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The map label for this gene is cvrA [H]

Identifier: 13473222

GI number: 13473222

Start: 3019839

End: 3021722

Strand: Direct

Name: cvrA [H]

Synonym: mlr3752

Alternate gene names: 13473222

Gene position: 3019839-3021722 (Clockwise)

Preceding gene: 13473221

Following gene: 13473223

Centisome position: 42.92

GC content: 67.68

Gene sequence:

>1884_bases
ATGGAGCATGCGATCTATCTCGTTACGCTGGTCGGCACGGCGCTCGTTGTCGCCGCCGCGTTTTCGAGCCTGATCGCCTT
CCGCTTCGGTGCCCCCCTCCTGCTGCTCTTTCTCTGCATCGGGCTCGCCACCGGAACCGATGGCCTCGGCATAGAATTCG
ACAATGCCCGCATCGCCTATTTTGCCGGCTCACTGGCTCTCGCCGTCATCCTGTTCGATTCCGGCTTCGGCACGCCGCTC
AACGCCTTGCGGCAGGCGGCCGGCCCGGCGCTGTCGCTGGCGACCTTCGGCGTGCTTCTCACCACCGGCCTGTTCGGCGC
CGCGGCCTACTATCTGCTTGACCTCACCTGGCTGGAATCCTTCCTGCTCGGCGCCGCCGTCGCTTCGACCGACGCCGCGG
CGGTGTTCTTCCTGCTGCGCGCCGGCGAGATCAATCTGCGTGAGCGTGTGCGCTCGACGCTCGAGGTGGAATCCGGCACC
AACGACCCGATCGCCATCTTCCTGACCATCACCCTCGTCGAGGTCATCGCCGCCCACGCCAACCCCGAAACCAATGTCCT
GGTCACCAACCTGATCCTCGGCTTCCTCGTCAATATGGGCCTTGGCGCCGTCGTCGGCGCGCTCGGTGGCCTTGCCATCG
TGCGTCTCGTCGACCGGCTCAATCTCGACCACGGCCTGCTGCCGATCTTCGTGCTGACCCTGTCACTGATGGTCTTCGCC
GCCGCCGGCGCCATCGGCGGCTCGGGCTTCCTGGCGGTCTATATCGCCGGCCTCATTGCCGGCAATTCCGACATCCGCGC
CGTCACCATCCTCAAGCGCTTCCAGGACGGCATGTCGTGGCTGGCGCAGATCATCATGTTCCTGATCCTCGGCCTGTTCG
CCACCCCCTCGCAATTTCCGGCGATCATGGTGCCGGCGATAGCGCTTGGCCTGTTCCTGATGTTTGTCGCCCGCCCGATC
GCTGTCTGGCTCTGCCTGATCCCGTTCCGCCTGCCGCGCCCCGAAGTCGCCTTCGTCTCCTGGGTCGGCCTGCGCGGCGC
CGTCTCGATCCTGCTCGCCATCACACCGCTGCTCGGCGGGCTGGAGAACGGCCGCACCATCTTCAACGCCGCCTTCATCA
TCGTACTGGTGTCGCTGGTCATCCAGGGCTGGACCGTCGGACCGCTGGCGCGTCGCCTCGGTCTCATCGTGCCGGCGCGC
CTTGGACCGCTGGACAAGGTCGAGCTGGAATTGCCGGGCTCCGCCCATCACGAGCTTCTCGCCTATCGCGTGGCGCATGG
CAGCCCGGTGGCGCGCGGCGAGCGCATTCCGCGTTGGGCGCGGCCCTCGCTGGTGCTGCGCGACGGCCGCTCGATGCGCT
TTCAGGACATGGGCCGGCTCGCCGCCGGCGACCAGGTCTACATCTTCGTGCCGGACCGCTACCCGCGCCTGCTCGACAAG
CTGTTCGCCAGCCGCGCGGTGGTCGACCCGGAAGACGCCGATTTCTTCGGCGCCTTCGCCGTCGACCCGGCGCGCGCCGC
GGCCGAATTGGAGGCAGCGTACGCGCCGGGTCTGACCGAGGCGGAGCAGAAGCTCACCGTCGGCGCGCTGGTCACGGCGC
GGCTTGGCGGCCATGCCGAATACGCCGATCGCGTGCTGATCGGCTCGATCGAGCTGATCGTCAGGGATGTCGACGACAAG
GGCAGGATCACGGGTCTCGGTCTTTCCTTCGAGCCGACCGCGCCGGTGGCGCGGGTGCCGGTGTTCCTGAGCGCCGGCGA
GATGGGCGACCGCCTCGGCGCCTTCATCCGCAATTGGCGCAAGCCGACCGAGACGCAGGAAGCGGCAGCACAGGCCGAAG
ACGCCCCCAAGCCGCCGGTTGAAAAAGCCACGACCGGGAGCTGA

Upstream 100 bases:

>100_bases
GCATAGGGCAAAAAACCACCCTCCCGCCTTGCACTGGCCATGCCTTCGCCCCACTCTCCCGTAAATCGATAGAAAGAGGA
ATTCGAGGGGCAAATCACGG

Downstream 100 bases:

>100_bases
GAAGGGCGATCGCTGGCCCTGCCCCGTCATCACCGGGCGATGTTCACGGACTATGTTCCTGCCCGCCTGAAAATTTCGCA
TCGCGTCGCGGCCAAAGCCT

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 627; Mature: 627

Protein sequence:

>627_residues
MEHAIYLVTLVGTALVVAAAFSSLIAFRFGAPLLLLFLCIGLATGTDGLGIEFDNARIAYFAGSLALAVILFDSGFGTPL
NALRQAAGPALSLATFGVLLTTGLFGAAAYYLLDLTWLESFLLGAAVASTDAAAVFFLLRAGEINLRERVRSTLEVESGT
NDPIAIFLTITLVEVIAAHANPETNVLVTNLILGFLVNMGLGAVVGALGGLAIVRLVDRLNLDHGLLPIFVLTLSLMVFA
AAGAIGGSGFLAVYIAGLIAGNSDIRAVTILKRFQDGMSWLAQIIMFLILGLFATPSQFPAIMVPAIALGLFLMFVARPI
AVWLCLIPFRLPRPEVAFVSWVGLRGAVSILLAITPLLGGLENGRTIFNAAFIIVLVSLVIQGWTVGPLARRLGLIVPAR
LGPLDKVELELPGSAHHELLAYRVAHGSPVARGERIPRWARPSLVLRDGRSMRFQDMGRLAAGDQVYIFVPDRYPRLLDK
LFASRAVVDPEDADFFGAFAVDPARAAAELEAAYAPGLTEAEQKLTVGALVTARLGGHAEYADRVLIGSIELIVRDVDDK
GRITGLGLSFEPTAPVARVPVFLSAGEMGDRLGAFIRNWRKPTETQEAAAQAEDAPKPPVEKATTGS

Sequences:

>Translated_627_residues
MEHAIYLVTLVGTALVVAAAFSSLIAFRFGAPLLLLFLCIGLATGTDGLGIEFDNARIAYFAGSLALAVILFDSGFGTPL
NALRQAAGPALSLATFGVLLTTGLFGAAAYYLLDLTWLESFLLGAAVASTDAAAVFFLLRAGEINLRERVRSTLEVESGT
NDPIAIFLTITLVEVIAAHANPETNVLVTNLILGFLVNMGLGAVVGALGGLAIVRLVDRLNLDHGLLPIFVLTLSLMVFA
AAGAIGGSGFLAVYIAGLIAGNSDIRAVTILKRFQDGMSWLAQIIMFLILGLFATPSQFPAIMVPAIALGLFLMFVARPI
AVWLCLIPFRLPRPEVAFVSWVGLRGAVSILLAITPLLGGLENGRTIFNAAFIIVLVSLVIQGWTVGPLARRLGLIVPAR
LGPLDKVELELPGSAHHELLAYRVAHGSPVARGERIPRWARPSLVLRDGRSMRFQDMGRLAAGDQVYIFVPDRYPRLLDK
LFASRAVVDPEDADFFGAFAVDPARAAAELEAAYAPGLTEAEQKLTVGALVTARLGGHAEYADRVLIGSIELIVRDVDDK
GRITGLGLSFEPTAPVARVPVFLSAGEMGDRLGAFIRNWRKPTETQEAAAQAEDAPKPPVEKATTGS
>Mature_627_residues
MEHAIYLVTLVGTALVVAAAFSSLIAFRFGAPLLLLFLCIGLATGTDGLGIEFDNARIAYFAGSLALAVILFDSGFGTPL
NALRQAAGPALSLATFGVLLTTGLFGAAAYYLLDLTWLESFLLGAAVASTDAAAVFFLLRAGEINLRERVRSTLEVESGT
NDPIAIFLTITLVEVIAAHANPETNVLVTNLILGFLVNMGLGAVVGALGGLAIVRLVDRLNLDHGLLPIFVLTLSLMVFA
AAGAIGGSGFLAVYIAGLIAGNSDIRAVTILKRFQDGMSWLAQIIMFLILGLFATPSQFPAIMVPAIALGLFLMFVARPI
AVWLCLIPFRLPRPEVAFVSWVGLRGAVSILLAITPLLGGLENGRTIFNAAFIIVLVSLVIQGWTVGPLARRLGLIVPAR
LGPLDKVELELPGSAHHELLAYRVAHGSPVARGERIPRWARPSLVLRDGRSMRFQDMGRLAAGDQVYIFVPDRYPRLLDK
LFASRAVVDPEDADFFGAFAVDPARAAAELEAAYAPGLTEAEQKLTVGALVTARLGGHAEYADRVLIGSIELIVRDVDDK
GRITGLGLSFEPTAPVARVPVFLSAGEMGDRLGAFIRNWRKPTETQEAAAQAEDAPKPPVEKATTGS

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=560, Percent_Identity=38.3928571428571, Blast_Score=313, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI71999821, Length=358, Percent_Identity=24.8603351955307, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71999819, Length=380, Percent_Identity=24.2105263157895, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71999817, Length=358, Percent_Identity=24.8603351955307, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018421
- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 66548; Mature: 66548

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHAIYLVTLVGTALVVAAAFSSLIAFRFGAPLLLLFLCIGLATGTDGLGIEFDNARIAY
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCEEECCCEEEE
FAGSLALAVILFDSGFGTPLNALRQAAGPALSLATFGVLLTTGLFGAAAYYLLDLTWLES
EHHHHHHEEHEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLLGAAVASTDAAAVFFLLRAGEINLRERVRSTLEVESGTNDPIAIFLTITLVEVIAAHA
HHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHEECCCCCCCEEEHHHHHHHHHHHHCC
NPETNVLVTNLILGFLVNMGLGAVVGALGGLAIVRLVDRLNLDHGLLPIFVLTLSLMVFA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AAGAIGGSGFLAVYIAGLIAGNSDIRAVTILKRFQDGMSWLAQIIMFLILGLFATPSQFP
HHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AIMVPAIALGLFLMFVARPIAVWLCLIPFRLPRPEVAFVSWVGLRGAVSILLAITPLLGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
LENGRTIFNAAFIIVLVSLVIQGWTVGPLARRLGLIVPARLGPLDKVELELPGSAHHELL
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCEECCCCCCCCCEEEECCCCHHHHHH
AYRVAHGSPVARGERIPRWARPSLVLRDGRSMRFQDMGRLAAGDQVYIFVPDRYPRLLDK
HHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHCCCCCCCEEEEEECCCCHHHHHH
LFASRAVVDPEDADFFGAFAVDPARAAAELEAAYAPGLTEAEQKLTVGALVTARLGGHAE
HHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHH
YADRVLIGSIELIVRDVDDKGRITGLGLSFEPTAPVARVPVFLSAGEMGDRLGAFIRNWR
HHCHHHHEEEEEEEECCCCCCCEEEECCCCCCCCCHHHCCEEEECCHHHHHHHHHHHHCC
KPTETQEAAAQAEDAPKPPVEKATTGS
CCCHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEHAIYLVTLVGTALVVAAAFSSLIAFRFGAPLLLLFLCIGLATGTDGLGIEFDNARIAY
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCEEECCCEEEE
FAGSLALAVILFDSGFGTPLNALRQAAGPALSLATFGVLLTTGLFGAAAYYLLDLTWLES
EHHHHHHEEHEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLLGAAVASTDAAAVFFLLRAGEINLRERVRSTLEVESGTNDPIAIFLTITLVEVIAAHA
HHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHEECCCCCCCEEEHHHHHHHHHHHHCC
NPETNVLVTNLILGFLVNMGLGAVVGALGGLAIVRLVDRLNLDHGLLPIFVLTLSLMVFA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AAGAIGGSGFLAVYIAGLIAGNSDIRAVTILKRFQDGMSWLAQIIMFLILGLFATPSQFP
HHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AIMVPAIALGLFLMFVARPIAVWLCLIPFRLPRPEVAFVSWVGLRGAVSILLAITPLLGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
LENGRTIFNAAFIIVLVSLVIQGWTVGPLARRLGLIVPARLGPLDKVELELPGSAHHELL
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCEECCCCCCCCCEEEECCCCHHHHHH
AYRVAHGSPVARGERIPRWARPSLVLRDGRSMRFQDMGRLAAGDQVYIFVPDRYPRLLDK
HHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHCCCCCCCEEEEEECCCCHHHHHH
LFASRAVVDPEDADFFGAFAVDPARAAAELEAAYAPGLTEAEQKLTVGALVTARLGGHAE
HHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHH
YADRVLIGSIELIVRDVDDKGRITGLGLSFEPTAPVARVPVFLSAGEMGDRLGAFIRNWR
HHCHHHHEEEEEEEECCCCCCCEEEECCCCCCCCCHHHCCEEEECCHHHHHHHHHHHHCC
KPTETQEAAAQAEDAPKPPVEKATTGS
CCCHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA