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The map label for this gene is 13474011

Identifier: 13474011

GI number: 13474011

Start: 3807770

End: 3809512

Strand: Direct

Name: 13474011

Synonym: mlr4788

Alternate gene names: NA

Gene position: 3807770-3809512 (Clockwise)

Preceding gene: 13474010

Following gene: 13474012

Centisome position: 54.12

GC content: 65.75

Gene sequence:

>1743_bases
ATGGCAAAGCTCGACGCCATCACGCTTTCGGTCCTCCAGGCGGCCTTGCAGCAGGTCTGCGATGAGATGGACCTGACCTT
CTCCCGCGCCGCCTTCTCGCCGGTCATCGCCGAAGCCAACGACCGCTCCGACGGCATCTATTCAGCTGTCGACGGCTCGC
TGATCGCACAGGGAAGCCAAGGCCTGCCGGTGTTCGTCGGCGTCATGCAATATTCGACGAAAACGGTGATCGAGATGATC
GCCGACGGCCGTTGCCTGGCCCCTGAGCCGGGCGACATATACATCGTCAACGACCCCTATCTTGGCGGCACGCATCTGAT
GGATGTGCGCTTCGCCATGCCGGTCTACCGGGCGGGAAAGATCTTCTGCTGGCTGTCCAACACCGGCCACTGGCCCGATA
TTGGCGGCTCGGTGCCGGGTGGTTTCTCGGCCTCCGCCACCGCGGTCGAGCAGGAAGGCCTGCGGCTGCCGCCGGTGAAA
CTCTTCAAGAAGGGCGTGCTCGATCCCGAGATCTACGCCATCATCTGCTCCAACATCCGCGTCGCCGACCAGCGCATCGG
CGATATCAGGGCCCAGGCCGCCGCACTGCTGATCGGCCAGGATCGGCTCAATGGAATCCTGGATCGTTACGGTGACGAAA
CTGTTGTCGAAGCAATCGCCGAACTGCGCCGCCGCGCCGCCGAGCAGATGCGCGCCAACATAGCGGCTATTCCCGACGGC
ACCTATCATTCGAAGGCCTTTGTCGATTCCGATGGGGTGGTCAACGAGCCGCTGACCATCGCGCTAGCGGTGGAGAAACA
AGGCGACACGCTGACCTTCGATTTCGCCGGCTCATCCAAGCCTTGCGCCGGGCCGATGAACAGCGTGCTGGCGACGACCC
TGTCCTCGGTCTATCTCGCCATGCGTCATATCTTTCCGGATGTGCCGATCAGCGCCGGCGCCTTCGAGCCGTTGATCGTC
AGGCGGCCGGAAGGCACCTTCCTCGACGCCAAATACCCGCGTCCCGTGTCGGGCTGCGCGGCGGAAGTCTCGCAGCGCAT
CGCCGAGGCGGTGTTCGCGGCCATGGTGCAGGCATTGCCGGACAAGGTGACGGCGGCGCCCGCCGGCTCCAGCGGCAATT
TCGCGCTCGGCGGCAACGACCCGGCGCGCGGCCGCGATTACGTCATGTACCAGATCTCCGGTGGCGGCTATGGCGGCAAT
TCAGGCCATGACGGGCTGACCAATGGTTGCTCGACCATCGGCATTTCCAAGTCGCCGCCGGTCGAGATCATGGAGCAGGC
CTTTCCGGTGCTCTATCGCCACTATGCGTTGCGCGAAGGCTCGGGCGGCGCCGGCAAGCATCGCGGCGGTTTCGGCCTCG
CCTATGAGGTCGAGATCCTGCGCGGCGATGCGCGGGCCTCCTTCGTCATGGATCACGGCCGTTTCGGCCCGCAAGGCGCG
CTCGGCGGCAAGGATGGCGAACCCAACAGCGTGACCGTCTTCCGCGGCGGGGTGGCGCATGTGCCGCCGCATCTGTCCAA
GGAACAGGACATCCCGCTGAAGGCCGGCGACCGCGTGCGCGTTGGCACGCCGGGCGGCGGCGGCTATGGCGACCCGCGCG
AGCGCGACGCCGATCAGGTGCAGCGCGACGTGGCGCTGGGATACTACACCGCAGAGGAAGCCAGCGAGAAGTTTGGCGTG
GTCCTGTCGGCGGACGGTCTCACCGTTGACCGGAAGGCGACGGACGGGCAGCGCGCCGGCTAA

Upstream 100 bases:

>100_bases
GACGCCACCACCGTGCTCGAACCCGGCGACCGCGCCCGGTCGGATGCCGACGGCAACATCATCATCGACATTGGCGAGGC
CTGATATGCCTGACATTGAT

Downstream 100 bases:

>100_bases
ACACCGCCCCTTGCCACAATGTGGATCGCTCACGGCGCCGTGATCGCCGCAGCACATGTCGCTTCCGTCTCCGCCGAAAG
CACCAAAGCCCGTAGACTTC

Product: N-methylhydantoinase B

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: NA

Number of amino acids: Translated: 580; Mature: 579

Protein sequence:

>580_residues
MAKLDAITLSVLQAALQQVCDEMDLTFSRAAFSPVIAEANDRSDGIYSAVDGSLIAQGSQGLPVFVGVMQYSTKTVIEMI
ADGRCLAPEPGDIYIVNDPYLGGTHLMDVRFAMPVYRAGKIFCWLSNTGHWPDIGGSVPGGFSASATAVEQEGLRLPPVK
LFKKGVLDPEIYAIICSNIRVADQRIGDIRAQAAALLIGQDRLNGILDRYGDETVVEAIAELRRRAAEQMRANIAAIPDG
TYHSKAFVDSDGVVNEPLTIALAVEKQGDTLTFDFAGSSKPCAGPMNSVLATTLSSVYLAMRHIFPDVPISAGAFEPLIV
RRPEGTFLDAKYPRPVSGCAAEVSQRIAEAVFAAMVQALPDKVTAAPAGSSGNFALGGNDPARGRDYVMYQISGGGYGGN
SGHDGLTNGCSTIGISKSPPVEIMEQAFPVLYRHYALREGSGGAGKHRGGFGLAYEVEILRGDARASFVMDHGRFGPQGA
LGGKDGEPNSVTVFRGGVAHVPPHLSKEQDIPLKAGDRVRVGTPGGGGYGDPRERDADQVQRDVALGYYTAEEASEKFGV
VLSADGLTVDRKATDGQRAG

Sequences:

>Translated_580_residues
MAKLDAITLSVLQAALQQVCDEMDLTFSRAAFSPVIAEANDRSDGIYSAVDGSLIAQGSQGLPVFVGVMQYSTKTVIEMI
ADGRCLAPEPGDIYIVNDPYLGGTHLMDVRFAMPVYRAGKIFCWLSNTGHWPDIGGSVPGGFSASATAVEQEGLRLPPVK
LFKKGVLDPEIYAIICSNIRVADQRIGDIRAQAAALLIGQDRLNGILDRYGDETVVEAIAELRRRAAEQMRANIAAIPDG
TYHSKAFVDSDGVVNEPLTIALAVEKQGDTLTFDFAGSSKPCAGPMNSVLATTLSSVYLAMRHIFPDVPISAGAFEPLIV
RRPEGTFLDAKYPRPVSGCAAEVSQRIAEAVFAAMVQALPDKVTAAPAGSSGNFALGGNDPARGRDYVMYQISGGGYGGN
SGHDGLTNGCSTIGISKSPPVEIMEQAFPVLYRHYALREGSGGAGKHRGGFGLAYEVEILRGDARASFVMDHGRFGPQGA
LGGKDGEPNSVTVFRGGVAHVPPHLSKEQDIPLKAGDRVRVGTPGGGGYGDPRERDADQVQRDVALGYYTAEEASEKFGV
VLSADGLTVDRKATDGQRAG
>Mature_579_residues
AKLDAITLSVLQAALQQVCDEMDLTFSRAAFSPVIAEANDRSDGIYSAVDGSLIAQGSQGLPVFVGVMQYSTKTVIEMIA
DGRCLAPEPGDIYIVNDPYLGGTHLMDVRFAMPVYRAGKIFCWLSNTGHWPDIGGSVPGGFSASATAVEQEGLRLPPVKL
FKKGVLDPEIYAIICSNIRVADQRIGDIRAQAAALLIGQDRLNGILDRYGDETVVEAIAELRRRAAEQMRANIAAIPDGT
YHSKAFVDSDGVVNEPLTIALAVEKQGDTLTFDFAGSSKPCAGPMNSVLATTLSSVYLAMRHIFPDVPISAGAFEPLIVR
RPEGTFLDAKYPRPVSGCAAEVSQRIAEAVFAAMVQALPDKVTAAPAGSSGNFALGGNDPARGRDYVMYQISGGGYGGNS
GHDGLTNGCSTIGISKSPPVEIMEQAFPVLYRHYALREGSGGAGKHRGGFGLAYEVEILRGDARASFVMDHGRFGPQGAL
GGKDGEPNSVTVFRGGVAHVPPHLSKEQDIPLKAGDRVRVGTPGGGGYGDPRERDADQVQRDVALGYYTAEEASEKFGVV
LSADGLTVDRKATDGQRAG

Specific function: Unknown

COG id: COG0146

COG function: function code EQ; N-methylhydantoinase B/acetone carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=564, Percent_Identity=27.4822695035461, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI133901900, Length=554, Percent_Identity=29.2418772563177, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI133901902, Length=533, Percent_Identity=29.4559099437148, Blast_Score=179, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6322634, Length=556, Percent_Identity=25.3597122302158, Blast_Score=178, Evalue=3e-45,
Organism=Drosophila melanogaster, GI45550492, Length=591, Percent_Identity=25.7191201353638, Blast_Score=146, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003692 [H]

Pfam domain/function: PF02538 Hydantoinase_B [H]

EC number: 3.5.2.14

Molecular weight: Translated: 61270; Mature: 61139

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLDAITLSVLQAALQQVCDEMDLTFSRAAFSPVIAEANDRSDGIYSAVDGSLIAQGSQ
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHCCCCCCCCCCEECCCCCEEECCCC
GLPVFVGVMQYSTKTVIEMIADGRCLAPEPGDIYIVNDPYLGGTHLMDVRFAMPVYRAGK
CCEEEEHHHHHHHHHHHHHHHCCCEECCCCCCEEEECCCCCCCCEEEEEHHHCCCCCCCE
IFCWLSNTGHWPDIGGSVPGGFSASATAVEQEGLRLPPVKLFKKGVLDPEIYAIICSNIR
EEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEECCCE
VADQRIGDIRAQAAALLIGQDRLNGILDRYGDETVVEAIAELRRRAAEQMRANIAAIPDG
EHHHHHHHHHHHHHHEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEECCCC
TYHSKAFVDSDGVVNEPLTIALAVEKQGDTLTFDFAGSSKPCAGPMNSVLATTLSSVYLA
CCCCCEEECCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
MRHIFPDVPISAGAFEPLIVRRPEGTFLDAKYPRPVSGCAAEVSQRIAEAVFAAMVQALP
HHHHCCCCCCCCCCCCCEEEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DKVTAAPAGSSGNFALGGNDPARGRDYVMYQISGGGYGGNSGHDGLTNGCSTIGISKSPP
CHHEECCCCCCCCEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
VEIMEQAFPVLYRHYALREGSGGAGKHRGGFGLAYEVEILRGDARASFVMDHGRFGPQGA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCC
LGGKDGEPNSVTVFRGGVAHVPPHLSKEQDIPLKAGDRVRVGTPGGGGYGDPRERDADQV
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHH
QRDVALGYYTAEEASEKFGVVLSADGLTVDRKATDGQRAG
HHHHHHEEEEHHHHHCCCCEEEECCCEEEECCCCCCCCCC
>Mature Secondary Structure 
AKLDAITLSVLQAALQQVCDEMDLTFSRAAFSPVIAEANDRSDGIYSAVDGSLIAQGSQ
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHCCCCCCCCCCEECCCCCEEECCCC
GLPVFVGVMQYSTKTVIEMIADGRCLAPEPGDIYIVNDPYLGGTHLMDVRFAMPVYRAGK
CCEEEEHHHHHHHHHHHHHHHCCCEECCCCCCEEEECCCCCCCCEEEEEHHHCCCCCCCE
IFCWLSNTGHWPDIGGSVPGGFSASATAVEQEGLRLPPVKLFKKGVLDPEIYAIICSNIR
EEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEECCCE
VADQRIGDIRAQAAALLIGQDRLNGILDRYGDETVVEAIAELRRRAAEQMRANIAAIPDG
EHHHHHHHHHHHHHHEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEECCCC
TYHSKAFVDSDGVVNEPLTIALAVEKQGDTLTFDFAGSSKPCAGPMNSVLATTLSSVYLA
CCCCCEEECCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
MRHIFPDVPISAGAFEPLIVRRPEGTFLDAKYPRPVSGCAAEVSQRIAEAVFAAMVQALP
HHHHCCCCCCCCCCCCCEEEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DKVTAAPAGSSGNFALGGNDPARGRDYVMYQISGGGYGGNSGHDGLTNGCSTIGISKSPP
CHHEECCCCCCCCEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
VEIMEQAFPVLYRHYALREGSGGAGKHRGGFGLAYEVEILRGDARASFVMDHGRFGPQGA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCC
LGGKDGEPNSVTVFRGGVAHVPPHLSKEQDIPLKAGDRVRVGTPGGGGYGDPRERDADQV
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHH
QRDVALGYYTAEEASEKFGVVLSADGLTVDRKATDGQRAG
HHHHHHEEEEHHHHHCCCCEEEECCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]