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The map label for this gene is nth [H]

Identifier: 13472772

GI number: 13472772

Start: 2545202

End: 2545918

Strand: Reverse

Name: nth [H]

Synonym: mll3176

Alternate gene names: 13472772

Gene position: 2545918-2545202 (Counterclockwise)

Preceding gene: 13472774

Following gene: 13472770

Centisome position: 36.18

GC content: 63.88

Gene sequence:

>717_bases
GTGCGGCGGACTCCGCGCTACAGTCCGGCGGAGGTGCACGAGATCTTCCGCCGTTTTTCGGTCCAGCGGCCGGAGCCGAA
GGGCGAGCTCGAACACGTCAACGCCTTCACGCTGCTGGTGGCGGTGGTGCTTTCGGCACAGGCGACGGACGCCGGCGTCA
ACAAGGCGACGCGCGCGCTATTCAAGGTCGCTGATACGCCGCGGAAGATGCTGGCGCTGGGTGAGGCCAAGGTCGGCGAC
TATATCAGGACCATCGGCCTGTGGCGCAACAAAGCCAAGAACGTCATCGCGCTGTCGGAAGCGCTGATCCGCGATCATGG
CGGCGTGGTGCCTGACGGTCGTGACGAGCTGGTCAAGCTGCCTGGCGTCGGGCGCAAGACCGCCAATGTCGTGCTGAACA
TGGCCTTCGGCCAGCATACGATGGCAGTCGACACGCACATCTTTCGGATCGGCAACCGGCTCGGCCTGGCGCCCGGCAAG
ACGCCCGAACAGGTCGAGCAAGGGCTGCTGAAGATCATCCCGGACGAATATATGCGCCATGCGCATCACTGGCTGATCCT
GCATGGCCGTTATGTCTGCAAGGCACGCAAGCCGGATTGCCCGGCCTGCGTCATCGCTGACATCTGTAAGGCTGAGGAGA
AGACGAGCAGCATTCCAGCGCCGCTGGTGCCGATCGCTCCGCTTGAAGCCGTGGCCGTTGGCGATCAGATACCGTAG

Upstream 100 bases:

>100_bases
GGAAATGGCGAGCCCCAAGTCCAAAGATTCTTCCATGCCCGAAAAAGACCTACCGGCCGGACGACGCGACGGCTCGAACG
CCAAGCCGCGCCCACGGCCG

Downstream 100 bases:

>100_bases
CCGCGCGCCATCGCCGCCGCGAAAACCGGGATCAGCAGGAAGACGAGCGCCTCGGCGCGGATATAGGTCTTCACCGAGGC
CAGTTCGCCCGCCGGCACGG

Product: endonuclease III

Products: NA

Alternate protein names: DNA-(apurinic or apyrimidinic site) lyase [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MRRTPRYSPAEVHEIFRRFSVQRPEPKGELEHVNAFTLLVAVVLSAQATDAGVNKATRALFKVADTPRKMLALGEAKVGD
YIRTIGLWRNKAKNVIALSEALIRDHGGVVPDGRDELVKLPGVGRKTANVVLNMAFGQHTMAVDTHIFRIGNRLGLAPGK
TPEQVEQGLLKIIPDEYMRHAHHWLILHGRYVCKARKPDCPACVIADICKAEEKTSSIPAPLVPIAPLEAVAVGDQIP

Sequences:

>Translated_238_residues
MRRTPRYSPAEVHEIFRRFSVQRPEPKGELEHVNAFTLLVAVVLSAQATDAGVNKATRALFKVADTPRKMLALGEAKVGD
YIRTIGLWRNKAKNVIALSEALIRDHGGVVPDGRDELVKLPGVGRKTANVVLNMAFGQHTMAVDTHIFRIGNRLGLAPGK
TPEQVEQGLLKIIPDEYMRHAHHWLILHGRYVCKARKPDCPACVIADICKAEEKTSSIPAPLVPIAPLEAVAVGDQIP
>Mature_238_residues
MRRTPRYSPAEVHEIFRRFSVQRPEPKGELEHVNAFTLLVAVVLSAQATDAGVNKATRALFKVADTPRKMLALGEAKVGD
YIRTIGLWRNKAKNVIALSEALIRDHGGVVPDGRDELVKLPGVGRKTANVVLNMAFGQHTMAVDTHIFRIGNRLGLAPGK
TPEQVEQGLLKIIPDEYMRHAHHWLILHGRYVCKARKPDCPACVIADICKAEEKTSSIPAPLVPIAPLEAVAVGDQIP

Specific function: Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site [H]

COG id: COG0177

COG function: function code L; Predicted EndoIII-related endonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI4505471, Length=184, Percent_Identity=32.6086956521739, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI1787920, Length=201, Percent_Identity=56.7164179104478, Blast_Score=233, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17554540, Length=200, Percent_Identity=33.5, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI45550361, Length=177, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR005759
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 26133; Mature: 26133

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRTPRYSPAEVHEIFRRFSVQRPEPKGELEHVNAFTLLVAVVLSAQATDAGVNKATRAL
CCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
FKVADTPRKMLALGEAKVGDYIRTIGLWRNKAKNVIALSEALIRDHGGVVPDGRDELVKL
HHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHEEEC
PGVGRKTANVVLNMAFGQHTMAVDTHIFRIGNRLGLAPGKTPEQVEQGLLKIIPDEYMRH
CCCCCHHHHHEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHH
AHHWLILHGRYVCKARKPDCPACVIADICKAEEKTSSIPAPLVPIAPLEAVAVGDQIP
HHHEEEEECEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCC
>Mature Secondary Structure
MRRTPRYSPAEVHEIFRRFSVQRPEPKGELEHVNAFTLLVAVVLSAQATDAGVNKATRAL
CCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
FKVADTPRKMLALGEAKVGDYIRTIGLWRNKAKNVIALSEALIRDHGGVVPDGRDELVKL
HHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHEEEC
PGVGRKTANVVLNMAFGQHTMAVDTHIFRIGNRLGLAPGKTPEQVEQGLLKIIPDEYMRH
CCCCCHHHHHEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHH
AHHWLILHGRYVCKARKPDCPACVIADICKAEEKTSSIPAPLVPIAPLEAVAVGDQIP
HHHEEEEECEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA