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The map label for this gene is xerD

Identifier: 13473085

GI number: 13473085

Start: 2880338

End: 2881255

Strand: Direct

Name: xerD

Synonym: mlr3575

Alternate gene names: 13473085

Gene position: 2880338-2881255 (Clockwise)

Preceding gene: 13473084

Following gene: 13473086

Centisome position: 40.94

GC content: 67.76

Gene sequence:

>918_bases
ATGAACAGCGCCGCCCGCATCGAGGCCTTTCTGGAAATGATGAGCGCCGAGCGCGGCGCCGCCGAAAACACACTGTCCTC
TTACCGCCGCGACCTCGAAGACGCTTCGAGCGGGATCGATGGTGGGCTTGCCGGTGCGGCCGCCGCCGATATCCGCGCCT
ATCTCGATGACATCGCCGAGCGCGGCTTCGCGCCGACCTCGCAGGCGCGCAAACTGTCGGCGATCCGCCAGTTCTTTAAG
TTCCTCTACGCCGAGGGCCTGCGCACCGACGACCCGACCGGCACGCTGGACAGCCCGAAAAAGGCCCGTCCGCTGCCCAA
GACGATGAGCGAGGCCGAGACCGGCCGGTTGATCGACCGCGCCGCGGTGGAAGCTGGCGACGCCGGGCTCGGCTACAGTG
ACAGGCTGGCCGCCCTGCGCCTGCATGCGCTGGTCGAGGTGCTCTACGCCACCGGCCTGCGCGTTTCCGAGCTGGTCGGC
CTACCGGTGACGGTTGCGCAGCGCGACGACCGTTTCTTCATGGTGCGCGGCAAGGGCGACAAGGAACGCATGGTGCCGCT
GTCGGCCAAGGCGCGGGTGGCGATGCGCGCCTGGCTTGCCGCCCGCGCCGGAGTGCCCGCCTTCGCCGACAGCCCGTTCC
TGTTTCCGGCCGCGTCCGACAGCGGCTATCTCTCGCGCCAGGTCTTTGCCCGTGACCTGAAAGGGCTGGCGGCGCGGGCC
GGCATCGCCTCGGCCAAGATATCGCCGCATGTGTTGCGCCATGCTTTCGCCAGCCATCTCCTGCAGAACGGCGCCGATCT
CAGGGCGGTACAGCAGCTGCTCGGCCATGCCGACATATCGACGACACAGATTTACACCCATGTGCTGGAGGAGCGGCTGG
TGCGGCTGGTCAACGATCATCATCCGCTTGCCGACTAG

Upstream 100 bases:

>100_bases
ATGTTCGTCGAGCCCAAAAGAGCGGAGATGAGCGTGCGTATCCCGCCGGAAAAGCTGAACCCCAAGAAAAACTGACCCAG
AAGAAAACTGATCCCCGAGG

Downstream 100 bases:

>100_bases
GCCTCATATCGCTATGTGAGGACGATATTTCACCGCCGGGAGCCTTGGTTTCAAGGGTTCCGCAGTCCTTGCCTTCCGAC
GTATCGGTCCGCTCAAGCAT

Product: site-specific tyrosine recombinase XerD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MNSAARIEAFLEMMSAERGAAENTLSSYRRDLEDASSGIDGGLAGAAAADIRAYLDDIAERGFAPTSQARKLSAIRQFFK
FLYAEGLRTDDPTGTLDSPKKARPLPKTMSEAETGRLIDRAAVEAGDAGLGYSDRLAALRLHALVEVLYATGLRVSELVG
LPVTVAQRDDRFFMVRGKGDKERMVPLSAKARVAMRAWLAARAGVPAFADSPFLFPAASDSGYLSRQVFARDLKGLAARA
GIASAKISPHVLRHAFASHLLQNGADLRAVQQLLGHADISTTQIYTHVLEERLVRLVNDHHPLAD

Sequences:

>Translated_305_residues
MNSAARIEAFLEMMSAERGAAENTLSSYRRDLEDASSGIDGGLAGAAAADIRAYLDDIAERGFAPTSQARKLSAIRQFFK
FLYAEGLRTDDPTGTLDSPKKARPLPKTMSEAETGRLIDRAAVEAGDAGLGYSDRLAALRLHALVEVLYATGLRVSELVG
LPVTVAQRDDRFFMVRGKGDKERMVPLSAKARVAMRAWLAARAGVPAFADSPFLFPAASDSGYLSRQVFARDLKGLAARA
GIASAKISPHVLRHAFASHLLQNGADLRAVQQLLGHADISTTQIYTHVLEERLVRLVNDHHPLAD
>Mature_305_residues
MNSAARIEAFLEMMSAERGAAENTLSSYRRDLEDASSGIDGGLAGAAAADIRAYLDDIAERGFAPTSQARKLSAIRQFFK
FLYAEGLRTDDPTGTLDSPKKARPLPKTMSEAETGRLIDRAAVEAGDAGLGYSDRLAALRLHALVEVLYATGLRVSELVG
LPVTVAQRDDRFFMVRGKGDKERMVPLSAKARVAMRAWLAARAGVPAFADSPFLFPAASDSGYLSRQVFARDLKGLAARA
GIASAKISPHVLRHAFASHLLQNGADLRAVQQLLGHADISTTQIYTHVLEERLVRLVNDHHPLAD

Specific function: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell div

COG id: COG4974

COG function: function code L; Site-specific recombinase XerD

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family. XerD subfamily

Homologues:

Organism=Escherichia coli, GI1789261, Length=306, Percent_Identity=46.4052287581699, Blast_Score=236, Evalue=1e-63,
Organism=Escherichia coli, GI1790244, Length=308, Percent_Identity=33.7662337662338, Blast_Score=154, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XERD_RHILO (Q98FX8)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_104652.1
- ProteinModelPortal:   Q98FX8
- SMR:   Q98FX8
- GeneID:   1227313
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr3575
- NMPDR:   fig|266835.1.peg.2756
- HOGENOM:   HBG727654
- OMA:   LDDYLGY
- ProtClustDB:   PRK00283
- GO:   GO:0005737
- HAMAP:   MF_01807
- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR010998
- InterPro:   IPR023109
- InterPro:   IPR004107
- InterPro:   IPR011932
- Gene3D:   G3DSA:1.10.150.130
- Gene3D:   G3DSA:1.10.443.10
- TIGRFAMs:   TIGR02225

Pfam domain/function: PF02899 Phage_integr_N; PF00589 Phage_integrase; SSF56349 DNA_brk_join_enz; SSF47823 L_intgrse_like_N

EC number: NA

Molecular weight: Translated: 32939; Mature: 32939

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: NA

Important sites: ACT_SITE 154-154 ACT_SITE 178-178 ACT_SITE 250-250 ACT_SITE 253-253 ACT_SITE 276-276 ACT_SITE 285-285

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSAARIEAFLEMMSAERGAAENTLSSYRRDLEDASSGIDGGLAGAAAADIRAYLDDIAE
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
RGFAPTSQARKLSAIRQFFKFLYAEGLRTDDPTGTLDSPKKARPLPKTMSEAETGRLIDR
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHH
AAVEAGDAGLGYSDRLAALRLHALVEVLYATGLRVSELVGLPVTVAQRDDRFFMVRGKGD
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEECCCEEEEEECCCC
KERMVPLSAKARVAMRAWLAARAGVPAFADSPFLFPAASDSGYLSRQVFARDLKGLAARA
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
GIASAKISPHVLRHAFASHLLQNGADLRAVQQLLGHADISTTQIYTHVLEERLVRLVNDH
CHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
HPLAD
CCCCC
>Mature Secondary Structure
MNSAARIEAFLEMMSAERGAAENTLSSYRRDLEDASSGIDGGLAGAAAADIRAYLDDIAE
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
RGFAPTSQARKLSAIRQFFKFLYAEGLRTDDPTGTLDSPKKARPLPKTMSEAETGRLIDR
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHH
AAVEAGDAGLGYSDRLAALRLHALVEVLYATGLRVSELVGLPVTVAQRDDRFFMVRGKGD
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEECCCEEEEEECCCC
KERMVPLSAKARVAMRAWLAARAGVPAFADSPFLFPAASDSGYLSRQVFARDLKGLAARA
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
GIASAKISPHVLRHAFASHLLQNGADLRAVQQLLGHADISTTQIYTHVLEERLVRLVNDH
CHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
HPLAD
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968