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The map label for this gene is degU [H]

Identifier: 13473840

GI number: 13473840

Start: 3630763

End: 3631425

Strand: Reverse

Name: degU [H]

Synonym: mll4567

Alternate gene names: 13473840

Gene position: 3631425-3630763 (Counterclockwise)

Preceding gene: 13473841

Following gene: 13473838

Centisome position: 51.61

GC content: 62.29

Gene sequence:

>663_bases
ATGATTGGCACTATCCGCATCGCTATTGTCGACGATCATCCGCTGTTTCGCGAAGGCGTGACGCGCAGCCTGTCGGAGAT
CGGAGGTTTCGAGATCGTCGGCGAAGGCGCGACAGCGCAAGATGCCGAACGCATCGCCTCGACGATGCAGCCTGACATAT
TGCTGCTCGATATCTCCATGCCGGGCGGCGGCCTGTCCGCGGTTGCAAGCATCCTTGCCGTCCATCCCGCCCAGAGGATC
GTCATGCTGACCGTGTCGGAGACCAATGCCGACGTAACCACGGCGCTGAACGCAGGCGTGCAGGGCTATATCCTCAAGGG
TGTCGGATCGCGCGCGCTTGCCGAAATCCTGCGCAATGTGGCGGCCGGCGAGAGCTATCTTTCGCCGACGCTGTCGGCGC
GGCTGCTTTCCGATCTCCAGTCCCCGCAATCTGCCAACGGCGCGGCGGACCGGTTGCGGCAACTGACCGAACGGCAAACT
GAAATCCTGCGGCTGGTGGCGGAGGGGCTCTCAAACAAGGAGGTCGCCTTGCGCCTGGAGCTGCAGGAGAAAACGGTCAA
GCACCACATGACCGGGGTGCTGTCGAAACTCAATGTGCGAAACCGCACCGAAGCGGCTCTCATGATGCGCGAATTCCGCG
AGCGGGACAGAAACCGCCCTTAG

Upstream 100 bases:

>100_bases
GCCTCAGGGAGCGGGTCGAAAGCATTGGCGGCCAGTTCGAGACCGTGACCGGAGCGCAAGGCACGCGATTGGTGATCAGT
CTTTCGGTCGAGGAGCAAGC

Downstream 100 bases:

>100_bases
AGCAATTCCAGGAAAAGTGTGGAACGGCCTTCCCGGGAAAAACGCGTAGCGTTTTCCCTTGGGAATTGCGTCAAAACTAA
ACCAGTTTCACAAGGCTTTT

Product: two-component system response regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MIGTIRIAIVDDHPLFREGVTRSLSEIGGFEIVGEGATAQDAERIASTMQPDILLLDISMPGGGLSAVASILAVHPAQRI
VMLTVSETNADVTTALNAGVQGYILKGVGSRALAEILRNVAAGESYLSPTLSARLLSDLQSPQSANGAADRLRQLTERQT
EILRLVAEGLSNKEVALRLELQEKTVKHHMTGVLSKLNVRNRTEAALMMREFRERDRNRP

Sequences:

>Translated_220_residues
MIGTIRIAIVDDHPLFREGVTRSLSEIGGFEIVGEGATAQDAERIASTMQPDILLLDISMPGGGLSAVASILAVHPAQRI
VMLTVSETNADVTTALNAGVQGYILKGVGSRALAEILRNVAAGESYLSPTLSARLLSDLQSPQSANGAADRLRQLTERQT
EILRLVAEGLSNKEVALRLELQEKTVKHHMTGVLSKLNVRNRTEAALMMREFRERDRNRP
>Mature_220_residues
MIGTIRIAIVDDHPLFREGVTRSLSEIGGFEIVGEGATAQDAERIASTMQPDILLLDISMPGGGLSAVASILAVHPAQRI
VMLTVSETNADVTTALNAGVQGYILKGVGSRALAEILRNVAAGESYLSPTLSARLLSDLQSPQSANGAADRLRQLTERQT
EILRLVAEGLSNKEVALRLELQEKTVKHHMTGVLSKLNVRNRTEAALMMREFRERDRNRP

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=210, Percent_Identity=35.7142857142857, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788222, Length=202, Percent_Identity=32.1782178217822, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1787473, Length=210, Percent_Identity=37.6190476190476, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1790102, Length=202, Percent_Identity=29.7029702970297, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788546, Length=204, Percent_Identity=27.9411764705882, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788712, Length=210, Percent_Identity=21.9047619047619, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786747, Length=199, Percent_Identity=23.1155778894472, Blast_Score=64, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23818; Mature: 23818

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGTIRIAIVDDHPLFREGVTRSLSEIGGFEIVGEGATAQDAERIASTMQPDILLLDISM
CCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEECC
PGGGLSAVASILAVHPAQRIVMLTVSETNADVTTALNAGVQGYILKGVGSRALAEILRNV
CCCCHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHCCCCEEEECCCCHHHHHHHHHHH
AAGESYLSPTLSARLLSDLQSPQSANGAADRLRQLTERQTEILRLVAEGLSNKEVALRLE
HCCCHHHCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
LQEKTVKHHMTGVLSKLNVRNRTEAALMMREFRERDRNRP
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIGTIRIAIVDDHPLFREGVTRSLSEIGGFEIVGEGATAQDAERIASTMQPDILLLDISM
CCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEECC
PGGGLSAVASILAVHPAQRIVMLTVSETNADVTTALNAGVQGYILKGVGSRALAEILRNV
CCCCHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHCCCCEEEECCCCHHHHHHHHHHH
AAGESYLSPTLSARLLSDLQSPQSANGAADRLRQLTERQTEILRLVAEGLSNKEVALRLE
HCCCHHHCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
LQEKTVKHHMTGVLSKLNVRNRTEAALMMREFRERDRNRP
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]