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The map label for this gene is dgoD [H]

Identifier: 13472126

GI number: 13472126

Start: 1872981

End: 1874147

Strand: Reverse

Name: dgoD [H]

Synonym: mll2323

Alternate gene names: 13472126

Gene position: 1874147-1872981 (Counterclockwise)

Preceding gene: 13472127

Following gene: 13472125

Centisome position: 26.64

GC content: 62.13

Gene sequence:

>1167_bases
ATGAAAATCACGAGCATCCGGCCGTGGCTGATCAAATCCGATGCGTCTTATTGGGGAGAGTACCTGTTCGTCGAAGTGAC
GACCGACGAAGGCGTGAGTGGCTGGGGAGAGATCACCACCACGACGAAGCTGGCCAACCGGGCGCTCTGCACGATCCTGC
GGCAGATCGGCGCCGCCGTGACCGGCGAGGATCCGGCGCGCATCGAGCACCTGTGGCACAAGATTTTCCGCAGCTTTACC
TATATGGGCAGCCGCGGCGCCGCCGTCGAATGCGTGAGCGCCATCGACATAGCGCTCTGGGATATCCGGGGCAAAGTCCT
CGGCAAGCCGATCTACGAGTTGCTGGGCGGACCGGTGCGCGATGAAATCGCGCTCTACACCCATCCCAACCAGGCCAAAT
TCACCAGCAAGGAGGCTGTGGTCCGCGAAATCCGCGACATCGTCGAGTCCGGGCATACGGGGCTCAAGTTCGATCCTTTC
CCGCATCAGGGCCGCGGCGCCGATGGGCTGTCGCGCGAGCAGCGGGACGGCTATCTCGATGGCAGCATGACCCGCAAGGA
CGAGCGTGAGGCAGCCGAACTCACGGCGCTGATCCGCGAAACGGCGGGCCCCGACGTCGACATCCTGATCGATGCGCATG
GCCGCTTCGACGTTCCCACCGCCATTCGTCTCTGTCGCAGCCTCGAGGAGGCCGCCCAGATCGACTGGTTCGAGGAGCCC
TGTCCGCCCGAAAGCCTCAACGCGCTGAAGCAGGTGCGTGACAAGGTCAGTGCCCCGATCTCGTGGGGCGAGCGCGGCCA
TACGAAATGGGATTTCGTGCCGGTACTCGAGAACAAGCTCGCCGACTACATCATGCCTGATGTCACCTGGACCGGCGGCA
TTACGGAACTCAAGAAGATTTCCGCCCTGTGCGAGGCCTACTACATCCCGGTCTCGCCACATGATGCCGCAGGGCCGATC
AACGTGGTCGCGGGGGCGCAGGTGATGATGACCGTTCCCAACTTCTACAAGCTCGAAACGTCGGAGTGGAACCTGGGCAA
ATACGATCATCTCATCGACAGACCGCTCGATGTTTCGAACGGCAGCCTCAAGCTGACGTCGAAGCCTGGTCTCGGTGTCG
AGATGAACCGCGACTACCTGCAAGCCCATGAGATCGAGCTGGGCTAG

Upstream 100 bases:

>100_bases
TCCTCGAACACATGCGCGCCCGCAACGCCGCCCGGGCAGGGTAGAACAATCGGCCCGGAACACCGCTCTTCGGGTCATTC
CAGATAAGGGTAGTTGAGAG

Downstream 100 bases:

>100_bases
CAACGCTCAATGCCGGGCGGCGCCTTGGGCGACAAGCCCCCGGCCAAAACGAGGACAAATCATGCCAAAGACGGATGGAG
CCGGCGAGGCTCTCAATCGG

Product: hypothetical protein

Products: NA

Alternate protein names: GalD [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MKITSIRPWLIKSDASYWGEYLFVEVTTDEGVSGWGEITTTTKLANRALCTILRQIGAAVTGEDPARIEHLWHKIFRSFT
YMGSRGAAVECVSAIDIALWDIRGKVLGKPIYELLGGPVRDEIALYTHPNQAKFTSKEAVVREIRDIVESGHTGLKFDPF
PHQGRGADGLSREQRDGYLDGSMTRKDEREAAELTALIRETAGPDVDILIDAHGRFDVPTAIRLCRSLEEAAQIDWFEEP
CPPESLNALKQVRDKVSAPISWGERGHTKWDFVPVLENKLADYIMPDVTWTGGITELKKISALCEAYYIPVSPHDAAGPI
NVVAGAQVMMTVPNFYKLETSEWNLGKYDHLIDRPLDVSNGSLKLTSKPGLGVEMNRDYLQAHEIELG

Sequences:

>Translated_388_residues
MKITSIRPWLIKSDASYWGEYLFVEVTTDEGVSGWGEITTTTKLANRALCTILRQIGAAVTGEDPARIEHLWHKIFRSFT
YMGSRGAAVECVSAIDIALWDIRGKVLGKPIYELLGGPVRDEIALYTHPNQAKFTSKEAVVREIRDIVESGHTGLKFDPF
PHQGRGADGLSREQRDGYLDGSMTRKDEREAAELTALIRETAGPDVDILIDAHGRFDVPTAIRLCRSLEEAAQIDWFEEP
CPPESLNALKQVRDKVSAPISWGERGHTKWDFVPVLENKLADYIMPDVTWTGGITELKKISALCEAYYIPVSPHDAAGPI
NVVAGAQVMMTVPNFYKLETSEWNLGKYDHLIDRPLDVSNGSLKLTSKPGLGVEMNRDYLQAHEIELG
>Mature_388_residues
MKITSIRPWLIKSDASYWGEYLFVEVTTDEGVSGWGEITTTTKLANRALCTILRQIGAAVTGEDPARIEHLWHKIFRSFT
YMGSRGAAVECVSAIDIALWDIRGKVLGKPIYELLGGPVRDEIALYTHPNQAKFTSKEAVVREIRDIVESGHTGLKFDPF
PHQGRGADGLSREQRDGYLDGSMTRKDEREAAELTALIRETAGPDVDILIDAHGRFDVPTAIRLCRSLEEAAQIDWFEEP
CPPESLNALKQVRDKVSAPISWGERGHTKWDFVPVLENKLADYIMPDVTWTGGITELKKISALCEAYYIPVSPHDAAGPI
NVVAGAQVMMTVPNFYKLETSEWNLGKYDHLIDRPLDVSNGSLKLTSKPGLGVEMNRDYLQAHEIELG

Specific function: Catalyzes the dehydration of D-galactonate to 2-keto-3- deoxy-D-galactonate [H]

COG id: COG4948

COG function: function code MR; L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily [H]

Homologues:

Organism=Homo sapiens, GI42544119, Length=408, Percent_Identity=21.8137254901961, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI186972148, Length=342, Percent_Identity=22.8070175438596, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI48994953, Length=384, Percent_Identity=30.7291666666667, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1787864, Length=379, Percent_Identity=26.9129287598945, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI226510960, Length=376, Percent_Identity=27.9255319148936, Blast_Score=111, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018110
- InterPro:   IPR013342
- InterPro:   IPR013341
- InterPro:   IPR001354 [H]

Pfam domain/function: PF01188 MR_MLE; PF02746 MR_MLE_N [H]

EC number: =4.2.1.6 [H]

Molecular weight: Translated: 43208; Mature: 43208

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITSIRPWLIKSDASYWGEYLFVEVTTDEGVSGWGEITTTTKLANRALCTILRQIGAAV
CCCCCCCCEEEECCHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
TGEDPARIEHLWHKIFRSFTYMGSRGAAVECVSAIDIALWDIRGKVLGKPIYELLGGPVR
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCHHHHCCHHHHHCCCCCC
DEIALYTHPNQAKFTSKEAVVREIRDIVESGHTGLKFDPFPHQGRGADGLSREQRDGYLD
CCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCC
GSMTRKDEREAAELTALIRETAGPDVDILIDAHGRFDVPTAIRLCRSLEEAAQIDWFEEP
CCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCC
CPPESLNALKQVRDKVSAPISWGERGHTKWDFVPVLENKLADYIMPDVTWTGGITELKKI
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCHHHHHHH
SALCEAYYIPVSPHDAAGPINVVAGAQVMMTVPNFYKLETSEWNLGKYDHLIDRPLDVSN
HHHHHHEEECCCCCCCCCCEEEEECCEEEEECCCEEEEECCCCCCCCHHHHHCCCCCCCC
GSLKLTSKPGLGVEMNRDYLQAHEIELG
CCEEEECCCCCCEEECHHHHHHHHCCCC
>Mature Secondary Structure
MKITSIRPWLIKSDASYWGEYLFVEVTTDEGVSGWGEITTTTKLANRALCTILRQIGAAV
CCCCCCCCEEEECCHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
TGEDPARIEHLWHKIFRSFTYMGSRGAAVECVSAIDIALWDIRGKVLGKPIYELLGGPVR
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCHHHHCCHHHHHCCCCCC
DEIALYTHPNQAKFTSKEAVVREIRDIVESGHTGLKFDPFPHQGRGADGLSREQRDGYLD
CCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCC
GSMTRKDEREAAELTALIRETAGPDVDILIDAHGRFDVPTAIRLCRSLEEAAQIDWFEEP
CCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCC
CPPESLNALKQVRDKVSAPISWGERGHTKWDFVPVLENKLADYIMPDVTWTGGITELKKI
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCHHHHHHH
SALCEAYYIPVSPHDAAGPINVVAGAQVMMTVPNFYKLETSEWNLGKYDHLIDRPLDVSN
HHHHHHEEECCCCCCCCCCEEEEECCEEEEECCCEEEEECCCCCCCCHHHHHCCCCCCCC
GSLKLTSKPGLGVEMNRDYLQAHEIELG
CCEEEECCCCCCEEECHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]