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The map label for this gene is tcmP [H]

Identifier: 13472774

GI number: 13472774

Start: 2546534

End: 2547349

Strand: Reverse

Name: tcmP [H]

Synonym: mll3178

Alternate gene names: 13472774

Gene position: 2547349-2546534 (Counterclockwise)

Preceding gene: 13472777

Following gene: 13472772

Centisome position: 36.2

GC content: 62.38

Gene sequence:

>816_bases
ATGACTGGCGAGAAAGTGCATCTGACCGGGGCAAAAGAAACCTTGCTGATGACGCTCTATGGCAAGGCGCTGGAGAGCCG
GCTGCCCCATTCGCTGCTTGGGGATCATTTCGCCGACGAGGCGGTGCGTAAGATCGACTATGACTTCTCCAGGCTCAAGG
TCGACGAGAATCTCGGCATCGGCCTGGCGATCCGGGCCAAGACACTGGACGTTCGTGTCGAGGATTTTCTGGCCAGAAAT
CCCGGCGCCATCGTGCTGCATCTGGGCTGCGGGCTCGACACGCGCGTCTTCCGTGTCGATCCGCCACCAGGCGTGGACTG
GTTCGATGCCGACTATCCCCAGGTCATCGAACTCAGGCGAAAGCTTTACCCGCCCCGCGACCATTATCATCTCATCGCTT
CGTCGGTGACCGAGCCCGGCTGGCTGGCCGAAGTGCCCCGCAACCGCCCGGCCATGGTGGTGGCGGAAGGGTTGACACCC
TATCTTCCCGCCGACGAAGGGCTGCGCCTGGTTTCGCGGCTTGTCTCGCATCTTGCCGGCGGCGAGCTGATGTTCGACGC
CTACAGCCGTTTCGGCCTGACGCTGCTTCGTCTCAGTCCGACCATCAAGGCGACGGGCGCCGAGGTTCACTGGGCGATCG
ACGATCCGCACGAGCTGGAACTGGCGGTTCCGAAACTGCGGTTCGTCGAGGATATTTCCGCCTACATGCCCGAACACGCC
GCCCGCATGGGCTGGTCGGCCAAACTCTTCGTTCGCCTGTGGAAACACATTCCGGCGCTGCGCAAGGTCGGCAGGCTTCT
GCGCTATCGATTCTAG

Upstream 100 bases:

>100_bases
GCCAGGAATATCGCCCCTTGGGGCGCCGATCGCCACCCGAAACTTGCCTTCTTGCCGCGCATACCCAGATAGACTCGGGC
TTCTTGCCCAGGAGTCGCTC

Downstream 100 bases:

>100_bases
ATTCAGCGCGCCTTGGCGGTCGCCAGCGCGCGTGAAAAAGCCGTCGCAAAACTCTCGCGGGACTCGGGATCGAGAAAACC
GCCGATCGGCACGTTCTGGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MTGEKVHLTGAKETLLMTLYGKALESRLPHSLLGDHFADEAVRKIDYDFSRLKVDENLGIGLAIRAKTLDVRVEDFLARN
PGAIVLHLGCGLDTRVFRVDPPPGVDWFDADYPQVIELRRKLYPPRDHYHLIASSVTEPGWLAEVPRNRPAMVVAEGLTP
YLPADEGLRLVSRLVSHLAGGELMFDAYSRFGLTLLRLSPTIKATGAEVHWAIDDPHELELAVPKLRFVEDISAYMPEHA
ARMGWSAKLFVRLWKHIPALRKVGRLLRYRF

Sequences:

>Translated_271_residues
MTGEKVHLTGAKETLLMTLYGKALESRLPHSLLGDHFADEAVRKIDYDFSRLKVDENLGIGLAIRAKTLDVRVEDFLARN
PGAIVLHLGCGLDTRVFRVDPPPGVDWFDADYPQVIELRRKLYPPRDHYHLIASSVTEPGWLAEVPRNRPAMVVAEGLTP
YLPADEGLRLVSRLVSHLAGGELMFDAYSRFGLTLLRLSPTIKATGAEVHWAIDDPHELELAVPKLRFVEDISAYMPEHA
ARMGWSAKLFVRLWKHIPALRKVGRLLRYRF
>Mature_270_residues
TGEKVHLTGAKETLLMTLYGKALESRLPHSLLGDHFADEAVRKIDYDFSRLKVDENLGIGLAIRAKTLDVRVEDFLARNP
GAIVLHLGCGLDTRVFRVDPPPGVDWFDADYPQVIELRRKLYPPRDHYHLIASSVTEPGWLAEVPRNRPAMVVAEGLTPY
LPADEGLRLVSRLVSHLAGGELMFDAYSRFGLTLLRLSPTIKATGAEVHWAIDDPHELELAVPKLRFVEDISAYMPEHAA
RMGWSAKLFVRLWKHIPALRKVGRLLRYRF

Specific function: O-methyltransferase that catalyzes the methylation of the C-9 carboxy group of tetracenomycin E (TCM E) to yield TCM A2. Catalyzes as well the following side reactions:methylation of 8- O-methyl-TCM D3 to 9-carboxymethyl-8-O-methyl-TCM D3; and of TCM B3 t

COG id: COG3315

COG function: function code Q; O-Methyltransferase involved in polyketide biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007213
- InterPro:   IPR016874 [H]

Pfam domain/function: PF04072 LCM [H]

EC number: NA

Molecular weight: Translated: 30618; Mature: 30487

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGEKVHLTGAKETLLMTLYGKALESRLPHSLLGDHFADEAVRKIDYDFSRLKVDENLGI
CCCCEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHEEECCCCCC
GLAIRAKTLDVRVEDFLARNPGAIVLHLGCGLDTRVFRVDPPPGVDWFDADYPQVIELRR
EEEEEEEEEEEEHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHHHHH
KLYPPRDHYHLIASSVTEPGWLAEVPRNRPAMVVAEGLTPYLPADEGLRLVSRLVSHLAG
HCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCC
GELMFDAYSRFGLTLLRLSPTIKATGAEVHWAIDDPHELELAVPKLRFVEDISAYMPEHA
CCEEHHHHHHHCEEEEEECCCEEECCCEEEEECCCCCCEEEECHHHHHHHHHHHHCCHHH
ARMGWSAKLFVRLWKHIPALRKVGRLLRYRF
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TGEKVHLTGAKETLLMTLYGKALESRLPHSLLGDHFADEAVRKIDYDFSRLKVDENLGI
CCCEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHEEECCCCCC
GLAIRAKTLDVRVEDFLARNPGAIVLHLGCGLDTRVFRVDPPPGVDWFDADYPQVIELRR
EEEEEEEEEEEEHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHHHHH
KLYPPRDHYHLIASSVTEPGWLAEVPRNRPAMVVAEGLTPYLPADEGLRLVSRLVSHLAG
HCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCC
GELMFDAYSRFGLTLLRLSPTIKATGAEVHWAIDDPHELELAVPKLRFVEDISAYMPEHA
CCEEHHHHHHHCEEEEEECCCEEECCCEEEEECCCCCCEEEECHHHHHHHHHHHHCCHHH
ARMGWSAKLFVRLWKHIPALRKVGRLLRYRF
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8509339 [H]