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The map label for this gene is fabA

Identifier: 13474639

GI number: 13474639

Start: 4470090

End: 4470605

Strand: Reverse

Name: fabA

Synonym: mll5569

Alternate gene names: 13474639

Gene position: 4470605-4470090 (Counterclockwise)

Preceding gene: 13474642

Following gene: 13474638

Centisome position: 63.54

GC content: 61.82

Gene sequence:

>516_bases
ATGGCGGGTAAATCCAGCTACGACTACGAAGAATTGCTGGCCTGCGCCCGCGGCGAGCTGTTCGGAGAGGGCAATGCCCA
GCTGCCCTACCCGCCGATGCTGATGTTCGACCGTATCACCGAGATCAGCGAGACCGGCGGCGCCTTCGACAAGGGCTTCA
TCCGTGCGGAGTTCGACATCAAGCCGGACCTGTGGTTCTTCGCCTGCCATTTCATCGGCAATCCGATCATGCCAGGATGC
CTCGGTCTGGACGCCTTGTGGCAGTTGACCGGCTTCTACCTTGGCTGGCTCGGCGAACCCGGCAAGGGAATGGCGCTGTC
GACCGGTGAGGTCAAGTTCAAGGGCATGGTCACGCCATCGGTCAAGAAGGTCGAGTACGGCGTGGATTTCAAGCGCGTCA
TGCGCGGCCGATTGGTGCTGGGCATCGCCGATGGCTGGATGAAGGCGGATGGCGAGCCCATATATGCGGCGACGGACCTG
AAGGTCGGTCTGTCCAAGCAGTCGGCGGTCGCTTGA

Upstream 100 bases:

>100_bases
CGGGTTAAGCGCAAACGCCGGTTTCCGGCCTGAAACAGATTGTGTTAGGACACCAACGACAAGGGCGCGCTACCGCCCGG
ACGATATGGGGACGAGATTG

Downstream 100 bases:

>100_bases
CCGCACCCTTGGCCGACCCACTGGCCAGCATCCCTGGAAGGAGTTGCGAATGAGACGTGTCGTAGTCACAGGCCTCGGCA
TCGTGTCGTCGATCGGCAAC

Product: 3-hydroxydecanoyl-(acyl carrier protein) dehydratase

Products: NA

Alternate protein names: Beta-hydroxydecanoyl thioester dehydrase

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MAGKSSYDYEELLACARGELFGEGNAQLPYPPMLMFDRITEISETGGAFDKGFIRAEFDIKPDLWFFACHFIGNPIMPGC
LGLDALWQLTGFYLGWLGEPGKGMALSTGEVKFKGMVTPSVKKVEYGVDFKRVMRGRLVLGIADGWMKADGEPIYAATDL
KVGLSKQSAVA

Sequences:

>Translated_171_residues
MAGKSSYDYEELLACARGELFGEGNAQLPYPPMLMFDRITEISETGGAFDKGFIRAEFDIKPDLWFFACHFIGNPIMPGC
LGLDALWQLTGFYLGWLGEPGKGMALSTGEVKFKGMVTPSVKKVEYGVDFKRVMRGRLVLGIADGWMKADGEPIYAATDL
KVGLSKQSAVA
>Mature_170_residues
AGKSSYDYEELLACARGELFGEGNAQLPYPPMLMFDRITEISETGGAFDKGFIRAEFDIKPDLWFFACHFIGNPIMPGCL
GLDALWQLTGFYLGWLGEPGKGMALSTGEVKFKGMVTPSVKKVEYGVDFKRVMRGRLVLGIADGWMKADGEPIYAATDLK
VGLSKQSAVA

Specific function: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzed the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabA subfamily

Homologues:

Organism=Escherichia coli, GI1787187, Length=166, Percent_Identity=61.4457831325301, Blast_Score=221, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABA_RHILO (Q98BH8)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_106208.1
- ProteinModelPortal:   Q98BH8
- SMR:   Q98BH8
- GeneID:   1228869
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll5569
- NMPDR:   fig|266835.1.peg.4312
- HOGENOM:   HBG433282
- OMA:   CHFKGDP
- ProtClustDB:   PRK05174
- BRENDA:   4.2.1.60
- GO:   GO:0005737
- HAMAP:   MF_00405
- InterPro:   IPR000794
- InterPro:   IPR010083
- InterPro:   IPR013114
- PANTHER:   PTHR11712
- TIGRFAMs:   TIGR01749

Pfam domain/function: PF07977 FabA

EC number: =4.2.1.60

Molecular weight: Translated: 18706; Mature: 18575

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: ACT_SITE 70-70

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGKSSYDYEELLACARGELFGEGNAQLPYPPMLMFDRITEISETGGAFDKGFIRAEFDI
CCCCCCCCHHHHHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECC
KPDLWFFACHFIGNPIMPGCLGLDALWQLTGFYLGWLGEPGKGMALSTGEVKFKGMVTPS
CCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEEECCCC
VKKVEYGVDFKRVMRGRLVLGIADGWMKADGEPIYAATDLKVGLSKQSAVA
CEEEECCCCHHHHHCCEEEEEEECCCCCCCCCEEEEEECCEECCCCCCCCC
>Mature Secondary Structure 
AGKSSYDYEELLACARGELFGEGNAQLPYPPMLMFDRITEISETGGAFDKGFIRAEFDI
CCCCCCCHHHHHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECC
KPDLWFFACHFIGNPIMPGCLGLDALWQLTGFYLGWLGEPGKGMALSTGEVKFKGMVTPS
CCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEEECCCC
VKKVEYGVDFKRVMRGRLVLGIADGWMKADGEPIYAATDLKVGLSKQSAVA
CEEEECCCCHHHHHCCEEEEEEECCCCCCCCCEEEEEECCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968