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The map label for this gene is ahpC [C]

Identifier: 13473217

GI number: 13473217

Start: 3014696

End: 3015355

Strand: Reverse

Name: ahpC [C]

Synonym: mll3745

Alternate gene names: 13473217

Gene position: 3015355-3014696 (Counterclockwise)

Preceding gene: 13473218

Following gene: 13473216

Centisome position: 42.86

GC content: 60.3

Gene sequence:

>660_bases
ATGAGCCTTCGTATCAACGACATCGCACCGGATTTCACCGCCGAGACCACGCAAGGGACGATCAGCTTTCACGACTGGAT
CGGTGACGGCTGGGCGATCCTGTTCAGCCACCCGAAGAATTTCACGCCGGTCTGCACGACCGAGCTTGGCACGATGGCCG
GGCTGGAAGGCGAGTTCAAGAAACGCAACGTCAAGATCATCGGCATCTCCGTCGATCCGGTTGCGAGCCACGACAAATGG
CAGGCCGACATCAAGACGGCGACCGGCCAGACGGTGCATTATCCGCTGATTGGCGACAAGGACCTCAAGGTCGCCAAGCT
CTACGACATGCTGCCCGCCGGCGCCGGCGAGACCTCGGAAGGCCGAACGCCCGCAGACAACGCCACCGTGCGCTCGGTCT
ATGTCATCGGACCGGACAAGAAGATCAAGCTGGTGCTGACCTATCCGATGACTACGGGCCGCAACTTCGATGAGATCCTG
CGCGCGGTCGATTCCATGCAGCTCACCGCCAAGCATCAGGTGGCGACACCGGCAAACTGGAAGCAAGGCGAGGACGTCAT
CATCACCGCCGCCGTTTCCAACGAGGATGCGATCAAGCGCTTTGGCGCCTTTGACACCATCCTGCCTTATCTCAGGAAAA
CCAAACAGCCGTCCGCCTGA

Upstream 100 bases:

>100_bases
TGCATCACTGCCGGGTGGCCTCACCGTTTTGAACGTCGCCGATGGAGTGGTAAAAAGGGTGGCAGACCGCCAACGGGCGG
CATTCACAGGGGTAGGAACC

Downstream 100 bases:

>100_bases
AACAGGCGCCGGAACGGCTTTTGCCTTTCCCACCCAGGCGGGCCAAGTCATGCTTGACTGGCCTGCCTCGGTGGACAACC
ATGCTCCTGTTGGAGCTTGG

Product: thiol-specific antioxidant enzyme such as rehydrin/peroxiredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MSLRINDIAPDFTAETTQGTISFHDWIGDGWAILFSHPKNFTPVCTTELGTMAGLEGEFKKRNVKIIGISVDPVASHDKW
QADIKTATGQTVHYPLIGDKDLKVAKLYDMLPAGAGETSEGRTPADNATVRSVYVIGPDKKIKLVLTYPMTTGRNFDEIL
RAVDSMQLTAKHQVATPANWKQGEDVIITAAVSNEDAIKRFGAFDTILPYLRKTKQPSA

Sequences:

>Translated_219_residues
MSLRINDIAPDFTAETTQGTISFHDWIGDGWAILFSHPKNFTPVCTTELGTMAGLEGEFKKRNVKIIGISVDPVASHDKW
QADIKTATGQTVHYPLIGDKDLKVAKLYDMLPAGAGETSEGRTPADNATVRSVYVIGPDKKIKLVLTYPMTTGRNFDEIL
RAVDSMQLTAKHQVATPANWKQGEDVIITAAVSNEDAIKRFGAFDTILPYLRKTKQPSA
>Mature_218_residues
SLRINDIAPDFTAETTQGTISFHDWIGDGWAILFSHPKNFTPVCTTELGTMAGLEGEFKKRNVKIIGISVDPVASHDKWQ
ADIKTATGQTVHYPLIGDKDLKVAKLYDMLPAGAGETSEGRTPADNATVRSVYVIGPDKKIKLVLTYPMTTGRNFDEILR
AVDSMQLTAKHQVATPANWKQGEDVIITAAVSNEDAIKRFGAFDTILPYLRKTKQPSA

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4758638, Length=225, Percent_Identity=49.3333333333333, Blast_Score=208, Evalue=4e-54,
Organism=Homo sapiens, GI4505591, Length=190, Percent_Identity=31.0526315789474, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI32455266, Length=190, Percent_Identity=31.0526315789474, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI32455264, Length=190, Percent_Identity=31.0526315789474, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI32189392, Length=189, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI5453549, Length=159, Percent_Identity=27.6729559748428, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI32483377, Length=161, Percent_Identity=27.9503105590062, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI5802974, Length=161, Percent_Identity=27.9503105590062, Blast_Score=71, Evalue=6e-13,
Organism=Escherichia coli, GI1786822, Length=155, Percent_Identity=29.6774193548387, Blast_Score=73, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25153706, Length=209, Percent_Identity=39.2344497607655, Blast_Score=157, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI193204376, Length=181, Percent_Identity=26.5193370165746, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI32565831, Length=181, Percent_Identity=26.5193370165746, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17554494, Length=208, Percent_Identity=23.5576923076923, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319407, Length=215, Percent_Identity=53.953488372093, Blast_Score=229, Evalue=4e-61,
Organism=Drosophila melanogaster, GI24581278, Length=223, Percent_Identity=47.9820627802691, Blast_Score=193, Evalue=7e-50,
Organism=Drosophila melanogaster, GI24652434, Length=224, Percent_Identity=43.3035714285714, Blast_Score=180, Evalue=5e-46,
Organism=Drosophila melanogaster, GI17975518, Length=212, Percent_Identity=44.3396226415094, Blast_Score=180, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24652436, Length=224, Percent_Identity=42.8571428571429, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI17738015, Length=184, Percent_Identity=28.2608695652174, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17157991, Length=169, Percent_Identity=29.585798816568, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24641739, Length=169, Percent_Identity=29.585798816568, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21357347, Length=202, Percent_Identity=27.2277227722772, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24656348, Length=169, Percent_Identity=27.810650887574, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17864676, Length=169, Percent_Identity=27.810650887574, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR022915
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 24006; Mature: 23874

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLRINDIAPDFTAETTQGTISFHDWIGDGWAILFSHPKNFTPVCTTELGTMAGLEGEFK
CCEEECCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCEEECCHHHHCCCCCCCC
KRNVKIIGISVDPVASHDKWQADIKTATGQTVHYPLIGDKDLKVAKLYDMLPAGAGETSE
CCCEEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCCC
GRTPADNATVRSVYVIGPDKKIKLVLTYPMTTGRNFDEILRAVDSMQLTAKHQVATPANW
CCCCCCCCEEEEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHEEECCCCCCCCCC
KQGEDVIITAAVSNEDAIKRFGAFDTILPYLRKTKQPSA
CCCCCEEEEEEECCCHHHHHHCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SLRINDIAPDFTAETTQGTISFHDWIGDGWAILFSHPKNFTPVCTTELGTMAGLEGEFK
CEEECCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCEEECCHHHHCCCCCCCC
KRNVKIIGISVDPVASHDKWQADIKTATGQTVHYPLIGDKDLKVAKLYDMLPAGAGETSE
CCCEEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCCC
GRTPADNATVRSVYVIGPDKKIKLVLTYPMTTGRNFDEILRAVDSMQLTAKHQVATPANW
CCCCCCCCEEEEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHEEECCCCCCCCCC
KQGEDVIITAAVSNEDAIKRFGAFDTILPYLRKTKQPSA
CCCCCEEEEEEECCCHHHHHHCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824 [H]