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The map label for this gene is actR [H]

Identifier: 13474428

GI number: 13474428

Start: 4236027

End: 4236590

Strand: Direct

Name: actR [H]

Synonym: mlr5308

Alternate gene names: 13474428

Gene position: 4236027-4236590 (Clockwise)

Preceding gene: 13474427

Following gene: 13474429

Centisome position: 60.2

GC content: 65.96

Gene sequence:

>564_bases
ATGACAGGCGATGAAAATATTGGCGCAATGGTTGAAGGCGAGGACACCTCGCTTCTGATCGTCGATGACGACAAGCCGTT
CCTCACGCGTCTGGCCCGCGCCATGGAAACCAGGGGGTTTGTGGTCGAGACCGCCGAGAGCGTCGAGGAGGCCGTGGGCA
AGGCCCGCGCCAATCCGCCGGCCTATGCCGTGGTCGACATGCGGCTCGGCGACGGCAACGGCCTCGATGTCGTCGCCGCC
ATTCGCGAGAAGCGCGAGGATTCCCGCACCATCATCCTGACCGGCTACGGCAACATCGCCACTGCGGTGACCGCGGTGAA
GCTTGGCGCCGTCGATTATCTGTCGAAGCCTGCCGACGCCGACGACATCTTCGCCGCCCTCACCCGCACCTCGGGCGAGC
GCGCCGCACCGCCGGAAAACCCGATGTCTGCAGACCGCGTGCGCTGGGAGCATATCCAGCGTGTCTACGAGATGTGCGAG
CGCAACGTCTCCGAAACCGCGCGCCGGCTCAACATGCACCGCCGCACGCTGCAGCGAATACTGGCCAAGCGCGCGCCGCG
CTGA

Upstream 100 bases:

>100_bases
GGAACGGCCCCGGCCACCATGTTTGACACTGCGTAGATTGGACAATAGCGGCGCAAAACTATATCTGCGTAAAATTAAGG
CAGCAGGAATTCTTACGACG

Downstream 100 bases:

>100_bases
GACTGTTTGGAACTTCTACTCTGGCGGCCATCTGATGGCGTTTTCTGCGCTTCCCCGTTCTACTGCGTGCAGTAGAACTG
AGCTCACGGAATGTCCGCTC

Product: two-component, response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MTGDENIGAMVEGEDTSLLIVDDDKPFLTRLARAMETRGFVVETAESVEEAVGKARANPPAYAVVDMRLGDGNGLDVVAA
IREKREDSRTIILTGYGNIATAVTAVKLGAVDYLSKPADADDIFAALTRTSGERAAPPENPMSADRVRWEHIQRVYEMCE
RNVSETARRLNMHRRTLQRILAKRAPR

Sequences:

>Translated_187_residues
MTGDENIGAMVEGEDTSLLIVDDDKPFLTRLARAMETRGFVVETAESVEEAVGKARANPPAYAVVDMRLGDGNGLDVVAA
IREKREDSRTIILTGYGNIATAVTAVKLGAVDYLSKPADADDIFAALTRTSGERAAPPENPMSADRVRWEHIQRVYEMCE
RNVSETARRLNMHRRTLQRILAKRAPR
>Mature_186_residues
TGDENIGAMVEGEDTSLLIVDDDKPFLTRLARAMETRGFVVETAESVEEAVGKARANPPAYAVVDMRLGDGNGLDVVAAI
REKREDSRTIILTGYGNIATAVTAVKLGAVDYLSKPADADDIFAALTRTSGERAAPPENPMSADRVRWEHIQRVYEMCER
NVSETARRLNMHRRTLQRILAKRAPR

Specific function: Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two- component sensor may be involved in pH sensing and/or response [H]

COG id: COG4567

COG function: function code TK; Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=116, Percent_Identity=31.0344827586207, Blast_Score=63, Evalue=9e-12,
Organism=Escherichia coli, GI1788905, Length=120, Percent_Identity=32.5, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 20614; Mature: 20482

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGDENIGAMVEGEDTSLLIVDDDKPFLTRLARAMETRGFVVETAESVEEAVGKARANPP
CCCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCCCC
AYAVVDMRLGDGNGLDVVAAIREKREDSRTIILTGYGNIATAVTAVKLGAVDYLSKPADA
CEEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCH
DDIFAALTRTSGERAAPPENPMSADRVRWEHIQRVYEMCERNVSETARRLNMHRRTLQRI
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LAKRAPR
HHHCCCC
>Mature Secondary Structure 
TGDENIGAMVEGEDTSLLIVDDDKPFLTRLARAMETRGFVVETAESVEEAVGKARANPP
CCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCCCC
AYAVVDMRLGDGNGLDVVAAIREKREDSRTIILTGYGNIATAVTAVKLGAVDYLSKPADA
CEEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCH
DDIFAALTRTSGERAAPPENPMSADRVRWEHIQRVYEMCERNVSETARRLNMHRRTLQRI
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LAKRAPR
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]