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The map label for this gene is gap [H]

Identifier: 13473221

GI number: 13473221

Start: 3018634

End: 3019644

Strand: Direct

Name: gap [H]

Synonym: mlr3750

Alternate gene names: 13473221

Gene position: 3018634-3019644 (Clockwise)

Preceding gene: 13473220

Following gene: 13473222

Centisome position: 42.9

GC content: 63.3

Gene sequence:

>1011_bases
ATGACCGTCAGAGTTGCCATCAACGGATTCGGCCGCATCGGCCGCAACATCCTGCGCGCCATCCATGAATCCGGCCGCAA
GGACATCGACGTCGTCGCCGTCAACGATCTCGGTCCGGTCGAGACCAATGCGCACCTGCTGCGCTACGACAGCGTGCACG
GCCGCTTCCCGCATGAAGTGTCGGTTTCCGGCGACCAGATCACCGTCGGCAAGGAAAAGTTCAAGGTCACCGCCATCAAG
GATCCGACGCAGCTGCCTTGGAAGGAGCTCGGTGTCGACATCGCGCTCGAATGCACCGGCATCTTCACCGCTCGGGACAA
GGCCGCCTCGCACCTGACCGCCGGCGCCAAGCGCGTGCTGGTCTCGGCACCTGCCGATGGCGCCGACCTGACCGTGGTCT
ACGGCATCAACCACGACAAGCTGACCAAGGACCATATCGTCATCTCGAACGCGTCCTGCACCACCAACTGCCTGGCGCCG
CTGGCCGCCGTGCTGCATGAGACGGTCGGCATCGAAAAAGGCATGATGACGACGATCCACTCCTACACCGGCGACCAGCC
GACGCTGGACACCATGCACAAGGATCTCTACCGCGCCCGTGCAGCGGCGCTGTCGCAGATCCCGACCTCGACCGGCGCGG
CCAAGGCCATCGGCCTCGTGCTCCCCGACCTCAAGGGCAAGCTCGACGGCATCTCGATCCGCGTGCCGACCCCGAACGTC
TCGGTCGTCGACTTCAAGTTCATCGCCAAGCGCGCCACCACCGTGCAGGAAATCAACGAAGCGGTCATCGCCGCCTCCAA
TGGCAAGCTGAAGGGAATTCTCGGCGTCACCCATCACCCGAATGTCTCGATCGACTTCAACCATGATCCGCGCTCCTCGA
TCATGGCGCTCGACCAGACCAAGGTGATGGACGGCAACTTCGTTTCGGTGCTGTCCTGGTACGACAATGAGTGGGGCTTC
TCCAACCGCATGGGCGACACCGCCGTCGCCTTCGGCAAGACCATCGCCTGA

Upstream 100 bases:

>100_bases
TCGATTTAAATCTGCGTCGCTGCGGCTGGATTCTTTGCCCATCCGCCGCTATGAAGCTGCGGACCCCATCGTCAGCCTTC
CAGCTCCCAGGGAGAGAAAA

Downstream 100 bases:

>100_bases
TCGAAGACTACCTTCTCGAGACCTGAAACGCCCGGCTTCGTCCGGGCGTTTTTCATTTGCCGGAGCAGCAACGCCAGTTG
CCGGAAAATCAGCGGCATAG

Product: glyceraldehyde-3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MTVRVAINGFGRIGRNILRAIHESGRKDIDVVAVNDLGPVETNAHLLRYDSVHGRFPHEVSVSGDQITVGKEKFKVTAIK
DPTQLPWKELGVDIALECTGIFTARDKAASHLTAGAKRVLVSAPADGADLTVVYGINHDKLTKDHIVISNASCTTNCLAP
LAAVLHETVGIEKGMMTTIHSYTGDQPTLDTMHKDLYRARAAALSQIPTSTGAAKAIGLVLPDLKGKLDGISIRVPTPNV
SVVDFKFIAKRATTVQEINEAVIAASNGKLKGILGVTHHPNVSIDFNHDPRSSIMALDQTKVMDGNFVSVLSWYDNEWGF
SNRMGDTAVAFGKTIA

Sequences:

>Translated_336_residues
MTVRVAINGFGRIGRNILRAIHESGRKDIDVVAVNDLGPVETNAHLLRYDSVHGRFPHEVSVSGDQITVGKEKFKVTAIK
DPTQLPWKELGVDIALECTGIFTARDKAASHLTAGAKRVLVSAPADGADLTVVYGINHDKLTKDHIVISNASCTTNCLAP
LAAVLHETVGIEKGMMTTIHSYTGDQPTLDTMHKDLYRARAAALSQIPTSTGAAKAIGLVLPDLKGKLDGISIRVPTPNV
SVVDFKFIAKRATTVQEINEAVIAASNGKLKGILGVTHHPNVSIDFNHDPRSSIMALDQTKVMDGNFVSVLSWYDNEWGF
SNRMGDTAVAFGKTIA
>Mature_335_residues
TVRVAINGFGRIGRNILRAIHESGRKDIDVVAVNDLGPVETNAHLLRYDSVHGRFPHEVSVSGDQITVGKEKFKVTAIKD
PTQLPWKELGVDIALECTGIFTARDKAASHLTAGAKRVLVSAPADGADLTVVYGINHDKLTKDHIVISNASCTTNCLAPL
AAVLHETVGIEKGMMTTIHSYTGDQPTLDTMHKDLYRARAAALSQIPTSTGAAKAIGLVLPDLKGKLDGISIRVPTPNVS
VVDFKFIAKRATTVQEINEAVIAASNGKLKGILGVTHHPNVSIDFNHDPRSSIMALDQTKVMDGNFVSVLSWYDNEWGFS
NRMGDTAVAFGKTIA

Specific function: Could Play A Role In Pyridoxal 5'-Phosphate Synthesis. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=326, Percent_Identity=44.7852760736196, Blast_Score=281, Evalue=6e-76,
Organism=Homo sapiens, GI7657116, Length=326, Percent_Identity=45.398773006135, Blast_Score=275, Evalue=5e-74,
Organism=Escherichia coli, GI1789295, Length=334, Percent_Identity=47.3053892215569, Blast_Score=325, Evalue=2e-90,
Organism=Escherichia coli, GI1788079, Length=327, Percent_Identity=48.3180428134557, Blast_Score=305, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI17534679, Length=331, Percent_Identity=47.4320241691843, Blast_Score=286, Evalue=9e-78,
Organism=Caenorhabditis elegans, GI17534677, Length=331, Percent_Identity=47.1299093655589, Blast_Score=285, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI32566163, Length=331, Percent_Identity=47.1299093655589, Blast_Score=280, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17568413, Length=331, Percent_Identity=47.1299093655589, Blast_Score=280, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6322468, Length=328, Percent_Identity=48.780487804878, Blast_Score=297, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6321631, Length=328, Percent_Identity=48.780487804878, Blast_Score=293, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6322409, Length=328, Percent_Identity=47.8658536585366, Blast_Score=293, Evalue=2e-80,
Organism=Drosophila melanogaster, GI17933600, Length=325, Percent_Identity=46.4615384615385, Blast_Score=276, Evalue=1e-74,
Organism=Drosophila melanogaster, GI18110149, Length=325, Percent_Identity=46.4615384615385, Blast_Score=276, Evalue=1e-74,
Organism=Drosophila melanogaster, GI85725000, Length=325, Percent_Identity=46.4615384615385, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI22023983, Length=325, Percent_Identity=46.4615384615385, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI19922412, Length=325, Percent_Identity=43.3846153846154, Blast_Score=264, Evalue=6e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 36094; Mature: 35963

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRVAINGFGRIGRNILRAIHESGRKDIDVVAVNDLGPVETNAHLLRYDSVHGRFPHEV
CEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCCEE
SVSGDQITVGKEKFKVTAIKDPTQLPWKELGVDIALECTGIFTARDKAASHLTAGAKRVL
ECCCCEEEECCCEEEEEEECCCCCCCHHHCCEEEEEEEEEEEEECHHHHHHHHCCCEEEE
VSAPADGADLTVVYGINHDKLTKDHIVISNASCTTNCLAPLAAVLHETVGIEKGMMTTIH
EECCCCCCCEEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
SYTGDQPTLDTMHKDLYRARAAALSQIPTSTGAAKAIGLVLPDLKGKLDGISIRVPTPNV
HCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEECCCCCCCCCCEEEEECCCCC
SVVDFKFIAKRATTVQEINEAVIAASNGKLKGILGVTHHPNVSIDFNHDPRSSIMALDQT
EEEEHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEECCCCCEEEEECCCCHHHEEEECCE
KVMDGNFVSVLSWYDNEWGFSNRMGDTAVAFGKTIA
EECCCCEEEEEEEECCCCCCCCCCCCHHHHCCCCCC
>Mature Secondary Structure 
TVRVAINGFGRIGRNILRAIHESGRKDIDVVAVNDLGPVETNAHLLRYDSVHGRFPHEV
EEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCCEE
SVSGDQITVGKEKFKVTAIKDPTQLPWKELGVDIALECTGIFTARDKAASHLTAGAKRVL
ECCCCEEEECCCEEEEEEECCCCCCCHHHCCEEEEEEEEEEEEECHHHHHHHHCCCEEEE
VSAPADGADLTVVYGINHDKLTKDHIVISNASCTTNCLAPLAAVLHETVGIEKGMMTTIH
EECCCCCCCEEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
SYTGDQPTLDTMHKDLYRARAAALSQIPTSTGAAKAIGLVLPDLKGKLDGISIRVPTPNV
HCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEECCCCCCCCCCEEEEECCCCC
SVVDFKFIAKRATTVQEINEAVIAASNGKLKGILGVTHHPNVSIDFNHDPRSSIMALDQT
EEEEHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEECCCCCEEEEECCCCHHHEEEECCE
KVMDGNFVSVLSWYDNEWGFSNRMGDTAVAFGKTIA
EECCCCEEEEEEEECCCCCCCCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7928974 [H]