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The map label for this gene is argH1

Identifier: 13473027

GI number: 13473027

Start: 2829873

End: 2831273

Strand: Direct

Name: argH1

Synonym: mlr3506

Alternate gene names: 13473027

Gene position: 2829873-2831273 (Clockwise)

Preceding gene: 13473025

Following gene: 13473028

Centisome position: 40.22

GC content: 64.67

Gene sequence:

>1401_bases
ATGAGCGACAAGAAGACCAGCAACCAGATGTGGGGCGGACGATTTGCCTCGGGTCCGGCCGCAATCATGGAAGCGATCAA
CGCGTCGATCTCGTTCGACCGCAAACTCTACGCGCAGGACATACGCGGCTCGATCGCCCATAGCGAGATGCTGGCGCAAA
CGGGCATTATTTCGACGGCCGATCAAGAAAAAATCGCTCACGGCCTGAACACGATCCTGAAAGAGATCGAGGCGGGCAGC
TTCGAGTTTTCGACCAGGCTCGAAGACATCCACATGAATGTCGAGGCCCGCCTCGCCGACCTGATCGGCTCGGCCGCCGG
CCGCCTGCACACCGCGCGCTCACGCAACGACCAGGTGGCGGTGGATCTGCGGCTCTGGGTCAAGGATGAGTGCTTCCGCG
TCGCCGAGGCGTTGAAGGGCCTGATCACCGCGCTGCTGGCGCGGGCCGAGGAGCACGCGGCGACCGTGATGCCGGGCTTC
ACCCATATGCAGGCGGCGCAGCCGGTGACCTTCGGCCATCACTGCATGGCCTATGTCGAGATGTTTGCACGCGACCTGTC
GCGCGTGCGCGACGCCATCGAGCGCATGGACGAGAGCCCGCTCGGCGCCGCCGCCCTTGCCGGCACCAGCTTCCCGATCG
ACCGCCACCGGACCGCCAAGGCGCTCGGCTTCCGCGAGCCGATGCGCAATTCGCTGGACAGCGTCTCCGATCGCGATTTC
GCGCTGGACTTCCTCGCCATGGCGGCGATCTGCGCCACGCATCTGTCGCGGCTGGCCGAGGAGATCATCATCTGGTCGAC
GCCGCAATTCGGCTTCATCAGGCTGTCGGATAGTTTTTCCACCGGCTCCTCGATCATGCCGCAGAAGAAGAACCCTGACG
CCGCCGAACTGGTGCGCGGCAAGACCGGCCGCGTCAACGGCCATCTGGTCGGCCTGCTGACGGTGATGAAGGGCATGCCT
TTGACCTATGGCAAGGACATGCAGGAGGACAAGGAATCGGTGTTCGACGCCGCCGAGACGCTCGACCTGATGCTGGCGGC
GATGACCGGCATGGTCTCGGACATGACGGTCAACGCGGCCGCGATGAAGAAGGCCGCCGGCTCCGGCCACGCGACCGCGA
CCGACCTCGCCGACTGGCTGGTGCGCACGCTCGGCCTGCCCTTCCGCGAGGCGCATCATGTCACCGGCCGCGCGGTGGCG
CTGGCCGAGGAGAAGAAGGTGAGCCTGGAAAAGCTTTCGCTGGAGGACCTGCAGTCGATCAATCCCGGCATCACGGCGGA
CATATTTTCGGTGCTGGCGGTTCAGAACTCGGTCAAGAGCCGCACCAGTTTCGGCGGCACCGCGCCGTCGGAAGTGAGGA
AGCAGATCCGCTATTGGAAAAAGCGGCTGGCCAAAGCCTGA

Upstream 100 bases:

>100_bases
CTCCCGCCACCAAAGCGGCGAGGATCAGGCGCGGGGCCGGGAAAAATCTGTTTCCGTCTGCCATTTTCTCAAAACTGCTC
CGAAGCACGGGTTTATAGCG

Downstream 100 bases:

>100_bases
GCCAGGGGTGCAATGCGCCGAGAACTCGGCTAAAAGCGGCGGCTGACAAAACGTTTCGGACGGATGGATCGATGACCGGA
AGCAGGATTTTGGTGACGCT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL 1; Arginosuccinase 1

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSDKKTSNQMWGGRFASGPAAIMEAINASISFDRKLYAQDIRGSIAHSEMLAQTGIISTADQEKIAHGLNTILKEIEAGS
FEFSTRLEDIHMNVEARLADLIGSAAGRLHTARSRNDQVAVDLRLWVKDECFRVAEALKGLITALLARAEEHAATVMPGF
THMQAAQPVTFGHHCMAYVEMFARDLSRVRDAIERMDESPLGAAALAGTSFPIDRHRTAKALGFREPMRNSLDSVSDRDF
ALDFLAMAAICATHLSRLAEEIIIWSTPQFGFIRLSDSFSTGSSIMPQKKNPDAAELVRGKTGRVNGHLVGLLTVMKGMP
LTYGKDMQEDKESVFDAAETLDLMLAAMTGMVSDMTVNAAAMKKAAGSGHATATDLADWLVRTLGLPFREAHHVTGRAVA
LAEEKKVSLEKLSLEDLQSINPGITADIFSVLAVQNSVKSRTSFGGTAPSEVRKQIRYWKKRLAKA

Sequences:

>Translated_466_residues
MSDKKTSNQMWGGRFASGPAAIMEAINASISFDRKLYAQDIRGSIAHSEMLAQTGIISTADQEKIAHGLNTILKEIEAGS
FEFSTRLEDIHMNVEARLADLIGSAAGRLHTARSRNDQVAVDLRLWVKDECFRVAEALKGLITALLARAEEHAATVMPGF
THMQAAQPVTFGHHCMAYVEMFARDLSRVRDAIERMDESPLGAAALAGTSFPIDRHRTAKALGFREPMRNSLDSVSDRDF
ALDFLAMAAICATHLSRLAEEIIIWSTPQFGFIRLSDSFSTGSSIMPQKKNPDAAELVRGKTGRVNGHLVGLLTVMKGMP
LTYGKDMQEDKESVFDAAETLDLMLAAMTGMVSDMTVNAAAMKKAAGSGHATATDLADWLVRTLGLPFREAHHVTGRAVA
LAEEKKVSLEKLSLEDLQSINPGITADIFSVLAVQNSVKSRTSFGGTAPSEVRKQIRYWKKRLAKA
>Mature_465_residues
SDKKTSNQMWGGRFASGPAAIMEAINASISFDRKLYAQDIRGSIAHSEMLAQTGIISTADQEKIAHGLNTILKEIEAGSF
EFSTRLEDIHMNVEARLADLIGSAAGRLHTARSRNDQVAVDLRLWVKDECFRVAEALKGLITALLARAEEHAATVMPGFT
HMQAAQPVTFGHHCMAYVEMFARDLSRVRDAIERMDESPLGAAALAGTSFPIDRHRTAKALGFREPMRNSLDSVSDRDFA
LDFLAMAAICATHLSRLAEEIIIWSTPQFGFIRLSDSFSTGSSIMPQKKNPDAAELVRGKTGRVNGHLVGLLTVMKGMPL
TYGKDMQEDKESVFDAAETLDLMLAAMTGMVSDMTVNAAAMKKAAGSGHATATDLADWLVRTLGLPFREAHHVTGRAVAL
AEEKKVSLEKLSLEDLQSINPGITADIFSVLAVQNSVKSRTSFGGTAPSEVRKQIRYWKKRLAKA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=451, Percent_Identity=44.5676274944568, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI68303542, Length=451, Percent_Identity=44.5676274944568, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI68303549, Length=451, Percent_Identity=43.0155210643016, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI68303547, Length=451, Percent_Identity=42.1286031042129, Blast_Score=374, Evalue=1e-104,
Organism=Escherichia coli, GI1790398, Length=457, Percent_Identity=47.2647702407002, Blast_Score=422, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6321806, Length=466, Percent_Identity=44.8497854077253, Blast_Score=392, Evalue=1e-110,
Organism=Drosophila melanogaster, GI221473854, Length=457, Percent_Identity=39.6061269146608, Blast_Score=354, Evalue=9e-98,
Organism=Drosophila melanogaster, GI78706858, Length=457, Percent_Identity=39.6061269146608, Blast_Score=354, Evalue=9e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY1_RHILO (Q98G36)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_104594.1
- ProteinModelPortal:   Q98G36
- SMR:   Q98G36
- GeneID:   1227255
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr3506
- NMPDR:   fig|266835.1.peg.2698
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   PRK00855
- BRENDA:   4.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 50779; Mature: 50648

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKKTSNQMWGGRFASGPAAIMEAINASISFDRKLYAQDIRGSIAHSEMLAQTGIISTA
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DQEKIAHGLNTILKEIEAGSFEFSTRLEDIHMNVEARLADLIGSAAGRLHTARSRNDQVA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEE
VDLRLWVKDECFRVAEALKGLITALLARAEEHAATVMPGFTHMQAAQPVTFGHHCMAYVE
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHH
MFARDLSRVRDAIERMDESPLGAAALAGTSFPIDRHRTAKALGFREPMRNSLDSVSDRDF
HHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCHH
ALDFLAMAAICATHLSRLAEEIIIWSTPQFGFIRLSDSFSTGSSIMPQKKNPDAAELVRG
HHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHCC
KTGRVNGHLVGLLTVMKGMPLTYGKDMQEDKESVFDAAETLDLMLAAMTGMVSDMTVNAA
CCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMKKAAGSGHATATDLADWLVRTLGLPFREAHHVTGRAVALAEEKKVSLEKLSLEDLQSI
HHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCHHEEHHHHHHHHHHHHCHHHHHHC
NPGITADIFSVLAVQNSVKSRTSFGGTAPSEVRKQIRYWKKRLAKA
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDKKTSNQMWGGRFASGPAAIMEAINASISFDRKLYAQDIRGSIAHSEMLAQTGIISTA
CCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DQEKIAHGLNTILKEIEAGSFEFSTRLEDIHMNVEARLADLIGSAAGRLHTARSRNDQVA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEE
VDLRLWVKDECFRVAEALKGLITALLARAEEHAATVMPGFTHMQAAQPVTFGHHCMAYVE
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHH
MFARDLSRVRDAIERMDESPLGAAALAGTSFPIDRHRTAKALGFREPMRNSLDSVSDRDF
HHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCHH
ALDFLAMAAICATHLSRLAEEIIIWSTPQFGFIRLSDSFSTGSSIMPQKKNPDAAELVRG
HHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHCC
KTGRVNGHLVGLLTVMKGMPLTYGKDMQEDKESVFDAAETLDLMLAAMTGMVSDMTVNAA
CCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMKKAAGSGHATATDLADWLVRTLGLPFREAHHVTGRAVALAEEKKVSLEKLSLEDLQSI
HHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCHHEEHHHHHHHHHHHHCHHHHHHC
NPGITADIFSVLAVQNSVKSRTSFGGTAPSEVRKQIRYWKKRLAKA
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968