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The map label for this gene is nhaA

Identifier: 13474429

GI number: 13474429

Start: 4236835

End: 4238031

Strand: Direct

Name: nhaA

Synonym: mlr5309

Alternate gene names: 13474429

Gene position: 4236835-4238031 (Clockwise)

Preceding gene: 13474428

Following gene: 13474433

Centisome position: 60.22

GC content: 65.5

Gene sequence:

>1197_bases
ATGCAGGATTTGAAGCAGCGGCCGGTTTCCGTCTTTCGCGAATTCCTCGACAGCGAGGCGGCCGGCGGTATCATCCTGAT
GGTGGCGGCGGCACTCGCCTTGATCGTCGCCAACTCACCGCTCGCCGAAACCTATTTCTCCGTTCTCCATGCCTATCTCG
GCCCGCTCAGCGTCTCGCATTGGGTCAATGACGGGCTGATGGCGGTGTTCTTCCTGCTTGTCGGGCTGGAGATCAAGCGC
GAGATGCTGGACGGCCAGCTGTCGACCTGGCCACGCCGCGTCCTGCCCGGCATCGCGGCGGCCGGCGGCATGCTGGTTCC
GGCGCTGGTCTATGTCTTCATCAACCGCAACAATTCAGCCGCACTCTCGGGCTGGGCGATCCCGACCGCCACCGACATCG
CCTTCGCGCTCGGCGTGCTGTCGCTGCTCGGCAGCCGCGTGCCGGCTTCGCTGAAAGTCTTCCTGACCGCGCTCGCCATC
ATCGACGACCTCGGCGCCGTCATCATCATCGCCATCTTCTATACGAGCGGCCTGTCGCTGGCCTATCTCGGTGCCGCCTT
CGCCGTCATTGCAGCGCTTGTCGTGCTCAACCGCATGCGGGTGATGACGCTGCTGCCCTATCTCGTGCTCGGCGCCATCC
TGTGGGTGCTGGTTCTCAAGTCGGGCGTCCACGCCACGCTTGCCGGCGTTGCGCTGGCGCTGACCATTCCGCTCGAGCGC
TCTGCCGGGGTCGGCCACGATCTCGATCATTCGCCGCTGCACCGGCTCGAGCATGGCCTGCACAAAATCGTGCCCTTTTT
CGTCATCCCGATCTTCGGCTTCGCCAATGCCGGCGTTTCGCTCGCCGGCCTCAGTCTTGGCGCGCTGATCGAGCCGCTGA
CGCTGGGCGTCGCCGCCGGCCTTGTTGTCGGCAAGCTCGTCGGCGTGTTCGGCTCTTCGGCGCTTGCCATAAGGCTCGGC
CTGGCCGACCTGCCGGCCCATACCGGCTGGTCACATATGATCGGCATCTCGCTGCTCTGCGGCATCGGCTTCACCATGAG
CCTGTTCATCGGCCTGCTCGCCTTCGCCAGCGATGTGGCTCTGCAGGACGCGGTCAAGGTCGGCATCCTCGCCGGCTCCT
TCGTCGCCGCCATACTCGGCGCCGCCGTGCTGCTGATGGCGCCGGCTGCGGGTGTTGCGGAAGAAGAGACGGAGTAG

Upstream 100 bases:

>100_bases
ATTTCGAAACAGTCTCTGAGGCGCCGAGTACGGTCGGATACTTGTCCGGGGGGCAGAGTTTTGAGCATCATCGCAAGTGA
CGCGGCTTAACGGAGGCGAC

Downstream 100 bases:

>100_bases
GGGCGGTTCGCCGTTCTGCGAACTACTCGCTTTCCCCCTCCAGCGCCGGTACCGAGACGCCGGCCAGCTCCGCCGCGAGC
AGCCGCGCCGCACCGGCGCG

Product: Na+/H+ antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MQDLKQRPVSVFREFLDSEAAGGIILMVAAALALIVANSPLAETYFSVLHAYLGPLSVSHWVNDGLMAVFFLLVGLEIKR
EMLDGQLSTWPRRVLPGIAAAGGMLVPALVYVFINRNNSAALSGWAIPTATDIAFALGVLSLLGSRVPASLKVFLTALAI
IDDLGAVIIIAIFYTSGLSLAYLGAAFAVIAALVVLNRMRVMTLLPYLVLGAILWVLVLKSGVHATLAGVALALTIPLER
SAGVGHDLDHSPLHRLEHGLHKIVPFFVIPIFGFANAGVSLAGLSLGALIEPLTLGVAAGLVVGKLVGVFGSSALAIRLG
LADLPAHTGWSHMIGISLLCGIGFTMSLFIGLLAFASDVALQDAVKVGILAGSFVAAILGAAVLLMAPAAGVAEEETE

Sequences:

>Translated_398_residues
MQDLKQRPVSVFREFLDSEAAGGIILMVAAALALIVANSPLAETYFSVLHAYLGPLSVSHWVNDGLMAVFFLLVGLEIKR
EMLDGQLSTWPRRVLPGIAAAGGMLVPALVYVFINRNNSAALSGWAIPTATDIAFALGVLSLLGSRVPASLKVFLTALAI
IDDLGAVIIIAIFYTSGLSLAYLGAAFAVIAALVVLNRMRVMTLLPYLVLGAILWVLVLKSGVHATLAGVALALTIPLER
SAGVGHDLDHSPLHRLEHGLHKIVPFFVIPIFGFANAGVSLAGLSLGALIEPLTLGVAAGLVVGKLVGVFGSSALAIRLG
LADLPAHTGWSHMIGISLLCGIGFTMSLFIGLLAFASDVALQDAVKVGILAGSFVAAILGAAVLLMAPAAGVAEEETE
>Mature_398_residues
MQDLKQRPVSVFREFLDSEAAGGIILMVAAALALIVANSPLAETYFSVLHAYLGPLSVSHWVNDGLMAVFFLLVGLEIKR
EMLDGQLSTWPRRVLPGIAAAGGMLVPALVYVFINRNNSAALSGWAIPTATDIAFALGVLSLLGSRVPASLKVFLTALAI
IDDLGAVIIIAIFYTSGLSLAYLGAAFAVIAALVVLNRMRVMTLLPYLVLGAILWVLVLKSGVHATLAGVALALTIPLER
SAGVGHDLDHSPLHRLEHGLHKIVPFFVIPIFGFANAGVSLAGLSLGALIEPLTLGVAAGLVVGKLVGVFGSSALAIRLG
LADLPAHTGWSHMIGISLLCGIGFTMSLFIGLLAFASDVALQDAVKVGILAGSFVAAILGAAVLLMAPAAGVAEEETE

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=382, Percent_Identity=50.7853403141361, Blast_Score=302, Evalue=3e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA_RHILO (Q98C38)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_105997.1
- HSSP:   P13738
- ProteinModelPortal:   Q98C38
- SMR:   Q98C38
- GeneID:   1228658
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr5309
- NMPDR:   fig|266835.1.peg.4101
- HOGENOM:   HBG665619
- OMA:   YFALRDL
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 41245; Mature: 41245

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x143108f0)-; HASH(0x14652774)-; HASH(0x14990be4)-; HASH(0x1481c0c4)-; HASH(0x14ca0bac)-; HASH(0x14c6448c)-; HASH(0x14419e70)-; HASH(0x14318510)-; HASH(0x130f63e0)-; HASH(0x14b9b8f8)-; HASH(0x1428c61c)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11214968