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The map label for this gene is fabB [H]

Identifier: 13474638

GI number: 13474638

Start: 4468820

End: 4470040

Strand: Reverse

Name: fabB [H]

Synonym: mll5566

Alternate gene names: 13474638

Gene position: 4470040-4468820 (Counterclockwise)

Preceding gene: 13474639

Following gene: 13474637

Centisome position: 63.53

GC content: 64.05

Gene sequence:

>1221_bases
ATGAGACGTGTCGTAGTCACAGGCCTCGGCATCGTGTCGTCGATCGGCAACAATGCCAACGAGGTGCAGACCTCGCTGCA
TGACGCCAGATCCGGCATCAGCTTTTCCGATTCCTTCGCCGAGCACGGCTTCCGTTGCCAGGTCTGGGGCGCGCCGACGC
TCGACCCCTCCGCCATGATCGACCGCCGCGCGATGCGCTTCCTGAGCCAAGGTGCCGCCTGGAACCACGTCGCCATGGAC
CAGGCGATCGCCGATGCGGGCCTCGGCGAAAGCGACATCACCAATGAGCGCACCGGCATCGTCATGGGCTCGGGCGGCCC
CTCCACCCGCACCATCGTCGAGGCGGCCGAAACCACGCTGAAGAACGGCAGCCCCAAGCGCATCGGCCCCTTCGCGGTAC
CGAAGGCGATGTCGTCGACCGCGTCGGCAACGCTGGCCACCTGGTTCAAGATCCACGGCGTCAACTATTCGATCTCGTCG
GCCTGCTCGACCTCGGCGCATTGCATCGGCAATGGCTACGAGCTGATCCAATGGGGCAAGCAGGACATGGTCTTTGCCGG
CGGCCATGAGGATCTCGACTGGACGATGTCGGACCTGTTCGACGCCATGGGCGCCATGTCGTCCAAGTTCAACGACAGGG
CCTCGGCTGCTTCCCGCGCCTATGACGTCAATCGCGACGGCTTCGTCATCGCCGGCGGCGCCGGCGTGCTGGTGCTGGAG
GAGCTCGAGCATGCCAAGGCGCGCGGCGCCAAGATCTACGCCGAGATCGTCGGCTACGGCGCAACCTCTGACGGCTACGA
CATGGTGGCCCCCTCCGGCGAAGGCGCGGTCCGCTGCATGCGCCAGGCGCTGGCGACGGTTTCCACGCCGGTCGACTACA
TCAACACCCATGGCACCTCGACGCCGGTCGGGGATTCCAAGGAAATGGGCGCCATCCGCGAGGTGTTCGGCGAGAAGATG
CCGTTCATCACCTCGACGAAATCGCTGACCGGCCATTCGCTGGGCGCGGCCGGCGTTCAGGAGTCGATCTATTCGATCCT
GATGATGCAAGGCGGCTTCATCGGCGAAAGCGCCCATATCGAAACCCTCGACCCCGAATTCGAGGGCATGCCGATCGTGC
GCAAGCGTATCGACAACGCCAAGATCGACACCGTCCTGTCAAATTCCTTCGGTTTCGGTGGCACCAACGCAACGCTCGTT
TTCCAGCGCTATTCCGCATAA

Upstream 100 bases:

>100_bases
GCGGCGACGGACCTGAAGGTCGGTCTGTCCAAGCAGTCGGCGGTCGCTTGACCGCACCCTTGGCCGACCCACTGGCCAGC
ATCCCTGGAAGGAGTTGCGA

Downstream 100 bases:

>100_bases
GGCCAGCGGTTTTCTAGGGGGATTGCCTGCCATGGACGGATTGATGAAGGGCAAGCGCGGGCTTGTCATGGGTGTCGCCA
ACGATCATTCGATCGCCTGG

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MRRVVVTGLGIVSSIGNNANEVQTSLHDARSGISFSDSFAEHGFRCQVWGAPTLDPSAMIDRRAMRFLSQGAAWNHVAMD
QAIADAGLGESDITNERTGIVMGSGGPSTRTIVEAAETTLKNGSPKRIGPFAVPKAMSSTASATLATWFKIHGVNYSISS
ACSTSAHCIGNGYELIQWGKQDMVFAGGHEDLDWTMSDLFDAMGAMSSKFNDRASAASRAYDVNRDGFVIAGGAGVLVLE
ELEHAKARGAKIYAEIVGYGATSDGYDMVAPSGEGAVRCMRQALATVSTPVDYINTHGTSTPVGDSKEMGAIREVFGEKM
PFITSTKSLTGHSLGAAGVQESIYSILMMQGGFIGESAHIETLDPEFEGMPIVRKRIDNAKIDTVLSNSFGFGGTNATLV
FQRYSA

Sequences:

>Translated_406_residues
MRRVVVTGLGIVSSIGNNANEVQTSLHDARSGISFSDSFAEHGFRCQVWGAPTLDPSAMIDRRAMRFLSQGAAWNHVAMD
QAIADAGLGESDITNERTGIVMGSGGPSTRTIVEAAETTLKNGSPKRIGPFAVPKAMSSTASATLATWFKIHGVNYSISS
ACSTSAHCIGNGYELIQWGKQDMVFAGGHEDLDWTMSDLFDAMGAMSSKFNDRASAASRAYDVNRDGFVIAGGAGVLVLE
ELEHAKARGAKIYAEIVGYGATSDGYDMVAPSGEGAVRCMRQALATVSTPVDYINTHGTSTPVGDSKEMGAIREVFGEKM
PFITSTKSLTGHSLGAAGVQESIYSILMMQGGFIGESAHIETLDPEFEGMPIVRKRIDNAKIDTVLSNSFGFGGTNATLV
FQRYSA
>Mature_406_residues
MRRVVVTGLGIVSSIGNNANEVQTSLHDARSGISFSDSFAEHGFRCQVWGAPTLDPSAMIDRRAMRFLSQGAAWNHVAMD
QAIADAGLGESDITNERTGIVMGSGGPSTRTIVEAAETTLKNGSPKRIGPFAVPKAMSSTASATLATWFKIHGVNYSISS
ACSTSAHCIGNGYELIQWGKQDMVFAGGHEDLDWTMSDLFDAMGAMSSKFNDRASAASRAYDVNRDGFVIAGGAGVLVLE
ELEHAKARGAKIYAEIVGYGATSDGYDMVAPSGEGAVRCMRQALATVSTPVDYINTHGTSTPVGDSKEMGAIREVFGEKM
PFITSTKSLTGHSLGAAGVQESIYSILMMQGGFIGESAHIETLDPEFEGMPIVRKRIDNAKIDTVLSNSFGFGGTNATLV
FQRYSA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=423, Percent_Identity=34.2789598108747, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI41872631, Length=336, Percent_Identity=24.702380952381, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI223972627, Length=138, Percent_Identity=39.8550724637681, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1788663, Length=404, Percent_Identity=61.6336633663366, Blast_Score=495, Evalue=1e-141,
Organism=Escherichia coli, GI1787337, Length=416, Percent_Identity=37.2596153846154, Blast_Score=244, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI71983541, Length=419, Percent_Identity=33.4128878281623, Blast_Score=201, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI71983535, Length=259, Percent_Identity=39.3822393822394, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI212642053, Length=339, Percent_Identity=25.9587020648968, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=277, Percent_Identity=25.2707581227437, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=30.5803571428571, Blast_Score=183, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24644341, Length=421, Percent_Identity=36.5795724465558, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI19920632, Length=337, Percent_Identity=27.893175074184, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI221330659, Length=337, Percent_Identity=27.893175074184, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24581345, Length=340, Percent_Identity=24.1176470588235, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 43001; Mature: 43001

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGLGIVSSIGNNANEVQTSLHDARSGISFSDSFAEHGFRCQVWGAPTLDPSAMI
CCEEEEECHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEECCCCCCCHHHHH
DRRAMRFLSQGAAWNHVAMDQAIADAGLGESDITNERTGIVMGSGGPSTRTIVEAAETTL
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHH
KNGSPKRIGPFAVPKAMSSTASATLATWFKIHGVNYSISSACSTSAHCIGNGYELIQWGK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCEEHHHHCCCCCCCCCCCHHHHHCCC
QDMVFAGGHEDLDWTMSDLFDAMGAMSSKFNDRASAASRAYDVNRDGFVIAGGAGVLVLE
CCEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCEECCCCCEEEECCCCEEEHH
ELEHAKARGAKIYAEIVGYGATSDGYDMVAPSGEGAVRCMRQALATVSTPVDYINTHGTS
HHHHHHHCCCEEEEEHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCHHHHHCCCCC
TPVGDSKEMGAIREVFGEKMPFITSTKSLTGHSLGAAGVQESIYSILMMQGGFIGESAHI
CCCCCCHHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCE
ETLDPEFEGMPIVRKRIDNAKIDTVLSNSFGFGGTNATLVFQRYSA
EECCCCCCCCHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MRRVVVTGLGIVSSIGNNANEVQTSLHDARSGISFSDSFAEHGFRCQVWGAPTLDPSAMI
CCEEEEECHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEECCCCCCCHHHHH
DRRAMRFLSQGAAWNHVAMDQAIADAGLGESDITNERTGIVMGSGGPSTRTIVEAAETTL
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHH
KNGSPKRIGPFAVPKAMSSTASATLATWFKIHGVNYSISSACSTSAHCIGNGYELIQWGK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCEEHHHHCCCCCCCCCCCHHHHHCCC
QDMVFAGGHEDLDWTMSDLFDAMGAMSSKFNDRASAASRAYDVNRDGFVIAGGAGVLVLE
CCEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCEECCCCCEEEECCCCEEEHH
ELEHAKARGAKIYAEIVGYGATSDGYDMVAPSGEGAVRCMRQALATVSTPVDYINTHGTS
HHHHHHHCCCEEEEEHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCHHHHHCCCCC
TPVGDSKEMGAIREVFGEKMPFITSTKSLTGHSLGAAGVQESIYSILMMQGGFIGESAHI
CCCCCCHHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCE
ETLDPEFEGMPIVRKRIDNAKIDTVLSNSFGFGGTNATLVFQRYSA
EECCCCCCCCHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]