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The map label for this gene is yngE [H]

Identifier: 13475024

GI number: 13475024

Start: 4861075

End: 4862658

Strand: Reverse

Name: yngE [H]

Synonym: mll6012

Alternate gene names: 13475024

Gene position: 4862658-4861075 (Counterclockwise)

Preceding gene: 13475025

Following gene: 13475023

Centisome position: 69.11

GC content: 64.71

Gene sequence:

>1584_bases
GTGCCAGTCATCCGCAGTTCGATCTCAACTTCTTCTGACCCGTTCCGAGCCAACGCGGGTCGCATGCGGAGCCTGATCTC
CGATATCAGCGAAAAGGCGAAGTCGATCAGCCTTGGTGGCCCTGACGACGCGCGCCAGCGCCACCTCTCCCGCGGCAAGC
TCCTGCCGCGGGAGCGGCTCGCGCAACTTCTCGATACGGGCTCGCCCTTTCTGGAAGTCGGCCAGTTCGCCGCATGGGGC
ATGTATGGCGACATTATCGCGTCGGCAGGCATGATCGCAGGCGTCGGCCGCGTCGAGAGCCGGGAGGTCATGATCGTCGT
GAACGACGCGACGGTGAAGGGCGGCACGTACTACCCGCTGACTGTAAAGAAGCATCTGCGGGCGCAGGAGATCGCGCGGG
AAAACAACCTGCCCTGCATCTACCTAGTCGATTCCGGCGGCGCGAACCTGCCGAACCAGCACGAAGTGTTTCCCGACCGC
GAGCACTTCGGCCGCATCTTCTACAATCAGGCAACAATGTCCGCTGCCGGCATCCCCCAGATCGCCTGCGTCATGGGTTC
GTGCACGGCGGGCGGCGCCTACGTTCCCGCGATGGCCGACGAATCCATCATGGTCCGCGATCAGGCCACGATTTTCCTGG
GCGGCCCGCCGTTGGTGAAGGCCGCGACGGGCGAGGATGTCAGCGCGGAGGATCTCGGCGGTGCGGACGTCCACACGCGC
CAGTCCGGCGTCGCCGACCACTACGCGCAGGACGACAACCATGCGCTGGCGATCACGCGACGGATCGTGCGCAACCTCAA
CCGCGTAAAGCCTTCTCAACTGCAACTCCGCGAGCCGCGTCCGCCGCTGCTCAACCCGCTCGAGATCCTCGGCGTCGTGC
CCTCCGATACGCGCACTCCCTACGACGTCCGCGAGGTCATCACCCGCGTAGTCGACGGCTCCGAGCTCGACGAATTCAAG
GCGAATTACGGCACGACGCTCGTCACCGGCTTCGCGCATATCCACGGCAACGGAGTGCTGTTCTCGGAAAGCGCGCTGAA
GGGCGCGCATTTCATCGAACTCTGCACGCAGCGGAAGATCCTGCTTGTGTTCCTGCAGAACATTACCGGCTTCATAGTCG
GCCGGAAATACGAGGCGGTCGGCATCGCGAAGGACGGCGCGAAGCTGGTCGCAGCGGTCGCGACCGCCAAGGTGCCGAAA
GTCACCGTCATCATCGGTGGCTCGTTCGGCGCCGGCAACTACGGCATGTGCGGCCGCGCCTACTCGCCGCGCTTCCTGTG
GATGTGGCCGAATGCCCGCATATCCGTCATGGGCGGCGAGCAGGCGGCGACGGTGCTGGCGTTGGTGAAGCGCGAAGGCA
TGGAACGCAAGGGTGGCAGCTGGAGCGCCGAGGAGGAAGCCGACTTCCGCCGGCCGATCCTCGATAAATACGAGCGCGAG
GGACACCCGCTCTATTCGTCCGCACGGCTTTGGGACGATGGCATCATCGACCCGACGAAGACGCGCGAGGTGCTGGCGCT
GAGCCTCTCGGCCGCGCTCAATGCCGAGATCAAGGACACCAAACCCGGCGTTTGGAGGATGTGA

Upstream 100 bases:

>100_bases
TCGCTTCAGAAGACGCAGTCGAAGGAGCTGCAGCCTTCAATGAAAAGCGTCCCCCGGTGTGGCGTGGCGTCTGACCCAAT
ACAGTATTCCGGAGAGCCAA

Downstream 100 bases:

>100_bases
GGATGGGCAAGCTGTTCTCAAAAATCCTCATCGCCAATCGCGGCGAAATCGCTTGCCGCGTCATCCGGACGGCGCGCAGG
CTCGGTATGGCGACCGTCGG

Product: acetyl/propionyl CoA carboxylase, beta subunit

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MPVIRSSISTSSDPFRANAGRMRSLISDISEKAKSISLGGPDDARQRHLSRGKLLPRERLAQLLDTGSPFLEVGQFAAWG
MYGDIIASAGMIAGVGRVESREVMIVVNDATVKGGTYYPLTVKKHLRAQEIARENNLPCIYLVDSGGANLPNQHEVFPDR
EHFGRIFYNQATMSAAGIPQIACVMGSCTAGGAYVPAMADESIMVRDQATIFLGGPPLVKAATGEDVSAEDLGGADVHTR
QSGVADHYAQDDNHALAITRRIVRNLNRVKPSQLQLREPRPPLLNPLEILGVVPSDTRTPYDVREVITRVVDGSELDEFK
ANYGTTLVTGFAHIHGNGVLFSESALKGAHFIELCTQRKILLVFLQNITGFIVGRKYEAVGIAKDGAKLVAAVATAKVPK
VTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAATVLALVKREGMERKGGSWSAEEEADFRRPILDKYERE
GHPLYSSARLWDDGIIDPTKTREVLALSLSAALNAEIKDTKPGVWRM

Sequences:

>Translated_527_residues
MPVIRSSISTSSDPFRANAGRMRSLISDISEKAKSISLGGPDDARQRHLSRGKLLPRERLAQLLDTGSPFLEVGQFAAWG
MYGDIIASAGMIAGVGRVESREVMIVVNDATVKGGTYYPLTVKKHLRAQEIARENNLPCIYLVDSGGANLPNQHEVFPDR
EHFGRIFYNQATMSAAGIPQIACVMGSCTAGGAYVPAMADESIMVRDQATIFLGGPPLVKAATGEDVSAEDLGGADVHTR
QSGVADHYAQDDNHALAITRRIVRNLNRVKPSQLQLREPRPPLLNPLEILGVVPSDTRTPYDVREVITRVVDGSELDEFK
ANYGTTLVTGFAHIHGNGVLFSESALKGAHFIELCTQRKILLVFLQNITGFIVGRKYEAVGIAKDGAKLVAAVATAKVPK
VTVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAATVLALVKREGMERKGGSWSAEEEADFRRPILDKYERE
GHPLYSSARLWDDGIIDPTKTREVLALSLSAALNAEIKDTKPGVWRM
>Mature_526_residues
PVIRSSISTSSDPFRANAGRMRSLISDISEKAKSISLGGPDDARQRHLSRGKLLPRERLAQLLDTGSPFLEVGQFAAWGM
YGDIIASAGMIAGVGRVESREVMIVVNDATVKGGTYYPLTVKKHLRAQEIARENNLPCIYLVDSGGANLPNQHEVFPDRE
HFGRIFYNQATMSAAGIPQIACVMGSCTAGGAYVPAMADESIMVRDQATIFLGGPPLVKAATGEDVSAEDLGGADVHTRQ
SGVADHYAQDDNHALAITRRIVRNLNRVKPSQLQLREPRPPLLNPLEILGVVPSDTRTPYDVREVITRVVDGSELDEFKA
NYGTTLVTGFAHIHGNGVLFSESALKGAHFIELCTQRKILLVFLQNITGFIVGRKYEAVGIAKDGAKLVAAVATAKVPKV
TVIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAATVLALVKREGMERKGGSWSAEEEADFRRPILDKYEREG
HPLYSSARLWDDGIIDPTKTREVLALSLSAALNAEIKDTKPGVWRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=522, Percent_Identity=63.6015325670498, Blast_Score=673, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=533, Percent_Identity=31.7073170731707, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI295821216, Length=553, Percent_Identity=30.5605786618445, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI310133460, Length=132, Percent_Identity=54.5454545454545, Blast_Score=140, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17552936, Length=533, Percent_Identity=60.0375234521576, Blast_Score=666, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=530, Percent_Identity=30, Blast_Score=214, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI25147359, Length=510, Percent_Identity=30.3921568627451, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24586065, Length=550, Percent_Identity=61.0909090909091, Blast_Score=672, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 57212; Mature: 57081

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVIRSSISTSSDPFRANAGRMRSLISDISEKAKSISLGGPDDARQRHLSRGKLLPRERL
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCCCHHHH
AQLLDTGSPFLEVGQFAAWGMYGDIIASAGMIAGVGRVESREVMIVVNDATVKGGTYYPL
HHHHHCCCCHHHHHHHHHHCHHHHHHHHCCHHHCCCCCCCCEEEEEEECCEECCCEEEEE
TVKKHLRAQEIARENNLPCIYLVDSGGANLPNQHEVFPDREHFGRIFYNQATMSAAGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHCEEEEECHHHCCCCCCC
IACVMGSCTAGGAYVPAMADESIMVRDQATIFLGGPPLVKAATGEDVSAEDLGGADVHTR
EEHHHCCCCCCCEEECCCCCCCEEEEECEEEEECCCCEEEECCCCCCCHHHCCCCCCCCC
QSGVADHYAQDDNHALAITRRIVRNLNRVKPSQLQLREPRPPLLNPLEILGVVPSDTRTP
CCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHEECCCCCCCCCHHHHEEECCCCCCCC
YDVREVITRVVDGSELDEFKANYGTTLVTGFAHIHGNGVLFSESALKGAHFIELCTQRKI
HHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEEEEECCEEEEECCHHCCHHHHHHHHCCHH
LLVFLQNITGFIVGRKYEAVGIAKDGAKLVAAVATAKVPKVTVIIGGSFGAGNYGMCGRA
HHHHHHHHHHEEECCEEEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCC
YSPRFLWMWPNARISVMGGEQAATVLALVKREGMERKGGSWSAEEEADFRRPILDKYERE
CCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCHHHHHHHHC
GHPLYSSARLWDDGIIDPTKTREVLALSLSAALNAEIKDTKPGVWRM
CCCCCCCCEECCCCCCCCCCCHHHHEEEHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
PVIRSSISTSSDPFRANAGRMRSLISDISEKAKSISLGGPDDARQRHLSRGKLLPRERL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCCCHHHH
AQLLDTGSPFLEVGQFAAWGMYGDIIASAGMIAGVGRVESREVMIVVNDATVKGGTYYPL
HHHHHCCCCHHHHHHHHHHCHHHHHHHHCCHHHCCCCCCCCEEEEEEECCEECCCEEEEE
TVKKHLRAQEIARENNLPCIYLVDSGGANLPNQHEVFPDREHFGRIFYNQATMSAAGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHCEEEEECHHHCCCCCCC
IACVMGSCTAGGAYVPAMADESIMVRDQATIFLGGPPLVKAATGEDVSAEDLGGADVHTR
EEHHHCCCCCCCEEECCCCCCCEEEEECEEEEECCCCEEEECCCCCCCHHHCCCCCCCCC
QSGVADHYAQDDNHALAITRRIVRNLNRVKPSQLQLREPRPPLLNPLEILGVVPSDTRTP
CCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHEECCCCCCCCCHHHHEEECCCCCCCC
YDVREVITRVVDGSELDEFKANYGTTLVTGFAHIHGNGVLFSESALKGAHFIELCTQRKI
HHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEEEEECCEEEEECCHHCCHHHHHHHHCCHH
LLVFLQNITGFIVGRKYEAVGIAKDGAKLVAAVATAKVPKVTVIIGGSFGAGNYGMCGRA
HHHHHHHHHHEEECCEEEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCC
YSPRFLWMWPNARISVMGGEQAATVLALVKREGMERKGGSWSAEEEADFRRPILDKYERE
CCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCHHHHHHHHC
GHPLYSSARLWDDGIIDPTKTREVLALSLSAALNAEIKDTKPGVWRM
CCCCCCCCEECCCCCCCCCCCHHHHEEEHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]