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The map label for this gene is hemH [H]

Identifier: 13472340

GI number: 13472340

Start: 2104401

End: 2105414

Strand: Reverse

Name: hemH [H]

Synonym: mll2603

Alternate gene names: 13472340

Gene position: 2105414-2104401 (Counterclockwise)

Preceding gene: 13472344

Following gene: 13472339

Centisome position: 29.92

GC content: 62.72

Gene sequence:

>1014_bases
ATGCATGGGGTCGACAGCTTATGCGAGGGCATTCATTTGCTCTGGCCACCTCTGCGGAAGGCGGGAAATCATATGCGGAC
CCTGTCGGATGCGTTCATTCCCGAGCTGCCGGGCTACTACAAGGGCAAGGTTCGAGAAAACTACGATCTGGCGGACGGGC
GGCGCATCATCATCGCCACCGACCGTCTCAGCGCCTTCGACATCATCCTGACCTCGATCCCGTTCAAGGGCGAGATCCTG
ACCCAGACGGCGCGCTACTGGTTCGAGGAAACCGCCGATATCTGCCCGAACCATGTGCTCGAATATCCCGACCCCAATGT
CGTCGTCGGCACGAGGCTCGACATCCTGCCCGTCGAGATCGTCGTGCGTGGCTATCTCGCCGGCACCACCAGCACCTCGA
TCCTGACCCGCTATCGTCGCGGCGAACGGGAGATGTATGGAATGCGCCTGCCTGACGGCCTGCGCGACAATGAGAAGCTG
GCCGCGCCCGTCATCACGCCGACGAGCAAGGCGGCGGATGGCGGCCATGACGAGCCGCTGTCGAGGGCCGAGATCCTCGC
GCAGGGCCTGCTCACGCAGGCGCAATGGGACACCGTCTCGGATTACGCCTTGAAGCTGTTCGCGCGCGGCCAGGCACGTG
CCGCCGAGCGCGGCCTGATCCTTGCCGACACCAAATACGAATTCGGCACAGACAAGAACGGCACGATCATCCTGGCCGAT
GAAATCCATACGCCCGACAGCAGCCGGTACTGGATCGCGGCGAGCTATGAACAGGCGCTGGCCAGCGGCACGCGGCCGGA
CAGCTTCGACAAGGATTTCATCCGCTCCTGGGTGGCGGCGCGCTGCGATCCTTACAAGGACCCGATCCCCAGGATTCCAG
ACGAGATCGTCGAACAGGCCTCGCGCATCTATGCCCAAGCCTACGAAGCGATCACGGGCAAGGCATTCGTTCCCGACCTT
TCCGGGGACACGGTTCTCGATCGCATCCGTTCGAACCTGGTGCGCTTCTTCTAG

Upstream 100 bases:

>100_bases
GACGGGTTCGCCGCGTCGCCGGGCCTTCCGGCATGCGTTGTGAAAAAAGCGACTGGAATGCGAGGTCGAGTTGCGGGGAA
TACCGACAATCGCGCTTGAT

Downstream 100 bases:

>100_bases
CAGCCAGGCGAAGCTTTTCCCGGCGCGCGTTGACGCGTTAGCGCCATGACGCTACGGGATCGAGGGCAGTCGATCTCAAG
CCTTCGACCTCGGGGGATTT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase 2 [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MHGVDSLCEGIHLLWPPLRKAGNHMRTLSDAFIPELPGYYKGKVRENYDLADGRRIIIATDRLSAFDIILTSIPFKGEIL
TQTARYWFEETADICPNHVLEYPDPNVVVGTRLDILPVEIVVRGYLAGTTSTSILTRYRRGEREMYGMRLPDGLRDNEKL
AAPVITPTSKAADGGHDEPLSRAEILAQGLLTQAQWDTVSDYALKLFARGQARAAERGLILADTKYEFGTDKNGTIILAD
EIHTPDSSRYWIAASYEQALASGTRPDSFDKDFIRSWVAARCDPYKDPIPRIPDEIVEQASRIYAQAYEAITGKAFVPDL
SGDTVLDRIRSNLVRFF

Sequences:

>Translated_337_residues
MHGVDSLCEGIHLLWPPLRKAGNHMRTLSDAFIPELPGYYKGKVRENYDLADGRRIIIATDRLSAFDIILTSIPFKGEIL
TQTARYWFEETADICPNHVLEYPDPNVVVGTRLDILPVEIVVRGYLAGTTSTSILTRYRRGEREMYGMRLPDGLRDNEKL
AAPVITPTSKAADGGHDEPLSRAEILAQGLLTQAQWDTVSDYALKLFARGQARAAERGLILADTKYEFGTDKNGTIILAD
EIHTPDSSRYWIAASYEQALASGTRPDSFDKDFIRSWVAARCDPYKDPIPRIPDEIVEQASRIYAQAYEAITGKAFVPDL
SGDTVLDRIRSNLVRFF
>Mature_337_residues
MHGVDSLCEGIHLLWPPLRKAGNHMRTLSDAFIPELPGYYKGKVRENYDLADGRRIIIATDRLSAFDIILTSIPFKGEIL
TQTARYWFEETADICPNHVLEYPDPNVVVGTRLDILPVEIVVRGYLAGTTSTSILTRYRRGEREMYGMRLPDGLRDNEKL
AAPVITPTSKAADGGHDEPLSRAEILAQGLLTQAQWDTVSDYALKLFARGQARAAERGLILADTKYEFGTDKNGTIILAD
EIHTPDSSRYWIAASYEQALASGTRPDSFDKDFIRSWVAARCDPYKDPIPRIPDEIVEQASRIYAQAYEAITGKAFVPDL
SGDTVLDRIRSNLVRFF

Specific function: Unknown

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=305, Percent_Identity=34.0983606557377, Blast_Score=176, Evalue=6e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 37754; Mature: 37754

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGVDSLCEGIHLLWPPLRKAGNHMRTLSDAFIPELPGYYKGKVRENYDLADGRRIIIAT
CCCHHHHHCCHHHHCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEE
DRLSAFDIILTSIPFKGEILTQTARYWFEETADICPNHVLEYPDPNVVVGTRLDILPVEI
CCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCCCCCEEEECCCCHHHHHH
VVRGYLAGTTSTSILTRYRRGEREMYGMRLPDGLRDNEKLAAPVITPTSKAADGGHDEPL
HHHHHHCCCCHHHHHHHHHHCCHHHCCCCCCCCCCCCCCEECCEECCCCCCCCCCCCCCH
SRAEILAQGLLTQAQWDTVSDYALKLFARGQARAAERGLILADTKYEFGTDKNGTIILAD
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHCCEEEEECCCCCCCCCCCEEEEEE
EIHTPDSSRYWIAASYEQALASGTRPDSFDKDFIRSWVAARCDPYKDPIPRIPDEIVEQA
CCCCCCCCCEEEEECHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
SRIYAQAYEAITGKAFVPDLSGDTVLDRIRSNLVRFF
HHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHGVDSLCEGIHLLWPPLRKAGNHMRTLSDAFIPELPGYYKGKVRENYDLADGRRIIIAT
CCCHHHHHCCHHHHCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEE
DRLSAFDIILTSIPFKGEILTQTARYWFEETADICPNHVLEYPDPNVVVGTRLDILPVEI
CCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCCCCCEEEECCCCHHHHHH
VVRGYLAGTTSTSILTRYRRGEREMYGMRLPDGLRDNEKLAAPVITPTSKAADGGHDEPL
HHHHHHCCCCHHHHHHHHHHCCHHHCCCCCCCCCCCCCCEECCEECCCCCCCCCCCCCCH
SRAEILAQGLLTQAQWDTVSDYALKLFARGQARAAERGLILADTKYEFGTDKNGTIILAD
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHCCEEEEECCCCCCCCCCCEEEEEE
EIHTPDSSRYWIAASYEQALASGTRPDSFDKDFIRSWVAARCDPYKDPIPRIPDEIVEQA
CCCCCCCCCEEEEECHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
SRIYAQAYEAITGKAFVPDLSGDTVLDRIRSNLVRFF
HHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]