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The map label for this gene is mdh [H]

Identifier: 13472696

GI number: 13472696

Start: 2473925

End: 2475097

Strand: Reverse

Name: mdh [H]

Synonym: mll3070

Alternate gene names: 13472696

Gene position: 2475097-2473925 (Counterclockwise)

Preceding gene: 13472697

Following gene: 13472695

Centisome position: 35.18

GC content: 64.45

Gene sequence:

>1173_bases
ATGTCCAAACTCATCTCCAAATGGAACTACCCCACCACCGTCCGCTTCGGCGCCGGGCGTATCAAGGAATTGCCTGAGGT
GCTCGAGGCCACCGGTATCAAGCGGCCGCTCTTCGTCACCGATCCGGGCCTGGCGAAACTGCCGGTCGTCGCTTCGACGC
TGAAGATCCTCGACGATGCCAAGGTGCCTTACGGTGTGTTTTCCGAGGTGAAGCCGAATCCGGTCGATTCCAACCTCACC
GCCGGCATCGCCGTGTTCAAGAAGGGCAAGCATGACGGCGTCATCGCCTTCGGCGGCGGCTCGGCGCTCGATCTCGGCAA
GCTGATCGCCTTCCAGGCCGGCCAGACGCGGCCGGTGTGGGATTTCGAGGATGTCGGCGACTGGTGGACGCGCGCCAATT
CGGATGCGATCGCGCCGATCATCGCCGTGCCGACGACGGCCGGCACCGGCTCGGAAGTCGGCCGCGCCGGCGTCATCACC
AATGAGGAGACGCACACCAAGAAGGTCATCTTCCATCCGAAGCTCTTGCCGGCGATCGTCATTGCCGATCCGGAACTGTC
GGTCGGCATGCCCGCCTTCATCACCGCCGGCACCGGCATGGATGCGCTTGCCCACTGCCTCGAGGCCTATTGCGCGCCGG
GTTACCATCCGATGGCTGACGGCATCGCGGTGGAAGGCATCCGGCTGGTGTTTGAAAACCTGCCGAAGGCCTATGCCAAC
GGCAAGGACCTGGTCGCGCGTGCCCATATGATGAGCGCGGCCGCCATGGGCGCCGCCGCCTTCCAGAAGGGGCTGGGCGC
CATCCACTCGCTGTCGCACCCGATCGGCGCGCTCTACGACACCCATCACGGCATGACCAATGCGGTGTTCATGCCTTATG
TGCTCGCCTTCAATCGTGACTCCATCGAGGAGCGTATCGCCCGGCTCGCCGCCTATTGCGGCATCAAGGGCGGCTTCGAC
GGCTTCGCCAAGGCGATCATCAAGCTGCGCAAGGAGTTGAAGGTGCCGCACGCGCTGCCGGGCCTGATCAAGGGGCTCGA
CATGGACAAGAAGCGCAAGGCGCTGATCGCCGACATGGCGGTGGTCGATCCGACCGCCGGCGGCAACCCGGTCAAGCTGA
CCAAGAAGGCGGCGCTGACGCTGCTGGAAAACGCTATCGCCGGCACGATCTGA

Upstream 100 bases:

>100_bases
CGGAAAGGGCGCGGGACTGTCGGCCATCGGCTACGACAATCTGACCCGGCCGAAATCCTTCCACCTGCGCGAAGCCATCT
GATTTTTCGAAAGACAAAAA

Downstream 100 bases:

>100_bases
CGGTCTCGTCATCGCCGGAAATTGATCTGGAAAATCAGGGCTAACCAAGGGGGAAAGGATGAAATGCAAGGCTGAAAGTG
ATTAGCCGGAAAAATAAGTG

Product: dehydrogenase, (iron-containing alcohol dehydrogenase, 4-hydroxybutyrate dehydrogenase, methanol dehydrogenase)

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MSKLISKWNYPTTVRFGAGRIKELPEVLEATGIKRPLFVTDPGLAKLPVVASTLKILDDAKVPYGVFSEVKPNPVDSNLT
AGIAVFKKGKHDGVIAFGGGSALDLGKLIAFQAGQTRPVWDFEDVGDWWTRANSDAIAPIIAVPTTAGTGSEVGRAGVIT
NEETHTKKVIFHPKLLPAIVIADPELSVGMPAFITAGTGMDALAHCLEAYCAPGYHPMADGIAVEGIRLVFENLPKAYAN
GKDLVARAHMMSAAAMGAAAFQKGLGAIHSLSHPIGALYDTHHGMTNAVFMPYVLAFNRDSIEERIARLAAYCGIKGGFD
GFAKAIIKLRKELKVPHALPGLIKGLDMDKKRKALIADMAVVDPTAGGNPVKLTKKAALTLLENAIAGTI

Sequences:

>Translated_390_residues
MSKLISKWNYPTTVRFGAGRIKELPEVLEATGIKRPLFVTDPGLAKLPVVASTLKILDDAKVPYGVFSEVKPNPVDSNLT
AGIAVFKKGKHDGVIAFGGGSALDLGKLIAFQAGQTRPVWDFEDVGDWWTRANSDAIAPIIAVPTTAGTGSEVGRAGVIT
NEETHTKKVIFHPKLLPAIVIADPELSVGMPAFITAGTGMDALAHCLEAYCAPGYHPMADGIAVEGIRLVFENLPKAYAN
GKDLVARAHMMSAAAMGAAAFQKGLGAIHSLSHPIGALYDTHHGMTNAVFMPYVLAFNRDSIEERIARLAAYCGIKGGFD
GFAKAIIKLRKELKVPHALPGLIKGLDMDKKRKALIADMAVVDPTAGGNPVKLTKKAALTLLENAIAGTI
>Mature_389_residues
SKLISKWNYPTTVRFGAGRIKELPEVLEATGIKRPLFVTDPGLAKLPVVASTLKILDDAKVPYGVFSEVKPNPVDSNLTA
GIAVFKKGKHDGVIAFGGGSALDLGKLIAFQAGQTRPVWDFEDVGDWWTRANSDAIAPIIAVPTTAGTGSEVGRAGVITN
EETHTKKVIFHPKLLPAIVIADPELSVGMPAFITAGTGMDALAHCLEAYCAPGYHPMADGIAVEGIRLVFENLPKAYANG
KDLVARAHMMSAAAMGAAAFQKGLGAIHSLSHPIGALYDTHHGMTNAVFMPYVLAFNRDSIEERIARLAAYCGIKGGFDG
FAKAIIKLRKELKVPHALPGLIKGLDMDKKRKALIADMAVVDPTAGGNPVKLTKKAALTLLENAIAGTI

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=339, Percent_Identity=30.0884955752212, Blast_Score=123, Evalue=3e-28,
Organism=Escherichia coli, GI48994951, Length=376, Percent_Identity=32.7127659574468, Blast_Score=198, Evalue=5e-52,
Organism=Escherichia coli, GI1789163, Length=383, Percent_Identity=30.5483028720627, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI87082107, Length=308, Percent_Identity=32.1428571428571, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1787493, Length=393, Percent_Identity=30.5343511450382, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1789386, Length=313, Percent_Identity=27.7955271565495, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17537053, Length=289, Percent_Identity=28.719723183391, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321181, Length=375, Percent_Identity=33.6, Blast_Score=213, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24657991, Length=328, Percent_Identity=26.5243902439024, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 41262; Mature: 41130

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLISKWNYPTTVRFGAGRIKELPEVLEATGIKRPLFVTDPGLAKLPVVASTLKILDDA
CCCHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCC
KVPYGVFSEVKPNPVDSNLTAGIAVFKKGKHDGVIAFGGGSALDLGKLIAFQAGQTRPVW
CCCCCHHHCCCCCCCCCCCHHHHHHEECCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCC
DFEDVGDWWTRANSDAIAPIIAVPTTAGTGSEVGRAGVITNEETHTKKVIFHPKLLPAIV
CHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEE
IADPELSVGMPAFITAGTGMDALAHCLEAYCAPGYHPMADGIAVEGIRLVFENLPKAYAN
EECCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
GKDLVARAHMMSAAAMGAAAFQKGLGAIHSLSHPIGALYDTHHGMTNAVFMPYVLAFNRD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHCCHH
SIEERIARLAAYCGIKGGFDGFAKAIIKLRKELKVPHALPGLIKGLDMDKKRKALIADMA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHH
VVDPTAGGNPVKLTKKAALTLLENAIAGTI
EECCCCCCCCEEEHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKLISKWNYPTTVRFGAGRIKELPEVLEATGIKRPLFVTDPGLAKLPVVASTLKILDDA
CCHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCC
KVPYGVFSEVKPNPVDSNLTAGIAVFKKGKHDGVIAFGGGSALDLGKLIAFQAGQTRPVW
CCCCCHHHCCCCCCCCCCCHHHHHHEECCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCC
DFEDVGDWWTRANSDAIAPIIAVPTTAGTGSEVGRAGVITNEETHTKKVIFHPKLLPAIV
CHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEE
IADPELSVGMPAFITAGTGMDALAHCLEAYCAPGYHPMADGIAVEGIRLVFENLPKAYAN
EECCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
GKDLVARAHMMSAAAMGAAAFQKGLGAIHSLSHPIGALYDTHHGMTNAVFMPYVLAFNRD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHCCHH
SIEERIARLAAYCGIKGGFDGFAKAIIKLRKELKVPHALPGLIKGLDMDKKRKALIADMA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHH
VVDPTAGGNPVKLTKKAALTLLENAIAGTI
EECCCCCCCCEEEHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]