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The map label for this gene is lhgO [H]

Identifier: 13473993

GI number: 13473993

Start: 3786943

End: 3788055

Strand: Reverse

Name: lhgO [H]

Synonym: mll4765

Alternate gene names: 13473993

Gene position: 3788055-3786943 (Counterclockwise)

Preceding gene: 13473994

Following gene: 13473992

Centisome position: 53.84

GC content: 66.13

Gene sequence:

>1113_bases
ATGCAGACAATCGATTGTGTCGTCGCCGGAGCGGGCGTCGTCGGGATTGCCGTCGCCAGGGCGCTTGCCGTGTCGGGCCG
CGAGGTGGTGGTGGTCGAGCAGGCGGACGCGATCGGCACCGTCACCAGTTCACGCAATTCCGAAGTCATCCATGCCGGGC
TCTACTACGCGCCGGGAAGCCTGAAGGCCCGGCTCTGCGTCGAAGGCCGCCAGCGTCTCTACGCCTATTGCGCCGAGCAC
GACATCGCCCATAAGCGTACCGGAAAGCTGATCGTGGCCAGCGAGCCTGGCCAGACCGACGGGTTGCGGAAGATCGAGGC
CAATGCGCGACGCAGCGGGGTCGACGATCTCCAGTTCCTGACACGTGACGAAGCCGAAAACCTGGAGCCGGCACTGACGT
GCGCGGGCGCGCTGCTGTCGCCATCGACCGGCATTGTCGACAGCCATGCGCTGATGCTGTCACTGCGCGGCGAGGCCGAA
GCGGCCGGTGCGTCCTTTGCTTTCCTGACCGCTGTTGCCGGGGCGACGATCGAGGCCGACGGGATCCGGATCGACACGCG
CGATGCCACTGGCGAGACCTTCGCCCTGGAGGCCGGCGCCTTTATCAATGCCGCAGGCCTTGAGGCGCAGGCCCTGGCCG
GCCGGATCGAGGGTTTCCCAAGGAATTTCATCCCCCGGCAATGGCTGGCGCGCGGAAATTATTTTGCGCTTCCGGGCCGG
TCGCCCTTTTCGCGGCTGATTTATCCAGTTCCGGTCGAAGGCGGCCTCGGCGTCCATCTGACGCTCGACCTCGGCGGCCG
TGCGCGCTTCGGGCCCGATGTCGAATGGATCGACCATGTGGATTACACGGTCGACCCCGGCCGGAGCGTCGTCTTCTACG
AAGCGATCCGGCGCTATTGGCCCGATCTTGCGGACGGGGCGCTGCAGCCGGCCTATGCCGGCATCAGGCCGAAGCTGTCA
GGTCCTGGCCAGCCTGCCGCCGATTTCATCATTCAGGGTCCGGCCGACCATGGCGCTGGGCGGATCGTCAACCTGTTCGG
CATTGAGAGCCCCGGCCTGACGGCAAGCCTGGCCATCGCCGACCATGTCGTCGAGTTGCTGTACCCGCGATAA

Upstream 100 bases:

>100_bases
GCCGACATCGTTGCGCTGTCGGACGGTCTCGACATAAGAAGCGTGTGGATCGGCGGCGACAAGGTGTTCGAGGCCGGCGC
TTCACGCTAAGAGCGGGGCC

Downstream 100 bases:

>100_bases
CGGGCGTGGTCAGGAATTTGCCGTCTCAAGCGGCCGTCATGAAACCTTTTGATTTCGAGCTCGTTGTCGGGGCGTATGTC
CGAGGCGAAACCCAGATCGA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MQTIDCVVAGAGVVGIAVARALAVSGREVVVVEQADAIGTVTSSRNSEVIHAGLYYAPGSLKARLCVEGRQRLYAYCAEH
DIAHKRTGKLIVASEPGQTDGLRKIEANARRSGVDDLQFLTRDEAENLEPALTCAGALLSPSTGIVDSHALMLSLRGEAE
AAGASFAFLTAVAGATIEADGIRIDTRDATGETFALEAGAFINAAGLEAQALAGRIEGFPRNFIPRQWLARGNYFALPGR
SPFSRLIYPVPVEGGLGVHLTLDLGGRARFGPDVEWIDHVDYTVDPGRSVVFYEAIRRYWPDLADGALQPAYAGIRPKLS
GPGQPAADFIIQGPADHGAGRIVNLFGIESPGLTASLAIADHVVELLYPR

Sequences:

>Translated_370_residues
MQTIDCVVAGAGVVGIAVARALAVSGREVVVVEQADAIGTVTSSRNSEVIHAGLYYAPGSLKARLCVEGRQRLYAYCAEH
DIAHKRTGKLIVASEPGQTDGLRKIEANARRSGVDDLQFLTRDEAENLEPALTCAGALLSPSTGIVDSHALMLSLRGEAE
AAGASFAFLTAVAGATIEADGIRIDTRDATGETFALEAGAFINAAGLEAQALAGRIEGFPRNFIPRQWLARGNYFALPGR
SPFSRLIYPVPVEGGLGVHLTLDLGGRARFGPDVEWIDHVDYTVDPGRSVVFYEAIRRYWPDLADGALQPAYAGIRPKLS
GPGQPAADFIIQGPADHGAGRIVNLFGIESPGLTASLAIADHVVELLYPR
>Mature_370_residues
MQTIDCVVAGAGVVGIAVARALAVSGREVVVVEQADAIGTVTSSRNSEVIHAGLYYAPGSLKARLCVEGRQRLYAYCAEH
DIAHKRTGKLIVASEPGQTDGLRKIEANARRSGVDDLQFLTRDEAENLEPALTCAGALLSPSTGIVDSHALMLSLRGEAE
AAGASFAFLTAVAGATIEADGIRIDTRDATGETFALEAGAFINAAGLEAQALAGRIEGFPRNFIPRQWLARGNYFALPGR
SPFSRLIYPVPVEGGLGVHLTLDLGGRARFGPDVEWIDHVDYTVDPGRSVVFYEAIRRYWPDLADGALQPAYAGIRPKLS
GPGQPAADFIIQGPADHGAGRIVNLFGIESPGLTASLAIADHVVELLYPR

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=405, Percent_Identity=26.9135802469136, Blast_Score=111, Evalue=9e-25,
Organism=Escherichia coli, GI87082148, Length=376, Percent_Identity=27.9255319148936, Blast_Score=118, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17565764, Length=408, Percent_Identity=28.4313725490196, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24585081, Length=380, Percent_Identity=29.7368421052632, Blast_Score=125, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 39124; Mature: 39124

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIDCVVAGAGVVGIAVARALAVSGREVVVVEQADAIGTVTSSRNSEVIHAGLYYAPGS
CCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCEEEEEEEECCCC
LKARLCVEGRQRLYAYCAEHDIAHKRTGKLIVASEPGQTDGLRKIEANARRSGVDDLQFL
CEEEEEHHHHHHHHHHHHHCCCCHHCCCCEEEECCCCCCCCCCHHHCCHHHCCCHHHHHH
TRDEAENLEPALTCAGALLSPSTGIVDSHALMLSLRGEAEAAGASFAFLTAVAGATIEAD
HHCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCEEECC
GIRIDTRDATGETFALEAGAFINAAGLEAQALAGRIEGFPRNFIPRQWLARGNYFALPGR
CEEEECCCCCCCEEEEECCCEEEECCCCHHHHHHHHCCCCCCCCCHHHHHCCCEEECCCC
SPFSRLIYPVPVEGGLGVHLTLDLGGRARFGPDVEWIDHVDYTVDPGRSVVFYEAIRRYW
CCHHHCEEEEECCCCCEEEEEEEECCCCCCCCCCHHHHCCCEEECCCCEEHHHHHHHHHC
PDLADGALQPAYAGIRPKLSGPGQPAADFIIQGPADHGAGRIVNLFGIESPGLTASLAIA
CCHHCCCCCCHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCEEEHHHH
DHVVELLYPR
HHHHHHHCCC
>Mature Secondary Structure
MQTIDCVVAGAGVVGIAVARALAVSGREVVVVEQADAIGTVTSSRNSEVIHAGLYYAPGS
CCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCEEEEEEEECCCC
LKARLCVEGRQRLYAYCAEHDIAHKRTGKLIVASEPGQTDGLRKIEANARRSGVDDLQFL
CEEEEEHHHHHHHHHHHHHCCCCHHCCCCEEEECCCCCCCCCCHHHCCHHHCCCHHHHHH
TRDEAENLEPALTCAGALLSPSTGIVDSHALMLSLRGEAEAAGASFAFLTAVAGATIEAD
HHCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCEEECC
GIRIDTRDATGETFALEAGAFINAAGLEAQALAGRIEGFPRNFIPRQWLARGNYFALPGR
CEEEECCCCCCCEEEEECCCEEEECCCCHHHHHHHHCCCCCCCCCHHHHHCCCEEECCCC
SPFSRLIYPVPVEGGLGVHLTLDLGGRARFGPDVEWIDHVDYTVDPGRSVVFYEAIRRYW
CCHHHCEEEEECCCCCEEEEEEEECCCCCCCCCCHHHHCCCEEECCCCEEHHHHHHHHHC
PDLADGALQPAYAGIRPKLSGPGQPAADFIIQGPADHGAGRIVNLFGIESPGLTASLAIA
CCHHCCCCCCHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCEEEHHHH
DHVVELLYPR
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]