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The map label for this gene is idhA [H]

Identifier: 13474167

GI number: 13474167

Start: 3958009

End: 3959004

Strand: Reverse

Name: idhA [H]

Synonym: mll4991

Alternate gene names: 13474167

Gene position: 3959004-3958009 (Counterclockwise)

Preceding gene: 13474168

Following gene: 13474166

Centisome position: 56.27

GC content: 64.06

Gene sequence:

>996_bases
ATGACTGTTCGTTTCGCCCTCCTCGGTGCCGGCCGCATCGGCAAGGTCCACGCCCGCGCCGTCGGCTCCAACCCCGATGC
AAAACTGGTGGCGGTGGCCGATGCCTTCGAGAAGGCGGCAAAGGAGCTGGCGAGCGCCTATGGCGCCGAGGTACGCACCA
TCGACGCCATCGAAAAATCCAAGGACATCGACGCCGTCGTCATCTGCACGCCGACCGACACCCATGCCGATCTGATCGAG
CGTTTCGCCAAGGCCGGCAAGGCGATCTTCTGCGAGAAGCCGATCGACCTGAACGTTAAGCGCGTCGAGAAATGCCTGGC
CGTGGTCGAGAAGGCCAAGGCGACGCTGATGGTCGGCTTCAACCGCCGCTTCGACCCGCATTTCGCCGCCGTGCGCAAGG
CGATCGACGACGGCGCCATCGGCACGGTCGAGATGGTCACCATCACCTCGCGCGATCCCGGCGCGCCGCCGATCGACTAC
ATCAAGCGCTCGGGCGGCATTTTCCGCGACATGACCATTCATGATTTCGACATGGCGCGCTTCCTGCTCGGCGAAGAGCC
GGTGGCGGTCTCCGCGCATGCTTCGGTGCTGGTCGACAAGAAGATTGGCGAGGCCGGCGATTTCGATAGCGTCAGCGTCA
TCCTGGAGACGGCTTCCGGCAAGCAGGCCGTCATCTCCAATTCGCGCCGCGCCACCTATGGCTATGATCAGCGCATCGAG
GTGCATGGCTCGAAAGGCATGATCGCGGCCGAGAACCAGCGGCCGGTGTCGATCGAACTGGCCAACGAGAAGGGCTATAC
GCGCCCGCCGCTGCACGATTTCTTCATGACCCGCTATCTCGACGCCTATGCCATCGAGATCGCCTCGTTCATCGCTGCCG
CGACGTCCGGCAAGAAGGCGGCGCCGAGCGGCGCCGACGGCCTCGTGGCGCTGAAGCTGGCGGATGCGGCGCTGAAGTCG
GCGACAACAGGCAAGACCGTTCGTCTCGACAAGTAA

Upstream 100 bases:

>100_bases
CGGGACGATCTGCCGCGCCTAGAAAATACCCCAGCCACCTTTCCCTGACAGGAAGGTGCGGACACAACGCTCTCGAACCC
ATCCCTCAAAGGAAATATCC

Downstream 100 bases:

>100_bases
GAACCGGAATCCAGGCCCAAGCCACAGGAGCAAAACGATGAGCGCATCTTCCGATCGCAATCATGAGACACGCGCCATCG
TCACCGGTGGCGCGCAAGGC

Product: myo-inositol dehydrogenase (idhA)

Products: NA

Alternate protein names: Myo-inositol 2-dehydrogenase; MI-dehydrogenase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MTVRFALLGAGRIGKVHARAVGSNPDAKLVAVADAFEKAAKELASAYGAEVRTIDAIEKSKDIDAVVICTPTDTHADLIE
RFAKAGKAIFCEKPIDLNVKRVEKCLAVVEKAKATLMVGFNRRFDPHFAAVRKAIDDGAIGTVEMVTITSRDPGAPPIDY
IKRSGGIFRDMTIHDFDMARFLLGEEPVAVSAHASVLVDKKIGEAGDFDSVSVILETASGKQAVISNSRRATYGYDQRIE
VHGSKGMIAAENQRPVSIELANEKGYTRPPLHDFFMTRYLDAYAIEIASFIAAATSGKKAAPSGADGLVALKLADAALKS
ATTGKTVRLDK

Sequences:

>Translated_331_residues
MTVRFALLGAGRIGKVHARAVGSNPDAKLVAVADAFEKAAKELASAYGAEVRTIDAIEKSKDIDAVVICTPTDTHADLIE
RFAKAGKAIFCEKPIDLNVKRVEKCLAVVEKAKATLMVGFNRRFDPHFAAVRKAIDDGAIGTVEMVTITSRDPGAPPIDY
IKRSGGIFRDMTIHDFDMARFLLGEEPVAVSAHASVLVDKKIGEAGDFDSVSVILETASGKQAVISNSRRATYGYDQRIE
VHGSKGMIAAENQRPVSIELANEKGYTRPPLHDFFMTRYLDAYAIEIASFIAAATSGKKAAPSGADGLVALKLADAALKS
ATTGKTVRLDK
>Mature_330_residues
TVRFALLGAGRIGKVHARAVGSNPDAKLVAVADAFEKAAKELASAYGAEVRTIDAIEKSKDIDAVVICTPTDTHADLIER
FAKAGKAIFCEKPIDLNVKRVEKCLAVVEKAKATLMVGFNRRFDPHFAAVRKAIDDGAIGTVEMVTITSRDPGAPPIDYI
KRSGGIFRDMTIHDFDMARFLLGEEPVAVSAHASVLVDKKIGEAGDFDSVSVILETASGKQAVISNSRRATYGYDQRIEV
HGSKGMIAAENQRPVSIELANEKGYTRPPLHDFFMTRYLDAYAIEIASFIAAATSGKKAAPSGADGLVALKLADAALKSA
TTGKTVRLDK

Specific function: Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gfo/idh/mocA family [H]

Homologues:

Organism=Escherichia coli, GI87082405, Length=260, Percent_Identity=27.3076923076923, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787574, Length=225, Percent_Identity=28, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87081947, Length=291, Percent_Identity=25.4295532646048, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789848, Length=261, Percent_Identity=27.9693486590038, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI145693182, Length=238, Percent_Identity=26.0504201680672, Blast_Score=62, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24581117, Length=253, Percent_Identity=26.8774703557312, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000683
- InterPro:   IPR004104 [H]

Pfam domain/function: PF01408 GFO_IDH_MocA; PF02894 GFO_IDH_MocA_C [H]

EC number: =1.1.1.18 [H]

Molecular weight: Translated: 35409; Mature: 35278

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRFALLGAGRIGKVHARAVGSNPDAKLVAVADAFEKAAKELASAYGAEVRTIDAIEKS
CEEEEEEEECCCCCEEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHCCCEEEEHHHHHC
KDIDAVVICTPTDTHADLIERFAKAGKAIFCEKPIDLNVKRVEKCLAVVEKAKATLMVGF
CCCCEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHCCEEEEEEC
NRRFDPHFAAVRKAIDDGAIGTVEMVTITSRDPGAPPIDYIKRSGGIFRDMTIHDFDMAR
CCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCHHHHHHCCCEEEECEECHHHHHH
FLLGEEPVAVSAHASVLVDKKIGEAGDFDSVSVILETASGKQAVISNSRRATYGYDQRIE
HHHCCCCEEEECCCEEEEECCCCCCCCCCCEEEEEEECCCCCHHHCCCCCCCCCCCCEEE
VHGSKGMIAAENQRPVSIELANEKGYTRPPLHDFFMTRYLDAYAIEIASFIAAATSGKKA
EECCCCEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
APSGADGLVALKLADAALKSATTGKTVRLDK
CCCCCCCEEEEEEHHHHHHHCCCCCEEEECC
>Mature Secondary Structure 
TVRFALLGAGRIGKVHARAVGSNPDAKLVAVADAFEKAAKELASAYGAEVRTIDAIEKS
EEEEEEEECCCCCEEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHCCCEEEEHHHHHC
KDIDAVVICTPTDTHADLIERFAKAGKAIFCEKPIDLNVKRVEKCLAVVEKAKATLMVGF
CCCCEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHCCEEEEEEC
NRRFDPHFAAVRKAIDDGAIGTVEMVTITSRDPGAPPIDYIKRSGGIFRDMTIHDFDMAR
CCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCHHHHHHCCCEEEECEECHHHHHH
FLLGEEPVAVSAHASVLVDKKIGEAGDFDSVSVILETASGKQAVISNSRRATYGYDQRIE
HHHCCCCEEEECCCEEEEECCCCCCCCCCCEEEEEEECCCCCHHHCCCCCCCCCCCCEEE
VHGSKGMIAAENQRPVSIELANEKGYTRPPLHDFFMTRYLDAYAIEIASFIAAATSGKKA
EECCCCEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
APSGADGLVALKLADAALKSATTGKTVRLDK
CCCCCCCEEEEEEHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9802033; 11481431 [H]