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The map label for this gene is ydjJ [C]

Identifier: 13474107

GI number: 13474107

Start: 3901016

End: 3902062

Strand: Direct

Name: ydjJ [C]

Synonym: mlr4915

Alternate gene names: 13474107

Gene position: 3901016-3902062 (Clockwise)

Preceding gene: 13474106

Following gene: 13474108

Centisome position: 55.44

GC content: 66.0

Gene sequence:

>1047_bases
ATGCGGGCACTGGTGCTTGAGAAAAAAGGCGAACTGTCGTTGCGCGAGATCGCGCTGCCGCTCGATGTCGGGCCGGATGA
TGTCAAGATCGCCATCCACACGGTCGGCGTCTGCGGCAGCGACGTGCACTATTACACGCATGGCGCCATCGGCAGCTATG
TCGTGCGCGCGCCGATGGTGCTAGGCCACGAAGCCGCGGGGACGGTCGTCGAGACCGGCGCCAATGTCGAGACGTTCAAG
GCCGGTGACCGCGTCTGCATGGAGCCCGGCGTGCCGAACCTGTCGTCGCGGGCGACCAAGCTCGGCATCTACAATGTCGA
CCCCGACGTCAGCTTCTGGGCGACGCCGCCGGTGCATGGCGTGCTGGCGCCCTACGCGGTGCACCCCGCCGCCTTCACCT
ACAAACTGCCGGACAATGTCTCCTTCGCCGAGGGGGCGATGGTCGAGCCCTTCGCCATAGGCATGCAGGCGGCAAGCCGT
GCCCGCATCGTTCCGGGCGATGTCGCCGTCGTCGTCGGCTGCGGCCCGATCGGCATCATGATCGCGCTTGCCGCCCTGGC
CGGCGGTTGTTCGAAAGTGCTGATCTCCGATTTTTCCGCGCCCAAGCTGAAGATCGCCGCGCAATATGCCGGCATCGTGC
CGGTCAATATCGGCGAGCGGTCGCTGGTCGACGCGGTCGCGGCGGCGACCGACAAGTGGGGCGCCGACATCGTCTTCGAG
GCCAGCGGCAGCCCGAAGGCTTTCGCCGATCTGTTCGATGTCGTGCGGCCGGGCGGCGCGGTGGTGCTGGTCGGCCTGCC
GGTGGAGCCGGTGGCCCTCAACGTGCCGGCGGCGATCTCGAAGGAGGTGCGCATCGAGACGGTGTTCCGCTACGCCAACA
TTTTCGACCGCGCCTTGCAACTGATCGCTTCCGGCAAGGTCGACCTCAAGCCGCTGATCACCGGCACCTATGATTTCGCC
GACAGCATCAAGGCATTCGAGCGGGCTGCCCAAGGCAATCCGGAAGACGTCAAGCTGCAGATCCTGCTCACCGGCGAGAA
GGGATGA

Upstream 100 bases:

>100_bases
CGTGCTCCTGTCGCTGCCGCCGCTGCTGTTCCTTGGCGTGCTCAGCGGCTTCCTGAATTCCGTTTTCCGGCAAAAAAAGA
CTTGATGTGAGGATTTCCCG

Downstream 100 bases:

>100_bases
TCATGTCCGCGATCGTTTGCTCCCATGTCGACAAGGCCTATGGCGCCACCACGGTCATCCGCGATCTCAACCTCAGCATT
GAAGAGCACGAATTCGTGGT

Product: xylitol (sorbitol) dehydrogenase

Products: NA

Alternate protein names: Xylitol dehydrogenase; XDH

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MRALVLEKKGELSLREIALPLDVGPDDVKIAIHTVGVCGSDVHYYTHGAIGSYVVRAPMVLGHEAAGTVVETGANVETFK
AGDRVCMEPGVPNLSSRATKLGIYNVDPDVSFWATPPVHGVLAPYAVHPAAFTYKLPDNVSFAEGAMVEPFAIGMQAASR
ARIVPGDVAVVVGCGPIGIMIALAALAGGCSKVLISDFSAPKLKIAAQYAGIVPVNIGERSLVDAVAAATDKWGADIVFE
ASGSPKAFADLFDVVRPGGAVVLVGLPVEPVALNVPAAISKEVRIETVFRYANIFDRALQLIASGKVDLKPLITGTYDFA
DSIKAFERAAQGNPEDVKLQILLTGEKG

Sequences:

>Translated_348_residues
MRALVLEKKGELSLREIALPLDVGPDDVKIAIHTVGVCGSDVHYYTHGAIGSYVVRAPMVLGHEAAGTVVETGANVETFK
AGDRVCMEPGVPNLSSRATKLGIYNVDPDVSFWATPPVHGVLAPYAVHPAAFTYKLPDNVSFAEGAMVEPFAIGMQAASR
ARIVPGDVAVVVGCGPIGIMIALAALAGGCSKVLISDFSAPKLKIAAQYAGIVPVNIGERSLVDAVAAATDKWGADIVFE
ASGSPKAFADLFDVVRPGGAVVLVGLPVEPVALNVPAAISKEVRIETVFRYANIFDRALQLIASGKVDLKPLITGTYDFA
DSIKAFERAAQGNPEDVKLQILLTGEKG
>Mature_348_residues
MRALVLEKKGELSLREIALPLDVGPDDVKIAIHTVGVCGSDVHYYTHGAIGSYVVRAPMVLGHEAAGTVVETGANVETFK
AGDRVCMEPGVPNLSSRATKLGIYNVDPDVSFWATPPVHGVLAPYAVHPAAFTYKLPDNVSFAEGAMVEPFAIGMQAASR
ARIVPGDVAVVVGCGPIGIMIALAALAGGCSKVLISDFSAPKLKIAAQYAGIVPVNIGERSLVDAVAAATDKWGADIVFE
ASGSPKAFADLFDVVRPGGAVVLVGLPVEPVALNVPAAISKEVRIETVFRYANIFDRALQLIASGKVDLKPLITGTYDFA
DSIKAFERAAQGNPEDVKLQILLTGEKG

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI156627571, Length=343, Percent_Identity=38.4839650145773, Blast_Score=249, Evalue=4e-66,
Organism=Escherichia coli, GI1788073, Length=325, Percent_Identity=40, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1790045, Length=344, Percent_Identity=31.1046511627907, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1790718, Length=332, Percent_Identity=27.1084337349398, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1787863, Length=338, Percent_Identity=28.1065088757396, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI226510992, Length=349, Percent_Identity=30.6590257879656, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788407, Length=351, Percent_Identity=24.5014245014245, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788075, Length=354, Percent_Identity=26.271186440678, Blast_Score=98, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17562876, Length=334, Percent_Identity=38.622754491018, Blast_Score=258, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17562878, Length=315, Percent_Identity=43.1746031746032, Blast_Score=244, Evalue=6e-65,
Organism=Saccharomyces cerevisiae, GI6323099, Length=346, Percent_Identity=40.4624277456647, Blast_Score=260, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6319955, Length=347, Percent_Identity=38.6167146974063, Blast_Score=232, Evalue=8e-62,
Organism=Saccharomyces cerevisiae, GI6322619, Length=347, Percent_Identity=38.6167146974063, Blast_Score=231, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6319257, Length=355, Percent_Identity=26.1971830985915, Blast_Score=109, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6319621, Length=273, Percent_Identity=30.4029304029304, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=376, Percent_Identity=25.531914893617, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=292, Percent_Identity=28.7671232876712, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17737897, Length=349, Percent_Identity=38.9684813753582, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI17137530, Length=340, Percent_Identity=37.6470588235294, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI221457811, Length=309, Percent_Identity=30.7443365695793, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI45550770, Length=309, Percent_Identity=30.7443365695793, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI45551930, Length=309, Percent_Identity=30.7443365695793, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XYLD_RHILO (Q98D10)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_105675.1
- ProteinModelPortal:   Q98D10
- SMR:   Q98D10
- GeneID:   1228336
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr4915
- NMPDR:   fig|266835.1.peg.3779
- HOGENOM:   HBG753318
- OMA:   RLEITHR
- ProtClustDB:   CLSK864144
- BRENDA:   1.1.1.9
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: =1.1.1.9

Molecular weight: Translated: 36355; Mature: 36355

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALVLEKKGELSLREIALPLDVGPDDVKIAIHTVGVCGSDVHYYTHGAIGSYVVRAPMV
CCEEEECCCCCCEEEEEEEECCCCCCCEEEEEEEEECCCCCCEEEECCCHHHHHHHCCCE
LGHEAAGTVVETGANVETFKAGDRVCMEPGVPNLSSRATKLGIYNVDPDVSFWATPPVHG
ECCCCCCCEEECCCCEEEEECCCEEEECCCCCCCCCCCEEEEEEECCCCCEEEECCCCCC
VLAPYAVHPAAFTYKLPDNVSFAEGAMVEPFAIGMQAASRARIVPGDVAVVVGCGPIGIM
CCCCCEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCEECCCCEEEEEECCHHHHH
IALAALAGGCSKVLISDFSAPKLKIAAQYAGIVPVNIGERSLVDAVAAATDKWGADIVFE
HHHHHHHCCCCEEHCCCCCCCCEEEEEEECCEEEECCCCHHHHHHHHHHCCCCCCEEEEE
ASGSPKAFADLFDVVRPGGAVVLVGLPVEPVALNVPAAISKEVRIETVFRYANIFDRALQ
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEECCCHHHCCCHHHHHHHHHHHHHHHHHH
LIASGKVDLKPLITGTYDFADSIKAFERAAQGNPEDVKLQILLTGEKG
HHHCCCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCC
>Mature Secondary Structure
MRALVLEKKGELSLREIALPLDVGPDDVKIAIHTVGVCGSDVHYYTHGAIGSYVVRAPMV
CCEEEECCCCCCEEEEEEEECCCCCCCEEEEEEEEECCCCCCEEEECCCHHHHHHHCCCE
LGHEAAGTVVETGANVETFKAGDRVCMEPGVPNLSSRATKLGIYNVDPDVSFWATPPVHG
ECCCCCCCEEECCCCEEEEECCCEEEECCCCCCCCCCCEEEEEEECCCCCEEEECCCCCC
VLAPYAVHPAAFTYKLPDNVSFAEGAMVEPFAIGMQAASRARIVPGDVAVVVGCGPIGIM
CCCCCEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCEECCCCEEEEEECCHHHHH
IALAALAGGCSKVLISDFSAPKLKIAAQYAGIVPVNIGERSLVDAVAAATDKWGADIVFE
HHHHHHHCCCCEEHCCCCCCCCEEEEEEECCEEEECCCCHHHHHHHHHHCCCCCCEEEEE
ASGSPKAFADLFDVVRPGGAVVLVGLPVEPVALNVPAAISKEVRIETVFRYANIFDRALQ
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEECCCHHHCCCHHHHHHHHHHHHHHHHHH
LIASGKVDLKPLITGTYDFADSIKAFERAAQGNPEDVKLQILLTGEKG
HHHCCCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968