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The map label for this gene is add

Identifier: 13472761

GI number: 13472761

Start: 2533673

End: 2534647

Strand: Reverse

Name: add

Synonym: mll3163

Alternate gene names: 13472761

Gene position: 2534647-2533673 (Counterclockwise)

Preceding gene: 13472765

Following gene: 13472760

Centisome position: 36.02

GC content: 64.1

Gene sequence:

>975_bases
ATGCCTTTGAAAGCGGAACTGCACTGCCACATTGAAGGGGCAGCGGCGCCCGAACTCGTCATCCGCCAGGCGCAGAAATA
CGGCAAGGACACCGCGCCCTATATCCAAAACGGTTCCTTCGTCTGGCACGATTTTACGTCCTTTCTCGCGGCTTACGATT
TTTCCGCCGAACTGTTCCGCACCGAAGAGGATTACGCCCGGCTGGCCGATCACTACCTGACCAGCCTTGCCCGCGATGGC
GCCATCTATTCCGAAGTCTTCACCTCGCCGGACCATGCGACGAAAGCCGGGCTCTCGCCCAAGGCCTATACCGATGCGCT
GGGCGAAGGCATGCTGCGCGCCAAGGCCAAGACCGGCATAGAGGGCCGCATGATCGTCACCGGCGTGCGCCATGTCGGCG
TGGAATCGATCGAACGGGCGGCGCGCTTCGCGGCGCGCTGCGGCAATCCGCTGGTCACTGGCTTCGGCGTTGCCGGCGAC
GAGCGCGTGGGTGAGATGGAGGACTATGTCAGGGCTTTCGAGATCGCGCGAGAGGCCGGGCTCGGCATCACCATCCATGC
CGGCGAACTGACGGGCTGGGAGACTGTCCAGGCGGCGCTTGACCATATCCGCCCCTCGCGCATCGGCCACGGCGTGCGCG
CCATCGAGAACCCGGACCTTGTCCGCCGCATCGCCGACGAAGGCATCGTTCTGGAGTGCTGCCCCGGCTCCAACATCGCG
CTCAAGGTGTTCGACAGTTTTGCCGACCATCCGCTCCCGGCCTTGCAGGCCGCCGGCTGCAAGGTGACGCTCAACTCCGA
CGACCCGCCCTATTTCTGGACCTCGCTGAAGCGCGAATACGATATCGCGGCGGAGCATTTTGCGATGAACGAAAAGGCGC
TTGCCGCCGTCACCAGAACCGCCATCGAAGCCGCCTTTGTCGACAGGAAGACCAAGGCGGCACTTCTTGCCCGGCTGAAC
GGCGCGGCGCGCTGA

Upstream 100 bases:

>100_bases
GCCGATCGATGCTGTGGGCGCTATTGTTTAAGGCGCGGTGTTCAGCCGCGCTTCCAGGTGGTGGGTTTTCAAGACCTGGA
CTGACCGACGGGATGTTTGA

Downstream 100 bases:

>100_bases
TTTTCTTCCGACAAAGCTGTGGTCGATGGCGGCCAAGCGGTTCCTTGGCCGGTCCATAGTCGCTAGGGTCGTTCCAGCTG
CCTGAAGCGCGTCCGCGCGC

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MPLKAELHCHIEGAAAPELVIRQAQKYGKDTAPYIQNGSFVWHDFTSFLAAYDFSAELFRTEEDYARLADHYLTSLARDG
AIYSEVFTSPDHATKAGLSPKAYTDALGEGMLRAKAKTGIEGRMIVTGVRHVGVESIERAARFAARCGNPLVTGFGVAGD
ERVGEMEDYVRAFEIAREAGLGITIHAGELTGWETVQAALDHIRPSRIGHGVRAIENPDLVRRIADEGIVLECCPGSNIA
LKVFDSFADHPLPALQAAGCKVTLNSDDPPYFWTSLKREYDIAAEHFAMNEKALAAVTRTAIEAAFVDRKTKAALLARLN
GAAR

Sequences:

>Translated_324_residues
MPLKAELHCHIEGAAAPELVIRQAQKYGKDTAPYIQNGSFVWHDFTSFLAAYDFSAELFRTEEDYARLADHYLTSLARDG
AIYSEVFTSPDHATKAGLSPKAYTDALGEGMLRAKAKTGIEGRMIVTGVRHVGVESIERAARFAARCGNPLVTGFGVAGD
ERVGEMEDYVRAFEIAREAGLGITIHAGELTGWETVQAALDHIRPSRIGHGVRAIENPDLVRRIADEGIVLECCPGSNIA
LKVFDSFADHPLPALQAAGCKVTLNSDDPPYFWTSLKREYDIAAEHFAMNEKALAAVTRTAIEAAFVDRKTKAALLARLN
GAAR
>Mature_323_residues
PLKAELHCHIEGAAAPELVIRQAQKYGKDTAPYIQNGSFVWHDFTSFLAAYDFSAELFRTEEDYARLADHYLTSLARDGA
IYSEVFTSPDHATKAGLSPKAYTDALGEGMLRAKAKTGIEGRMIVTGVRHVGVESIERAARFAARCGNPLVTGFGVAGDE
RVGEMEDYVRAFEIAREAGLGITIHAGELTGWETVQAALDHIRPSRIGHGVRAIENPDLVRRIADEGIVLECCPGSNIAL
KVFDSFADHPLPALQAAGCKVTLNSDDPPYFWTSLKREYDIAAEHFAMNEKALAAVTRTAIEAAFVDRKTKAALLARLNG
AAR

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family

Homologues:

Organism=Homo sapiens, GI47078295, Length=341, Percent_Identity=24.9266862170088, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI226693318, Length=330, Percent_Identity=21.8181818181818, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI61175224, Length=218, Percent_Identity=23.8532110091743, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1787910, Length=324, Percent_Identity=27.1604938271605, Blast_Score=115, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32565969, Length=336, Percent_Identity=23.8095238095238, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17538512, Length=336, Percent_Identity=23.8095238095238, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324188, Length=331, Percent_Identity=25.9818731117825, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24645260, Length=329, Percent_Identity=24.6200607902736, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADD_RHILO (Q98GV2)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_104328.1
- ProteinModelPortal:   Q98GV2
- SMR:   Q98GV2
- GeneID:   1226989
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll3163
- NMPDR:   fig|266835.1.peg.2432
- HOGENOM:   HBG630382
- OMA:   CHIEGAA
- ProtClustDB:   PRK09358
- BRENDA:   3.5.4.4
- HAMAP:   MF_00540
- InterPro:   IPR001365
- InterPro:   IPR006330
- PANTHER:   PTHR11409
- TIGRFAMs:   TIGR01430

Pfam domain/function: PF00962 A_deaminase

EC number: =3.5.4.4

Molecular weight: Translated: 35247; Mature: 35116

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00485 A_DEAMINASE

Important sites: ACT_SITE 189-189 BINDING 10-10 BINDING 12-12 BINDING 159-159 BINDING 268-268

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLKAELHCHIEGAAAPELVIRQAQKYGKDTAPYIQNGSFVWHDFTSFLAAYDFSAELFR
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEECCCEEEHHHHHHHHHHCCHHHHHC
TEEDYARLADHYLTSLARDGAIYSEVFTSPDHATKAGLSPKAYTDALGEGMLRAKAKTGI
CHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCC
EGRMIVTGVRHVGVESIERAARFAARCGNPLVTGFGVAGDERVGEMEDYVRAFEIAREAG
CCEEEEEHHHHHCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHC
LGITIHAGELTGWETVQAALDHIRPSRIGHGVRAIENPDLVRRIADEGIVLECCPGSNIA
CEEEEECCCCCCHHHHHHHHHHCCHHHHCCCHHHCCCHHHHHHHHCCCEEEEECCCCCEE
LKVFDSFADHPLPALQAAGCKVTLNSDDPPYFWTSLKREYDIAAEHFAMNEKALAAVTRT
EEEEHHHCCCCCCHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AIEAAFVDRKTKAALLARLNGAAR
HHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PLKAELHCHIEGAAAPELVIRQAQKYGKDTAPYIQNGSFVWHDFTSFLAAYDFSAELFR
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCEEECCCEEEHHHHHHHHHHCCHHHHHC
TEEDYARLADHYLTSLARDGAIYSEVFTSPDHATKAGLSPKAYTDALGEGMLRAKAKTGI
CHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCC
EGRMIVTGVRHVGVESIERAARFAARCGNPLVTGFGVAGDERVGEMEDYVRAFEIAREAG
CCEEEEEHHHHHCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHC
LGITIHAGELTGWETVQAALDHIRPSRIGHGVRAIENPDLVRRIADEGIVLECCPGSNIA
CEEEEECCCCCCHHHHHHHHHHCCHHHHCCCHHHCCCHHHHHHHHCCCEEEEECCCCCEE
LKVFDSFADHPLPALQAAGCKVTLNSDDPPYFWTSLKREYDIAAEHFAMNEKALAAVTRT
EEEEHHHCCCCCCHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AIEAAFVDRKTKAALLARLNGAAR
HHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968