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The map label for this gene is groEL

Identifier: 13474837

GI number: 13474837

Start: 4687261

End: 4688919

Strand: Reverse

Name: groEL

Synonym: mll5810

Alternate gene names: 13474837

Gene position: 4688919-4687261 (Counterclockwise)

Preceding gene: 13474838

Following gene: 13474836

Centisome position: 66.64

GC content: 63.53

Gene sequence:

>1659_bases
ATGGCTGCCAAAGACGTGAAATTCTCTCGTGATGCCCGCGAGCGCATGCTGCGCGGTGTCAACATCCTCGCCGACGCGGT
GAAGGTGACGCTCGGCCCCAAGGGCCGCAACGTCGTTATCGACAAGTCGTTCGGCGCCCCGCGCATCACCAAGGACGGCG
TCACCGTCGCCAAGGAAATCGAGCTTGAAGACAAGTTCGAAAACATGGGCGCTCAGATGGTCCGCGAAGTTGCTTCGAAG
ACCAACGACATCGCCGGTGACGGCACCACGACCGCAACCGTTCTGGCGCAGTCGATCGTCCAGGAAGGCCACAAGGCGGT
TGCTGCCGGCATGAACCCGATGGACCTGAAGCGCGGCATCGACCTCGCGGTTAGCGACGTCGTCTGGACGCTGATCAAGA
ACGCCACGAAGATCAAGACCTCGGAAGAGGTTGCCCAGGTCGGCACAATCGCCGGCAATGGCGACGAGTCGGTCGGCAAG
ATGATCGCGGAAGCGATGCAGAAGGTCGGCAACGAAGGCGTCATCACGGTTGAGGAAGCCAAGACCGCCGAGACGGAACT
CGAAGTCGTCGAAGGCATGCAGTTCGACCGCGGCTATCTCTCGCCCTACTTCGTCACCAACGCCGACAAGATGGTTGCCG
ATCTCGAGGACGCCTACATCCTGCTGCACGAGAAGAAGCTCTCGAACCTGCAGGCGATGCTGCCGGTTCTCGAAGCCGTC
GTGCAGACCTCGAAGCCGCTGCTCATCATCTCGGAAGACGTCGAAGGCGAGGCCCTGGCCACGCTGGTCGTCAACAAGCT
GCGTGGCGGTCTGAAGATCGCCGCCGTCAAGGCGCCGGGCTTCGGTGATCGCCGCAAGGCCATGCTGGAAGACATCGCCA
TCCTCACCGGTGGCCAGGTCATCTCGGAAGACCTCGGCATCAAGCTCGAGAACGTCGGCCTTGACATGCTCGGCCGCGCC
AAGAAGGTGTCGATCTCCAAGGAGAACACCACCATCGTAGACGGTGCCGGCAAGAAGGAAGAGATCCAGGGCCGCGTCGC
CCAGATCAAGCAGCAGATCGAGGAGACCACCTCGGACTACGACAAGGAGAAGCTGCAGGAGCGTCTCGCCAAGCTCGCGG
GCGGCGTTGCGGTGATCCGCGTCGGCGGTGCGACGGAAGTCGAAGTCAAGGAAAAGAAGGACCGCGTTGACGATGCGCTG
AACGCGACACGCGCAGCCGTCGAAGAAGGCATCGTTCCCGGCGGCGGCGTTGCCCTGCTGCGCGCTTCGCTGAGCATCAA
CGCTGTCGGCGCAAACTCCGACCAGACCGCTGGCATCAGCATCGTGCGTCGTGCGCTGCAGGCTCCGGCCCGCCAGATCG
CGGCCAACGCCGGTGCGGAAGCCTCGATCGTTGCCGGCAAGATCCTTGAGAACAAGGGCGCGACCTTCGGTTTCAACGCC
CAGACCGGCGAATATGGCGACATGATCGCCATGGGCATCGTCGATCCGGTCAAGGTCGTGCGCACGGCTCTCCAGGACGC
GGCCTCGGTCGCCGGCCTGCTGGTCACCACCGAAGCCATGATCGCGGAGGCTCCGAAGAAGGAGTCGGCTGGCGGCGGCG
GCATGCCTGGCGGCATGGGCGGCGGCGGCATGGGCGGCATGGGCGGCATGGATTTCTAA

Upstream 100 bases:

>100_bases
TGAAGGAAGCCGACATCATGGGCATCATCGGCTAACACGCCGCTGCCTTTCATCCGTACCATCCAATCTGAATTTCGGGC
GAAATGCCCAGGAGTACAAA

Downstream 100 bases:

>100_bases
TCTAGCCTCTATCAGCTTTCGGATACCGAGAGGGCGGCACCGACGCCGCCCCCTTTTTTTTGGGACGGAGCCGGTCGGAA
AAGGTTTGGGCTCGCGTGAT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 3; Protein Cpn60 3

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MAAKDVKFSRDARERMLRGVNILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEIELEDKFENMGAQMVREVASK
TNDIAGDGTTTATVLAQSIVQEGHKAVAAGMNPMDLKRGIDLAVSDVVWTLIKNATKIKTSEEVAQVGTIAGNGDESVGK
MIAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNADKMVADLEDAYILLHEKKLSNLQAMLPVLEAV
VQTSKPLLIISEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLENVGLDMLGRA
KKVSISKENTTIVDGAGKKEEIQGRVAQIKQQIEETTSDYDKEKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDAL
NATRAAVEEGIVPGGGVALLRASLSINAVGANSDQTAGISIVRRALQAPARQIAANAGAEASIVAGKILENKGATFGFNA
QTGEYGDMIAMGIVDPVKVVRTALQDAASVAGLLVTTEAMIAEAPKKESAGGGGMPGGMGGGGMGGMGGMDF

Sequences:

>Translated_552_residues
MAAKDVKFSRDARERMLRGVNILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEIELEDKFENMGAQMVREVASK
TNDIAGDGTTTATVLAQSIVQEGHKAVAAGMNPMDLKRGIDLAVSDVVWTLIKNATKIKTSEEVAQVGTIAGNGDESVGK
MIAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNADKMVADLEDAYILLHEKKLSNLQAMLPVLEAV
VQTSKPLLIISEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLENVGLDMLGRA
KKVSISKENTTIVDGAGKKEEIQGRVAQIKQQIEETTSDYDKEKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDAL
NATRAAVEEGIVPGGGVALLRASLSINAVGANSDQTAGISIVRRALQAPARQIAANAGAEASIVAGKILENKGATFGFNA
QTGEYGDMIAMGIVDPVKVVRTALQDAASVAGLLVTTEAMIAEAPKKESAGGGGMPGGMGGGGMGGMGGMDF
>Mature_551_residues
AAKDVKFSRDARERMLRGVNILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEIELEDKFENMGAQMVREVASKT
NDIAGDGTTTATVLAQSIVQEGHKAVAAGMNPMDLKRGIDLAVSDVVWTLIKNATKIKTSEEVAQVGTIAGNGDESVGKM
IAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNADKMVADLEDAYILLHEKKLSNLQAMLPVLEAVV
QTSKPLLIISEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLENVGLDMLGRAK
KVSISKENTTIVDGAGKKEEIQGRVAQIKQQIEETTSDYDKEKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDALN
ATRAAVEEGIVPGGGVALLRASLSINAVGANSDQTAGISIVRRALQAPARQIAANAGAEASIVAGKILENKGATFGFNAQ
TGEYGDMIAMGIVDPVKVVRTALQDAASVAGLLVTTEAMIAEAPKKESAGGGGMPGGMGGGGMGGMGGMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=53.9772727272727, Blast_Score=566, Evalue=1e-161,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=53.9772727272727, Blast_Score=566, Evalue=1e-161,
Organism=Escherichia coli, GI1790586, Length=531, Percent_Identity=68.1732580037665, Blast_Score=702, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=53.4971644612476, Blast_Score=560, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=54.5023696682464, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17564182, Length=559, Percent_Identity=22.7191413237925, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=57.4144486692015, Blast_Score=593, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6322524, Length=542, Percent_Identity=21.2177121771218, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=56.0606060606061, Blast_Score=588, Evalue=1e-168,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=56.0606060606061, Blast_Score=588, Evalue=1e-168,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=53.4090909090909, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=53.4090909090909, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=53.4090909090909, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI17864606, Length=556, Percent_Identity=44.4244604316547, Blast_Score=458, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24584129, Length=532, Percent_Identity=36.8421052631579, Blast_Score=344, Evalue=8e-95,
Organism=Drosophila melanogaster, GI19921262, Length=532, Percent_Identity=36.8421052631579, Blast_Score=344, Evalue=8e-95,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH603_RHILO (Q98AX9)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_106407.1
- ProteinModelPortal:   Q98AX9
- SMR:   Q98AX9
- GeneID:   1229066
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll5810
- NMPDR:   fig|266835.1.peg.4510
- HOGENOM:   HBG625289
- OMA:   CAITDIP
- ProtClustDB:   PRK12849
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57752; Mature: 57621

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFSRDARERMLRGVNILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCCCEEHHC
ELEDKFENMGAQMVREVASKTNDIAGDGTTTATVLAQSIVQEGHKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
DLAVSDVVWTLIKNATKIKTSEEVAQVGTIAGNGDESVGKMIAEAMQKVGNEGVITVEEA
CHHHHHHHHHHHHCCHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECC
KTAETELEVVEGMQFDRGYLSPYFVTNADKMVADLEDAYILLHEKKLSNLQAMLPVLEAV
CCHHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHCHHEEEEEHHHHHHHHHHHHHHHHH
VQTSKPLLIISEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEDLGIKLENVGLDMLGRAKKVSISKENTTIVDGAGKKEEIQGRVAQIKQQIEETTSDY
HHHHHCEEEECCCHHHHCCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHC
DKEKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDALNATRAAVEEGIVPGGGVALL
CHHHHHHHHHHHHCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHE
RASLSINAVGANSDQTAGISIVRRALQAPARQIAANAGAEASIVAGKILENKGATFGFNA
EECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEECCCC
QTGEYGDMIAMGIVDPVKVVRTALQDAASVAGLLVTTEAMIAEAPKKESAGGGGMPGGMG
CCCCCCCEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GGGMGGMGGMDF
CCCCCCCCCCCC
>Mature Secondary Structure 
AAKDVKFSRDARERMLRGVNILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEI
CCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCCCEEHHC
ELEDKFENMGAQMVREVASKTNDIAGDGTTTATVLAQSIVQEGHKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
DLAVSDVVWTLIKNATKIKTSEEVAQVGTIAGNGDESVGKMIAEAMQKVGNEGVITVEEA
CHHHHHHHHHHHHCCHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECC
KTAETELEVVEGMQFDRGYLSPYFVTNADKMVADLEDAYILLHEKKLSNLQAMLPVLEAV
CCHHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHCHHEEEEEHHHHHHHHHHHHHHHHH
VQTSKPLLIISEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEDLGIKLENVGLDMLGRAKKVSISKENTTIVDGAGKKEEIQGRVAQIKQQIEETTSDY
HHHHHCEEEECCCHHHHCCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHC
DKEKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDALNATRAAVEEGIVPGGGVALL
CHHHHHHHHHHHHCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHE
RASLSINAVGANSDQTAGISIVRRALQAPARQIAANAGAEASIVAGKILENKGATFGFNA
EECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEECCCC
QTGEYGDMIAMGIVDPVKVVRTALQDAASVAGLLVTTEAMIAEAPKKESAGGGGMPGGMG
CCCCCCCEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GGGMGGMGGMDF
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968