Click here to switch to the map view.

The map label for this gene is hsrA [H]

Identifier: 13471679

GI number: 13471679

Start: 1442683

End: 1444116

Strand: Reverse

Name: hsrA [H]

Synonym: mll1728

Alternate gene names: 13471679

Gene position: 1444116-1442683 (Counterclockwise)

Preceding gene: 13471682

Following gene: 13471678

Centisome position: 20.52

GC content: 65.69

Gene sequence:

>1434_bases
ATGACTGCCATTCCCGAGACTGAAGCCTTACCCGAAACGGCCACCAATGCGCGGCGCGTGGCGCTGATCGTCGCCATCGC
CTTCTTCATGCAGCTGCTGGATTCGACGATCATCTCGACCTCGCTGCCGCAGATGGGCCAGTCCTACGGCGTGCCGGCGG
TGGCGATGAGCGTCGGCATCACCGTCTACATGCTGACCATGGCGGTGTTCGTGCCGCTGTCGGGCTGGCTCGCCGACCGC
TTCGGCGCGCGCAACATTTTCCTCGTGGCTATCGCGCTGTTCACGCTGGCCTCGCTCGCCTGCGGCTTCTCGCAAAATCT
GACCCAATTCGTTGCCGCTCGCGCCGTGCAGGGGCTGGGCAGTGCGCTGATGACGCCGGTCGGCCGCATCCTCGTCCTGC
GCAATGCATCGAAATCCGAGCTGCTCAACGCCACCGCGCTGATCACCTGGCCGGCGCTGTTCGCGCCGGTGGTCGGTCCG
GTGCTTGGCGGCTTCATCACCACCACTCTGTCCTGGCACTGGAATTTCTTCATCAACATCCCGCTTGGGCTGATCGGGCT
GGCGCTGGTTGCCCGCTTCATCCCGGGCGATCGCGTGGCCAATCCCAAGCCGCTCGACTGGCCAGGGTTTTTCCTGACGT
CGCTCGGGCTCGCCTGCCTGCTCTACGGCCTCGAGCGCATCGCGCATCCCGAGGATGGCATGCTGCCGACGGTGCTGCTG
ATCGCGGCGGGCATCGTCATCGGCTGGCTGGCGGTGCGGCATCTGCGGCGCGCGCCACATCCGCTGCTCGACCTCTCCTC
GTTCAAGGTGCTGACCTTCGCCATCTCGACGCTTGCAGCCGGCACCATCTTCCGGGTGGCGATCAACGCCACGCCGTTCC
TGTTGCCGCTTTTGTTCCAGCTCGGCTTCGGCCTGTCGCCCGTCGATGCCGGCCTGATGATCCTGGCCTATTTCGTCGGC
AATCTCGGCATGAAGACGGTGACGACGCCGACGCTGCGGCGTTTCGGGTTCCGTTCGGTGATGGTGGTCAACGGCATCAT
CGCCTCGGCCTCGATCATGGCTTGCGGGGTGATCTCGCCGCAGACGCCGCAGGCGCTGGTGGTGGTGCTGATGCTGATCG
CCGGCCTGTCGCGCTCGATGCAGTTCACCGCGCTCAACACCCTGGCCTTCGCCGACATCGACGCCGCGCGGCGGAGCTCG
GCGGCGACGTTGTCCTCGATGCTGCAGCAGGTGGCGATGCTGTTCGGCGTTGCCGTGGCCGCGGCGATCCTCAATCTGTC
GCAGATCGCCAGGGCGCAACCGTCGCTCGACCTCGTCGATTTTCGAATCGCCTTTTTCGTGATCGGCGCCATCGGGCTGG
TGGCGGCGTTGCGTTTTCTGGTGCTGCCACGAGCTGCGGGAGCCGAGGTTTCCGGTCACGTGCCGGGGAATTGA

Upstream 100 bases:

>100_bases
CTCGCCCCGTCCATCCCATAGCAGGCCGCGACGCGACACGAAAGTTTGTTGCGCTGGCTATGGACGCAGCCGGCCAGATG
CTGTTCAAACCCGTACCGAC

Downstream 100 bases:

>100_bases
AAATTGGATTTTCTCGCCTGATGCGGAGATAAATTCCGCCTCATCCTTTCGCCTTGATGCAGCACTTTCGCGAAATGGCT
GCGATAGCGCAATCGATTGC

Product: transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: High-copy suppressor of rspA [H]

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MTAIPETEALPETATNARRVALIVAIAFFMQLLDSTIISTSLPQMGQSYGVPAVAMSVGITVYMLTMAVFVPLSGWLADR
FGARNIFLVAIALFTLASLACGFSQNLTQFVAARAVQGLGSALMTPVGRILVLRNASKSELLNATALITWPALFAPVVGP
VLGGFITTTLSWHWNFFINIPLGLIGLALVARFIPGDRVANPKPLDWPGFFLTSLGLACLLYGLERIAHPEDGMLPTVLL
IAAGIVIGWLAVRHLRRAPHPLLDLSSFKVLTFAISTLAAGTIFRVAINATPFLLPLLFQLGFGLSPVDAGLMILAYFVG
NLGMKTVTTPTLRRFGFRSVMVVNGIIASASIMACGVISPQTPQALVVVLMLIAGLSRSMQFTALNTLAFADIDAARRSS
AATLSSMLQQVAMLFGVAVAAAILNLSQIARAQPSLDLVDFRIAFFVIGAIGLVAALRFLVLPRAAGAEVSGHVPGN

Sequences:

>Translated_477_residues
MTAIPETEALPETATNARRVALIVAIAFFMQLLDSTIISTSLPQMGQSYGVPAVAMSVGITVYMLTMAVFVPLSGWLADR
FGARNIFLVAIALFTLASLACGFSQNLTQFVAARAVQGLGSALMTPVGRILVLRNASKSELLNATALITWPALFAPVVGP
VLGGFITTTLSWHWNFFINIPLGLIGLALVARFIPGDRVANPKPLDWPGFFLTSLGLACLLYGLERIAHPEDGMLPTVLL
IAAGIVIGWLAVRHLRRAPHPLLDLSSFKVLTFAISTLAAGTIFRVAINATPFLLPLLFQLGFGLSPVDAGLMILAYFVG
NLGMKTVTTPTLRRFGFRSVMVVNGIIASASIMACGVISPQTPQALVVVLMLIAGLSRSMQFTALNTLAFADIDAARRSS
AATLSSMLQQVAMLFGVAVAAAILNLSQIARAQPSLDLVDFRIAFFVIGAIGLVAALRFLVLPRAAGAEVSGHVPGN
>Mature_476_residues
TAIPETEALPETATNARRVALIVAIAFFMQLLDSTIISTSLPQMGQSYGVPAVAMSVGITVYMLTMAVFVPLSGWLADRF
GARNIFLVAIALFTLASLACGFSQNLTQFVAARAVQGLGSALMTPVGRILVLRNASKSELLNATALITWPALFAPVVGPV
LGGFITTTLSWHWNFFINIPLGLIGLALVARFIPGDRVANPKPLDWPGFFLTSLGLACLLYGLERIAHPEDGMLPTVLLI
AAGIVIGWLAVRHLRRAPHPLLDLSSFKVLTFAISTLAAGTIFRVAINATPFLLPLLFQLGFGLSPVDAGLMILAYFVGN
LGMKTVTTPTLRRFGFRSVMVVNGIIASASIMACGVISPQTPQALVVVLMLIAGLSRSMQFTALNTLAFADIDAARRSSA
ATLSSMLQQVAMLFGVAVAAAILNLSQIARAQPSLDLVDFRIAFFVIGAIGLVAALRFLVLPRAAGAEVSGHVPGN

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=447, Percent_Identity=36.9127516778523, Blast_Score=278, Evalue=7e-76,
Organism=Escherichia coli, GI1788392, Length=428, Percent_Identity=35.0467289719626, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1788710, Length=424, Percent_Identity=27.8301886792453, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1789042, Length=431, Percent_Identity=27.1461716937355, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI87081983, Length=296, Percent_Identity=27.7027027027027, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319770, Length=405, Percent_Identity=26.4197530864197, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6325455, Length=135, Percent_Identity=28.1481481481481, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50454; Mature: 50323

Theoretical pI: Translated: 10.85; Mature: 10.85

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAIPETEALPETATNARRVALIVAIAFFMQLLDSTIISTSLPQMGQSYGVPAVAMSVGI
CCCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHH
TVYMLTMAVFVPLSGWLADRFGARNIFLVAIALFTLASLACGFSQNLTQFVAARAVQGLG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
SALMTPVGRILVLRNASKSELLNATALITWPALFAPVVGPVLGGFITTTLSWHWNFFINI
HHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEC
PLGLIGLALVARFIPGDRVANPKPLDWPGFFLTSLGLACLLYGLERIAHPEDGMLPTVLL
CHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
IAAGIVIGWLAVRHLRRAPHPLLDLSSFKVLTFAISTLAAGTIFRVAINATPFLLPLLFQ
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHH
LGFGLSPVDAGLMILAYFVGNLGMKTVTTPTLRRFGFRSVMVVNGIIASASIMACGVISP
HCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
QTPQALVVVLMLIAGLSRSMQFTALNTLAFADIDAARRSSAATLSSMLQQVAMLFGVAVA
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAILNLSQIARAQPSLDLVDFRIAFFVIGAIGLVAALRFLVLPRAAGAEVSGHVPGN
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAIPETEALPETATNARRVALIVAIAFFMQLLDSTIISTSLPQMGQSYGVPAVAMSVGI
CCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHH
TVYMLTMAVFVPLSGWLADRFGARNIFLVAIALFTLASLACGFSQNLTQFVAARAVQGLG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
SALMTPVGRILVLRNASKSELLNATALITWPALFAPVVGPVLGGFITTTLSWHWNFFINI
HHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEC
PLGLIGLALVARFIPGDRVANPKPLDWPGFFLTSLGLACLLYGLERIAHPEDGMLPTVLL
CHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
IAAGIVIGWLAVRHLRRAPHPLLDLSSFKVLTFAISTLAAGTIFRVAINATPFLLPLLFQ
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHH
LGFGLSPVDAGLMILAYFVGNLGMKTVTTPTLRRFGFRSVMVVNGIIASASIMACGVISP
HCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
QTPQALVVVLMLIAGLSRSMQFTALNTLAFADIDAARRSSAATLSSMLQQVAMLFGVAVA
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAILNLSQIARAQPSLDLVDFRIAFFVIGAIGLVAALRFLVLPRAAGAEVSGHVPGN
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]