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The map label for this gene is gyaR [H]

Identifier: 13471958

GI number: 13471958

Start: 1716829

End: 1717860

Strand: Direct

Name: gyaR [H]

Synonym: mlr2095

Alternate gene names: 13471958

Gene position: 1716829-1717860 (Clockwise)

Preceding gene: 13471956

Following gene: 13471959

Centisome position: 24.4

GC content: 67.83

Gene sequence:

>1032_bases
GTGCCAGACAAGGATTTGCCGCTGGTGATCAGCGCGCCGGAACCGCGCTCGCTGGAGCTGATCTTCACGCCGCCGCAGCT
GGCGCGCTTTCGGGCGAAATACCGCATCGTGGAGACCACGGCCGACGGCGTCGCCAAGCTCCCGGCCGATGTGCTGGCGC
AGGCCCGCTATATCGTCGGCCAGCCGCCGATCTCTTCCGAGACGCTGGGTCGGATGACGGCGCTGCGCTGCGTCTTCAAT
GTGGAGTCCAACCTCCTCAACAACATGCCTTACGAGACGCTGTTCGCGCGCGGCATCCATGTCGTCACCACCGGTCTGGT
CTTCGCCGAGCCGGTGGCCGAGCTCGGCCTTGCCATGGCGCTGAACCTTGCCCGCGACATCGTCGATGCCGACCTCGCCT
TCCGCAAGGGCGAAGAGCTGTGGGGCGGCGACGGCAACCAGACGGCGCGGCTGCTGTCGGGCGCCAATGTCGGCATCATC
GGCTTCGGCGATCTCGGCCGCGCGCTGAACCGGCTGCTGACGGGTTTCCGCGTCAGCACCAAAGTCTTCGATCCCTGGCT
GCCGCCGTCGATCCTGATCGACAATGGCGTCGAGCCGGCTTCGCTGGACGAGGTGCTGACATCGAGCGACTTCGTCTTCG
TCGTCGCCTCGGTGACCTCCGAGAACCAGGGCTTTCTCGGCGCGGACGCTTTCGCCAGCATGCGCAAGGGCGCCGCCTTC
ATCCTGCTCAGCCGCGCCGGCGTCGTCGATTTCCCCGCCCTTATGGCGGCGGTGAAGAGCGGCCATATCGTCGCCGCCAG
CGACGTCTTCCCAGAAGAGCCGCTGGCGAGCGACCATCCGGTCCGCACCTTGCCCGGCTTCCTGCGCTCGGCCCACCGCG
CCGGGGCGCTCGACATCGCTTTCAAGCGCATGGGCGACATGGTGCTGGAGGACATGGACCTGATCGACCGCGGCCTGCCG
CCGCTGCGCTCCAAGCGCGCCGAGCGCGAAACGGTCTCGCGCATGCGCTCCAGGCCGGTGGACCGGAACTGA

Upstream 100 bases:

>100_bases
CCGCGAAGCCACATGTCGCCCAAAACTGAAAAACGGTTTTGGACAACGACATGGGCAAAGCAAAAATGCGCGGCGTCGGA
CCGCGCCGGGAGGAATCGTC

Downstream 100 bases:

>100_bases
CGGAGGCGGCCGTTCAGGCGATTTGTCCGTGGCTTGATAAACACCGCACTCCACAGACAAGCTCAAACCGCAATGGCGCG
CGCCATAACGTGACCCTGGT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MPDKDLPLVISAPEPRSLELIFTPPQLARFRAKYRIVETTADGVAKLPADVLAQARYIVGQPPISSETLGRMTALRCVFN
VESNLLNNMPYETLFARGIHVVTTGLVFAEPVAELGLAMALNLARDIVDADLAFRKGEELWGGDGNQTARLLSGANVGII
GFGDLGRALNRLLTGFRVSTKVFDPWLPPSILIDNGVEPASLDEVLTSSDFVFVVASVTSENQGFLGADAFASMRKGAAF
ILLSRAGVVDFPALMAAVKSGHIVAASDVFPEEPLASDHPVRTLPGFLRSAHRAGALDIAFKRMGDMVLEDMDLIDRGLP
PLRSKRAERETVSRMRSRPVDRN

Sequences:

>Translated_343_residues
MPDKDLPLVISAPEPRSLELIFTPPQLARFRAKYRIVETTADGVAKLPADVLAQARYIVGQPPISSETLGRMTALRCVFN
VESNLLNNMPYETLFARGIHVVTTGLVFAEPVAELGLAMALNLARDIVDADLAFRKGEELWGGDGNQTARLLSGANVGII
GFGDLGRALNRLLTGFRVSTKVFDPWLPPSILIDNGVEPASLDEVLTSSDFVFVVASVTSENQGFLGADAFASMRKGAAF
ILLSRAGVVDFPALMAAVKSGHIVAASDVFPEEPLASDHPVRTLPGFLRSAHRAGALDIAFKRMGDMVLEDMDLIDRGLP
PLRSKRAERETVSRMRSRPVDRN
>Mature_342_residues
PDKDLPLVISAPEPRSLELIFTPPQLARFRAKYRIVETTADGVAKLPADVLAQARYIVGQPPISSETLGRMTALRCVFNV
ESNLLNNMPYETLFARGIHVVTTGLVFAEPVAELGLAMALNLARDIVDADLAFRKGEELWGGDGNQTARLLSGANVGIIG
FGDLGRALNRLLTGFRVSTKVFDPWLPPSILIDNGVEPASLDEVLTSSDFVFVVASVTSENQGFLGADAFASMRKGAAFI
LLSRAGVVDFPALMAAVKSGHIVAASDVFPEEPLASDHPVRTLPGFLRSAHRAGALDIAFKRMGDMVLEDMDLIDRGLPP
LRSKRAERETVSRMRSRPVDRN

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=227, Percent_Identity=31.7180616740088, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI23308577, Length=190, Percent_Identity=31.0526315789474, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI145580578, Length=240, Percent_Identity=27.9166666666667, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI4557499, Length=240, Percent_Identity=27.9166666666667, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI61743967, Length=240, Percent_Identity=27.9166666666667, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI4557497, Length=240, Percent_Identity=27.9166666666667, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI145580575, Length=240, Percent_Identity=27.9166666666667, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI87082289, Length=264, Percent_Identity=29.9242424242424, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787645, Length=204, Percent_Identity=28.4313725490196, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789279, Length=242, Percent_Identity=27.6859504132231, Blast_Score=68, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320925, Length=260, Percent_Identity=30, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322116, Length=183, Percent_Identity=33.879781420765, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28571528, Length=237, Percent_Identity=29.535864978903, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI62472511, Length=218, Percent_Identity=27.5229357798165, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24646446, Length=218, Percent_Identity=27.5229357798165, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24646448, Length=218, Percent_Identity=27.5229357798165, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24646452, Length=218, Percent_Identity=27.5229357798165, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24646450, Length=218, Percent_Identity=27.5229357798165, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28574286, Length=219, Percent_Identity=26.9406392694064, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 37119; Mature: 36988

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDKDLPLVISAPEPRSLELIFTPPQLARFRAKYRIVETTADGVAKLPADVLAQARYIVG
CCCCCCCEEEECCCCCCEEEEECCHHHHHHHHHHEEEEECCCHHHHCCHHHHHHHHHHCC
QPPISSETLGRMTALRCVFNVESNLLNNMPYETLFARGIHVVTTGLVFAEPVAELGLAMA
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LNLARDIVDADLAFRKGEELWGGDGNQTARLLSGANVGIIGFGDLGRALNRLLTGFRVST
HHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHH
KVFDPWLPPSILIDNGVEPASLDEVLTSSDFVFVVASVTSENQGFLGADAFASMRKGAAF
HHCCCCCCCCEEECCCCCCCHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCEE
ILLSRAGVVDFPALMAAVKSGHIVAASDVFPEEPLASDHPVRTLPGFLRSAHRAGALDIA
EEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHH
FKRMGDMVLEDMDLIDRGLPPLRSKRAERETVSRMRSRPVDRN
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PDKDLPLVISAPEPRSLELIFTPPQLARFRAKYRIVETTADGVAKLPADVLAQARYIVG
CCCCCCEEEECCCCCCEEEEECCHHHHHHHHHHEEEEECCCHHHHCCHHHHHHHHHHCC
QPPISSETLGRMTALRCVFNVESNLLNNMPYETLFARGIHVVTTGLVFAEPVAELGLAMA
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LNLARDIVDADLAFRKGEELWGGDGNQTARLLSGANVGIIGFGDLGRALNRLLTGFRVST
HHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHH
KVFDPWLPPSILIDNGVEPASLDEVLTSSDFVFVVASVTSENQGFLGADAFASMRKGAAF
HHCCCCCCCCEEECCCCCCCHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCEE
ILLSRAGVVDFPALMAAVKSGHIVAASDVFPEEPLASDHPVRTLPGFLRSAHRAGALDIA
EEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHH
FKRMGDMVLEDMDLIDRGLPPLRSKRAERETVSRMRSRPVDRN
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA