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The map label for this gene is panB [H]

Identifier: 13471682

GI number: 13471682

Start: 1446743

End: 1447546

Strand: Reverse

Name: panB [H]

Synonym: mll1731

Alternate gene names: 13471682

Gene position: 1447546-1446743 (Counterclockwise)

Preceding gene: 13471683

Following gene: 13471679

Centisome position: 20.57

GC content: 65.17

Gene sequence:

>804_bases
ATGAGCCGAAAGAGACCGACCGTCGCCGATCTGCGCGCGATGAAGGGCAAGCGCCAGCTGACCATGCTGCGCGTGCTCAA
CCTGGACGAGGCGCAGGCCGCCGAGCGGGCTGGGGTCGACATCGTCTCGGTGCCGCCCGAACTGGTGCTCAACCCGCAGT
ATCGCGATGCCGCGCCCAGCCTGTTCACCATGCCGGGCGAGAATTTCTTCGAGATCGGCACTGCGGATGATTTCGTGCGC
TGGGCCTTCCGGCTCTACAAGGCAAGCGCCGACGCGGTCTATTGCAGCGCCGGCTATGCCACGATCAAACGGATGGCGGA
CGATGCCATTCCCGTCATCGGCCATGTCGGCCTCATTCCGTCACGCGCCACCTGGACCGGCGGCTTCAAGGCGGTCGGCA
AGACCGCCGACACAGCCATCCAGGTTTTCGAAGCGGTGAAGCAGCTGGAGGCCGCCGGTGCTGTCGGCGCCGAGATCGAA
GTGGTGCCGGTCGAGGTCGCCAAGGCGATCTCGGAGCGCACCTCGCTGATCATGCTGTCGATGGGGGCGGGCACCGGCTG
CGACGCGCAATATCTGTTCGCCGACGACATTCTCGGCCAGAACCGGGGTCACATGCCGCGCCACTCCAAGGTCTACCGCA
ACTTCGCCGCCGAGTATGACAGGCTGCAGGCCGAGCGGGTGGCGGCGTTCTCCGAATATGTCGCCGACGTCAACAGCGGC
GCCTATCCCGAGGACAGGCACGTCGTGCACATGGACCCGGCCGAGCTCAGCCTGTTCATGAAAAGGGTAGACGCAAAGAG
CTGA

Upstream 100 bases:

>100_bases
GTCAATCTCGTGACCTATCCGGTAAAGATCGAGGCCGGTAAGGTGATGATCCAGATTTGACGCGCGGCAACCGATCCAGC
ATCACAAAGGGGACGTTTTA

Downstream 100 bases:

>100_bases
TTATTCGGATTCTTTGCTGATCATCGCTGCGCCTCGCCACGCTCCATCGGCGAGCATGGCGTGGAGCACCTCGGCGTCGT
TCCCAAGCGGCCGGTCGTCT

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MSRKRPTVADLRAMKGKRQLTMLRVLNLDEAQAAERAGVDIVSVPPELVLNPQYRDAAPSLFTMPGENFFEIGTADDFVR
WAFRLYKASADAVYCSAGYATIKRMADDAIPVIGHVGLIPSRATWTGGFKAVGKTADTAIQVFEAVKQLEAAGAVGAEIE
VVPVEVAKAISERTSLIMLSMGAGTGCDAQYLFADDILGQNRGHMPRHSKVYRNFAAEYDRLQAERVAAFSEYVADVNSG
AYPEDRHVVHMDPAELSLFMKRVDAKS

Sequences:

>Translated_267_residues
MSRKRPTVADLRAMKGKRQLTMLRVLNLDEAQAAERAGVDIVSVPPELVLNPQYRDAAPSLFTMPGENFFEIGTADDFVR
WAFRLYKASADAVYCSAGYATIKRMADDAIPVIGHVGLIPSRATWTGGFKAVGKTADTAIQVFEAVKQLEAAGAVGAEIE
VVPVEVAKAISERTSLIMLSMGAGTGCDAQYLFADDILGQNRGHMPRHSKVYRNFAAEYDRLQAERVAAFSEYVADVNSG
AYPEDRHVVHMDPAELSLFMKRVDAKS
>Mature_266_residues
SRKRPTVADLRAMKGKRQLTMLRVLNLDEAQAAERAGVDIVSVPPELVLNPQYRDAAPSLFTMPGENFFEIGTADDFVRW
AFRLYKASADAVYCSAGYATIKRMADDAIPVIGHVGLIPSRATWTGGFKAVGKTADTAIQVFEAVKQLEAAGAVGAEIEV
VPVEVAKAISERTSLIMLSMGAGTGCDAQYLFADDILGQNRGHMPRHSKVYRNFAAEYDRLQAERVAAFSEYVADVNSGA
YPEDRHVVHMDPAELSLFMKRVDAKS

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=199, Percent_Identity=33.1658291457286, Blast_Score=105, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6319653, Length=167, Percent_Identity=26.3473053892216, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 29162; Mature: 29030

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKRPTVADLRAMKGKRQLTMLRVLNLDEAQAAERAGVDIVSVPPELVLNPQYRDAAPS
CCCCCCCHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHCCEEEECCHHHEECCCCCCCCCC
LFTMPGENFFEIGTADDFVRWAFRLYKASADAVYCSAGYATIKRMADDAIPVIGHVGLIP
EEECCCCCEEECCCHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCHHHHCCCCC
SRATWTGGFKAVGKTADTAIQVFEAVKQLEAAGAVGAEIEVVPVEVAKAISERTSLIMLS
CCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCEEEEEE
MGAGTGCDAQYLFADDILGQNRGHMPRHSKVYRNFAAEYDRLQAERVAAFSEYVADVNSG
ECCCCCCCCEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AYPEDRHVVHMDPAELSLFMKRVDAKS
CCCCCCEEEEECHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SRKRPTVADLRAMKGKRQLTMLRVLNLDEAQAAERAGVDIVSVPPELVLNPQYRDAAPS
CCCCCCHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHCCEEEECCHHHEECCCCCCCCCC
LFTMPGENFFEIGTADDFVRWAFRLYKASADAVYCSAGYATIKRMADDAIPVIGHVGLIP
EEECCCCCEEECCCHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCHHHHCCCCC
SRATWTGGFKAVGKTADTAIQVFEAVKQLEAAGAVGAEIEVVPVEVAKAISERTSLIMLS
CCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCEEEEEE
MGAGTGCDAQYLFADDILGQNRGHMPRHSKVYRNFAAEYDRLQAERVAAFSEYVADVNSG
ECCCCCCCCEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AYPEDRHVVHMDPAELSLFMKRVDAKS
CCCCCCEEEEECHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA