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The map label for this gene is upp

Identifier: 13472760

GI number: 13472760

Start: 2532917

End: 2533546

Strand: Reverse

Name: upp

Synonym: mll3162

Alternate gene names: 13472760

Gene position: 2533546-2532917 (Counterclockwise)

Preceding gene: 13472761

Following gene: 13472759

Centisome position: 36.01

GC content: 63.49

Gene sequence:

>630_bases
ATGAAGGGCGTCACCGTCGTCGACCATCCGCTTGTCCAGCACAAGCTGACCATCATGCGCAAGAAGGAGACGTCCACGGC
CGGTTTCAGGCGGCTGTTGCGCGAGATATCGCTGCTGCTCGGCTACGAGGTCACGCGCAATCTCGAGCTGACGACAACAA
CCATCGAAACGCCGATCGAGACCATGGAAGCGCCGACGCTGGAGGGCAAGAAGCTGGTGTTTGCTTCGGTGCTGCGCGCC
GGCAACGGTCTGCTGGAAGGCCTGCTCGACCTGGTGCCGGCGGCGCGCGTCGCCCATATCGGCCTCTATCGCGACCACGA
GACGCTGGAAGCGGTCGAATATTTCTTCAAGGCGCCGAGCGATCTCGCCGACCGGCTGGTGATCGTCGTCGACCCGATGC
TGGCGACCGCCAATTCGGCGATCGCGGCGATCGACAAGCTGAAAGGGCGCGGCGCCACAAATATCCGCTTCCTCTGCCTT
TTGGCGGCACCCGAAGGCATCGAGCGCTTCACCAAGGCGCATCCGGACGTTCCGGTCTTCACCGCGTCCATCGACCGCCA
GCTCAACGAGAAGGGCTACATCATGCCCGGCCTTGGTGACGCCGGCGACCGCATGTACGGGACGAAGTAG

Upstream 100 bases:

>100_bases
TGGCGGCCAAGCGGTTCCTTGGCCGGTCCATAGTCGCTAGGGTCGTTCCAGCTGCCTGAAGCGCGTCCGCGCGCCGGGCG
ACACGCATCAGGAGAACATC

Downstream 100 bases:

>100_bases
TAACAGGTTGCCTGGTACGATTTACCAAGCGTTTACGCAAAGACATGGTTTCGGCGCCCGTTAAAGCGGCGAACACCATC
CGGCGATAATGAATCGGCTC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MKGVTVVDHPLVQHKLTIMRKKETSTAGFRRLLREISLLLGYEVTRNLELTTTTIETPIETMEAPTLEGKKLVFASVLRA
GNGLLEGLLDLVPAARVAHIGLYRDHETLEAVEYFFKAPSDLADRLVIVVDPMLATANSAIAAIDKLKGRGATNIRFLCL
LAAPEGIERFTKAHPDVPVFTASIDRQLNEKGYIMPGLGDAGDRMYGTK

Sequences:

>Translated_209_residues
MKGVTVVDHPLVQHKLTIMRKKETSTAGFRRLLREISLLLGYEVTRNLELTTTTIETPIETMEAPTLEGKKLVFASVLRA
GNGLLEGLLDLVPAARVAHIGLYRDHETLEAVEYFFKAPSDLADRLVIVVDPMLATANSAIAAIDKLKGRGATNIRFLCL
LAAPEGIERFTKAHPDVPVFTASIDRQLNEKGYIMPGLGDAGDRMYGTK
>Mature_209_residues
MKGVTVVDHPLVQHKLTIMRKKETSTAGFRRLLREISLLLGYEVTRNLELTTTTIETPIETMEAPTLEGKKLVFASVLRA
GNGLLEGLLDLVPAARVAHIGLYRDHETLEAVEYFFKAPSDLADRLVIVVDPMLATANSAIAAIDKLKGRGATNIRFLCL
LAAPEGIERFTKAHPDVPVFTASIDRQLNEKGYIMPGLGDAGDRMYGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=206, Percent_Identity=29.6116504854369, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI57863312, Length=206, Percent_Identity=29.6116504854369, Blast_Score=81, Evalue=8e-16,
Organism=Escherichia coli, GI87082118, Length=203, Percent_Identity=52.2167487684729, Blast_Score=217, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=23.8805970149254, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=23.8805970149254, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321920, Length=193, Percent_Identity=38.3419689119171, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28573516, Length=210, Percent_Identity=31.9047619047619, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28573514, Length=210, Percent_Identity=31.9047619047619, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28573512, Length=210, Percent_Identity=31.9047619047619, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45550449, Length=210, Percent_Identity=31.9047619047619, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_RHILO (Q98GV3)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_104327.1
- ProteinModelPortal:   Q98GV3
- SMR:   Q98GV3
- GeneID:   1226988
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll3162
- NMPDR:   fig|266835.1.peg.2431
- HOGENOM:   HBG326432
- OMA:   LRAGNGF
- ProtClustDB:   PRK00129
- BRENDA:   2.4.2.9
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22927; Mature: 22927

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: NA

Important sites: BINDING 79-79 BINDING 104-104 BINDING 194-194 BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGVTVVDHPLVQHKLTIMRKKETSTAGFRRLLREISLLLGYEVTRNLELTTTTIETPIE
CCCCEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHHCCHH
TMEAPTLEGKKLVFASVLRAGNGLLEGLLDLVPAARVAHIGLYRDHETLEAVEYFFKAPS
HHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCH
DLADRLVIVVDPMLATANSAIAAIDKLKGRGATNIRFLCLLAAPEGIERFTKAHPDVPVF
HHHCCEEEEECCHHHHCCHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHCCCCCCEE
TASIDRQLNEKGYIMPGLGDAGDRMYGTK
EHHHHHHHCCCCCEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKGVTVVDHPLVQHKLTIMRKKETSTAGFRRLLREISLLLGYEVTRNLELTTTTIETPIE
CCCCEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHHCCHH
TMEAPTLEGKKLVFASVLRAGNGLLEGLLDLVPAARVAHIGLYRDHETLEAVEYFFKAPS
HHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCH
DLADRLVIVVDPMLATANSAIAAIDKLKGRGATNIRFLCLLAAPEGIERFTKAHPDVPVF
HHHCCEEEEECCHHHHCCHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHCCCCCCEE
TASIDRQLNEKGYIMPGLGDAGDRMYGTK
EHHHHHHHCCCCCEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968