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The map label for this gene is pntAA [H]

Identifier: 13474321

GI number: 13474321

Start: 4115645

End: 4116934

Strand: Direct

Name: pntAA [H]

Synonym: mlr5181

Alternate gene names: 13474321

Gene position: 4115645-4116934 (Clockwise)

Preceding gene: 13474318

Following gene: 13474322

Centisome position: 58.49

GC content: 65.43

Gene sequence:

>1290_bases
GTGGGACAGACGGTTTTCATCCCTCGTGAGCTTGACGCGAACGAGCCGCGCGTCGCGGCCTCGCCCGATACGGTCAAGCG
GCTGGCAGGGCTGGGCTTCGACGTGATTGTCGAAACCGGCGCCGGCACGAGGTCGCGCATCCCCGACGAGGAGTTCGCCA
AGGCAGGTGCCGTCATCAGCAAGGCCGCGGATGTCGGTAAGGCCGATGTCGTGCTGAAGGTCCGCCGGCCTACGGAAGCC
GAGCTGAAGAGCTATAAATCCGGCGCTGCCGTGATCGCCATCATGGATCCCTACGGCAACGATGCCGCCGTTGCGGCGCT
GGCAAAGGCCGGTGTCACTGCCTTCTCGATGGAATTCATGCCGCGCATTACCCGCGCGCAATCGATGGACGTGCTGTCCA
GCCAGGCAAATCTTGCCGGCTATCAGGCGGTCATTGACGGTGCCTCGGAATATGATCGTGCCTTGCCGATGATGATGACG
GCGGCCGGCACGGTGCCAGCGGCGAAAATCTTCATCATGGGTGTCGGCGTCGCCGGCCTGCAAGCGATCGCCACGGCGCG
CCGCCTTGGTGCCGTTGTCACCGCCACCGACGTGCGCCCCGCCGCCAAGGAACAGGTCGCCTCGCTCGGCGCAAAGTTCC
TGGCCGTCGAGGACGAGGAGTTCAAGGCCGCCGAAACGGCTGGCGGCTACGCCAAGGAAATGTCCAAGGAATACCAGGCC
AAGCAGGCGGCACTCACCGCCGAGCACATCGCCAAGCAGGACATCGTCATCACCACGGCGCTGATCCCCGGCCGGCCGGC
GCCGACGCTGGTGTCGGCGGCGATGGTCGCCTCGATGAAGCCGGGCTCGGTGCTCGTCGACCTCGCCGTCGAACGTGGCG
GCAATGTCGAAGGTGCTCAGCCGGGTCGGGTGGTGACCACGGCCAATGGCGTAAAGATCGTCGGCCACCTCAACGTGCCC
GGCCGCGTCGCCGCATCCGCCTCGCTGCTCTACGCCAAGAACCTGTTCGCTTTCCTCGAGACGCTGGTCGACAAGACCAC
CAAGACGCTGGCCATCAAGCGCGATGACGAACTGGTCAAGGCCACCATGCTGACCGACGGCGGCAAGGTGGTTCATCCGG
CCTTCGCCAAGGCCGACCAGCAGCCTCATGTCGAACCCGCGGCGATCCCGGCCACAACCATGGTCGCCGATGCTTCGGCT
GCGCCCAAAAAGCCCGCGCCAAAGAAGACAGCCGCGTCCAAATCGTCCTCGCCCAAGTCGTCCTCGCCCAAGTCGAAAGG
CACAGCGTGA

Upstream 100 bases:

>100_bases
CATTCTGCGATAGACCTTCCAAAACCCAGTTGCCATTGACCTCGCCGGATATTCCGGCCGACACTTTGCGCAAACAGGTT
CCAGCCGAAAGGATCATGCG

Downstream 100 bases:

>100_bases
TGGATCAGTCCCTGCAGAAAGCCCTCGACCAGCTCGACCAGGCCTCCGCCGCCGTCAGGCTTGCGGTGCAGAACCTGGCC
AATGCTCCAGGTGGCGCCGA

Product: nicotinamide nucleotide transhydrogenase, subunit alpha1

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MGQTVFIPRELDANEPRVAASPDTVKRLAGLGFDVIVETGAGTRSRIPDEEFAKAGAVISKAADVGKADVVLKVRRPTEA
ELKSYKSGAAVIAIMDPYGNDAAVAALAKAGVTAFSMEFMPRITRAQSMDVLSSQANLAGYQAVIDGASEYDRALPMMMT
AAGTVPAAKIFIMGVGVAGLQAIATARRLGAVVTATDVRPAAKEQVASLGAKFLAVEDEEFKAAETAGGYAKEMSKEYQA
KQAALTAEHIAKQDIVITTALIPGRPAPTLVSAAMVASMKPGSVLVDLAVERGGNVEGAQPGRVVTTANGVKIVGHLNVP
GRVAASASLLYAKNLFAFLETLVDKTTKTLAIKRDDELVKATMLTDGGKVVHPAFAKADQQPHVEPAAIPATTMVADASA
APKKPAPKKTAASKSSSPKSSSPKSKGTA

Sequences:

>Translated_429_residues
MGQTVFIPRELDANEPRVAASPDTVKRLAGLGFDVIVETGAGTRSRIPDEEFAKAGAVISKAADVGKADVVLKVRRPTEA
ELKSYKSGAAVIAIMDPYGNDAAVAALAKAGVTAFSMEFMPRITRAQSMDVLSSQANLAGYQAVIDGASEYDRALPMMMT
AAGTVPAAKIFIMGVGVAGLQAIATARRLGAVVTATDVRPAAKEQVASLGAKFLAVEDEEFKAAETAGGYAKEMSKEYQA
KQAALTAEHIAKQDIVITTALIPGRPAPTLVSAAMVASMKPGSVLVDLAVERGGNVEGAQPGRVVTTANGVKIVGHLNVP
GRVAASASLLYAKNLFAFLETLVDKTTKTLAIKRDDELVKATMLTDGGKVVHPAFAKADQQPHVEPAAIPATTMVADASA
APKKPAPKKTAASKSSSPKSSSPKSKGTA
>Mature_428_residues
GQTVFIPRELDANEPRVAASPDTVKRLAGLGFDVIVETGAGTRSRIPDEEFAKAGAVISKAADVGKADVVLKVRRPTEAE
LKSYKSGAAVIAIMDPYGNDAAVAALAKAGVTAFSMEFMPRITRAQSMDVLSSQANLAGYQAVIDGASEYDRALPMMMTA
AGTVPAAKIFIMGVGVAGLQAIATARRLGAVVTATDVRPAAKEQVASLGAKFLAVEDEEFKAAETAGGYAKEMSKEYQAK
QAALTAEHIAKQDIVITTALIPGRPAPTLVSAAMVASMKPGSVLVDLAVERGGNVEGAQPGRVVTTANGVKIVGHLNVPG
RVAASASLLYAKNLFAFLETLVDKTTKTLAIKRDDELVKATMLTDGGKVVHPAFAKADQQPHVEPAAIPATTMVADASAA
PKKPAPKKTAASKSSSPKSSSPKSKGTA

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=386, Percent_Identity=41.4507772020725, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI122939153, Length=386, Percent_Identity=41.4507772020725, Blast_Score=263, Evalue=3e-70,
Organism=Escherichia coli, GI1787887, Length=368, Percent_Identity=43.4782608695652, Blast_Score=305, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI17550456, Length=366, Percent_Identity=43.7158469945355, Blast_Score=292, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 44262; Mature: 44131

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQTVFIPRELDANEPRVAASPDTVKRLAGLGFDVIVETGAGTRSRIPDEEFAKAGAVIS
CCCEEEEECCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHH
KAADVGKADVVLKVRRPTEAELKSYKSGAAVIAIMDPYGNDAAVAALAKAGVTAFSMEFM
HHHCCCCCEEEEEECCCCHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHH
PRITRAQSMDVLSSQANLAGYQAVIDGASEYDRALPMMMTAAGTVPAAKIFIMGVGVAGL
HHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHH
QAIATARRLGAVVTATDVRPAAKEQVASLGAKFLAVEDEEFKAAETAGGYAKEMSKEYQA
HHHHHHHHHCEEEEECCCCHHHHHHHHHCCCEEEEECCHHHHHHHHCCHHHHHHHHHHHH
KQAALTAEHIAKQDIVITTALIPGRPAPTLVSAAMVASMKPGSVLVDLAVERGGNVEGAQ
HHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCC
PGRVVTTANGVKIVGHLNVPGRVAASASLLYAKNLFAFLETLVDKTTKTLAIKRDDELVK
CCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHEEEEECCCHHEE
ATMLTDGGKVVHPAFAKADQQPHVEPAAIPATTMVADASAAPKKPAPKKTAASKSSSPKS
EEEECCCCCEECHHHHCCCCCCCCCCCCCCCHHEEECCCCCCCCCCCCCHHCCCCCCCCC
SSPKSKGTA
CCCCCCCCC
>Mature Secondary Structure 
GQTVFIPRELDANEPRVAASPDTVKRLAGLGFDVIVETGAGTRSRIPDEEFAKAGAVIS
CCEEEEECCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHH
KAADVGKADVVLKVRRPTEAELKSYKSGAAVIAIMDPYGNDAAVAALAKAGVTAFSMEFM
HHHCCCCCEEEEEECCCCHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHH
PRITRAQSMDVLSSQANLAGYQAVIDGASEYDRALPMMMTAAGTVPAAKIFIMGVGVAGL
HHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHH
QAIATARRLGAVVTATDVRPAAKEQVASLGAKFLAVEDEEFKAAETAGGYAKEMSKEYQA
HHHHHHHHHCEEEEECCCCHHHHHHHHHCCCEEEEECCHHHHHHHHCCHHHHHHHHHHHH
KQAALTAEHIAKQDIVITTALIPGRPAPTLVSAAMVASMKPGSVLVDLAVERGGNVEGAQ
HHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCC
PGRVVTTANGVKIVGHLNVPGRVAASASLLYAKNLFAFLETLVDKTTKTLAIKRDDELVK
CCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHEEEEECCCHHEE
ATMLTDGGKVVHPAFAKADQQPHVEPAAIPATTMVADASAAPKKPAPKKTAASKSSSPKS
EEEECCCCCEECHHHHCCCCCCCCCCCCCCCHHEEECCCCCCCCCCCCCHHCCCCCCCCC
SSPKSKGTA
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]