCE
FCSGMDLKAFLDGEADDILFGEGRLGGLVSRNLTKPLVAAVHGVAVAGGFELMLACDLVV
EECCCCEEEEECCCCCCEEECCCCCCCHHHHCCHHHHHHHHHHHHHHCCHHEEHHHHHHH
SADTCRFGLPEAKRGLVAGAGGAFRLGEILPPVIAAEILLTGELFGAQRAYELGLVNRIV
CCCCCCCCCCHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
PESEVLETALMMARAIALNAPMSRKASLDLARASLATGRSLRWAMNDDLLKTLIASEDAV
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHCCHHH
EGAAAFNEKRPPVWRGV
HHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-Carnitine; D-carnitinyl-CoA [C]

Specific reaction: D-Carnitine = L-Carnitine. D-carnitinyl-CoA = L-carnitinyl-CoA [C]

General reaction: Isomerases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA