Click here to switch to the map view.

The map label for this gene is accA1 [H]

Identifier: 13475023

GI number: 13475023

Start: 4859111

End: 4861072

Strand: Reverse

Name: accA1 [H]

Synonym: mll6011

Alternate gene names: 13475023

Gene position: 4861072-4859111 (Counterclockwise)

Preceding gene: 13475024

Following gene: 13475020

Centisome position: 69.09

GC content: 62.54

Gene sequence:

>1962_bases
ATGGGCAAGCTGTTCTCAAAAATCCTCATCGCCAATCGCGGCGAAATCGCTTGCCGCGTCATCCGGACGGCGCGCAGGCT
CGGTATGGCGACCGTCGGTGTCTACTCCGATGCCGACGCGAAATCGCTTCATGTAGCAATGGCCGGCGAGGCAGTGCATA
TCGGCGCCTCCCCCGTCGCCGAAAGCTACCTGAAGGCTGACCGCATCATCGACGCGGCTCTCAAGACCGGCGCGCAGGCG
ATCCACCCGGGCTATGGCTTCCTGTCGGAGGCCCCGGATTTCGTCGAGCGGGTGGAAGCGGCAGGACTGGTGTTCATCGG
ACCGTCGGCTTCGTCGATCCGCGCCATGGGTCTGAAGGACGCTGCCAAGCGCCTGATGGAAATAACCGGTGTGCCGGTCG
TGCCGGGTTATCATGGCGAAGCGCAGGATCCTGCCTTGCTGGCCTCCAGGGCCATAGAGATCGGCTTTCCTGTCCTGATC
AAGGCGCGTGCGGGAGGCGGCGGCAAGGGCATGCGCCGTGTCGAGACTGCCGGAGAATTCGCCGATGCGCTCGCGTCGGC
GCAGCGCGAAGCGAAAGCCTCCTTCGGCGACGACAAGGTGTTGATCGAGAAGTACGTAGAGAAGCCGCGCCACATCGAGG
TGCAGGTCTTCGGCGACAATCACGGCAATGGGGTCCATCTCTTCGAGCGCGACTGCTCCGCCCAGCGCCGCCACCAGAAG
GTCATTGAGGAAGCGCCTGCCCCCGGCATGACGCCGGAGATGCGCGTGGCGATGACCCACGCCGCCGTGAAGGCCGCGAA
GGCGATCAATTACTCCGGTGCCGGTACGATCGAGTTCATCGTCGACGCGTCGGAGGGCCTTCGCGCGGACCGATTCTGGT
TCATGGAGATGAATACGCGTCTTCAGGTCGAACACCCTATGACGGAGATGGTGACCGGACAGGATCTCGTTGAATGGCAG
ATACGCGTCGCTGCTGGCGAGCTACTGCCGCTCACGCAAGATGACATCCATCTCGACGGGCACGCCTTTGAAGCGCGGCT
CTACGCCGAAGACGCATCGCGCGGCTTCTTGCCGGCGACCGGCACATTGTATCATCTGAGGTTCCCGCCGGAAGCCTCGT
CGATTCGCATAGAAACCGGTGTTCGACAGGGCGATACGATTTCATCTTTCTATGACCCGATGATCGCCAAGATCGTCACG
AAAGGAAGCGACCGGAAAGATGCTCTAGAACTGCTTGTCAGCGCGCTGGCAGTCACTGAGGTTGCCGGCTCAACCGTTAA
CACCGCCTTCCTTTCGGCGCTTGCTCAGGACGAAGACTTCGCCACCGGCGATGTCGATACGGGCCTCATCGCGCGCAAGC
AGGGGGCGTTGACCGCCCTGGCCGAAGCATCTGCTCGTTCGAAGGCGCTCGCAGCGCTCAGGGTCGCAAGTGTTGACGAG
GCCACGTCGAATGACCCCTGGGCCAGCCTGACTGGCTACGACCATTTCGGATCGACTGCCAAAGCGATCTCGCTCGGCGA
GTCCGGCGAGATCAGTGTTTCCCTAACTGCAGAGACAAATGGCGCTTGGCGCGCTGAGGTCGATGAACAGACTATCCGTT
TCTCTCCCACGTCGCTGCCCGAAGCACTCGCATCGGCCGTCATCTGGCCCGGCCACGTCACCGTCTTCGACGGCGCGGTC
AGCCACACCTTCATCGCCCGCGATCCTCTCGACGAAGCTGCCGATGCTTATGGTGGCGCCGGCAGCCTGCGCGCGCCGAT
GCCCGGTCTCGTCAAGCTCGTGCGCGCCAAGCCCGGCTTCAAGGTCAGCAAGGGCGATCCACTTCTTATCCTCGAGGCGA
TGAAGATGGAGCATACGATCACGGCACCTCATGATGGCACGATCGCCAAGATCGCCGCCGAGGGTGCGCAGGTCGCTGAC
GGAACCGTGCTTGTCCGCTTCGAAGAGTCGGGAGGAAACTGA

Upstream 100 bases:

>100_bases
TCGACCCGACGAAGACGCGCGAGGTGCTGGCGCTGAGCCTCTCGGCCGCGCTCAATGCCGAGATCAAGGACACCAAACCC
GGCGTTTGGAGGATGTGAGG

Downstream 100 bases:

>100_bases
TGCACGGGCTTTATCTGGAGGAATTCGACGTCGGCATGGTCATCCGCCATCCGATCACGCGCACCGTCACCGAGAGCGAC
AACATGATGTTCTCGATGAT

Product: 3-methylcrotonyl-CoA carboxylase biotin-containing subunit

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 653; Mature: 652

Protein sequence:

>653_residues
MGKLFSKILIANRGEIACRVIRTARRLGMATVGVYSDADAKSLHVAMAGEAVHIGASPVAESYLKADRIIDAALKTGAQA
IHPGYGFLSEAPDFVERVEAAGLVFIGPSASSIRAMGLKDAAKRLMEITGVPVVPGYHGEAQDPALLASRAIEIGFPVLI
KARAGGGGKGMRRVETAGEFADALASAQREAKASFGDDKVLIEKYVEKPRHIEVQVFGDNHGNGVHLFERDCSAQRRHQK
VIEEAPAPGMTPEMRVAMTHAAVKAAKAINYSGAGTIEFIVDASEGLRADRFWFMEMNTRLQVEHPMTEMVTGQDLVEWQ
IRVAAGELLPLTQDDIHLDGHAFEARLYAEDASRGFLPATGTLYHLRFPPEASSIRIETGVRQGDTISSFYDPMIAKIVT
KGSDRKDALELLVSALAVTEVAGSTVNTAFLSALAQDEDFATGDVDTGLIARKQGALTALAEASARSKALAALRVASVDE
ATSNDPWASLTGYDHFGSTAKAISLGESGEISVSLTAETNGAWRAEVDEQTIRFSPTSLPEALASAVIWPGHVTVFDGAV
SHTFIARDPLDEAADAYGGAGSLRAPMPGLVKLVRAKPGFKVSKGDPLLILEAMKMEHTITAPHDGTIAKIAAEGAQVAD
GTVLVRFEESGGN

Sequences:

>Translated_653_residues
MGKLFSKILIANRGEIACRVIRTARRLGMATVGVYSDADAKSLHVAMAGEAVHIGASPVAESYLKADRIIDAALKTGAQA
IHPGYGFLSEAPDFVERVEAAGLVFIGPSASSIRAMGLKDAAKRLMEITGVPVVPGYHGEAQDPALLASRAIEIGFPVLI
KARAGGGGKGMRRVETAGEFADALASAQREAKASFGDDKVLIEKYVEKPRHIEVQVFGDNHGNGVHLFERDCSAQRRHQK
VIEEAPAPGMTPEMRVAMTHAAVKAAKAINYSGAGTIEFIVDASEGLRADRFWFMEMNTRLQVEHPMTEMVTGQDLVEWQ
IRVAAGELLPLTQDDIHLDGHAFEARLYAEDASRGFLPATGTLYHLRFPPEASSIRIETGVRQGDTISSFYDPMIAKIVT
KGSDRKDALELLVSALAVTEVAGSTVNTAFLSALAQDEDFATGDVDTGLIARKQGALTALAEASARSKALAALRVASVDE
ATSNDPWASLTGYDHFGSTAKAISLGESGEISVSLTAETNGAWRAEVDEQTIRFSPTSLPEALASAVIWPGHVTVFDGAV
SHTFIARDPLDEAADAYGGAGSLRAPMPGLVKLVRAKPGFKVSKGDPLLILEAMKMEHTITAPHDGTIAKIAAEGAQVAD
GTVLVRFEESGGN
>Mature_652_residues
GKLFSKILIANRGEIACRVIRTARRLGMATVGVYSDADAKSLHVAMAGEAVHIGASPVAESYLKADRIIDAALKTGAQAI
HPGYGFLSEAPDFVERVEAAGLVFIGPSASSIRAMGLKDAAKRLMEITGVPVVPGYHGEAQDPALLASRAIEIGFPVLIK
ARAGGGGKGMRRVETAGEFADALASAQREAKASFGDDKVLIEKYVEKPRHIEVQVFGDNHGNGVHLFERDCSAQRRHQKV
IEEAPAPGMTPEMRVAMTHAAVKAAKAINYSGAGTIEFIVDASEGLRADRFWFMEMNTRLQVEHPMTEMVTGQDLVEWQI
RVAAGELLPLTQDDIHLDGHAFEARLYAEDASRGFLPATGTLYHLRFPPEASSIRIETGVRQGDTISSFYDPMIAKIVTK
GSDRKDALELLVSALAVTEVAGSTVNTAFLSALAQDEDFATGDVDTGLIARKQGALTALAEASARSKALAALRVASVDEA
TSNDPWASLTGYDHFGSTAKAISLGESGEISVSLTAETNGAWRAEVDEQTIRFSPTSLPEALASAVIWPGHVTVFDGAVS
HTFIARDPLDEAADAYGGAGSLRAPMPGLVKLVRAKPGFKVSKGDPLLILEAMKMEHTITAPHDGTIAKIAAEGAQVADG
TVLVRFEESGGN

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=677, Percent_Identity=47.1196454948301, Blast_Score=590, Evalue=1e-168,
Organism=Homo sapiens, GI295821183, Length=665, Percent_Identity=40, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI65506442, Length=450, Percent_Identity=49.1111111111111, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI189095269, Length=450, Percent_Identity=49.1111111111111, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI106049528, Length=474, Percent_Identity=42.4050632911392, Blast_Score=338, Evalue=7e-93,
Organism=Homo sapiens, GI106049295, Length=474, Percent_Identity=42.4050632911392, Blast_Score=338, Evalue=7e-93,
Organism=Homo sapiens, GI106049292, Length=474, Percent_Identity=42.4050632911392, Blast_Score=338, Evalue=7e-93,
Organism=Homo sapiens, GI38679974, Length=735, Percent_Identity=28.0272108843537, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI38679971, Length=735, Percent_Identity=28.0272108843537, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI38679977, Length=735, Percent_Identity=28.0272108843537, Blast_Score=240, Evalue=3e-63,
Organism=Homo sapiens, GI38679967, Length=735, Percent_Identity=28.0272108843537, Blast_Score=240, Evalue=3e-63,
Organism=Homo sapiens, GI38679960, Length=735, Percent_Identity=28.0272108843537, Blast_Score=240, Evalue=4e-63,
Organism=Homo sapiens, GI134142062, Length=518, Percent_Identity=30.5019305019305, Blast_Score=221, Evalue=2e-57,
Organism=Escherichia coli, GI1789654, Length=455, Percent_Identity=46.8131868131868, Blast_Score=383, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71987519, Length=660, Percent_Identity=47.2727272727273, Blast_Score=537, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17567343, Length=682, Percent_Identity=40.3225806451613, Blast_Score=442, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17562816, Length=455, Percent_Identity=41.978021978022, Blast_Score=324, Evalue=9e-89,
Organism=Caenorhabditis elegans, GI71997163, Length=507, Percent_Identity=29.585798816568, Blast_Score=222, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI71997168, Length=507, Percent_Identity=29.585798816568, Blast_Score=221, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI133931226, Length=713, Percent_Identity=28.0504908835905, Blast_Score=221, Evalue=8e-58,
Organism=Saccharomyces cerevisiae, GI6319685, Length=464, Percent_Identity=43.5344827586207, Blast_Score=395, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6319695, Length=453, Percent_Identity=42.8256070640177, Blast_Score=311, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6321376, Length=453, Percent_Identity=43.046357615894, Blast_Score=299, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6324343, Length=732, Percent_Identity=28.8251366120219, Blast_Score=246, Evalue=6e-66,
Organism=Saccharomyces cerevisiae, GI6323863, Length=684, Percent_Identity=28.3625730994152, Blast_Score=233, Evalue=6e-62,
Organism=Drosophila melanogaster, GI24651757, Length=674, Percent_Identity=46.7359050445104, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24651759, Length=636, Percent_Identity=44.9685534591195, Blast_Score=500, Evalue=1e-141,
Organism=Drosophila melanogaster, GI281363050, Length=457, Percent_Identity=43.1072210065646, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24652224, Length=457, Percent_Identity=43.1072210065646, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24652222, Length=457, Percent_Identity=43.1072210065646, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24652220, Length=457, Percent_Identity=43.1072210065646, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24652218, Length=457, Percent_Identity=43.1072210065646, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24652212, Length=457, Percent_Identity=43.1072210065646, Blast_Score=326, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24652210, Length=457, Percent_Identity=43.1072210065646, Blast_Score=326, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24652214, Length=457, Percent_Identity=43.1072210065646, Blast_Score=326, Evalue=3e-89,
Organism=Drosophila melanogaster, GI19921944, Length=457, Percent_Identity=43.1072210065646, Blast_Score=326, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24652216, Length=457, Percent_Identity=43.1072210065646, Blast_Score=326, Evalue=3e-89,
Organism=Drosophila melanogaster, GI161076407, Length=721, Percent_Identity=29.4036061026352, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24586460, Length=721, Percent_Identity=29.4036061026352, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI161076409, Length=721, Percent_Identity=29.126213592233, Blast_Score=244, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24586458, Length=721, Percent_Identity=29.126213592233, Blast_Score=243, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 69273; Mature: 69142

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKLFSKILIANRGEIACRVIRTARRLGMATVGVYSDADAKSLHVAMAGEAVHIGASPVA
CCHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCEEEECCCHHH
ESYLKADRIIDAALKTGAQAIHPGYGFLSEAPDFVERVEAAGLVFIGPSASSIRAMGLKD
HHHHHHHHHHHHHHHCCCCEECCCCCCHHCCHHHHHHHHHCCEEEECCCCCCHHHCCHHH
AAKRLMEITGVPVVPGYHGEAQDPALLASRAIEIGFPVLIKARAGGGGKGMRRVETAGEF
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHH
ADALASAQREAKASFGDDKVLIEKYVEKPRHIEVQVFGDNHGNGVHLFERDCSAQRRHQK
HHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCHHHHHHHHH
VIEEAPAPGMTPEMRVAMTHAAVKAAKAINYSGAGTIEFIVDASEGLRADRFWFMEMNTR
HHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCEEEEEEECCE
LQVEHPMTEMVTGQDLVEWQIRVAAGELLPLTQDDIHLDGHAFEARLYAEDASRGFLPAT
EEECCCHHHHHCCCCCEEEEEEEECCCEECCCCCCEEECCCEEEEEEEECCCCCCCCCCC
GTLYHLRFPPEASSIRIETGVRQGDTISSFYDPMIAKIVTKGSDRKDALELLVSALAVTE
CEEEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VAGSTVNTAFLSALAQDEDFATGDVDTGLIARKQGALTALAEASARSKALAALRVASVDE
HCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCC
ATSNDPWASLTGYDHFGSTAKAISLGESGEISVSLTAETNGAWRAEVDEQTIRFSPTSLP
CCCCCCCCCCCCCCCCCCCHHEEECCCCCCEEEEEEEECCCCEEEECCCCEEEECCCHHH
EALASAVIWPGHVTVFDGAVSHTFIARDPLDEAADAYGGAGSLRAPMPGLVKLVRAKPGF
HHHHHHEECCCEEEEECCCHHCEEEECCCHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCC
KVSKGDPLLILEAMKMEHTITAPHDGTIAKIAAEGAQVADGTVLVRFEESGGN
EECCCCCEEEEEEECCCCEEECCCCCCEEEEECCCCEECCCEEEEEEECCCCC
>Mature Secondary Structure 
GKLFSKILIANRGEIACRVIRTARRLGMATVGVYSDADAKSLHVAMAGEAVHIGASPVA
CHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCEEEECCCHHH
ESYLKADRIIDAALKTGAQAIHPGYGFLSEAPDFVERVEAAGLVFIGPSASSIRAMGLKD
HHHHHHHHHHHHHHHCCCCEECCCCCCHHCCHHHHHHHHHCCEEEECCCCCCHHHCCHHH
AAKRLMEITGVPVVPGYHGEAQDPALLASRAIEIGFPVLIKARAGGGGKGMRRVETAGEF
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHH
ADALASAQREAKASFGDDKVLIEKYVEKPRHIEVQVFGDNHGNGVHLFERDCSAQRRHQK
HHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCHHHHHHHHH
VIEEAPAPGMTPEMRVAMTHAAVKAAKAINYSGAGTIEFIVDASEGLRADRFWFMEMNTR
HHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCEEEEEEECCE
LQVEHPMTEMVTGQDLVEWQIRVAAGELLPLTQDDIHLDGHAFEARLYAEDASRGFLPAT
EEECCCHHHHHCCCCCEEEEEEEECCCEECCCCCCEEECCCEEEEEEEECCCCCCCCCCC
GTLYHLRFPPEASSIRIETGVRQGDTISSFYDPMIAKIVTKGSDRKDALELLVSALAVTE
CEEEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VAGSTVNTAFLSALAQDEDFATGDVDTGLIARKQGALTALAEASARSKALAALRVASVDE
HCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCC
ATSNDPWASLTGYDHFGSTAKAISLGESGEISVSLTAETNGAWRAEVDEQTIRFSPTSLP
CCCCCCCCCCCCCCCCCCCHHEEECCCCCCEEEEEEEECCCCEEEECCCCEEEECCCHHH
EALASAVIWPGHVTVFDGAVSHTFIARDPLDEAADAYGGAGSLRAPMPGLVKLVRAKPGF
HHHHHHEECCCEEEEECCCHHCEEEECCCHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCC
KVSKGDPLLILEAMKMEHTITAPHDGTIAKIAAEGAQVADGTVLVRFEESGGN
EECCCCCEEEEEEECCCCEEECCCCCCEEEEECCCCEECCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]