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The map label for this gene is phbA [H]

Identifier: 13473296

GI number: 13473296

Start: 3084984

End: 3086162

Strand: Direct

Name: phbA [H]

Synonym: mlr3847

Alternate gene names: 13473296

Gene position: 3084984-3086162 (Clockwise)

Preceding gene: 13473294

Following gene: 13473297

Centisome position: 43.85

GC content: 67.43

Gene sequence:

>1179_bases
ATGTCCGATTCCATCGTCATTGCCAGCGCCGCGCGCACGGCCGTCGGCTCCTTCAACGGCGCGTTTGCCGCCACGCCCGC
GCATGAGCTCGGTGCCGTCGTCATCAAGGAACTTCTATCGCGCGCGGGTGTCGAGGCAGCCGAGGTCGACGAGGTCATCC
TCGGCCAGGTGCTGACGGCGGCCCAGGGCCAGAACCCAGCCCGCCAGGCTTCTATCATTGCCGGCCTGCCCAAGGAGACC
ACCGCCTGGGGCCTCAACCAGGTTTGCGGCTCGGGCCTGCGCGCCATCGCGCTCGGCATGCAGCAGATCGCCACCGGCGA
CGCCAAGGTTATCATCGCCGGCGGCCAGGAATCGATGTCGCTGTCGCCGCACGCCGAGCATCTGCGCGCCGGCGTCAAGA
TGGGCGACTACAAGATGATCGACACCATGATCAAGGACGGCCTGTGGGACGCCTTCAACGGCTACCACATGGGCAACACC
GCCGAAAACGTCGCCCGCCAGTTCCAGATCACCCGCGACGATCAGGACCAGTTCGCGCTGGCCTCGCAGAACAAGGCCGA
GGCCGCGCAGAAGGCCGGCAAGTTCAAGGACGAGATCGTCGCCTTCACCATCAAGGGCAAGAAGGGCGACACCATCGTCG
ACCAGGATGAATACATCCGTCATGGCGCCACGCTCGACGCCATGACCAAGCTGAAGCCTGCCTTCGACAAGGACGGCACG
GTGACCGCCGCCAACGCCTCCGGCATCAATGACGGTGCGGCCGGCGCGCTGCTGATGAGCGAAGCGGAGGCCGCAAGGCG
CGGCATCACACCGCTGGCGCGCATCGCGTCCTGGGCAACCGCCGGCGTCGATCCGGCGATCATGGGCACCGGCCCGATCC
CCGCCTCGCGCAAGGCTTTGGAGAAGGCCGGCTGGTCGGCCGGCGATCTCGACCTGGTCGAGGCCAACGAGGCATTCGCC
GCGCAGGCCTGCGCCGTCAACAAGGGCATGGGCTGGGATCCCTCGATCGTCAATGTCAATGGCGGCGCCATCGCCATCGG
CCATCCGATCGGCGCCTCGGGCGCCCGCGTCTTCAACACGCTGGTCTACGAGATGCGCCGCCGCGGCGCCAAGAAGGGCC
TCGCCACGCTGTGCATTGGCGGCGGCATGGGCGTCGCCATGTGCGTGGAAGCCCTCTGA

Upstream 100 bases:

>100_bases
CGCATGGGCGCCATGCCGATTTCCGGTTTGACTTGGGGTTGGGAAAGGGCAAGAAAAGTCCTCAACGACAGAACAACATC
CTTGAAGTCTGGAGAAGAAA

Downstream 100 bases:

>100_bases
GAAAACGATGACCGGGCGGCGCGAGCCGCCCGTTCCATATCCAGTGACTGCCAAGCCCGAAAACAGGGCGATATCAAAAA
GGGGAAATGCATGACCAAGG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSDSIVIASAARTAVGSFNGAFAATPAHELGAVVIKELLSRAGVEAAEVDEVILGQVLTAAQGQNPARQASIIAGLPKET
TAWGLNQVCGSGLRAIALGMQQIATGDAKVIIAGGQESMSLSPHAEHLRAGVKMGDYKMIDTMIKDGLWDAFNGYHMGNT
AENVARQFQITRDDQDQFALASQNKAEAAQKAGKFKDEIVAFTIKGKKGDTIVDQDEYIRHGATLDAMTKLKPAFDKDGT
VTAANASGINDGAAGALLMSEAEAARRGITPLARIASWATAGVDPAIMGTGPIPASRKALEKAGWSAGDLDLVEANEAFA
AQACAVNKGMGWDPSIVNVNGGAIAIGHPIGASGARVFNTLVYEMRRRGAKKGLATLCIGGGMGVAMCVEAL

Sequences:

>Translated_392_residues
MSDSIVIASAARTAVGSFNGAFAATPAHELGAVVIKELLSRAGVEAAEVDEVILGQVLTAAQGQNPARQASIIAGLPKET
TAWGLNQVCGSGLRAIALGMQQIATGDAKVIIAGGQESMSLSPHAEHLRAGVKMGDYKMIDTMIKDGLWDAFNGYHMGNT
AENVARQFQITRDDQDQFALASQNKAEAAQKAGKFKDEIVAFTIKGKKGDTIVDQDEYIRHGATLDAMTKLKPAFDKDGT
VTAANASGINDGAAGALLMSEAEAARRGITPLARIASWATAGVDPAIMGTGPIPASRKALEKAGWSAGDLDLVEANEAFA
AQACAVNKGMGWDPSIVNVNGGAIAIGHPIGASGARVFNTLVYEMRRRGAKKGLATLCIGGGMGVAMCVEAL
>Mature_391_residues
SDSIVIASAARTAVGSFNGAFAATPAHELGAVVIKELLSRAGVEAAEVDEVILGQVLTAAQGQNPARQASIIAGLPKETT
AWGLNQVCGSGLRAIALGMQQIATGDAKVIIAGGQESMSLSPHAEHLRAGVKMGDYKMIDTMIKDGLWDAFNGYHMGNTA
ENVARQFQITRDDQDQFALASQNKAEAAQKAGKFKDEIVAFTIKGKKGDTIVDQDEYIRHGATLDAMTKLKPAFDKDGTV
TAANASGINDGAAGALLMSEAEAARRGITPLARIASWATAGVDPAIMGTGPIPASRKALEKAGWSAGDLDLVEANEAFAA
QACAVNKGMGWDPSIVNVNGGAIAIGHPIGASGARVFNTLVYEMRRRGAKKGLATLCIGGGMGVAMCVEAL

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=55.4987212276215, Blast_Score=457, Evalue=1e-129,
Organism=Homo sapiens, GI167614485, Length=393, Percent_Identity=43.0025445292621, Blast_Score=319, Evalue=2e-87,
Organism=Homo sapiens, GI4557237, Length=390, Percent_Identity=41.2820512820513, Blast_Score=297, Evalue=1e-80,
Organism=Homo sapiens, GI4501853, Length=393, Percent_Identity=38.9312977099237, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=33.2547169811321, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI194353979, Length=388, Percent_Identity=29.1237113402062, Blast_Score=132, Evalue=4e-31,
Organism=Escherichia coli, GI87082165, Length=387, Percent_Identity=54.5219638242894, Blast_Score=428, Evalue=1e-121,
Organism=Escherichia coli, GI1788554, Length=389, Percent_Identity=54.2416452442159, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI1787663, Length=394, Percent_Identity=43.6548223350254, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=41.25, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1788683, Length=425, Percent_Identity=34.3529411764706, Blast_Score=205, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=42.3076923076923, Blast_Score=314, Evalue=6e-86,
Organism=Caenorhabditis elegans, GI25147385, Length=386, Percent_Identity=42.4870466321244, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=38.7341772151899, Blast_Score=255, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI17551802, Length=424, Percent_Identity=32.5471698113208, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17535917, Length=394, Percent_Identity=32.741116751269, Blast_Score=174, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6325229, Length=399, Percent_Identity=43.609022556391, Blast_Score=289, Evalue=6e-79,
Organism=Saccharomyces cerevisiae, GI6322031, Length=397, Percent_Identity=36.272040302267, Blast_Score=209, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=56.8877551020408, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24640423, Length=392, Percent_Identity=42.0918367346939, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI17648125, Length=396, Percent_Identity=40.6565656565657, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=32.4705882352941, Blast_Score=188, Evalue=5e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40491; Mature: 40359

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSIVIASAARTAVGSFNGAFAATPAHELGAVVIKELLSRAGVEAAEVDEVILGQVLTA
CCCCEEEEHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AQGQNPARQASIIAGLPKETTAWGLNQVCGSGLRAIALGMQQIATGDAKVIIAGGQESMS
HCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCCCC
LSPHAEHLRAGVKMGDYKMIDTMIKDGLWDAFNGYHMGNTAENVARQFQITRDDQDQFAL
CCCCHHHHHHCCCCCCHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHH
ASQNKAEAAQKAGKFKDEIVAFTIKGKKGDTIVDQDEYIRHGATLDAMTKLKPAFDKDGT
HCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHCCCCHHHHHHHCCCCCCCCC
VTAANASGINDGAAGALLMSEAEAARRGITPLARIASWATAGVDPAIMGTGPIPASRKAL
EEECCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEECCCCCCHHHHHH
EKAGWSAGDLDLVEANEAFAAQACAVNKGMGWDPSIVNVNGGAIAIGHPIGASGARVFNT
HHCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCCCCHHHHHHH
LVYEMRRRGAKKGLATLCIGGGMGVAMCVEAL
HHHHHHHHHHHCCCEEEEECCCCHHHHHHHCC
>Mature Secondary Structure 
SDSIVIASAARTAVGSFNGAFAATPAHELGAVVIKELLSRAGVEAAEVDEVILGQVLTA
CCCEEEEHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AQGQNPARQASIIAGLPKETTAWGLNQVCGSGLRAIALGMQQIATGDAKVIIAGGQESMS
HCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCCCC
LSPHAEHLRAGVKMGDYKMIDTMIKDGLWDAFNGYHMGNTAENVARQFQITRDDQDQFAL
CCCCHHHHHHCCCCCCHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHH
ASQNKAEAAQKAGKFKDEIVAFTIKGKKGDTIVDQDEYIRHGATLDAMTKLKPAFDKDGT
HCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHCCCCHHHHHHHCCCCCCCCC
VTAANASGINDGAAGALLMSEAEAARRGITPLARIASWATAGVDPAIMGTGPIPASRKAL
EEECCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEECCCCCCHHHHHH
EKAGWSAGDLDLVEANEAFAAQACAVNKGMGWDPSIVNVNGGAIAIGHPIGASGARVFNT
HHCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCCCCHHHHHHH
LVYEMRRRGAKKGLATLCIGGGMGVAMCVEAL
HHHHHHHHHHHCCCEEEEECCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7582015; 11481430 [H]