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The map label for this gene is 13473162

Identifier: 13473162

GI number: 13473162

Start: 2961426

End: 2962736

Strand: Reverse

Name: 13473162

Synonym: mll3668

Alternate gene names: NA

Gene position: 2962736-2961426 (Counterclockwise)

Preceding gene: 13473163

Following gene: 13473158

Centisome position: 42.11

GC content: 65.22

Gene sequence:

>1311_bases
TTGACGGACGAACTGGAAAGAACCGACGTCGTCATCGTTGGTGCCGGCTTCACCGGCCTGTCGGCGGCGCTTGAACTGAA
GCGGGCTGGCATCAATTTCGTGCTGCTGGAGGCACGCGATCGTGTCGGCGGACGGGTGGAAGCCGTTCGGAATGGACTTG
GCGAGCGCATCGACAGCGGCGGCCAATTCCTGTGCGAGGACATGCCGGAACTGATGGCGCTGGCGAGGGCGCGCGGCAAG
ACATTCGTCGAAACCTATGTCGAGGGCGACTTCATCACGCATCCGTCGATGCCGCCCAAAGACGCCAAGCAGACTTATCA
CGGCGCGATGGCGATCCGCGAGCGCATGAACGGCATCGAGCCGGACGACCCGTCGATAAAAGGCATGAGTGTCGCCGCCT
GGCTCGAGCGCCAGCCTGATCCCATCGATGCCAGGACGGCCTTCCGCTCGATGATCGAAGGCCTGTGGTGCCTGCCGATG
GACAGGGTGCCGCTCTGGTACCTGATCGACAATGATCGGCGCATCACCAACGAGGTGCCGGAGCTGCAATATTCCTTGCG
CGAGACCATGCAGTCGCTTGCCGAGGATATTTCTGGTGATCTCGGCGACCGGGTGCGGCTCGGCGAACCGGCCACGCGCG
TCGAGCATAGGCCGCAGGGCGTTCGTGTCGTCACGGGCAAAGGTGCGATGGAAGCGCGCCAGCTGCTGGTCGCGCTGCCG
CCGGCGACGGCCGCGAAGCTCGATTTCGCGCCTACCTTGCCGGCGAGACTCGCGAAGGCGCTTGGCGTCTGGGAAAGTGG
CGCGGTGATCAAGATCCTCGTGCGCTATCCCAGGCCATTCTGGCGCGAGCAGGGTTTGAGCGGCATGGTGATGTGGCGCG
ATCTGCCGGGGCTGTTTGCCTGCGACGCCAGCAAGGACGCGGAGCATGCCGCGCTCGTCGTCTTCGTCGGCGGGCCGCTG
GCGTTGCGCTGGCGTGTGCTGGACGAGGCGGGGCTGCGCGCGGAAGTGACCGGCCGATTGCAGGAGGCGCTCGGCCCCGA
TGCCGGCGACATCATCGATTTCAGCTCGCGCGACTGGATAAAGGATCGCTGGAGCGGCGGCGCCTATAGCGACCTCATCG
TCGACGTGACGGCCAGGGATGCCGAGCGGACGATTCTTTCGGGTGCGCCGCCGGTGCATTTCGCCGCTTCGGAGCTGTCG
CCGTCATTTCCCGGTTATGTCGAAGGCGCGATCGTCGCCGGGCGCATCGCGGCCAGAAAAATAATCGCCGAGCTTCAATC
CCCCATCGCCACCAGCGCCTCGGGATCGTAG

Upstream 100 bases:

>100_bases
ACATCGACAAGTTCCTCGACAAGACGCTGTTCCAGCAGCCGGTCGCGCCCGAGCTGAAGAAGCGCATGGTCGACGAATTC
GAGAAGATCAAGGCCGGCTA

Downstream 100 bases:

>100_bases
GCAAGTCGGATCGTGGTGCCGACCGGAATGTCGTCGGCGCCGAAATCGTTGGTCTCGGTCACCGAGAGCGGTTTTTCCAA
GCCGGGTATCTCGACGATCA

Product: monoamine oxidase A

Products: RCHO; NH3; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MTDELERTDVVIVGAGFTGLSAALELKRAGINFVLLEARDRVGGRVEAVRNGLGERIDSGGQFLCEDMPELMALARARGK
TFVETYVEGDFITHPSMPPKDAKQTYHGAMAIRERMNGIEPDDPSIKGMSVAAWLERQPDPIDARTAFRSMIEGLWCLPM
DRVPLWYLIDNDRRITNEVPELQYSLRETMQSLAEDISGDLGDRVRLGEPATRVEHRPQGVRVVTGKGAMEARQLLVALP
PATAAKLDFAPTLPARLAKALGVWESGAVIKILVRYPRPFWREQGLSGMVMWRDLPGLFACDASKDAEHAALVVFVGGPL
ALRWRVLDEAGLRAEVTGRLQEALGPDAGDIIDFSSRDWIKDRWSGGAYSDLIVDVTARDAERTILSGAPPVHFAASELS
PSFPGYVEGAIVAGRIAARKIIAELQSPIATSASGS

Sequences:

>Translated_436_residues
MTDELERTDVVIVGAGFTGLSAALELKRAGINFVLLEARDRVGGRVEAVRNGLGERIDSGGQFLCEDMPELMALARARGK
TFVETYVEGDFITHPSMPPKDAKQTYHGAMAIRERMNGIEPDDPSIKGMSVAAWLERQPDPIDARTAFRSMIEGLWCLPM
DRVPLWYLIDNDRRITNEVPELQYSLRETMQSLAEDISGDLGDRVRLGEPATRVEHRPQGVRVVTGKGAMEARQLLVALP
PATAAKLDFAPTLPARLAKALGVWESGAVIKILVRYPRPFWREQGLSGMVMWRDLPGLFACDASKDAEHAALVVFVGGPL
ALRWRVLDEAGLRAEVTGRLQEALGPDAGDIIDFSSRDWIKDRWSGGAYSDLIVDVTARDAERTILSGAPPVHFAASELS
PSFPGYVEGAIVAGRIAARKIIAELQSPIATSASGS
>Mature_435_residues
TDELERTDVVIVGAGFTGLSAALELKRAGINFVLLEARDRVGGRVEAVRNGLGERIDSGGQFLCEDMPELMALARARGKT
FVETYVEGDFITHPSMPPKDAKQTYHGAMAIRERMNGIEPDDPSIKGMSVAAWLERQPDPIDARTAFRSMIEGLWCLPMD
RVPLWYLIDNDRRITNEVPELQYSLRETMQSLAEDISGDLGDRVRLGEPATRVEHRPQGVRVVTGKGAMEARQLLVALPP
ATAAKLDFAPTLPARLAKALGVWESGAVIKILVRYPRPFWREQGLSGMVMWRDLPGLFACDASKDAEHAALVVFVGGPLA
LRWRVLDEAGLRAEVTGRLQEALGPDAGDIIDFSSRDWIKDRWSGGAYSDLIVDVTARDAERTILSGAPPVHFAASELSP
SFPGYVEGAIVAGRIAARKIIAELQSPIATSASGS

Specific function: Unknown

COG id: COG1231

COG function: function code E; Monoamine oxidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the flavin monoamine oxidase family [H]

Homologues:

Organism=Homo sapiens, GI4557735, Length=458, Percent_Identity=26.6375545851528, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI38202207, Length=465, Percent_Identity=27.0967741935484, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001613
- InterPro:   IPR002937 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: 1.4.3.4

Molecular weight: Translated: 47538; Mature: 47407

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDELERTDVVIVGAGFTGLSAALELKRAGINFVLLEARDRVGGRVEAVRNGLGERIDSG
CCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCC
GQFLCEDMPELMALARARGKTFVETYVEGDFITHPSMPPKDAKQTYHGAMAIRERMNGIE
CCCHHHHHHHHHHHHHHCCCCEEHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
PDDPSIKGMSVAAWLERQPDPIDARTAFRSMIEGLWCLPMDRVPLWYLIDNDRRITNEVP
CCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCEEECCCCCCCEEEEECCCCCHHHHHH
ELQYSLRETMQSLAEDISGDLGDRVRLGEPATRVEHRPQGVRVVTGKGAMEARQLLVALP
HHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHCCCCCCEEEEECCCHHHHHHEEEECC
PATAAKLDFAPTLPARLAKALGVWESGAVIKILVRYPRPFWREQGLSGMVMWRDLPGLFA
CCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCHHHHHCCCCEEEEEECCCCEEE
CDASKDAEHAALVVFVGGPLALRWRVLDEAGLRAEVTGRLQEALGPDAGDIIDFSSRDWI
ECCCCCCCCEEEEEEECCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEECCCCCCHH
KDRWSGGAYSDLIVDVTARDAERTILSGAPPVHFAASELSPSFPGYVEGAIVAGRIAARK
HHHCCCCCCCEEEEEEECCCCHHHHHCCCCCCEEEHHHCCCCCCCHHCCHHHHHHHHHHH
IIAELQSPIATSASGS
HHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TDELERTDVVIVGAGFTGLSAALELKRAGINFVLLEARDRVGGRVEAVRNGLGERIDSG
CCCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCC
GQFLCEDMPELMALARARGKTFVETYVEGDFITHPSMPPKDAKQTYHGAMAIRERMNGIE
CCCHHHHHHHHHHHHHHCCCCEEHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
PDDPSIKGMSVAAWLERQPDPIDARTAFRSMIEGLWCLPMDRVPLWYLIDNDRRITNEVP
CCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCEEECCCCCCCEEEEECCCCCHHHHHH
ELQYSLRETMQSLAEDISGDLGDRVRLGEPATRVEHRPQGVRVVTGKGAMEARQLLVALP
HHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHCCCCCCEEEEECCCHHHHHHEEEECC
PATAAKLDFAPTLPARLAKALGVWESGAVIKILVRYPRPFWREQGLSGMVMWRDLPGLFA
CCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCHHHHHCCCCEEEEEECCCCEEE
CDASKDAEHAALVVFVGGPLALRWRVLDEAGLRAEVTGRLQEALGPDAGDIIDFSSRDWI
ECCCCCCCCEEEEEEECCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEECCCCCCHH
KDRWSGGAYSDLIVDVTARDAERTILSGAPPVHFAASELSPSFPGYVEGAIVAGRIAARK
HHHCCCCCCCEEEEEEECCCCHHHHHCCCCCCEEEHHHCCCCCCCHHCCHHHHHHHHHHH
IIAELQSPIATSASGS
HHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: RCH2NH2; H2O; O2

Specific reaction: RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]