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The map label for this gene is dnaX [H]

Identifier: 13474589

GI number: 13474589

Start: 4414355

End: 4416169

Strand: Direct

Name: dnaX [H]

Synonym: mlr5503

Alternate gene names: 13474589

Gene position: 4414355-4416169 (Clockwise)

Preceding gene: 13474585

Following gene: 13474590

Centisome position: 62.74

GC content: 67.33

Gene sequence:

>1815_bases
ATGAGCGAAGGAAATTCGGGGCCAAAAAGCCCGGAGAATGGAAAGGCCGCCGCCTACCGCGTGCTGGCGCGCAAATACCG
TCCGTCGAATTTTTCCGAATTGGTCGGCCAGGAGCCGATGGTGCGCACCCTCACCAACGCCTTTGCCACCGGCCGCATTG
CCCAGGCCTGGATGCTGACCGGCGTGCGCGGTGTCGGCAAGACCACCACGGCGCGCATCCTGGCGCGGGCGCTGAACTAC
AAGACCGCGACCGTCGACCAGCCTTCCGTCGACCTCGCCGTGCTCGGCGAGCATTGCCAGGCGATCATGGAAGGCCGCCA
CGTCGACGTCATCGAAATGGACGCCGCCTCGCACACCGGCATCGACGACATCAGGGACATCATCGAGCGCGTGCGCTACG
CGCCGGTCTCGGCCCGCTACAAGGTCTACATCATCGACGAAGTGCACATGCTGTCGACGCAGGCCTTCAACGGCCTGCTG
AAAACGCTGGAAGAGCCGCCGCCGCACGTCAAATTCATCTTCGCCACCACCGAAATCCGCAAGGTTCCGATCACCGTCCT
GTCGCGCTGCCAGCGCTTTGACCTAAGGCGCATCGACGCCGGCGCGTTGGTGGCGCATCTCTCCTCGATCGCTGCCAAGG
AAGGCATTTCGGTCGACGACGACGCGCTGGCGATGATCGCACGTGCGGCCGAAGGCTCGGCCCGCGATTCGCTCTCCATT
CTCGACCAGGCGATCGCGCATGGCGCCGGCGCCGTCAGCGCCGAAGCGGTGCGGGCCATGCTGGGACTGGCCGACCGCGC
CCGCATCGTCGATCTGTTCGAACATGTGATGAAGGGCGACGTGGCGGCGGCACTCGCCGAATTCCGCACGCAATACGACA
CCGGCGCCGATCCGGCCGCCGTGTTGACCGATCTTGCCGAGTTCAACCATCTCGTCACCCGGCTGCGTTTCGTGCCGACC
GCCATGGACGATGCATCGCTGTCGCAGGACGAGCGCCAGCGCGGCGCCGATTTTGCCAGGGCGCTGTCGGTCCGCGTGCT
GTCGCGGACCTGGCAGATGCTGCTCAAGGGCATTCCCGAGGTGCAGTCCTCCAACCGGCCGGTCAGTGCCGCCGAAATGG
TGCTGATCCGGCTGGCGCATGCCGCCGACCTGCCGACGCTGGACGAGGCGCTGCGATCCCTGGACGGGGCAGCAACAGTT
CAGAATGGCGCATCGCGCCCGAACGGGGCACCCGGCGGCCCCGGCAATGGCGGTGGGGCCGGCGCGGTGGCGCAGACGCG
CATGCCATCCGGTTCCAGTGGTGCGCAGACCATGCGGCTGGTCGAGGCCGCGCCCGCGCTGGCCGCCTTCGTCGCGCCGC
CCGCGCCGGTGTCCGAGCCGCAGCAGGTGCCGGTCAGGTCGCTGGCCGACATTGTTGCCCTTGCCGACGCGCAGCGCGAC
ATCGCCTTCAAGGTGCTGGTCAAGCGCTGCATCCGTCCCGTGCGCTTCGAGCCCGGCCGCATCGACGTCAGCCTGACCGA
CGATGCGCCCAAGCTGCTGCTCAACGACCTGACGACGAAACTACGCGCCTGGACCGGCCGCAACTGGCTGGTGTCGCTGT
CGAAGGAAGAGGGCGGCCAGACGCTGGCCGAAATGGAATCGACCAAGCGCGAAAACGCCTTCCTCGATGCCAAGAGCGAT
CCGACGGTTGCCGCCATCCTGGCGCGCTTTCCCGGCGCCAAGATCATCGACGTGCGCATTCCCGACGCGCCGGAGGTAGA
CGCGACCGAAGCCGAAGTGCCGGTCGAGCCGCCGGCGGATGACGACGAGACCTGA

Upstream 100 bases:

>100_bases
ATCGGCCCACCTCGCGACATTGACGACGCATTGCAGCGCGGGCGAGACTATGCGCAGGAATGGCGCCCTGAGGCGCGGCC
TTTTGGAGCTTAACGGGCGA

Downstream 100 bases:

>100_bases
CAAACCAAGACAAGGACCGGACCATGAAAGATCTTCTCGGCCTGATGGGCAAGGCGAAGGAAATGCAGGCCAAGTTCCAG
GCCATGCAGGATGAGATCGC

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 604; Mature: 603

Protein sequence:

>604_residues
MSEGNSGPKSPENGKAAAYRVLARKYRPSNFSELVGQEPMVRTLTNAFATGRIAQAWMLTGVRGVGKTTTARILARALNY
KTATVDQPSVDLAVLGEHCQAIMEGRHVDVIEMDAASHTGIDDIRDIIERVRYAPVSARYKVYIIDEVHMLSTQAFNGLL
KTLEEPPPHVKFIFATTEIRKVPITVLSRCQRFDLRRIDAGALVAHLSSIAAKEGISVDDDALAMIARAAEGSARDSLSI
LDQAIAHGAGAVSAEAVRAMLGLADRARIVDLFEHVMKGDVAAALAEFRTQYDTGADPAAVLTDLAEFNHLVTRLRFVPT
AMDDASLSQDERQRGADFARALSVRVLSRTWQMLLKGIPEVQSSNRPVSAAEMVLIRLAHAADLPTLDEALRSLDGAATV
QNGASRPNGAPGGPGNGGGAGAVAQTRMPSGSSGAQTMRLVEAAPALAAFVAPPAPVSEPQQVPVRSLADIVALADAQRD
IAFKVLVKRCIRPVRFEPGRIDVSLTDDAPKLLLNDLTTKLRAWTGRNWLVSLSKEEGGQTLAEMESTKRENAFLDAKSD
PTVAAILARFPGAKIIDVRIPDAPEVDATEAEVPVEPPADDDET

Sequences:

>Translated_604_residues
MSEGNSGPKSPENGKAAAYRVLARKYRPSNFSELVGQEPMVRTLTNAFATGRIAQAWMLTGVRGVGKTTTARILARALNY
KTATVDQPSVDLAVLGEHCQAIMEGRHVDVIEMDAASHTGIDDIRDIIERVRYAPVSARYKVYIIDEVHMLSTQAFNGLL
KTLEEPPPHVKFIFATTEIRKVPITVLSRCQRFDLRRIDAGALVAHLSSIAAKEGISVDDDALAMIARAAEGSARDSLSI
LDQAIAHGAGAVSAEAVRAMLGLADRARIVDLFEHVMKGDVAAALAEFRTQYDTGADPAAVLTDLAEFNHLVTRLRFVPT
AMDDASLSQDERQRGADFARALSVRVLSRTWQMLLKGIPEVQSSNRPVSAAEMVLIRLAHAADLPTLDEALRSLDGAATV
QNGASRPNGAPGGPGNGGGAGAVAQTRMPSGSSGAQTMRLVEAAPALAAFVAPPAPVSEPQQVPVRSLADIVALADAQRD
IAFKVLVKRCIRPVRFEPGRIDVSLTDDAPKLLLNDLTTKLRAWTGRNWLVSLSKEEGGQTLAEMESTKRENAFLDAKSD
PTVAAILARFPGAKIIDVRIPDAPEVDATEAEVPVEPPADDDET
>Mature_603_residues
SEGNSGPKSPENGKAAAYRVLARKYRPSNFSELVGQEPMVRTLTNAFATGRIAQAWMLTGVRGVGKTTTARILARALNYK
TATVDQPSVDLAVLGEHCQAIMEGRHVDVIEMDAASHTGIDDIRDIIERVRYAPVSARYKVYIIDEVHMLSTQAFNGLLK
TLEEPPPHVKFIFATTEIRKVPITVLSRCQRFDLRRIDAGALVAHLSSIAAKEGISVDDDALAMIARAAEGSARDSLSIL
DQAIAHGAGAVSAEAVRAMLGLADRARIVDLFEHVMKGDVAAALAEFRTQYDTGADPAAVLTDLAEFNHLVTRLRFVPTA
MDDASLSQDERQRGADFARALSVRVLSRTWQMLLKGIPEVQSSNRPVSAAEMVLIRLAHAADLPTLDEALRSLDGAATVQ
NGASRPNGAPGGPGNGGGAGAVAQTRMPSGSSGAQTMRLVEAAPALAAFVAPPAPVSEPQQVPVRSLADIVALADAQRDI
AFKVLVKRCIRPVRFEPGRIDVSLTDDAPKLLLNDLTTKLRAWTGRNWLVSLSKEEGGQTLAEMESTKRENAFLDAKSDP
TVAAILARFPGAKIIDVRIPDAPEVDATEAEVPVEPPADDDET

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI31563534, Length=301, Percent_Identity=24.9169435215947, Blast_Score=80, Evalue=8e-15,
Organism=Escherichia coli, GI1786676, Length=360, Percent_Identity=41.3888888888889, Blast_Score=277, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI71986063, Length=298, Percent_Identity=23.8255033557047, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17541988, Length=236, Percent_Identity=27.1186440677966, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17554730, Length=270, Percent_Identity=23.3333333333333, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322528, Length=331, Percent_Identity=22.9607250755287, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324478, Length=236, Percent_Identity=25.8474576271186, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324039, Length=224, Percent_Identity=23.2142857142857, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17647857, Length=287, Percent_Identity=27.1777003484321, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI18859927, Length=258, Percent_Identity=24.4186046511628, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI19921076, Length=313, Percent_Identity=23.3226837060703, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 64667; Mature: 64536

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEGNSGPKSPENGKAAAYRVLARKYRPSNFSELVGQEPMVRTLTNAFATGRIAQAWMLT
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GVRGVGKTTTARILARALNYKTATVDQPSVDLAVLGEHCQAIMEGRHVDVIEMDAASHTG
CCCCCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
IDDIRDIIERVRYAPVSARYKVYIIDEVHMLSTQAFNGLLKTLEEPPPHVKFIFATTEIR
HHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHH
KVPITVLSRCQRFDLRRIDAGALVAHLSSIAAKEGISVDDDALAMIARAAEGSARDSLSI
HCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHH
LDQAIAHGAGAVSAEAVRAMLGLADRARIVDLFEHVMKGDVAAALAEFRTQYDTGADPAA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
VLTDLAEFNHLVTRLRFVPTAMDDASLSQDERQRGADFARALSVRVLSRTWQMLLKGIPE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VQSSNRPVSAAEMVLIRLAHAADLPTLDEALRSLDGAATVQNGASRPNGAPGGPGNGGGA
HHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCC
GAVAQTRMPSGSSGAQTMRLVEAAPALAAFVAPPAPVSEPQQVPVRSLADIVALADAQRD
CCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
IAFKVLVKRCIRPVRFEPGRIDVSLTDDAPKLLLNDLTTKLRAWTGRNWLVSLSKEEGGQ
HHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCH
TLAEMESTKRENAFLDAKSDPTVAAILARFPGAKIIDVRIPDAPEVDATEAEVPVEPPAD
HHHHHHHHHHHCCEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
DDET
CCCC
>Mature Secondary Structure 
SEGNSGPKSPENGKAAAYRVLARKYRPSNFSELVGQEPMVRTLTNAFATGRIAQAWMLT
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GVRGVGKTTTARILARALNYKTATVDQPSVDLAVLGEHCQAIMEGRHVDVIEMDAASHTG
CCCCCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
IDDIRDIIERVRYAPVSARYKVYIIDEVHMLSTQAFNGLLKTLEEPPPHVKFIFATTEIR
HHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHH
KVPITVLSRCQRFDLRRIDAGALVAHLSSIAAKEGISVDDDALAMIARAAEGSARDSLSI
HCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHH
LDQAIAHGAGAVSAEAVRAMLGLADRARIVDLFEHVMKGDVAAALAEFRTQYDTGADPAA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
VLTDLAEFNHLVTRLRFVPTAMDDASLSQDERQRGADFARALSVRVLSRTWQMLLKGIPE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VQSSNRPVSAAEMVLIRLAHAADLPTLDEALRSLDGAATVQNGASRPNGAPGGPGNGGGA
HHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCC
GAVAQTRMPSGSSGAQTMRLVEAAPALAAFVAPPAPVSEPQQVPVRSLADIVALADAQRD
CCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
IAFKVLVKRCIRPVRFEPGRIDVSLTDDAPKLLLNDLTTKLRAWTGRNWLVSLSKEEGGQ
HHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCH
TLAEMESTKRENAFLDAKSDPTVAAILARFPGAKIIDVRIPDAPEVDATEAEVPVEPPAD
HHHHHHHHHHHCCEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
DDET
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]